Abstract:
:The hedgehog (Hh) signaling pathway plays many roles in invertebrate and vertebrate development. For example, specific inhibition of sonic Hh expression is critical during early stages of pancreas organogenesis, but an active Hh pathway appears to be required for maintenance of adult endocrine functions. Mutational inactivation of the Hh pathway has been demonstrated in human malignancies of the skin, cerebellum, and skeletal muscle. Now, two papers implicate aberrant Hh signaling in human upper gastrointestinal cancers including those developing from the esophagus, stomach, biliary tract, and pancreas.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Xie K,Abbruzzese JLdoi
10.1016/s1535-6108(03)00246-0keywords:
subject
Has Abstractpub_date
2003-10-01 00:00:00pages
245-7issue
4eissn
1535-6108issn
1878-3686pii
S1535610803002460journal_volume
4pub_type
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