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Successful targeting of ErbB2 receptors-is PTEN the key?

Abstract：

:Women with ErbB2-positive breast cancer have a poor prognosis, and frequently, chemotherapy treatment is ineffective. The ErbB2-targeted antibody trastuzumab improves survival when given with chemotherapy to patients with ErbB2-overexpressing metastatic disease, but treatment is not curative, and primary resistance is common. Postulated mechanisms of action for trastuzumab include immune-mediated cytotoxicity and receptor downmodulation. A study in this issue of Cancer Cell suggests that trastuzumab causes rapid activation of the PTEN lipid phosphatase, which in turn downregulates the phosphatidylinositol 3'-kinase (PI3K) pathway. Resistance to trastuzumab occurs when PTEN function is lost, suggesting that PTEN activation is a critical component of the therapeutic effect.

journal_name

Cancer Cell

journal_title

Cancer cell

authors

Crowder RJ,Lombardi DP,Ellis MJ

doi

10.1016/j.ccr.2004.08.001

keywords:

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

103-4

issue

2

eissn

1535-6108

issn

1878-3686

pii

S1535610804002119

journal_volume

6

pub_type

评论,杂志文章

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