Abstract:
:Rhabdomyosarcoma is a soft-tissue sarcoma with molecular and cellular features of developing skeletal muscle. Rhabdomyosarcoma has two major histologic subtypes, embryonal and alveolar, each with distinct clinical, molecular, and genetic features. Genomic analysis shows that embryonal tumors have more structural and copy number variations than alveolar tumors. Mutations in the RAS/NF1 pathway are significantly associated with intermediate- and high-risk embryonal rhabdomyosarcomas (ERMS). In contrast, alveolar rhabdomyosarcomas (ARMS) have fewer genetic lesions overall and no known recurrently mutated cancer consensus genes. To identify therapeutics for ERMS, we developed and characterized orthotopic xenografts of tumors that were sequenced in our study. High-throughput screening of primary cultures derived from those xenografts identified oxidative stress as a pathway of therapeutic relevance for ERMS.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Chen X,Stewart E,Shelat AA,Qu C,Bahrami A,Hatley M,Wu G,Bradley C,McEvoy J,Pappo A,Spunt S,Valentine MB,Valentine V,Krafcik F,Lang WH,Wierdl M,Tsurkan L,Tolleman V,Federico SM,Morton C,Lu C,Ding L,Easton J,Rdoi
10.1016/j.ccr.2013.11.002subject
Has Abstractpub_date
2013-12-09 00:00:00pages
710-24issue
6eissn
1535-6108issn
1878-3686pii
S1535-6108(13)00490-Xjournal_volume
24pub_type
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