In vitro and ex vivo effect of hyaluronic acid on erythrocyte flow properties.

abstract：:Exposure of cells and organs to heat shock is associated with numerous changes in various cellular metabolic parameters and overexpression of proteins collectively known as heat shock proteins (HSP). In this communication we review the cell-signaling events that are altered in response to heat shock as they relate to ...

journal_title：Journal of biomedical science

authors： Gong Kiang J,Tsokos GC

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Whether microgravity might influence tumour growth and carcinogenesis is still an open issue. It is not clear also if and how normal and transformed cells are differently solicited by microgravity. The present study was designed to verify this issue. METHODS:Two normal, LB and HSC93, and two transformed, Ju...

journal_title：Journal of biomedical science

authors： Cuccarolo P,Barbieri F,Sancandi M,Viaggi S,Degan P

更新日期：2010-07-28 00:00:00

abstract：BACKGROUND:The apolipoprotein E4 (apoE4) genotype is a major risk factor for developing late-onset Alzheimer's disease (AD). Inheritance of apoE4 is also associated with impairments in olfactory function in early stages of AD. In this project we examined the effects of the three common isoforms of human apoE (apoE2, ap...

journal_title：Journal of biomedical science

authors： Hussain A,Luong M,Pooley A,Nathan BP

更新日期：2013-07-12 00:00:00

abstract：:We studied 42 individuals, including 8 patients with either complete or partial syndrome of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS), 8 patients with either complete or partial syndrome of myoclonic epilepsy with ragged-red fibers (MERRF) and 26 maternal family members w...

journal_title：Journal of biomedical science

authors： Huang CC,Kuo HC,Chu CC,Liou CW,Ma YS,Wei YH

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:The probability of local tumor control after radiotherapy (RT) remains still miserably poor in pediatric rhabdomyosarcoma (RMS). Thus, understanding the molecular mechanisms responsible of tumor relapse is essential to identify personalized RT-based strategies. Contrary to what has been done so far, a correc...

journal_title：Journal of biomedical science

authors： Petragnano F,Pietrantoni I,Camero S,Codenotti S,Milazzo L,Vulcano F,Macioce G,Giordani I,Tini P,Cheleschi S,Gravina GL,Festuccia C,Rossetti A,Delle Monache S,Ordinelli A,Ciccarelli C,Mauro A,Barbara B,Antinozzi C,Sc

更新日期：2020-08-27 00:00:00

abstract：:The first- and second-generation epidermal growth factor receptor tyrosine kinase inhibitors (1/2G EGFR-TKIs) gefitinib, erlotinib, and afatinib have all been approved as standard first-line treatments for advanced EGFR mutation-positive non-small cell lung cancer. The third-generation (3G) EGFR-TKIs have been develop...

journal_title：Journal of biomedical science

authors： Liao BC,Lin CC,Lee JH,Yang JC

更新日期：2016-12-03 00:00:00

abstract：:An isolated thoracic spinal cord of the neonatal rat in vitro spontaneously generates sympathetic nerve discharge (SND) at ~25 degrees C, but it fails in SND genesis at < or = 10 degrees C. Basal levels of the c-Fos expression in the spinal cords incubated at < or = 10 degrees C and ~25 degrees C were compared to dete...

journal_title：Journal of biomedical science

authors： Su CK,Ho CM,Kuo HH,Wen YC,Chai CY

更新日期：2009-05-01 00:00:00

abstract：:To identify novel genes associated with apoptosis in glioma cells, we treated T98G glioma cells with okadaic acid (OA). Differential display using 15 random primers was performed on RNA extracted from these cells. Upregulated bands were excised from polyacrylamide gels and cloned. Northern blots were used to confirm R...

journal_title：Journal of biomedical science

authors： Chin LS,Singh SK,Wang Q,Murray SF

更新日期：2000-03-01 00:00:00

abstract：:The goal of this study was to evaluate the effect of chronic Zn2+ administration (1 mg/kg/day for 1 month) in Sprague-Dawley rats (n = 11) on motility and rearing behaviors (number of events/10 min measured in motility cage), on memory (percentage of failures using a foot-shock double T maze), on the number of muscari...

journal_title：Journal of biomedical science

authors： Bonfante-Cabarcas R,Bravo I,Nello C,Gutiérrez-Reyes E,Loureiro Dos Santos NE,Moreno-Yanes JA

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Pseudomonas aeruginosa is a Gram-negative pathogen that frequently causes life-threatening infections in immunocompromised patients. We previously showed that subinhibitory concentrations of short synthetic peptides permeabilize P. aeruginosa and enhance the lethal action of co-administered antibiotics. MET...

journal_title：Journal of biomedical science

authors： Rázquin-Olazarán I,Shahrour H,Martínez-de-Tejada G

更新日期：2020-08-06 00:00:00

abstract：:The dual signal hypothesis of apoptosis holds that a common signal can activate both apoptotic and proliferative pathways. The fate of a cell is dependent on which of these two pathways predominates. In the MAPK family of kinases, ERK and JNK have been proposed to mediate apoptosis whereas the PI3K-stimulated kinase, ...

journal_title：Journal of biomedical science

authors： Chin LS,Murray SF,Harter DH,Doherty PF,Singh SK

更新日期：1999-05-01 00:00:00

abstract：:Different human retroviruses, such as Human Immunodeficiency Virus (HIV) and Human T-cell Lymphotropic Virus (HTLV), can cause neurologic infection. However, a definitive diagnosis may be hampered by several factors. Quantification of the viral or proviral load in cerebrospinal fluid (CSF) may be helpful in the diagno...

journal_title：Journal of biomedical science

authors： Rosadas C,Puccioni-Sohler M

更新日期：2015-08-08 00:00:00

abstract：:Based on the tertiary structure of the ribosome-inactivating protein alpha-sarcin, domains that are responsible for hydrolyzing ribosomes and naked RNA have been dissected. In this study, we found that the head-to-tail interaction between the first amino beta-strand and the last carboxyl beta-strand is not involved in...

journal_title：Journal of biomedical science

authors： Hwu L,Huang K,Chen D,Lin A

更新日期：2000-09-01 00:00:00

abstract：:Fibroblasts derived from glucose-6-phosphate dehydrogenase (G6PD)-deficient patients display retarded growth and accelerated cellular senescence that is attributable to increased accumulation of oxidative DNA damage and increased sensitivity to oxidant-induced senescence, but not to accelerated telomere attrition. Her...

journal_title：Journal of biomedical science

authors： Wu YH,Cheng ML,Ho HY,Chiu DT,Wang TC

更新日期：2009-02-05 00:00:00

abstract：:Zebrafish tbx5 expresses in the heart, pectoral fins and eyes of zebrafish during embryonic development. In zebrafish, injection of tbx5 morpholino antisense RNA caused changes of heart conformation, defect of heart looping, pericardium effusion, dropsy of ventral position and decreased heart rate. We suggested that c...

journal_title：Journal of biomedical science

authors： Lu JH,Lu JK,Choo SL,Li YC,Yeh HW,Shiue JF,Yeh VC

更新日期：2008-11-01 00:00:00

abstract：:The Tat proteins of human immunodeficiency virus types 1 (HIV-1) and 2 (HIV-2), termed Tat-1 and Tat-2, respectively, are essential for efficient viral replication. Tat proteins activate viral transcription by binding to the TAR RNA stem-loop structure at the 5' end of viral transcripts. We used an in vitro selection ...

journal_title：Journal of biomedical science

authors： Rhim H,Rice AP

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Glioma stem-like cells (GSCs) are proposed to be responsible for high resistance in glioblastoma multiforme (GBM) treatment. In order to find new strategies aimed at reducing GSC stemness and improving GBM patient survival, we investigated the effects and mechanism of a histone deacetylases (HDACs) inhibitor...

journal_title：Journal of biomedical science

authors： Hsu CC,Chang WC,Hsu TI,Liu JJ,Yeh SH,Wang JY,Liou JP,Ko CY,Chang KY,Chuang JY

更新日期：2016-11-18 00:00:00

abstract：BACKGROUND:Activating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER)-localised protein and member of the leucine zipper family of transcription factors. Best known for its role in transducing signals linked to stress to the endoplasmic reticulum, the 50 kDa activated form of ATF6 is now emerging as a ma...

journal_title：Journal of biomedical science

authors： Hillary RF,FitzGerald U

更新日期：2018-05-25 00:00:00

abstract：:The signaling pathways leading to extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) activation by N-formyl-Met-Leu-Phe (fMLP) or platelet activating factor (PAF) in human neutrophils were examined. Previously, we found that changes of intracellular Ca2+ ([Ca2+]i) stimulated by...

journal_title：Journal of biomedical science

authors： Chen LW,Lin MW,Hsu CM

更新日期：2005-01-01 00:00:00

abstract：:Spinal muscular atrophy (SMA) is an autosomal recessive disorder characterized by degeneration of lower motor neurons. We have assayed deletions in two candidate genes, the survival motor neuron (SMN) and neuronal apoptosis inhibitory protein (NAIP) genes, in 108 samples, of which 46 were from SMA patients, and 62 wer...

journal_title：Journal of biomedical science

authors： Haider MZ,Moosa A,Dalal H,Habib Y,Reynold L

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Most of the circulating Vitamin D (VitD) is transported bound to vitamin D-binding protein (DBP), and several DBP single nucleotide polymorphisms (SNPs) have been related to circulating VitD concentration and disease. In this study, we evaluated the association among DBP SNPs and AIDS progression in antiretr...

journal_title：Journal of biomedical science

authors： Jiménez-Sousa MÁ,Jiménez JL,Fernández-Rodríguez A,Bellón JM,Rodríguez C,Riera M,Portilla J,Castro Á,Muñoz-Fernández MÁ,Resino S

更新日期：2019-10-23 00:00:00

abstract：:Mitochondria are the major intracellular source and target sites of reactive oxygen species (ROS) that are continually generated as by-products of aerobic metabolism in animal and human cells. It has been demonstrated that mitochondrial respiratory function declines with age in various human tissues and that a defecti...

journal_title：Journal of biomedical science

authors： Lee HC,Wei YH

更新日期：1997-11-01 00:00:00

abstract：:The effects of a single or repeated dermal administration of methyl parathion on motor function, learning and memory were investigated in adult female rats and correlated with blood cholinesterase activity. Exposure to a single dose of 50 mg/kg methyl parathion (75% of the dermal LD(50)) resulted in an 88% inhibition ...

journal_title：Journal of biomedical science

authors： Zhu H,Rockhold RW,Baker RC,Kramer RE,Ho IK

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:Parkinson's disease is the second most common neurodegenerative disorders after Alzheimer's disease. The main cause of the disease is the massive degeneration of dopaminergic neurons in the substantia nigra. Neuronal apoptosis and neuroinflammation are thought to be the key contributors to the neuronal degen...

journal_title：Journal of biomedical science

authors： Lin YL,Tsay HJ,Lai TH,Tzeng TT,Shiao YJ

更新日期：2015-05-28 00:00:00

abstract：:Sequencing of HIV-1(GER) long terminal repeat (LTR) has demonstrated, for the first time in an HIV-1 primary isolate, a TAR duplication referred to as TAR1 (nucleotides +1 through +68) and TAR2 (nucleotides +69 through +136). This TAR duplication is stable during replication of HIV-1(GER) isolate in CEM cells. Analysi...

journal_title：Journal of biomedical science

authors： Emiliani S,Coudronnière N,Delsert C,Devaux C

更新日期：1996-01-01 00:00:00

abstract：:Purinergic P2X7 receptor (P2X7R), an ATP-gated cation channel, is unique among all other family members because of its ability to respond to various stimuli and to modulate pro-inflammatory signaling. The activation of P2X7R in immune cells is absolutely required for mature interleukin -1beta (IL-1beta) and IL-18 prod...

journal_title：Journal of biomedical science

authors： Mishra A

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Sensing tissue acidosis is an important function of the somatosensory nervous system to response to noxious stimuli. MAIN BODY:In the pain clinic, acid or soreness sensation is a characteristic sensory phenotype of various acute and chronic pain syndromes, such as delayed onset muscle soreness, fibromyalgia...

journal_title：Journal of biomedical science

authors： Lin JH,Hung CH,Han DS,Chen ST,Lee CH,Sun WZ,Chen CC

更新日期：2018-11-29 00:00:00

abstract：:Human mesenchymal stem cells (MSCs) are multilineage somatic progenitor/stem cells that have been shown to possess immunomodulatory properties in recent years. Initially met with much skepticism, MSC immunomodulation has now been well reproduced across tissue sources and species to be clinically relevant. This has ope...

journal_title：Journal of biomedical science

authors： Wang LT,Ting CH,Yen ML,Liu KJ,Sytwu HK,Wu KK,Yen BL

更新日期：2016-11-04 00:00:00

abstract：:Engineering approaches were adopted for liver microsystems to recapitulate cell arrangements and culture microenvironments in vivo for sensitive, high-throughput and biomimetic drug screening. This review introduces liver microsystems in vitro for drug hepatotoxicity, drug-drug interactions, metabolic function and enz...

journal_title：Journal of biomedical science

authors： Lee JH,Ho KL,Fan SK

更新日期：2019-10-28 00:00:00

abstract：:Critical assessment of experimental muscle-pain models resulting from maximal muscle contraction may provide a means of assessing hypersensitivity and the central nociceptive mechanisms involved in diffused muscle pain. The aim of the present study was, therefore, to investigate the patterns of nociceptive behavior an...

journal_title：Journal of biomedical science

authors： Wang SF,Chen CC,Liao WS,Shyu BC

更新日期：2005-01-01 00:00:00