Relevance of retrovirus quantification in cerebrospinal fluid for neurologic diagnosis.

abstract：:Exposure of cells and organs to heat shock is associated with numerous changes in various cellular metabolic parameters and overexpression of proteins collectively known as heat shock proteins (HSP). In this communication we review the cell-signaling events that are altered in response to heat shock as they relate to ...

journal_title：Journal of biomedical science

authors： Gong Kiang J,Tsokos GC

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:This study aimed at developing nerve growth factor (NGF) mimetics that selectively activate specific biological signals and, as a result, lack the side effects of the full-length protein. Two dimeric dipeptides, bis-(N-aminocaproyl-glycyl-L-lysine) hexamethylenediamide (GK-6) and bis(N-succinyl-L-glutamyl-L-...

journal_title：Journal of biomedical science

authors： Gudasheva TA,Povarnina PY,Antipova TA,Firsova YN,Konstantinopolsky MA,Seredenin SB

更新日期：2015-12-08 00:00:00

abstract：:Advances in Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated system (CRISPR/Cas9) has dramatically reshaped our ability to edit genomes. The scientific community is using CRISPR/Cas9 for various biotechnological and medical purposes. One of its most important uses is developing potential the...

journal_title：Journal of biomedical science

authors： Khan S,Mahmood MS,Rahman SU,Zafar H,Habibullah S,Khan Z,Ahmad A

更新日期：2018-03-28 00:00:00

abstract：BACKGROUND:Dengue virus (DENV), a member of the family Flaviviridae, is at present the most widespread causative agent of a human viral disease transmitted by mosquitoes. Despite the increasing incidence of this pathogen, there are no antiviral drugs or vaccines currently available for treatment or prevention. In a pre...

journal_title：Journal of biomedical science

authors： Mazzucco MB,Talarico LB,Vatansever S,Carro AC,Fascio ML,D'Accorso NB,García CC,Damonte EB

更新日期：2015-04-17 00:00:00

abstract：:Influence of adjuvants i.e., alpha-tocopherol (25 mg/kg, p.o.) and piperine (10 mg/kg, p.o.) on therapeutic potential of chelator tiferron (300 mg/kg, i.p.) was evaluated to encounter toxicogenic events of beryllium exposure. Albino rats were exposed to beryllium nitrate (1 mg/kg, i.p.) daily for 28 days followed by t...

journal_title：Journal of biomedical science

authors： Nirala SK,Bhadauria M,Mathur R,Mathur A

更新日期：2007-05-01 00:00:00

abstract：:A large group of small Rab GTPases which mediate secretory and endosomal membrane transport, as well as autophagosome biogenesis, are essential components of vesicle trafficking machinery. Specific Rab protein together with the cognate effectors coordinates the dynamics of trafficking pathway and determines the cargo ...

journal_title：Journal of biomedical science

authors： Tzeng HT,Wang YC

更新日期：2016-10-06 00:00:00

abstract：BACKGROUND:Increased levels of blood plasma urea were used as phenotypic parameter for establishing novel mouse models for kidney diseases on the genetic background of C3H inbred mice in the phenotype-driven Munich ENU mouse mutagenesis project. The phenotypically dominant mutant line HST014 was established and further...

journal_title：Journal of biomedical science

authors： Kumar S,Rathkolb B,Sabrautzki S,Krebs S,Kemter E,Becker L,Beckers J,Bekeredjian R,Brommage R,Calzada-Wack J,Garrett L,Hölter SM,Horsch M,Klingenspor M,Klopstock T,Moreth K,Neff F,Rozman J,Fuchs H,Gailus-Durner V,H

更新日期：2017-08-17 00:00:00

abstract：:The apolipoprotein (Apo) E gene is known to be polymorphic. Three common alleles determine six phenotypes which can easily be detected by restriction fragment length polymorphism. We performed apo E genotyping in myocardial infarction survivors and healthy controls for the first time in the Turkish population. DNA was...

journal_title：Journal of biomedical science

authors： Hergenc G,Taga Y,Emerk K,Cirakoglu B

更新日期：1995-01-01 00:00:00

abstract：:We studied 42 individuals, including 8 patients with either complete or partial syndrome of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS), 8 patients with either complete or partial syndrome of myoclonic epilepsy with ragged-red fibers (MERRF) and 26 maternal family members w...

journal_title：Journal of biomedical science

authors： Huang CC,Kuo HC,Chu CC,Liou CW,Ma YS,Wei YH

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Epigallocatechin-3-gallate (EGCg) with its potent anti-oxidative capabilities is known for its beneficial effects ameliorating oxidative injury to cardiac cells. Although studies have provided convincing evidence to support the cardioprotective effects of EGCg, it remains unclear whether EGCg affect trans-me...

journal_title：Journal of biomedical science

authors： Hsieh SR,Hsu CS,Lu CH,Chen WC,Chiu CH,Liou YM

更新日期：2013-11-19 00:00:00

abstract：BACKGROUND:Granulocyte colony-stimulating factor (G-CSF), a hematopoietic cytokine, was recently used to treat patients of acute myocardial infarction with beneficial effect. However, controversy exists as some patients developed re-stenosis and worsened condition post G-CSF delivery. This study presents a new disease ...

journal_title：Journal of biomedical science

authors： Lian WS,Lin H,Cheng WT,Kikuchi T,Cheng CF

更新日期：2011-04-15 00:00:00

abstract：:Based on the tertiary structure of the ribosome-inactivating protein alpha-sarcin, domains that are responsible for hydrolyzing ribosomes and naked RNA have been dissected. In this study, we found that the head-to-tail interaction between the first amino beta-strand and the last carboxyl beta-strand is not involved in...

journal_title：Journal of biomedical science

authors： Hwu L,Huang K,Chen D,Lin A

更新日期：2000-09-01 00:00:00

abstract：:The goal of this study was to evaluate the effect of chronic Zn2+ administration (1 mg/kg/day for 1 month) in Sprague-Dawley rats (n = 11) on motility and rearing behaviors (number of events/10 min measured in motility cage), on memory (percentage of failures using a foot-shock double T maze), on the number of muscari...

journal_title：Journal of biomedical science

authors： Bonfante-Cabarcas R,Bravo I,Nello C,Gutiérrez-Reyes E,Loureiro Dos Santos NE,Moreno-Yanes JA

更新日期：2002-11-01 00:00:00

abstract：:The polymeric immunoglobulin receptor (PIGR) mediates transport of IgA and IgM antibodies across mucosal and glandular epithelia. Several studies have utilized immunohistochemistry to demonstrate that PIGR expression varies in different types of lung carcinoma, and is down-regulated during tumor progression. We have p...

journal_title：Journal of biomedical science

authors： Khattar NH,Lele SM,Kaetzel CS

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Naturally occurring pre-S deletion mutants have been identified in hepatitis B carriers and shown to be associated with the development of hepatocellular carcinoma. The phenotypes of these pre-S deletion genomes remain unclear, and they were investigated in this study. METHODS:The pre-S deletion genomes: (1...

journal_title：Journal of biomedical science

authors： Lin CM,Wang GM,Jow GM,Chen BF

更新日期：2012-02-07 00:00:00

abstract：:Mutations at codon 215 of HIV-1 reverse transcriptase (RT) confer resistance to nucleoside analogs through RT-catalyzed ATP-dependent phosphorolysis. We showed that mutation T215Y is predominant over T215F (respectively 38.8 vs. 7.04% of 7312 sequences from a cohort of patients receiving antiretroviral therapy in Fran...

journal_title：Journal of biomedical science

authors： Yahi N,Fantini J,Henry M,Tourrès C,Tamalet C

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:Lead (Pb2+) is an environmental neurotoxicant that disrupts neurodevelopment, communication, and organization through competition with Ca2+ signaling. How perinatal Pb2+ exposure affects Ca2+-related gene regulation remains unclear. However, Ca2+ activates the L-Type voltage sensitive calcium channel β-3 sub...

journal_title：Journal of biomedical science

authors： Neuwirth LS,Phillips GR,El Idrissi A

更新日期：2018-05-24 00:00:00

abstract：:Dextromethorphan (DM), an antitussive agent, has been claimed to have anti-inflammatory and immunomodulatory effects in vitro. Thus, the aim of this study was to evaluate the effects of DM on sepsis induced by intravenous (i.v.) administration of lipopolysaccharide (LPS) in anesthetized Wistar rats and by intraperiton...

journal_title：Journal of biomedical science

authors： Wang CC,Lee YM,Wei HP,Chu CC,Yen MH

更新日期：2004-11-01 00:00:00

abstract：:We have generated peptide antisera against selected regions in HIV-1 and HIV-2 reverse transcriptase (RT) and integrase (IN) to investigate the specificity of determinants governing the immune response. Peptides representing homologous regions (>50%) in the N- and C-termini and central portions of these proteins were ...

journal_title：Journal of biomedical science

authors： Klutch M,Woerner AM,Marcus-Sekura CJ,Levin JG

更新日期：1998-01-01 00:00:00

abstract：:Sensory innervation of the skin subserves protective sensations for the body to prevent thermal and noxious injuries. Neurophysiologically, they belong to the categories of Adelta and C fibers, usually with caliber less than one micro m in diameter. Morphological demonstration of the terminals of these nerves in the e...

journal_title：Journal of biomedical science

authors： Hsieh ST,Lin WM,Chiang HY,Huang IT,Ko MH,Chang YC,Chen WP

更新日期：1997-01-01 00:00:00

abstract：:The envelope gene of Moloney murine leukemia virus (Mo-MLV) and its various functional domains have been studied extensively but not as much in terms of their biological effects on cell growth. In this study, we report the biological characterization of a truncated Mo-MLV envelope gene, LN11, which is devoid of a sign...

journal_title：Journal of biomedical science

authors： Chen H,Chung SW,Wong PM

更新日期：2000-11-01 00:00:00

abstract：:Spinal muscular atrophy (SMA) is an autosomal recessive disorder characterized by degeneration of lower motor neurons. We have assayed deletions in two candidate genes, the survival motor neuron (SMN) and neuronal apoptosis inhibitory protein (NAIP) genes, in 108 samples, of which 46 were from SMA patients, and 62 wer...

journal_title：Journal of biomedical science

authors： Haider MZ,Moosa A,Dalal H,Habib Y,Reynold L

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:CIP4 is a scaffold protein that regulates membrane deformation and tubulation, organization of the actin cytoskeleton, endocytosis of growth factor receptors, and vesicle trafficking. Although expressed in the heart, CIP4 has not been studied with regards to its potential function in cardiac myocytes. RESUL...

journal_title：Journal of biomedical science

authors： Rusconi F,Thakur H,Li J,Kapiloff MS

更新日期：2013-08-03 00:00:00

abstract：BACKGROUND:Iron homeostasis is chiefly regulated by hepcidin whose expression is tightly controlled by inflammation, iron stores, and hypoxia. Hemojuvelin (HJV) is a bone morphogenetic protein co-receptor that has been identified as a main upstream regulator of hepcidin expression; HJV mutations are associated with a s...

journal_title：Journal of biomedical science

authors： Salama MF,Bayele HK,Srai SS

更新日期：2012-09-21 00:00:00

abstract：BACKGROUND:Lipopolysaccharide (LPS) is recognized as the most potent microbial mediator presaging the threat of invasion of Gram-negative bacteria that implicated in the pathogenesis of sepsis and septic shock. This study was designed to examine the microRNA (miRNA) expression in whole blood from mice injected with int...

journal_title：Journal of biomedical science

authors： Hsieh CH,Rau CS,Jeng JC,Chen YC,Lu TH,Wu CJ,Wu YC,Tzeng SL,Yang JC

更新日期：2012-07-31 00:00:00

abstract：:The effects of a single or repeated dermal administration of methyl parathion on motor function, learning and memory were investigated in adult female rats and correlated with blood cholinesterase activity. Exposure to a single dose of 50 mg/kg methyl parathion (75% of the dermal LD(50)) resulted in an 88% inhibition ...

journal_title：Journal of biomedical science

authors： Zhu H,Rockhold RW,Baker RC,Kramer RE,Ho IK

更新日期：2001-11-01 00:00:00

abstract：:The relationship between diet and colorectal cancer has been previously demonstrated and supported with strong epidemiological evidence. The role of genetic polymorphisms has, however, been less well elaborated upon. We conducted a hospital-based case-control study including 727 cases and 736 healthy controls to evalu...

journal_title：Journal of biomedical science

authors： Yeh CC,Sung FC,Tang R,Chang-Chieh CR,Hsieh LL

更新日期：2007-03-01 00:00:00

abstract：:Fibroblasts derived from glucose-6-phosphate dehydrogenase (G6PD)-deficient patients display retarded growth and accelerated cellular senescence that is attributable to increased accumulation of oxidative DNA damage and increased sensitivity to oxidant-induced senescence, but not to accelerated telomere attrition. Her...

journal_title：Journal of biomedical science

authors： Wu YH,Cheng ML,Ho HY,Chiu DT,Wang TC

更新日期：2009-02-05 00:00:00

abstract：:Oxidative stress and inflammation contributed to the propagation of acute liver injury (ALI). The present study was undertaken to determine whether D-galactosamine (D-GalN) induces ALI via the mitochondrial apoptosis- and proinflammatory cytokine-signaling pathways, and possible mechanism(s) by which green tea (GT) ex...

journal_title：Journal of biomedical science

authors： Lin BR,Yu CJ,Chen WC,Lee HS,Chang HM,Lee YC,Chien CT,Chen CF

更新日期：2009-03-25 00:00:00

abstract：BACKGROUND:Despite the recent progress in screening and therapy, a majority of prostate cancer cases eventually attain hormone refractory and chemo-resistant attributes. Conventional chemotherapeutic strategies are effective at very high doses for only palliative management of these prostate cancers. Therefore chemo-se...

journal_title：Journal of biomedical science

authors： Gara RK,Srivastava VK,Duggal S,Bagga JK,Bhatt M,Sanyal S,Mishra DP

更新日期：2015-04-01 00:00:00