Pharmacological doses of Zn2+ induce a muscarinic cholinergic supersensitivity.

abstract：BACKGROUND:Mounting evidences have showed the important role of transforming growth factor-β (TGF-β) in immunological surveillance of tumors. Some studies have also indicated human leukocyte antigen (HLA)-G-associated immune escape involving TGF-β management in gastric cancer (GC). However, the mechanism underlying it ...

journal_title：Journal of biomedical science

authors： Guan Z,Song B,Liu F,Sun D,Wang K,Qu H

更新日期：2015-12-02 00:00:00

abstract：:The nucleotide sequences of the putative envelope region (E1) and the junction between the E1 and envelope 2/nonstructural 1 (E2/NS1) region of the hepatitis C virus (HCV) genome are divergent among different genotypes. To characterize them, we introduced a set of nested primers that are conserved among four different...

journal_title：Journal of biomedical science

authors： Kao JH,Chen PJ,Lai MY,Yang PM,Sheu JC,Wang TH,Chen DS

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND:Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe side effects, including nephrotoxicity and acute kidney injury (AKI) which develop due to renal accumulation and biotransformation of CDDP. The allevi...

journal_title：Journal of biomedical science

authors： Volarevic V,Djokovic B,Jankovic MG,Harrell CR,Fellabaum C,Djonov V,Arsenijevic N

更新日期：2019-03-13 00:00:00

abstract：BACKGROUND:Autophagy has been shown recently to play an important role in the intracellular survival of several pathogenic bacteria. In this study, we investigated the effect of a novel small-molecule autophagy-inducing agent, AR-12, on the survival of Francisella tularensis, the causative bacterium of tularemia in hum...

journal_title：Journal of biomedical science

authors： Chiu HC,Soni S,Kulp SK,Curry H,Wang D,Gunn JS,Schlesinger LS,Chen CS

更新日期：2009-12-09 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) promoter 1 (LP1) is an inducible and cell type-specific promoter involved in regulating the production of an 8.3-kb primary LAT transcript during acute and latent infection of peripheral sensory neurons and during subsequent virus reactivation...

journal_title：Journal of biomedical science

authors： Millhouse S,Kenny JJ,Quinn PG,Lee V,Wigdahl B

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Sensing tissue acidosis is an important function of the somatosensory nervous system to response to noxious stimuli. MAIN BODY:In the pain clinic, acid or soreness sensation is a characteristic sensory phenotype of various acute and chronic pain syndromes, such as delayed onset muscle soreness, fibromyalgia...

journal_title：Journal of biomedical science

authors： Lin JH,Hung CH,Han DS,Chen ST,Lee CH,Sun WZ,Chen CC

更新日期：2018-11-29 00:00:00

abstract：BACKGROUND:Naturally occurring pre-S deletion mutants have been identified in hepatitis B carriers and shown to be associated with the development of hepatocellular carcinoma. The phenotypes of these pre-S deletion genomes remain unclear, and they were investigated in this study. METHODS:The pre-S deletion genomes: (1...

journal_title：Journal of biomedical science

authors： Lin CM,Wang GM,Jow GM,Chen BF

更新日期：2012-02-07 00:00:00

abstract：BACKGROUND:The conserved Notch signaling pathway regulates cell fate decisions and maintains stem cells in multicellular organisms. Up-regulation of Notch signaling is observed in several types of cancer and is causally involved in proliferation and survival of cancer cells. Thus, it is of great interest to look for an...

journal_title：Journal of biomedical science

authors： Pi H,Huang YC,Chen IC,Lin CD,Yeh HF,Pai LM

更新日期：2011-06-17 00:00:00

abstract：:Reactive oxygen species (ROS) have been long considered simply as harmful by-products of metabolism, which damage cellular proteins, lipids, and nucleic acids. ROS are also known as a weapon of phagocytes, employed against pathogens invading the host. However, during the last decade, an understanding has emerged that ...

journal_title：Journal of biomedical science

authors： Belikov AV,Schraven B,Simeoni L

更新日期：2015-10-15 00:00:00

abstract：:An isolated thoracic spinal cord of the neonatal rat in vitro spontaneously generates sympathetic nerve discharge (SND) at ~25 degrees C, but it fails in SND genesis at < or = 10 degrees C. Basal levels of the c-Fos expression in the spinal cords incubated at < or = 10 degrees C and ~25 degrees C were compared to dete...

journal_title：Journal of biomedical science

authors： Su CK,Ho CM,Kuo HH,Wen YC,Chai CY

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:To develop an individually-tailored dynamic risk assessment model following a multistep, multifactorial process of the Correa's gastric cancer model. METHODS:First, we estimated the state-to-state transition rates following Correa's five-step carcinogenic model and assessed the effect of risk factors, inclu...

journal_title：Journal of biomedical science

authors： Fann JC,Chiang TH,Yen AM,Lee YC,Wu MS,Chen HH

更新日期：2018-11-19 00:00:00

abstract：BACKGROUND:Granulocyte colony-stimulating factor (G-CSF), a hematopoietic cytokine, was recently used to treat patients of acute myocardial infarction with beneficial effect. However, controversy exists as some patients developed re-stenosis and worsened condition post G-CSF delivery. This study presents a new disease ...

journal_title：Journal of biomedical science

authors： Lian WS,Lin H,Cheng WT,Kikuchi T,Cheng CF

更新日期：2011-04-15 00:00:00

abstract：BACKGROUND:Helicobacter pylori bacteria colonize human gastric mucosa, cause chronic inflammation, peptic ulcers and gastric cancer. Colonization is mediated by H. pylori adhesins, which preferentially bind mucin 5 (MUC5AC) and Lewis (Le) determinants. The aim of this study was to evaluate the influence of H. pylori an...

journal_title：Journal of biomedical science

authors： Gonciarz W,Walencka M,Moran AP,Hinc K,Obuchowski M,Chmiela M

更新日期：2019-03-06 00:00:00

abstract：:Dengue virus infection presents a wide spectrum of manifestations including asymptomatic condition, dengue fever (DF), or severe forms, such as dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) in affected individuals. The early prediction of severe dengue in patients without any warning signs who may lat...

journal_title：Journal of biomedical science

authors： John DV,Lin YS,Perng GC

更新日期：2015-10-14 00:00:00

abstract：:The CDC4 gene of Saccharomyces cerevisiae encodes an essential function that is required for G1-S and G2-M transitions during mitosis and at various stages during meiosis. We have isolated a functional homologue of CDC4 (CaCDC4) from the pathogenic yeast Candida albicans by complementing the S. cerevisiae cdc4-3 mutat...

journal_title：Journal of biomedical science

authors： Shieh JC,White A,Cheng YC,Rosamond J

更新日期：2005-12-01 00:00:00

abstract：:Phospholipase D (PLD) is a phosphodiesterase that catalyses hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline. In the presence of ethanol, PLD also catalyses the formation of phosphatidylethanol, which is a unique characteristic of this enzyme. Muscarinic receptor-induced changes in the activi...

journal_title：Journal of biomedical science

authors： Mamoon AM,Smith J,Baker RC,Farley JM

更新日期：1999-03-01 00:00:00

abstract：:The antitumor activity of Anoectochilus formosanus Hayata (Orchidaceae), a popularly used folk medicine in the treatment of cancers in Asia, was investigated in MCF-7 human mammary carcinoma cells. Plant extracts of A. formosanus were observed to induce apoptosis of MCF-7 cells as evidenced by cell-morphological chang...

journal_title：Journal of biomedical science

authors： Shyur LF,Chen CH,Lo CP,Wang SY,Kang PL,Sun SJ,Chang CA,Tzeng CM,Yang NS

更新日期：2004-11-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV), also designated human herpesvirus 8 (HHV-8), has been linked to Kaposi's sarcoma, as well as to primary effusion lymphoma (PEL), and a subset of multicentric Castleman's disease. KSHV genomes are maintained as episomes within infected cells and the virus exhibits a bipha...

journal_title：Journal of biomedical science

authors： Campbell M,Izumiya Y

更新日期：2020-03-07 00:00:00

abstract：:The purpose of this study was to determine whether beta-adrenergically mediated cardiovascular functions such as arterial pressure (AP), heart rate (HR), stroke volume (SV), cardiac output (CO), peripheral resistance (R(p)), arterial impedance (Z(c)), mean arterial compliance (C(m)) and pulse wave reflection (P(b)) we...

journal_title：Journal of biomedical science

authors： Hu CT,Wu CY,Chen HI

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:Our previous report suggested that centrosomal P4.1-associated protein (CPAP) is required for Hepatitis B virus (HBV) encoded non-structure protein X (HBx)-mediated nuclear factor kappa light chain enhancer of activated B cells (NF-κB) activation. CPAP is overexpressed in HBV-associated hepatocellular carcin...

journal_title：Journal of biomedical science

authors： Yen CJ,Yang ST,Chen RY,Huang W,Chayama K,Lee MH,Yang SJ,Lai HS,Yen HY,Hsiao YW,Wang JM,Lin YJ,Hung LY

更新日期：2019-06-06 00:00:00

abstract：:Mediation of the respiratory reflex effects of an exogenous serotonin challenge goes beyond the lung vagi and is suggested to involve the nodose ganglia. In the present experiments the effects of an intravenous serotonin challenge on breathing pattern were studied in 8 pentobarbitone-chloralose anaesthetised cats. Bol...

journal_title：Journal of biomedical science

authors： Kopczyńska B,Szereda-Przestaszewska M

更新日期：2003-11-01 00:00:00

abstract：INTRODUCTION:Head and neck squamous carcinoma (HNSCC) is one of the most invasive types of cancer with high mortality. A previous study has indicated that low levels of let-7d and miR-205 in HNSCC patients are correlated with poor survival. Let-7d and miR-205 are tumor suppressors and regulators of epithelial-to-mesenc...

journal_title：Journal of biomedical science

authors： Kolenda T,Guglas K,Teresiak A,Bliźniak R,Lamperska K

更新日期：2019-02-13 00:00:00

abstract：BACKGROUND:Recent evidence suggests that drugs targeting Kv7 channels could be used to modulate vascular function and blood pressure. Here, we studied whether Kv7 channel inhibitors can be utilized to stabilize hemodynamics and reduce resuscitation fluid requirements after hemorrhagic shock. METHODS:Anesthetized male ...

journal_title：Journal of biomedical science

authors： Nassoiy SP,Byron KL,Majetschak M

更新日期：2017-01-17 00:00:00

abstract：BACKGROUND:Zerumbone, a sesquiterpene compound isolated from subtropical ginger, Zingiber zerumbet Smith, has been documented to exert antitumoral and anti- inflammatory activities. In this study, we demonstrate that zerumbone induces apoptosis in human glioblastoma multiforme (GBM8401) cells and investigate the apopto...

journal_title：Journal of biomedical science

authors： Weng HY,Hsu MJ,Wang CC,Chen BC,Hong CY,Chen MC,Chiu WT,Lin CH

更新日期：2012-10-05 00:00:00

abstract：:The matrin 3 family of nuclear proteins consists of members with potentially diverse activities. Matrin 3 and NP220 share RNA-binding domains, and NP220 has been shown to recognize and bind to the DNA sequence, CCCCC (G/C). We have isolated and characterized another member of the matrin 3 family, designated NP94, from...

journal_title：Journal of biomedical science

authors： Warder DE,Keherly MJ

更新日期：2003-07-01 00:00:00

abstract：:A large group of small Rab GTPases which mediate secretory and endosomal membrane transport, as well as autophagosome biogenesis, are essential components of vesicle trafficking machinery. Specific Rab protein together with the cognate effectors coordinates the dynamics of trafficking pathway and determines the cargo ...

journal_title：Journal of biomedical science

authors： Tzeng HT,Wang YC

更新日期：2016-10-06 00:00:00

abstract：BACKGROUND:The association of functionality and phenotype of follicular helper T cells (Tfh) with dengue virus (DENV) specific antibody responses and clinical disease severity has not been well studied. METHODS:We investigated the phenotype and functionality of Tfh cells and plasmablasts in adult patients (DF = 18, DH...

journal_title：Journal of biomedical science

authors： Wijesinghe A,Gamage J,Goonewardena H,Gomes L,Jayathilaka D,Wijeratne DT,de Alwis R,Jeewandara C,Wijewickrama A,Ogg GS,Malavige GN

更新日期：2020-04-08 00:00:00

abstract：BACKGROUND:Chemotherapy and targeted therapies have made important strides in cancer treatment yet they often fail and new therapies are still needed. Here, we employed a phenotypic screen to identify and analyze the mechanism of action of novel small molecules that interfere with critical pathways involved in tumor ce...

journal_title：Journal of biomedical science

authors： Ghosh SK,Ganta A,Spanjaard RA

更新日期：2018-02-08 00:00:00

abstract：:In many solid tumor types, tumor-associated macrophages (TAMs) are important components of the tumor microenvironment (TME). Moreover, TAMs infiltration is strongly associated with poor survival in solid tumor patients. In this review, we describe the origins of TAMs and their polarization state dictated by the TME. W...

journal_title：Journal of biomedical science

authors： Chen Y,Song Y,Du W,Gong L,Chang H,Zou Z

更新日期：2019-10-20 00:00:00

abstract：BACKGROUND:The apolipoprotein E4 (apoE4) genotype is a major risk factor for developing late-onset Alzheimer's disease (AD). Inheritance of apoE4 is also associated with impairments in olfactory function in early stages of AD. In this project we examined the effects of the three common isoforms of human apoE (apoE2, ap...

journal_title：Journal of biomedical science

authors： Hussain A,Luong M,Pooley A,Nathan BP

更新日期：2013-07-12 00:00:00