Supranodose vagotomy precludes reflex respiratory responses to serotonin in cats.

abstract：:The envelope gene of Moloney murine leukemia virus (Mo-MLV) and its various functional domains have been studied extensively but not as much in terms of their biological effects on cell growth. In this study, we report the biological characterization of a truncated Mo-MLV envelope gene, LN11, which is devoid of a sign...

journal_title：Journal of biomedical science

authors： Chen H,Chung SW,Wong PM

更新日期：2000-11-01 00:00:00

abstract：:The present study was to investigate the effects and action mechanisms of dehydroepiandrosterone (DHEA) on steroidogenesis in rat adrenal zona glomerulosa cells (ZG). ZG cells were incubated with DHEA in the presence or absence of angiotensin II (AngII), a high concentration of potassium, 8-Br-cAMP, forskolin, 25-OH-c...

journal_title：Journal of biomedical science

authors： Chang LL,Wun WS,Wang PS

更新日期：2008-07-01 00:00:00

abstract：:Plasma nitric oxide (NO) levels in Duchenne muscular dystrophy (DMD) patients were significantly lower than those observed in both healthy controls and in patients with other neuromuscular disorders. The correlation between NO level and ejection fraction was significant (r = -0.384, p = 0.0391) in the DMD group. Disru...

journal_title：Journal of biomedical science

authors： Kasai T,Abeyama K,Hashiguchi T,Fukunaga H,Osame M,Maruyama I

更新日期：2004-07-01 00:00:00

abstract：:Metabolic diseases such as obesity, type 2 diabetes (T2D) and insulin resistance have attracted great attention from biomedical researchers and clinicians because of the astonishing increase in its prevalence. Decrease in the capacity of oxidative metabolism and mitochondrial dysfunction are a major contributor to the...

journal_title：Journal of biomedical science

authors： Wang CH,Wei YH

更新日期：2017-09-07 00:00:00

abstract：BACKGROUND:The probability of local tumor control after radiotherapy (RT) remains still miserably poor in pediatric rhabdomyosarcoma (RMS). Thus, understanding the molecular mechanisms responsible of tumor relapse is essential to identify personalized RT-based strategies. Contrary to what has been done so far, a correc...

journal_title：Journal of biomedical science

authors： Petragnano F,Pietrantoni I,Camero S,Codenotti S,Milazzo L,Vulcano F,Macioce G,Giordani I,Tini P,Cheleschi S,Gravina GL,Festuccia C,Rossetti A,Delle Monache S,Ordinelli A,Ciccarelli C,Mauro A,Barbara B,Antinozzi C,Sc

更新日期：2020-08-27 00:00:00

abstract：:Purinergic P2X7 receptor (P2X7R), an ATP-gated cation channel, is unique among all other family members because of its ability to respond to various stimuli and to modulate pro-inflammatory signaling. The activation of P2X7R in immune cells is absolutely required for mature interleukin -1beta (IL-1beta) and IL-18 prod...

journal_title：Journal of biomedical science

authors： Mishra A

更新日期：2013-05-01 00:00:00

abstract：:Dehydroepiandrosterone (DHEA) is a putative anti-stress agent and stress is associated with the secretion of catecholamine from the adrenal gland, but the effects of DHEA on catecholamine secretion are not fully understood. Using bovine chromaffin cells, we found that DHEA inhibited catecholamine secretion and cytosol...

journal_title：Journal of biomedical science

authors： Liu PS,Wang PY

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Pseudomonas aeruginosa is a Gram-negative pathogen that frequently causes life-threatening infections in immunocompromised patients. We previously showed that subinhibitory concentrations of short synthetic peptides permeabilize P. aeruginosa and enhance the lethal action of co-administered antibiotics. MET...

journal_title：Journal of biomedical science

authors： Rázquin-Olazarán I,Shahrour H,Martínez-de-Tejada G

更新日期：2020-08-06 00:00:00

abstract：:Oxidative stress and inflammation contributed to the propagation of acute liver injury (ALI). The present study was undertaken to determine whether D-galactosamine (D-GalN) induces ALI via the mitochondrial apoptosis- and proinflammatory cytokine-signaling pathways, and possible mechanism(s) by which green tea (GT) ex...

journal_title：Journal of biomedical science

authors： Lin BR,Yu CJ,Chen WC,Lee HS,Chang HM,Lee YC,Chien CT,Chen CF

更新日期：2009-03-25 00:00:00

abstract：BACKGROUND:The association between ischemic stroke and 2 single nucleotide polymorphisms (SNPs) on chromosome 12p13, rs12425791 and rs11833579 appears inconsistent across different samples. These SNPs are close to the ninjurin2 gene which may alter the risk of stroke by affecting brain response to ischemic injury. The ...

journal_title：Journal of biomedical science

authors： Hsieh YC,Seshadri S,Chung WT,Hsieh FI,Hsu YH,Lin HJ,Tseng HP,Lien LM,Bai CH,Hu CJ,Jeng JS,Tang SC,Chen CI,Yu CC,Chiou HY,Formosa Stroke Genetic Consortium (FSGC).

更新日期：2012-01-03 00:00:00

abstract：BACKGROUND:Our previous report suggested that centrosomal P4.1-associated protein (CPAP) is required for Hepatitis B virus (HBV) encoded non-structure protein X (HBx)-mediated nuclear factor kappa light chain enhancer of activated B cells (NF-κB) activation. CPAP is overexpressed in HBV-associated hepatocellular carcin...

journal_title：Journal of biomedical science

authors： Yen CJ,Yang ST,Chen RY,Huang W,Chayama K,Lee MH,Yang SJ,Lai HS,Yen HY,Hsiao YW,Wang JM,Lin YJ,Hung LY

更新日期：2019-06-06 00:00:00

abstract：:Spinal muscular atrophy (SMA) is an autosomal recessive disorder characterized by degeneration of lower motor neurons. We have assayed deletions in two candidate genes, the survival motor neuron (SMN) and neuronal apoptosis inhibitory protein (NAIP) genes, in 108 samples, of which 46 were from SMA patients, and 62 wer...

journal_title：Journal of biomedical science

authors： Haider MZ,Moosa A,Dalal H,Habib Y,Reynold L

更新日期：2001-03-01 00:00:00

abstract：:Influence of adjuvants i.e., alpha-tocopherol (25 mg/kg, p.o.) and piperine (10 mg/kg, p.o.) on therapeutic potential of chelator tiferron (300 mg/kg, i.p.) was evaluated to encounter toxicogenic events of beryllium exposure. Albino rats were exposed to beryllium nitrate (1 mg/kg, i.p.) daily for 28 days followed by t...

journal_title：Journal of biomedical science

authors： Nirala SK,Bhadauria M,Mathur R,Mathur A

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Peroxisome proliferator activated receptor gamma (PPARG) belongs to the nuclear receptor superfamily functioning as transcription factors to regulate cellular differentiation, development and metabolism. Moreover, it has been implicated in the regulation of lipid metabolism, as well as the maturation of mono...

journal_title：Journal of biomedical science

authors： García-Ricobaraza M,García-Bermúdez M,Torres-Espinola FJ,Segura Moreno MT,Bleyere MN,Díaz-Prieto LE,Nova E,Marcos A,Campoy C

更新日期：2020-11-30 00:00:00

abstract：BACKGROUND:This study aimed at developing nerve growth factor (NGF) mimetics that selectively activate specific biological signals and, as a result, lack the side effects of the full-length protein. Two dimeric dipeptides, bis-(N-aminocaproyl-glycyl-L-lysine) hexamethylenediamide (GK-6) and bis(N-succinyl-L-glutamyl-L-...

journal_title：Journal of biomedical science

authors： Gudasheva TA,Povarnina PY,Antipova TA,Firsova YN,Konstantinopolsky MA,Seredenin SB

更新日期：2015-12-08 00:00:00

abstract：:5-methoxytryptophan (5-MTP) is an endothelial factor with anti-inflammatory properties. It is synthesized from L-tryptophan via two enzymatic steps: tryptophan hydroxylase-1 (TPH-1) and hydroxyindole O-methyltransferase. Lipopolysaccharide (LPS) and pro-inflammatory cytokines suppress endothelial 5-MTP production by i...

journal_title：Journal of biomedical science

authors： Wu KK,Kuo CC,Yet SF,Lee CM,Liou JY

更新日期：2020-07-07 00:00:00

abstract：:Diabetes is a multifactorial disease that has now been recognized to involve overproduction of reactive oxygen species and pro-inflammatory cytokines. Peroxisomes are subcellular organelles with several important metabolic functions, and their role in the regulation of cellular oxidative stress is now well established...

journal_title：Journal of biomedical science

authors： Dhaunsi GS,Bitar MS

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Homeostasis of reactive oxygen species (ROS) in the skin is regulated by antioxidant defenses. The inflammatory states of skin diseases which range from acute rashes to chronic conditions are related to the level of ROS. The involvement of superoxide dismutase (SOD) in restoring the antioxidant capacity can ...

journal_title：Journal of biomedical science

authors： Liu TP,Chen YP,Chou CM,Chiu TT,Chen CT

更新日期：2016-01-20 00:00:00

abstract：:The effects of N omega-nitro-L: -arginine (L: -NOARG) and N(G)-monomethyl-L: -arginine (L: -NMMA) on the spatial distribution of diaphragmatic microvascular blood flow were assessed in anesthetized, mechanically ventilated rats. Microvascular blood flow was measured after different periods at either a fixed site (Q st...

journal_title：Journal of biomedical science

authors： Lee CH,Chang HY,Chen CW,Hsiue TR

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe side effects, including nephrotoxicity and acute kidney injury (AKI) which develop due to renal accumulation and biotransformation of CDDP. The allevi...

journal_title：Journal of biomedical science

authors： Volarevic V,Djokovic B,Jankovic MG,Harrell CR,Fellabaum C,Djonov V,Arsenijevic N

更新日期：2019-03-13 00:00:00

abstract：:Schistosomiasis causes significant levels of morbidity and mortality in many geographical regions of the world. The disease is caused by infections with parasitic blood flukes known as schistosomes. The control of schistosomiasis over the last several decades has been centered on the mass drug administration (MDA) of ...

journal_title：Journal of biomedical science

authors： Molehin AJ

更新日期：2020-01-22 00:00:00

abstract：:Chronic inflammation may lead to endothelial dysfunction, which manifests as an impaired coronary reactivity. Impairment in coronary flow reserve (CFR), preceding the clinical symptoms of coronary artery disease, can be measured noninvasively by positron emission tomography. Myeloperoxidase (MPO) is an oxidative enzym...

journal_title：Journal of biomedical science

authors： Mäkelä R,Laaksonen R,Janatuinen T,Vesalainen R,Nuutila P,Jaakkola O,Knuuti J,Lehtimäki T

更新日期：2004-01-01 00:00:00

abstract：:Extracellular vesicles (EVs) are cell-derived membrane-bound vesicles that serve a means of cell-cell communication. Studying EVs at a single-particle level is important because EVs are inherently heterogeneous. Novel micro- and nanotechnological tools have open opportunities for realizing single-EV measurements explo...

journal_title：Journal of biomedical science

authors： Chiang CY,Chen C

更新日期：2019-01-15 00:00:00

abstract：:Mutations at codon 215 of HIV-1 reverse transcriptase (RT) confer resistance to nucleoside analogs through RT-catalyzed ATP-dependent phosphorolysis. We showed that mutation T215Y is predominant over T215F (respectively 38.8 vs. 7.04% of 7312 sequences from a cohort of patients receiving antiretroviral therapy in Fran...

journal_title：Journal of biomedical science

authors： Yahi N,Fantini J,Henry M,Tourrès C,Tamalet C

更新日期：2005-10-01 00:00:00

abstract：:This study investigated the involvement of neutrophil infiltration, disturbances in nitric oxide (NO) generation and oxidative stress in indomethacin-induced gastric ulcer, and the possible gastroprotective potentials of leptin, known for its angiogenic effect. Male Wistar albino rats (180-220 g) were allocated into a...

journal_title：Journal of biomedical science

authors： Motawi TK,Abd Elgawad HM,Shahin NN

更新日期：2008-05-01 00:00:00

abstract：:Developmentally regulated endothelial cell locus-1 (Del1) is an embryonic angiogenic factor expressed in early embryonic endothelial cells, but recently has been found to be expressed in some forms of cancers including colon and breast cancers, and melanoma, and human cancer cell lines. Overexpression of Del1 accelera...

journal_title：Journal of biomedical science

authors： Zou X,Qiao H,Jiang X,Dong X,Jiang H,Sun X

更新日期：2009-01-01 00:00:00

abstract：:Our objective was to determine the role that bone marrow-derived stromal cells have on human hematopoiesis in HIV infection. In particular, we dissected the heterogeneous bone marrow microenvironment to study the effect HIV expression might have on the cell population capable of producing the cytokines which will supp...

journal_title：Journal of biomedical science

authors： Mosca JD,Kaushal S,Gartner S,Kessler SW,La Russa VF,Terwilliger EF,Kim JH,Carroll RG,Hall ER,Perera LP,Yu Z,Ritchey DW,Xu J,St Louis DC,Mayers DL

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:Asthma has become an important public health issue and approximately 300 million people have suffered from the disease worldwide. Nowadays, the use of acupuncture in asthma is increasing. This study intended to systematically analyze and compare the gene expression profiles between the asthmatic and acupunct...

journal_title：Journal of biomedical science

authors： Yin LM,Jiang GH,Wang Y,Wang Y,Liu YY,Jin WR,Xu YD,Zhang QH,Yang YQ

更新日期：2009-05-06 00:00:00

abstract：:DNA vaccines have emerged as an attractive approach for generating antigen-specific immunotherapy. Strategies that enhance antigen presentation may potentially be used to enhance DNA vaccine potency. Previous experiments showed that chimeric DNA vaccines utilizing endoplasmic reticulum (ER) chaperone molecules, such a...

journal_title：Journal of biomedical science

authors： Lin CT,Chang TC,Chao A,Dzeng E,Soong YK,Hung CF,Lai CH

更新日期：2005-01-01 00:00:00

abstract：:Hypoxia is an important microenvironmental factor that induces cancer metastasis. Hypoxia/hypoxia-inducible factor-1α (HIF-1α) regulates many important steps of the metastatic processes, especially epithelial-mesenchymal transition (EMT) that is one of the crucial mechanisms to cause early stage of tumor metastasis. T...

journal_title：Journal of biomedical science

authors： Tsai YP,Wu KJ

更新日期：2012-12-14 00:00:00