Abstract：
:Schistosomiasis causes significant levels of morbidity and mortality in many geographical regions of the world. The disease is caused by infections with parasitic blood flukes known as schistosomes. The control of schistosomiasis over the last several decades has been centered on the mass drug administration (MDA) of praziquantel (PZQ), which is the only drug currently available for treatment. Despite the concerted efforts of MDA programs, the prevalence and transmission of schistosomiasis has remained largely unchecked due to the fact that PZQ is ineffective against juvenile schistosomes, does not prevent re-infection and the emergence of PZQ-resistant parasites. In addition, other measures such as the water, sanitation and hygiene programs and snail intermediate hosts control have had little to no impact. These drawbacks indicate that the current control strategies are severely inadequate at interrupting transmission and therefore, implementation of other control strategies are required. Ideally, an efficient vaccine is what is needed for long term protection thereby eliminating the current efforts of repeated mass drug administration. However, the general consensus in the field is that the integration of a viable vaccine with MDA and other control measures offer the best chance of achieving the goal of schistosomiasis elimination. This review focuses on the present status of schistosomiasis vaccine candidates in different phases of human clinical trials and provide some insight into future vaccine discovery and design.
journal_name
J Biomed Scijournal_title
Journal of biomedical scienceauthors
Molehin AJdoi
10.1186/s12929-020-0621-ysubject
Has Abstractpub_date
2020-01-22 00:00:00pages
28issue
1eissn
1021-7770issn
1423-0127pii
10.1186/s12929-020-0621-yjournal_volume
27pub_type
杂志文章,评审abstract：BACKGROUND:Stroke is one of the leading causes of neuronal death. Sesamin is known for neuroprotection by its antioxidant and anti-inflammatory properties but it lacks blood-brain barrier (BBB) activity. A panel of sesamin derivatives was screened and 3-bis (3-methoxybenzyl) butane-1,4-diol (BBD) was selected for high ...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1186/1423-0127-21-15
更新日期：2014-02-18 00:00:00
abstract：BACKGROUND:Next-generation sequencing (NGS) is a powerful and high-throughput method for the detection of viral mutations. This article provides a brief overview about optimization of NGS analysis for hepatocellular carcinoma (HCC)-associated hepatitis B virus (HBV) mutations, and hepatocarcinogenesis of relevant mutat...
journal_title：Journal of biomedical science
pub_type： 杂志文章,评审
doi：10.1186/s12929-018-0442-4
更新日期：2018-06-02 00:00:00
abstract：BACKGROUND:Fallopian tube epithelial cells (FTEC) were thought to be the origin of high-grade serous ovarian carcinoma (HGSOC). Knowledge of the stemness or initiating characteristics of FTEC is insufficient. Previously, we have characterized the stemness cell marker of FTEC, this study aims to further characterize the...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1186/s12929-019-0602-1
更新日期：2020-02-08 00:00:00
abstract：BACKGROUND:Sensing tissue acidosis is an important function of the somatosensory nervous system to response to noxious stimuli. MAIN BODY:In the pain clinic, acid or soreness sensation is a characteristic sensory phenotype of various acute and chronic pain syndromes, such as delayed onset muscle soreness, fibromyalgia...
journal_title：Journal of biomedical science
pub_type： 杂志文章,评审
doi：10.1186/s12929-018-0486-5
更新日期：2018-11-29 00:00:00
abstract：BACKGROUND:Activating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER)-localised protein and member of the leucine zipper family of transcription factors. Best known for its role in transducing signals linked to stress to the endoplasmic reticulum, the 50 kDa activated form of ATF6 is now emerging as a ma...
journal_title：Journal of biomedical science
pub_type： 杂志文章,评审
doi：10.1186/s12929-018-0453-1
更新日期：2018-05-25 00:00:00
abstract：:Human mesenchymal stem cells (hMSCs) are multipotent cells that can differentiate into various tissue types, including bone, cartilage, tendon, adipocytes, and marrow stroma, making them potentially useful for human cell and gene therapies. Our objective was to demonstrate the utility of glass needle-mediated microinj...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1007/BF02256452
更新日期：2003-05-01 00:00:00
abstract：:In all eukaryotes, the plasma membrane is critically important as it maintains the architectural integrity of the cell. Proper anchorage and interaction between the plasma membrane and the cytoskeleton is critical for normal cellular processes. The ERM (ezrin-radixin-moesin) proteins are a class of highly homologous p...
journal_title：Journal of biomedical science
pub_type： 杂志文章,评审
doi：10.1186/s12929-016-0246-3
更新日期：2016-03-17 00:00:00
abstract：:Endotoxin shock is characterized by systemic hypotension, hyporeactiveness to vasoconstrictors and acute lung edema. A nitric oxide synthase (NOS) inhibitor, NG-monomethyl-L-arginine (L-NMMA) has been shown to be effective in reversing acute lung injury. In the present study, we evaluated the effects of NOS blockade b...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1007/BF02256421
更新日期：1999-01-01 00:00:00
abstract：:Hypoxia is an important microenvironmental factor that induces cancer metastasis. Hypoxia/hypoxia-inducible factor-1α (HIF-1α) regulates many important steps of the metastatic processes, especially epithelial-mesenchymal transition (EMT) that is one of the crucial mechanisms to cause early stage of tumor metastasis. T...
journal_title：Journal of biomedical science
pub_type： 杂志文章,评审
doi：10.1186/1423-0127-19-102
更新日期：2012-12-14 00:00:00
abstract：INTRODUCTION:Head and neck squamous carcinoma (HNSCC) is one of the most invasive types of cancer with high mortality. A previous study has indicated that low levels of let-7d and miR-205 in HNSCC patients are correlated with poor survival. Let-7d and miR-205 are tumor suppressors and regulators of epithelial-to-mesenc...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1186/s12929-019-0511-3
更新日期：2019-02-13 00:00:00
abstract：:The ability of cells of the human monocyte/macrophage lineage to host HIV-1 replication while resisting cell death is believed to significantly contribute to their ability to serve as a reservoir for viral replication in the host. Although macrophages are generally resistant to apoptosis, interruption of anti-apoptoti...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1007/BF02256024
更新日期：2002-03-01 00:00:00
abstract：:Chronic inflammation may lead to endothelial dysfunction, which manifests as an impaired coronary reactivity. Impairment in coronary flow reserve (CFR), preceding the clinical symptoms of coronary artery disease, can be measured noninvasively by positron emission tomography. Myeloperoxidase (MPO) is an oxidative enzym...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1007/BF02256549
更新日期：2004-01-01 00:00:00
abstract：BACKGROUND:Dengue virus (DENV), a member of the family Flaviviridae, is at present the most widespread causative agent of a human viral disease transmitted by mosquitoes. Despite the increasing incidence of this pathogen, there are no antiviral drugs or vaccines currently available for treatment or prevention. In a pre...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1186/s12929-015-0134-2
更新日期：2015-04-17 00:00:00
abstract：:Zebrafish tbx5 expresses in the heart, pectoral fins and eyes of zebrafish during embryonic development. In zebrafish, injection of tbx5 morpholino antisense RNA caused changes of heart conformation, defect of heart looping, pericardium effusion, dropsy of ventral position and decreased heart rate. We suggested that c...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1007/s11373-008-9268-5
更新日期：2008-11-01 00:00:00
abstract：BACKGROUND:Despite the recent progress in screening and therapy, a majority of prostate cancer cases eventually attain hormone refractory and chemo-resistant attributes. Conventional chemotherapeutic strategies are effective at very high doses for only palliative management of these prostate cancers. Therefore chemo-se...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1186/s12929-015-0127-1
更新日期：2015-04-01 00:00:00
abstract：:Different human retroviruses, such as Human Immunodeficiency Virus (HIV) and Human T-cell Lymphotropic Virus (HTLV), can cause neurologic infection. However, a definitive diagnosis may be hampered by several factors. Quantification of the viral or proviral load in cerebrospinal fluid (CSF) may be helpful in the diagno...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1186/s12929-015-0170-y
更新日期：2015-08-08 00:00:00
abstract：BACKGROUND:LncRNA Gas5 is known to be a key control element during growth, differentiation and development in mammalian species. However, the role and function of Gas5 in growth plate chondrocytes has not been determined. METHODS:The overexpression and knockdown models of Gas5 and miR-21 in cells and animals were cons...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1186/s12929-018-0424-6
更新日期：2018-02-28 00:00:00
abstract：:Although hypercholesterolemia is a well-known risk factor for atherosclerosis, little is known about the effect of hypercholesterolemia on cardiac contractile function. The objective of this study was to examine the effect of hypercholesterolemia on myocardial contractility. Fifteen New Zealand white rabbits were fed ...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1007/BF02254368
更新日期：2004-11-01 00:00:00
abstract：:To determine the involvement of the globus pallidus in mediating epilepsy, the effects of microinjection of a GABA uptake blocker (tiagabine), a benzodiazepine agonist (zolpidem) and a GABA-B receptor agonist (baclofen) on pentylenetetrazol (PTZ)-induced tonic seizure were examined in adult rats. Administration of PTZ...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1007/BF02256094
更新日期：2004-07-01 00:00:00
abstract：:While virus-like particles (VLPs) containing subgenomic replicons, which can transduce replicons into target cells efficiently for studying viral replication and vectors of gene therapy and vaccine, have been established for several flaviviruses, none has been reported for the four serotypes of dengue virus, the causa...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1007/s11373-007-9204-0
更新日期：2008-01-01 00:00:00
abstract：:Sensory innervation of the skin subserves protective sensations for the body to prevent thermal and noxious injuries. Neurophysiologically, they belong to the categories of Adelta and C fibers, usually with caliber less than one micro m in diameter. Morphological demonstration of the terminals of these nerves in the e...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1007/BF02253428
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:Whether microgravity might influence tumour growth and carcinogenesis is still an open issue. It is not clear also if and how normal and transformed cells are differently solicited by microgravity. The present study was designed to verify this issue. METHODS:Two normal, LB and HSC93, and two transformed, Ju...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1186/1423-0127-17-63
更新日期：2010-07-28 00:00:00
abstract：:The isoprostanes (IsoPs) are a unique series of prostaglandin-like compounds formed in vivo from the free radical-catalyzed peroxidation of arachidonic acid. This review summarizes our current knowledge regarding these compounds. Novel aspects of the biochemistry and bioactivity of IsoPs are detailed and methods by wh...
journal_title：Journal of biomedical science
pub_type： 杂志文章,评审
doi：10.1007/BF02253564
更新日期：1999-07-01 00:00:00
abstract：:The progression and metastasis of solid tumors, including head and neck squamous cell carcinoma (HNSCC), have been related to the behavior of a small subpopulation of cancer stem cells. Here, we have established a highly malignant HNSCC cell line, SASVO3, from primary tumors using three sequential rounds of xenotransp...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1186/1423-0127-16-100
更新日期：2009-11-16 00:00:00
abstract：:Extracellular vesicles (EVs) are cell-derived membrane-bound vesicles that serve a means of cell-cell communication. Studying EVs at a single-particle level is important because EVs are inherently heterogeneous. Novel micro- and nanotechnological tools have open opportunities for realizing single-EV measurements explo...
journal_title：Journal of biomedical science
pub_type： 杂志文章,评审
doi：10.1186/s12929-019-0502-4
更新日期：2019-01-15 00:00:00
abstract：BACKGROUND:Noopept (N-phenyl-acetyl-L-prolylglycine ethyl ester) was constructed as a dipeptide analog of the standard cognition enhancer, piracetam. Our previous experiments have demonstrated the cognition restoring effect of noopept in several animal models of Alzheimer disease (AD). Noopept was also shown to prevent...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1186/s12929-014-0074-2
更新日期：2014-08-06 00:00:00
abstract：:Spinal muscular atrophy (SMA) is an autosomal recessive disorder characterized by degeneration of lower motor neurons. We have assayed deletions in two candidate genes, the survival motor neuron (SMN) and neuronal apoptosis inhibitory protein (NAIP) genes, in 108 samples, of which 46 were from SMA patients, and 62 wer...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1007/BF02256412
更新日期：2001-03-01 00:00:00
abstract：:Myostatin, a member of the TGF-beta superfamily, is a potent negative regulator of skeletal muscle and growth. Previously, we reported Mstn1 from zebrafish and studied its influence on muscle development. In this study, we identified another form of Myostatin protein which is referred to as Mstn2. The size of Mstn2 cD...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1007/s11373-008-9250-2
更新日期：2008-09-01 00:00:00
abstract：:The aim of this study was to determine whether the common forms of dyslipidemia could affect either the lipid composition or insulin receptor processing (down-regulation) of erythrocytes. The study included 22 patients with type IIa hypercholesterolemia, 15 patients with type IV hypertriglyceridemia and 12 patients wi...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1007/BF02253384
更新日期：1995-08-01 00:00:00
abstract：:In this study, we examined the postnatal expression patterns of p63 and other keratinocyte stem cell markers in the rat cornea in an attempt to determine the markers that best represent characteristics of corneal keratinocyte stem cells. We show that the expression of p63 in the rat cornea is unique and differs from t...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1007/BF02256130
更新日期：2004-09-01 00:00:00
