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Distinct population of highly malignant cells in a head and neck squamous cell carcinoma cell line established by xenograft model.

Abstract：

:The progression and metastasis of solid tumors, including head and neck squamous cell carcinoma (HNSCC), have been related to the behavior of a small subpopulation of cancer stem cells. Here, we have established a highly malignant HNSCC cell line, SASVO3, from primary tumors using three sequential rounds of xenotransplantation. SASVO3 possesses enhanced tumorigenic ability both in vitro and in vivo. Moreover, SASVO3 exhibits properties of cancer stem cells, including that increased the abilities of sphere-forming, the number of side population cells, the potential of transplanted tumor growth and elevated expression of the stem cell marker Bmi1. Injection of SASVO3 into the tail vein of nude mice resulted in lung metastases. These results are consistent with the postulate that the malignant and/or metastasis potential of HNSCC cells may reside in a stem-like subpopulation.

journal_name

J Biomed Sci

journal_title

Journal of biomedical science

authors

Chen CY,Chiou SH,Huang CY,Jan CI,Lin SC,Tsai ML,Lo JF

doi

10.1186/1423-0127-16-100

subject

Has Abstract

pub_date

2009-11-16 00:00:00

pages

100

eissn

1021-7770

issn

1423-0127

pii

1423-0127-16-100

journal_volume

16

pub_type

杂志文章

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