Abstract：
:In this study, we examined the postnatal expression patterns of p63 and other keratinocyte stem cell markers in the rat cornea in an attempt to determine the markers that best represent characteristics of corneal keratinocyte stem cells. We show that the expression of p63 in the rat cornea is unique and differs from that observed in humans. It changes with age, from central cornea-positive, peripheral cornea-positive, and limbus-positive, to central cornea-positive, peripheral cornea-positive, and limbus-negative, and finally to central cornea-negative, peripheral cornea-positive, and limbus-negative, as examined by immunohistochemical staining. However, when a more sensitive staining method was used, the limbus was also shown to be positive for p63, indicating a lower level of expression than that of the peripheral cornea. The basal layer of the rat limbal epithelium is the site where beta-catenin+, K14+, PCNA-, and K3- cells reside. This cell layer is also the site where slow-cycling cells are located. In contrast with observations made in humans, our results clearly indicate that p63 is expressed in stem cells and young transient amplifying cells of the rat cornea, with higher levels of expression in the latter.
journal_name
J Biomed Scijournal_title
Journal of biomedical scienceauthors
Hsueh YJ,Wang DY,Cheng CC,Chen JKdoi
10.1007/BF02256130keywords:
subject
Has Abstractpub_date
2004-09-01 00:00:00pages
641-51issue
5eissn
1021-7770issn
1423-0127pii
79677journal_volume
11pub_type
杂志文章abstract：:The present study was undertaken to elucidate the mechanism of intra-arterial propofol-induced vascular permeability change resulting in tissue edema. The mechanism of propofol-induced hyperpermeability was examined in a rat femoral artery injection model. Vascular permeability was determined by measuring the Evans bl...
journal_title：Journal of biomedical science
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更新日期：2016-12-03 00:00:00
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更新日期：2018-08-27 00:00:00
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journal_title：Journal of biomedical science
pub_type： 杂志文章,评审
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更新日期：2005-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2006-11-01 00:00:00
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journal_title：Journal of biomedical science
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更新日期：1998-01-01 00:00:00
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更新日期：2002-11-01 00:00:00
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journal_title：Journal of biomedical science
pub_type： 杂志文章,评审
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更新日期：2020-04-07 00:00:00
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pub_type： 杂志文章
doi：10.1007/BF02257924
更新日期：1995-01-01 00:00:00
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更新日期：2001-01-01 00:00:00
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journal_title：Journal of biomedical science
pub_type： 杂志文章,评审
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更新日期：2014-08-19 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2015-10-14 00:00:00
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更新日期：2001-05-01 00:00:00
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更新日期：2015-12-08 00:00:00
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