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Genomic landscape in acute myeloid leukemia and its implications in risk classification and targeted therapies.

Abstract：

:Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy in terms of clinical features, underlying pathogenesis and treatment outcomes. Recent advances in genomic techniques have unraveled the molecular complexity of AML leukemogenesis, which in turn have led to refinement of risk stratification and personalized therapeutic strategies for patients with AML. Incorporation of prognostic and druggable genetic biomarkers into clinical practice to guide patient-specific treatment is going to be the mainstay in AML therapeutics. Since 2017 there has been an explosion of novel treatment options to tailor personalized therapy for AML patients. In the past 3 years, the U.S. Food and Drug Administration approved a total of eight drugs for the treatment of AML; most specifically target certain gene mutations, biological pathways, or surface antigen. These novel agents are especially beneficial for older patients or those with comorbidities, in whom the treatment choice is limited and the clinical outcome is very poor. How to balance efficacy and toxicity to further improve patient outcome is clinically relevant. In this review article, we give an overview of the most relevant genetic markers in AML with special focus on the therapeutic implications of these aberrations.

journal_name

J Biomed Sci

journal_title

Journal of biomedical science

authors

Hou HA,Tien HF

doi

10.1186/s12929-020-00674-7

subject

Has Abstract

pub_date

2020-07-21 00:00:00

pages

81

issue

1

eissn

1021-7770

issn

1423-0127

pii

10.1186/s12929-020-00674-7

journal_volume

27

pub_type

杂志文章,评审

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