Abstract:
:Microfluidics has become an important tool in diagnosing many diseases, including neurological and genetic disorders. Alzheimer's disease (AD) is a neurodegenerative disease that irreversibly and progressively destroys memory, language ability, and thinking skills. Commonly, detection of AD is expensive and complex. Fluorescence in situ hybridization (FISH)-based microfluidic chip platform is capable of diagnosing AD at an early stage and they are effective tools for the diagnosis with low cost, high speed, and high sensitivity. In this review, we tried to provide basic information on the diagnosis of AD via FISH-based microfluidics. Different sample preparations using a microfluidic chip for diagnosis of AD are highlighted. Moreover, rapid innovations in nanotechnology for diagnosis are explained. This review will provide information on dynamic quantification methods for the diagnosis and treatment of AD. The knowledge provided in this review will help develop new integration diagnostic techniques based on FISH and microfluidics.
journal_name
J Biomed Scijournal_title
Journal of biomedical scienceauthors
Devadhasan JP,Kim S,An Jdoi
10.1186/1423-0127-18-33subject
Has Abstractpub_date
2011-05-28 00:00:00pages
33eissn
1021-7770issn
1423-0127pii
1423-0127-18-33journal_volume
18pub_type
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