Current use of autologous adipose tissue-derived stromal vascular fraction cells for orthopedic applications.

abstract：BACKGROUND:Wedelolactone (WEL), a major coumestan ingredient in Wedelia chinensis, has been used to treat septic shock, hepatitis and venom poisoning in traditional Chinese medicines. The objective of the study was to elucidate the anti-inflammatory effects and mechanism of WEL with a cellular model of lipopolysacchari...

journal_title：Journal of biomedical science

authors： Yuan F,Chen J,Sun PP,Guan S,Xu J

更新日期：2013-10-31 00:00:00

abstract：BACKGROUND:The probability of local tumor control after radiotherapy (RT) remains still miserably poor in pediatric rhabdomyosarcoma (RMS). Thus, understanding the molecular mechanisms responsible of tumor relapse is essential to identify personalized RT-based strategies. Contrary to what has been done so far, a correc...

journal_title：Journal of biomedical science

authors： Petragnano F,Pietrantoni I,Camero S,Codenotti S,Milazzo L,Vulcano F,Macioce G,Giordani I,Tini P,Cheleschi S,Gravina GL,Festuccia C,Rossetti A,Delle Monache S,Ordinelli A,Ciccarelli C,Mauro A,Barbara B,Antinozzi C,Sc

更新日期：2020-08-27 00:00:00

abstract：:The dual signal hypothesis of apoptosis holds that a common signal can activate both apoptotic and proliferative pathways. The fate of a cell is dependent on which of these two pathways predominates. In the MAPK family of kinases, ERK and JNK have been proposed to mediate apoptosis whereas the PI3K-stimulated kinase, ...

journal_title：Journal of biomedical science

authors： Chin LS,Murray SF,Harter DH,Doherty PF,Singh SK

更新日期：1999-05-01 00:00:00

abstract：:The first- and second-generation epidermal growth factor receptor tyrosine kinase inhibitors (1/2G EGFR-TKIs) gefitinib, erlotinib, and afatinib have all been approved as standard first-line treatments for advanced EGFR mutation-positive non-small cell lung cancer. The third-generation (3G) EGFR-TKIs have been develop...

journal_title：Journal of biomedical science

authors： Liao BC,Lin CC,Lee JH,Yang JC

更新日期：2016-12-03 00:00:00

abstract：BACKGROUND:Calcium oxalate (CaOx) is the major constituent of about 75% of all urinary stone and the secondary hyperoxaluria is a primary risk factor. Current treatment options for the patients with hyperoxaluria and CaOx stone diseases are limited. Oxalate degrading bacteria might have beneficial effects on urinary ox...

journal_title：Journal of biomedical science

authors： Sasikumar P,Gomathi S,Anbazhagan K,Abhishek A,Paul E,Vasudevan V,Sasikumar S,Selvam GS

更新日期：2014-08-30 00:00:00

abstract：:Oxidative stress and inflammation contributed to the propagation of acute liver injury (ALI). The present study was undertaken to determine whether D-galactosamine (D-GalN) induces ALI via the mitochondrial apoptosis- and proinflammatory cytokine-signaling pathways, and possible mechanism(s) by which green tea (GT) ex...

journal_title：Journal of biomedical science

authors： Lin BR,Yu CJ,Chen WC,Lee HS,Chang HM,Lee YC,Chien CT,Chen CF

更新日期：2009-03-25 00:00:00

abstract：:The sigma-1 receptor (Sig-1R) is a chaperone that resides mainly at the mitochondrion-associated endoplasmic reticulum (ER) membrane (called the MAMs) and acts as a dynamic pluripotent modulator in living systems. At the MAM, the Sig-1R is known to play a role in regulating the Ca2+ signaling between ER and mitochondr...

journal_title：Journal of biomedical science

authors： Weng TY,Tsai SA,Su TP

更新日期：2017-09-16 00:00:00

abstract：BACKGROUND:Epigallocatechin-3-gallate (EGCg) with its potent anti-oxidative capabilities is known for its beneficial effects ameliorating oxidative injury to cardiac cells. Although studies have provided convincing evidence to support the cardioprotective effects of EGCg, it remains unclear whether EGCg affect trans-me...

journal_title：Journal of biomedical science

authors： Hsieh SR,Hsu CS,Lu CH,Chen WC,Chiu CH,Liou YM

更新日期：2013-11-19 00:00:00

abstract：:The ACTGCTGA sequence (CTG motif) is located immediately upstream of the NF-kappaB enhancer in the human immunodeficiency virus type-1 (HIV-1) long terminal repeat (LTR). We previously reported on the frequent duplication of this motif in HIV-1-infected individuals. In this study we further characterized the role of t...

journal_title：Journal of biomedical science

authors： Koken SE,van Wamel JL,Geelen JL,Berkhout B

更新日期：1994-03-01 00:00:00

abstract：:Myostatin, a member of the TGF-beta superfamily, is a potent negative regulator of skeletal muscle and growth. Previously, we reported Mstn1 from zebrafish and studied its influence on muscle development. In this study, we identified another form of Myostatin protein which is referred to as Mstn2. The size of Mstn2 cD...

journal_title：Journal of biomedical science

authors： Amali AA,Lin CJ,Chen YH,Wang WL,Gong HY,Rekha RD,Lu JK,Chen TT,Wu JL

更新日期：2008-09-01 00:00:00

abstract：:Reactive oxygen species (ROS) have been long considered simply as harmful by-products of metabolism, which damage cellular proteins, lipids, and nucleic acids. ROS are also known as a weapon of phagocytes, employed against pathogens invading the host. However, during the last decade, an understanding has emerged that ...

journal_title：Journal of biomedical science

authors： Belikov AV,Schraven B,Simeoni L

更新日期：2015-10-15 00:00:00

abstract：:Alterations in eIF3-p48/INT6 gene expression have been implicated in murine and human mammary carcinogenesis. We examined levels of INT6 protein in human tumors and determined that breast and colon tumors clustered into distinct groups based on levels of INT6 expression and clinicopathological variables. We performed ...

journal_title：Journal of biomedical science

authors： Traicoff JL,Chung JY,Braunschweig T,Mazo I,Shu Y,Ramesh A,D'Amico MW,Galperin MM,Knezevic V,Hewitt SM

更新日期：2007-05-01 00:00:00

abstract：:The isoprostanes (IsoPs) are a unique series of prostaglandin-like compounds formed in vivo from the free radical-catalyzed peroxidation of arachidonic acid. This review summarizes our current knowledge regarding these compounds. Novel aspects of the biochemistry and bioactivity of IsoPs are detailed and methods by wh...

journal_title：Journal of biomedical science

authors： Liu T,Stern A,Roberts LJ,Morrow JD

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Increased lipid accumulation and mitochondrial dysfunction within skeletal muscle have been shown to be strongly associated with insulin resistance. However, the role of mitofusion-2 (MFN2), a key factor in mitochondrial function and energy metabolism, in skeletal muscle lipid intermediate accumulation remai...

journal_title：Journal of biomedical science

authors： Zhang X,Wang C,Song G,Gan K,Kong D,Nie Q,Ren L

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Our previous report suggested that centrosomal P4.1-associated protein (CPAP) is required for Hepatitis B virus (HBV) encoded non-structure protein X (HBx)-mediated nuclear factor kappa light chain enhancer of activated B cells (NF-κB) activation. CPAP is overexpressed in HBV-associated hepatocellular carcin...

journal_title：Journal of biomedical science

authors： Yen CJ,Yang ST,Chen RY,Huang W,Chayama K,Lee MH,Yang SJ,Lai HS,Yen HY,Hsiao YW,Wang JM,Lin YJ,Hung LY

更新日期：2019-06-06 00:00:00

abstract：:The ARFP/F protein is synthesized from the +1 reading frame of the hepatitis C virus (HCV) core protein gene. The function of this protein remains unknown. To study the function of the HCV ARFP/F protein, we have conducted the yeast two-hybrid screening experiment to identify cellular proteins that may interact with t...

journal_title：Journal of biomedical science

authors： Ma HC,Lin TW,Li H,Iguchi-Ariga SM,Ariga H,Chuang YL,Ou JH,Lo SY

更新日期：2008-07-01 00:00:00

abstract：:To identify novel genes associated with apoptosis in glioma cells, we treated T98G glioma cells with okadaic acid (OA). Differential display using 15 random primers was performed on RNA extracted from these cells. Upregulated bands were excised from polyacrylamide gels and cloned. Northern blots were used to confirm R...

journal_title：Journal of biomedical science

authors： Chin LS,Singh SK,Wang Q,Murray SF

更新日期：2000-03-01 00:00:00

abstract：:Schistosomiasis causes significant levels of morbidity and mortality in many geographical regions of the world. The disease is caused by infections with parasitic blood flukes known as schistosomes. The control of schistosomiasis over the last several decades has been centered on the mass drug administration (MDA) of ...

journal_title：Journal of biomedical science

authors： Molehin AJ

更新日期：2020-01-22 00:00:00

abstract：BACKGROUND:Whereas brain death is a vitally important clinical phenomenon, our contemporary understanding on its underlying cellular mechanisms remains elusive. This study evaluated whether the ubiquitin-proteasome system (UPS) in the rostral ventrolateral medulla (RVLM), a neural substrate that our laboratory identifi...

journal_title：Journal of biomedical science

authors： Wu CH,Chan JY,Chou JL,Chan SH,Chang AY

更新日期：2012-04-30 00:00:00

abstract：:Cancer has been the leading cause of death in Taiwan over the past two decades and liver cancer is the leading cause of all cancer deaths in Taiwan with a trend of increase in incidence. Therapeutic options and efficacy for liver cancer have been limited and the 5-year survival rate is less than 7% in the Unite States...

journal_title：Journal of biomedical science

authors： Chuu JJ,Liu JM,Tsou MH,Huang CL,Chen CP,Wang HS,Chen CT

更新日期：2007-03-01 00:00:00

abstract：:The ability of cells of the human monocyte/macrophage lineage to host HIV-1 replication while resisting cell death is believed to significantly contribute to their ability to serve as a reservoir for viral replication in the host. Although macrophages are generally resistant to apoptosis, interruption of anti-apoptoti...

journal_title：Journal of biomedical science

authors： Zhang M,Li X,Pang X,Ding L,Wood O,Clouse KA,Hewlett I,Dayton AI

更新日期：2002-03-01 00:00:00

abstract：:Mitochondria are the major intracellular source and target sites of reactive oxygen species (ROS) that are continually generated as by-products of aerobic metabolism in animal and human cells. It has been demonstrated that mitochondrial respiratory function declines with age in various human tissues and that a defecti...

journal_title：Journal of biomedical science

authors： Lee HC,Wei YH

更新日期：1997-11-01 00:00:00

abstract：:The present study was to investigate the effects and action mechanisms of dehydroepiandrosterone (DHEA) on steroidogenesis in rat adrenal zona glomerulosa cells (ZG). ZG cells were incubated with DHEA in the presence or absence of angiotensin II (AngII), a high concentration of potassium, 8-Br-cAMP, forskolin, 25-OH-c...

journal_title：Journal of biomedical science

authors： Chang LL,Wun WS,Wang PS

更新日期：2008-07-01 00:00:00

abstract：:Hypoxia is an important microenvironmental factor that induces cancer metastasis. Hypoxia/hypoxia-inducible factor-1α (HIF-1α) regulates many important steps of the metastatic processes, especially epithelial-mesenchymal transition (EMT) that is one of the crucial mechanisms to cause early stage of tumor metastasis. T...

journal_title：Journal of biomedical science

authors： Tsai YP,Wu KJ

更新日期：2012-12-14 00:00:00

abstract：BACKGROUND:Developing brain is a major target for alcohol's actions and neurological/functional abnormalities include microencephaly, reduced frontal cortex, mental retardation and attention-deficits. Previous studies have shown that ethanol altered the lateral ventricular neuroepithelial cell proliferation. However, t...

journal_title：Journal of biomedical science

authors： Riar AK,Narasimhan M,Rathinam ML,Henderson GI,Mahimainathan L

更新日期：2016-01-19 00:00:00

abstract：:The SARS related Coronavirus genome contains a variety of novel accessory genes. One of these, called ORF7a or ORF8, code for a protein, known as 7a, U122 or X4. We set out to determine the three-dimensional structure of the soluble ectodomain of this type-I transmembrane protein by nuclear magnetic resonance spectros...

journal_title：Journal of biomedical science

authors： Hänel K,Stangler T,Stoldt M,Willbold D

更新日期：2006-05-01 00:00:00

abstract：:Activation of hepatic stellate cells (HSCs) plays a crucial role in liver fibrogenesis. armepavine (Arm, C19H23O3N), an active compound from Nelumbo nucifera, has been shown to exert immunosuppressive effects on T lymphocytes and on lupus nephritic mice. The aim of this study was to investigate whether Arm could exert...

journal_title：Journal of biomedical science

authors： Weng TC,Shen CC,Chiu YT,Lin YL,Kuo CD,Huang YT

更新日期：2009-09-02 00:00:00

abstract：:The purpose of this study was to determine whether beta-adrenergically mediated cardiovascular functions such as arterial pressure (AP), heart rate (HR), stroke volume (SV), cardiac output (CO), peripheral resistance (R(p)), arterial impedance (Z(c)), mean arterial compliance (C(m)) and pulse wave reflection (P(b)) we...

journal_title：Journal of biomedical science

authors： Hu CT,Wu CY,Chen HI

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:Bisphosphonates are an important class of antiresorptive drugs used in the treatment of metabolic bone diseases. Recent studies have shown that nitrogen-containing bisphosphonates induced apoptosis in rabbit osteoclasts and prevented prenylated small GTPase. However, whether bisphosphonates inhibit osteoclas...

journal_title：Journal of biomedical science

authors： Tsubaki M,Komai M,Itoh T,Imano M,Sakamoto K,Shimaoka H,Takeda T,Ogawa N,Mashimo K,Fujiwara D,Mukai J,Sakaguchi K,Satou T,Nishida S

更新日期：2014-02-03 00:00:00

abstract：:The intracellular mechanisms underlying oxidized low-density lipoprotein (oxLDL)-signaling pathways in platelets are not yet completely understood. Therefore, the aim of this study was to further examine the effects of oxLDL in prevention of platelet aggregation. In this study, oxLDL concentration-dependently (40-120 ...

journal_title：Journal of biomedical science

authors： Chou DS,Chan CH,Hsiao G,Shen MY,Tsai YJ,Chen TF,Sheu JR

更新日期：2006-05-01 00:00:00