Abstract：
:The sigma-1 receptor (Sig-1R) is a chaperone that resides mainly at the mitochondrion-associated endoplasmic reticulum (ER) membrane (called the MAMs) and acts as a dynamic pluripotent modulator in living systems. At the MAM, the Sig-1R is known to play a role in regulating the Ca2+ signaling between ER and mitochondria and in maintaining the structural integrity of the MAM. The MAM serves as bridges between ER and mitochondria regulating multiple functions such as Ca2+ transfer, energy exchange, lipid synthesis and transports, and protein folding that are pivotal to cell survival and defense. Recently, emerging evidences indicate that the MAM is critical in maintaining neuronal homeostasis. Thus, given the specific localization of the Sig-1R at the MAM, we highlight and propose that the direct or indirect regulations of the Sig-1R on mitochondrial functions may relate to neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS). In addition, the promising use of Sig-1R ligands to rescue mitochondrial dysfunction-induced neurodegeneration is addressed.
journal_name
J Biomed Scijournal_title
Journal of biomedical scienceauthors
Weng TY,Tsai SA,Su TPdoi
10.1186/s12929-017-0380-6subject
Has Abstractpub_date
2017-09-16 00:00:00pages
74issue
1eissn
1021-7770issn
1423-0127pii
10.1186/s12929-017-0380-6journal_volume
24pub_type
杂志文章,评审abstract：:The technology of "Lab-on-a-Chip" allows the synthesis and analysis of chemicals and biological substance within a portable or handheld device. The 3D printed structures enable precise control of various geometries. The combination of these two technologies in recent years makes a significant progress. The current app...
journal_title：Journal of biomedical science
pub_type： 杂志文章,评审
doi：10.1186/s12929-017-0384-2
更新日期：2017-10-18 00:00:00
abstract：:Zebrafish tbx5 expresses in the heart, pectoral fins and eyes of zebrafish during embryonic development. In zebrafish, injection of tbx5 morpholino antisense RNA caused changes of heart conformation, defect of heart looping, pericardium effusion, dropsy of ventral position and decreased heart rate. We suggested that c...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1007/s11373-008-9268-5
更新日期：2008-11-01 00:00:00
abstract：:Previously we have reported the presence of endogenous ligands that are involved in the regulation of the binding of muscimol to the GABA binding site of the GABAA receptors. Here, we report the presence of multiple forms of endogenous ligands in the brain which modulate the binding of flunitrazepam (FNZP) to the benz...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1007/BF02255859
更新日期：1998-07-01 00:00:00
abstract：:Schistosomiasis causes significant levels of morbidity and mortality in many geographical regions of the world. The disease is caused by infections with parasitic blood flukes known as schistosomes. The control of schistosomiasis over the last several decades has been centered on the mass drug administration (MDA) of ...
journal_title：Journal of biomedical science
pub_type： 杂志文章,评审
doi：10.1186/s12929-020-0621-y
更新日期：2020-01-22 00:00:00
abstract：BACKGROUND:Oxidative stress is a major factor in retinal pigment epithelium (RPE) cells injury that contributes to age-related macular degeneration (AMD). NaIO3 is an oxidative toxic agent and its selective RPE cell damage makes it as a reproducible model of AMD. Although NaIO3 is an oxidative stress inducer, the roles...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1186/s12929-019-0531-z
更新日期：2019-05-22 00:00:00
abstract：BACKGROUND:Since our previous report on WHO CARDIAC Study data demonstrated that 24-hour urinary (24U) taurine (Tau) excretion was a useful biomarker of seafood (SF) intake and inversely related to the mortality rates of stroke and coronary heart diseases in the world, we determined that SF is important in the risk red...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1186/1423-0127-17-S1-S43
更新日期：2010-08-24 00:00:00
abstract：:While virus-like particles (VLPs) containing subgenomic replicons, which can transduce replicons into target cells efficiently for studying viral replication and vectors of gene therapy and vaccine, have been established for several flaviviruses, none has been reported for the four serotypes of dengue virus, the causa...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1007/s11373-007-9204-0
更新日期：2008-01-01 00:00:00
abstract：:DNA vaccines have emerged as an attractive approach for generating antigen-specific immunotherapy. Strategies that enhance antigen presentation may potentially be used to enhance DNA vaccine potency. Previous experiments showed that chimeric DNA vaccines utilizing endoplasmic reticulum (ER) chaperone molecules, such a...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1007/s11373-005-0334-y
更新日期：2005-01-01 00:00:00
abstract：:To search for cellular genes up-regulated by vaccinia virus (VV) infection, differential display-reverse transcription-polymerase chain reaction (ddRT-PCR) assays were used to examine the expression of mRNAs from mock-infected and VV-infected HeLa cells. Two mitochondrial genes for proteins that are part of the electr...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1186/1423-0127-16-80
更新日期：2009-09-02 00:00:00
abstract：:The midbrain periaqueductal gray matter (PAG) is an important brain region for the coordination of mu-opioid-induced pharmacological actions. The present study was designed to determine whether newly isolated mu-opioid peptide endomorphins can activate G proteins through mu-opioid receptors in the PAG by monitoring th...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1007/BF02255469
更新日期：2000-05-01 00:00:00
abstract：:Adeno-associated virus (AAV) vectors were shown capable of high efficiency transduction of both dividing and nondividing cells and tissues. AAV-mediated transduction leads to stable, long-term transgene expression in the absence of apparent immune response. These properties and the broad host range of AAV vectors indi...
journal_title：Journal of biomedical science
pub_type： 杂志文章,评审
doi：10.1007/BF02253246
更新日期：2000-07-01 00:00:00
abstract：BACKGROUND:Detection of cholangiocarcinoma (CCA) remains a diagnostic challenge. We established diagnostic peptide biomarkers in bile and urine based on capillary electrophoresis coupled to mass spectrometry (CE-MS) to detect both local and systemic changes during CCA progression. In a prospective cohort study we recen...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1186/s12929-019-0599-5
更新日期：2020-01-03 00:00:00
abstract：:Serologically defined primary dengue virus infection and/or subsequent homologous serotype infection is known to be associated with less severe disease as compared with secondary subsequent heterologous serotype infection. In geographical locales of high dengue endemicity, almost all individuals in the population are ...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1186/1423-0127-20-34
更新日期：2013-05-31 00:00:00
abstract：:Dehydroepiandrosterone (DHEA) is a putative anti-stress agent and stress is associated with the secretion of catecholamine from the adrenal gland, but the effects of DHEA on catecholamine secretion are not fully understood. Using bovine chromaffin cells, we found that DHEA inhibited catecholamine secretion and cytosol...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1007/BF02256563
更新日期：2004-03-01 00:00:00
abstract：BACKGROUND:To mimic systemic inflammation in humans, different animal models have been developed. Since these models are still discussed controversially, we aimed to comparatively evaluate the most widely used models with respect to the systemic effects, the influence on organ functions and to the underlying pathophysi...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1186/s12929-017-0370-8
更新日期：2017-08-24 00:00:00
abstract：BACKGROUND:Oxidized low-density lipoprotein (oxLDL) mediates the transformation of macrophages (MΦ) to cholesterol-rich foam cells and the release of pro-inflammatory cytokines during atherogenesis. JAB1 (Jun activation domain binding protein-1) is present in all stages of human plaques, involved in the Toll-like recep...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1186/s12929-017-0320-5
更新日期：2017-02-07 00:00:00
abstract：:Diabetes is a multifactorial disease that has now been recognized to involve overproduction of reactive oxygen species and pro-inflammatory cytokines. Peroxisomes are subcellular organelles with several important metabolic functions, and their role in the regulation of cellular oxidative stress is now well established...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1159/000079667
更新日期：2004-09-01 00:00:00
abstract：:Accumulative evidence has supported the role of nitric oxide (NO) in a variety of normal physiological functions as well as many pathological conditions. In this study, we examined the possible diabetogenicity of NO by measuring the expression of the insulin receptor substrate (IRS)-1 in rat hepatocytes and skeletal m...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1007/s11373-006-9073-y
更新日期：2006-07-01 00:00:00
abstract：:Ischemia and reperfusion (I/R) - induced injury has been described as one of the main factors that contribute to the observed morbidity and mortality in a variety of clinical entities, including myocardial infarction, ischemic stroke, cardiac arrest and trauma. An imbalance between oxygen demand and supply, within the...
journal_title：Journal of biomedical science
pub_type： 杂志文章,评审
doi：10.1186/s12929-016-0220-0
更新日期：2016-01-19 00:00:00
abstract：BACKGROUND:Among a variety of inflammatory mediators, visfatin is a proinflammatory adipocytokine associated with inflammatory reactions in obesity, metabolic syndrome, chronic inflammatory disease, and autoimmune disease. However, the biological role of visfatin in secretion of major mucins in human airway epithelial ...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1186/1423-0127-21-49
更新日期：2014-05-20 00:00:00
abstract：:The signaling pathways leading to extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) activation by N-formyl-Met-Leu-Phe (fMLP) or platelet activating factor (PAF) in human neutrophils were examined. Previously, we found that changes of intracellular Ca2+ ([Ca2+]i) stimulated by...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1007/s11373-005-1704-1
更新日期：2005-01-01 00:00:00
abstract：:Based on the tertiary structure of the ribosome-inactivating protein alpha-sarcin, domains that are responsible for hydrolyzing ribosomes and naked RNA have been dissected. In this study, we found that the head-to-tail interaction between the first amino beta-strand and the last carboxyl beta-strand is not involved in...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1007/BF02255817
更新日期：2000-09-01 00:00:00
abstract：:Sequencing of HIV-1(GER) long terminal repeat (LTR) has demonstrated, for the first time in an HIV-1 primary isolate, a TAR duplication referred to as TAR1 (nucleotides +1 through +68) and TAR2 (nucleotides +69 through +136). This TAR duplication is stable during replication of HIV-1(GER) isolate in CEM cells. Analysi...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1007/BF02253576
更新日期：1996-01-01 00:00:00
abstract：:The likelihood that expression of a foreign gene in a mammalian cell is deleterious to viability is confronted whenever novel transgenic animals are made. A pathological response to transgene expression is even desired in transgenic mouse models of human disease. The derivation of HIV-transgenic mice in our laboratory...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1007/BF02253065
更新日期：1995-04-01 00:00:00
abstract：BACKGROUND:CIP4 is a scaffold protein that regulates membrane deformation and tubulation, organization of the actin cytoskeleton, endocytosis of growth factor receptors, and vesicle trafficking. Although expressed in the heart, CIP4 has not been studied with regards to its potential function in cardiac myocytes. RESUL...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1186/1423-0127-20-56
更新日期：2013-08-03 00:00:00
abstract：:The aim of this study was to determine whether the common forms of dyslipidemia could affect either the lipid composition or insulin receptor processing (down-regulation) of erythrocytes. The study included 22 patients with type IIa hypercholesterolemia, 15 patients with type IV hypertriglyceridemia and 12 patients wi...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1007/BF02253384
更新日期：1995-08-01 00:00:00
abstract：BACKGROUND:Chemotherapy and targeted therapies have made important strides in cancer treatment yet they often fail and new therapies are still needed. Here, we employed a phenotypic screen to identify and analyze the mechanism of action of novel small molecules that interfere with critical pathways involved in tumor ce...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1186/s12929-018-0408-6
更新日期：2018-02-08 00:00:00
abstract：BACKGROUND:Glioma stem-like cells (GSCs) are proposed to be responsible for high resistance in glioblastoma multiforme (GBM) treatment. In order to find new strategies aimed at reducing GSC stemness and improving GBM patient survival, we investigated the effects and mechanism of a histone deacetylases (HDACs) inhibitor...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1186/s12929-016-0296-6
更新日期：2016-11-18 00:00:00
abstract：BACKGROUND:Dioscin, a typical steroid saponin, is isolated from Dioscorea nipponica Makino and Dioscorea zingiberensis Wright. It has estrogenic activity and many studies have also reported that dioscorea plants have an effect in preventing and treating osteoporosis. However, the molecular mechanisms underlying their e...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1186/1423-0127-21-30
更新日期：2014-04-17 00:00:00
abstract：:Human mesenchymal stem cells (hMSCs) are multipotent cells that can differentiate into various tissue types, including bone, cartilage, tendon, adipocytes, and marrow stroma, making them potentially useful for human cell and gene therapies. Our objective was to demonstrate the utility of glass needle-mediated microinj...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1007/BF02256452
更新日期：2003-05-01 00:00:00
