Epigallocatechin-3-gallate-mediated cardioprotection by Akt/GSK-3β/caveolin signalling in H9c2 rat cardiomyoblasts.

abstract：:The nucleotide sequences of the putative envelope region (E1) and the junction between the E1 and envelope 2/nonstructural 1 (E2/NS1) region of the hepatitis C virus (HCV) genome are divergent among different genotypes. To characterize them, we introduced a set of nested primers that are conserved among four different...

journal_title：Journal of biomedical science

authors： Kao JH,Chen PJ,Lai MY,Yang PM,Sheu JC,Wang TH,Chen DS

更新日期：1994-06-01 00:00:00

abstract：:Over the past few years, long non-coding RNAs (lncRNAs) are recognized as key regulators of gene expression at chromatin, transcriptional and posttranscriptional level with pivotal roles in various biological and pathological processes, including cancer. Hypoxia, a common feature of the tumor microenvironment, profoun...

journal_title：Journal of biomedical science

authors： Kuo TC,Kung HJ,Shih JW

更新日期：2020-05-05 00:00:00

abstract：:Upon cell adhesion to extracellular matrix proteins, focal adhesion kinase (FAK) rapidly undergoes autophosphorylation on its Tyr-397 which consequently serves as a binding site for the Src homology 2 domains of the Src family protein kinases and several other intracellular signaling molecules. In this study, we have ...

journal_title：Journal of biomedical science

authors： Chang LC,Huang CH,Cheng CH,Chen BH,Chen HC

更新日期：2005-01-01 00:00:00

abstract：:Angiogenesis is essential for development, growth and advancement of solid tumors. Cyclooxygenase (COX)-2 is recognized as an angiogenic factor in various tumors. This prompted us to study the clinical implications of COX-2 expression related to angiogenesis in uterine cervical cancers. There was a significant correla...

journal_title：Journal of biomedical science

authors： Fujimoto J,Toyoki H,Sato E,Sakaguchi H,Jahan I,Alam SM,Tamaya T

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:The blood-spinal cord barrier (BSCB) is composed of a monolayer of endothelium linked with tight junctions and extracellular matrix (ECM)-rich basement membranes and is surrounded by astrocyte foot processes. Endothelial permeability is regulated by interaction between endothelial cells and ECM proteins. Fib...

journal_title：Journal of biomedical science

authors： Lee TH,Hsieh ST,Chiang HY

更新日期：2019-05-16 00:00:00

abstract：BACKGROUND:Autophagy has been shown recently to play an important role in the intracellular survival of several pathogenic bacteria. In this study, we investigated the effect of a novel small-molecule autophagy-inducing agent, AR-12, on the survival of Francisella tularensis, the causative bacterium of tularemia in hum...

journal_title：Journal of biomedical science

authors： Chiu HC,Soni S,Kulp SK,Curry H,Wang D,Gunn JS,Schlesinger LS,Chen CS

更新日期：2009-12-09 00:00:00

abstract：:Influence of adjuvants i.e., alpha-tocopherol (25 mg/kg, p.o.) and piperine (10 mg/kg, p.o.) on therapeutic potential of chelator tiferron (300 mg/kg, i.p.) was evaluated to encounter toxicogenic events of beryllium exposure. Albino rats were exposed to beryllium nitrate (1 mg/kg, i.p.) daily for 28 days followed by t...

journal_title：Journal of biomedical science

authors： Nirala SK,Bhadauria M,Mathur R,Mathur A

更新日期：2007-05-01 00:00:00

abstract：:The midbrain periaqueductal gray matter (PAG) is an important brain region for the coordination of mu-opioid-induced pharmacological actions. The present study was designed to determine whether newly isolated mu-opioid peptide endomorphins can activate G proteins through mu-opioid receptors in the PAG by monitoring th...

journal_title：Journal of biomedical science

authors： Narita M,Mizoguchi H,Narita M,Dun NJ,Hwang BH,Endoh T,Suzuki T,Nagase H,Suzuki T,Tseng LF

更新日期：2000-05-01 00:00:00

abstract：:The HIV pol sequentially encodes protease (PR), reverse transcriptase (RT), and integrase (IN) from the 5'-3' direction. We explored the significance of this gene arrangement. All six possible gene dispositions were examined. In two situations where PR was removed from the leading place and no two genes were in their ...

journal_title：Journal of biomedical science

authors： Chang YY,Yu SL,Syu WJ

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Dioscin, a typical steroid saponin, is isolated from Dioscorea nipponica Makino and Dioscorea zingiberensis Wright. It has estrogenic activity and many studies have also reported that dioscorea plants have an effect in preventing and treating osteoporosis. However, the molecular mechanisms underlying their e...

journal_title：Journal of biomedical science

authors： Zhang C,Peng J,Wu S,Jin Y,Xia F,Wang C,Liu K,Sun H,Liu M

更新日期：2014-04-17 00:00:00

abstract：:Diazoxide is a selective mitochondria ATP-sensitive potassium (K(ATP)) channel opener, which has been reported to preserve the microvascular integrity of ischemia-reperfusion (I/R)-injured tissues. Our study aimed to assess diazoxide's effects on I/R-injured cremaster muscles and to further elucidate its underlying me...

journal_title：Journal of biomedical science

authors： Wei W,Wei FC,Hung LM

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Human papillomavirus (HPV) is the most common sexually transmitted virus in women worldwide. The persistence of the virus may cause warts that are considered benign lesions and low or high grade intraepithelial lesions (LSIL/HSIL). Immunological system plays an important role in the resolution of infections....

journal_title：Journal of biomedical science

authors： Okuyama NCM,Cezar-Dos-Santos F,Pereira ÉR,Trugilo KP,Cebinelli GCM,Sena MM,Pereira APL,Aranome AMF,Mangieri LFL,Ferreira RS,Watanabe MAE,de Oliveira KB

更新日期：2018-09-18 00:00:00

abstract：:In many solid tumor types, tumor-associated macrophages (TAMs) are important components of the tumor microenvironment (TME). Moreover, TAMs infiltration is strongly associated with poor survival in solid tumor patients. In this review, we describe the origins of TAMs and their polarization state dictated by the TME. W...

journal_title：Journal of biomedical science

authors： Chen Y,Song Y,Du W,Gong L,Chang H,Zou Z

更新日期：2019-10-20 00:00:00

abstract：:Recent transcriptome analyses have revealed that noncoding RNAs (ncRNAs) are broadly expressed in mammalian cells and abundant in the CNS, with tissue and cell type-specific expression patterns. Moreover, ncRNAs have been found to intricately and dynamically regulate various signaling pathways in neurodegeneration. As...

journal_title：Journal of biomedical science

authors： Wu YY,Kuo HC

更新日期：2020-04-07 00:00:00

abstract：BACKGROUND:The association of TGF beta1 polymorphisms and atrial fibrillation (AF) in essential hypertensive (EH) subjects remains unknown. Methods EH subjects with AF (EH+AF+) and sinus rhythm (EH+AF-) were enrolled. The polymorphisms of +869 T --> C at codon 10 and + 915 G --> C at codon 25, were genotyped. The clini...

journal_title：Journal of biomedical science

authors： Wang Y,Hou X,Li Y

更新日期：2010-03-31 00:00:00

abstract：:The sigma-1 receptor (Sig-1R) is a chaperone that resides mainly at the mitochondrion-associated endoplasmic reticulum (ER) membrane (called the MAMs) and acts as a dynamic pluripotent modulator in living systems. At the MAM, the Sig-1R is known to play a role in regulating the Ca2+ signaling between ER and mitochondr...

journal_title：Journal of biomedical science

authors： Weng TY,Tsai SA,Su TP

更新日期：2017-09-16 00:00:00

abstract：:The CDC4 gene of Saccharomyces cerevisiae encodes an essential function that is required for G1-S and G2-M transitions during mitosis and at various stages during meiosis. We have isolated a functional homologue of CDC4 (CaCDC4) from the pathogenic yeast Candida albicans by complementing the S. cerevisiae cdc4-3 mutat...

journal_title：Journal of biomedical science

authors： Shieh JC,White A,Cheng YC,Rosamond J

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Increased lipid accumulation and mitochondrial dysfunction within skeletal muscle have been shown to be strongly associated with insulin resistance. However, the role of mitofusion-2 (MFN2), a key factor in mitochondrial function and energy metabolism, in skeletal muscle lipid intermediate accumulation remai...

journal_title：Journal of biomedical science

authors： Zhang X,Wang C,Song G,Gan K,Kong D,Nie Q,Ren L

更新日期：2013-07-01 00:00:00

abstract：:A number of infectious agents have been implicated in the development of vascular diseases such as atherosclerosis and posttransplantation arterial restenosis. Cytomegalovirus (CMV) has been reported to cause obliteration of coronary arteries by a progressive vasculopathy that involves proliferation of medial smooth m...

journal_title：Journal of biomedical science

authors： Dhaunsi GS,Kaur J,Turner RB

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:Breast cancer is considered as an increasing major life-threatening concern among the malignancies encountered globally in females. Traditional therapy is far from satisfactory due to drug resistance and various side effects, thus a search for complementary/alternative medicines from natural sources with les...

journal_title：Journal of biomedical science

authors： Banerjee M,Chattopadhyay S,Choudhuri T,Bera R,Kumar S,Chakraborty B,Mukherjee SK

更新日期：2016-04-16 00:00:00

abstract：BACKGROUND:Cervical cancer is the second-most-common cause of malignancies in women worldwide, and the oncogenic activity of the human papilloma virus types (HPV) E7 protein has a crucial role in anogenital tumors. In this study, we have designed a therapeutic vaccine based on chitosan nanodelivery systems to deliver H...

journal_title：Journal of biomedical science

authors： Tahamtan A,Ghaemi A,Gorji A,Kalhor HR,Sajadian A,Tabarraei A,Moradi A,Atyabi F,Kelishadi M

更新日期：2014-07-31 00:00:00

abstract：BACKGROUND:Activating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER)-localised protein and member of the leucine zipper family of transcription factors. Best known for its role in transducing signals linked to stress to the endoplasmic reticulum, the 50 kDa activated form of ATF6 is now emerging as a ma...

journal_title：Journal of biomedical science

authors： Hillary RF,FitzGerald U

更新日期：2018-05-25 00:00:00

abstract：BACKGROUND:Pulmonary emphysema is characterized histologically by destruction of alveolar walls and enlargement of air spaces due to lung epithelial cell apoptosis. Cell adhesion molecule 1 (CADM1) is an immunoglobulin superfamily member expressed in lung epithelial cells. CADM1 generates a membrane-associated C-termin...

journal_title：Journal of biomedical science

authors： Hagiyama M,Yoneshige A,Inoue T,Sato Y,Mimae T,Okada M,Ito A

更新日期：2015-08-11 00:00:00

abstract：BACKGROUND:To develop an individually-tailored dynamic risk assessment model following a multistep, multifactorial process of the Correa's gastric cancer model. METHODS:First, we estimated the state-to-state transition rates following Correa's five-step carcinogenic model and assessed the effect of risk factors, inclu...

journal_title：Journal of biomedical science

authors： Fann JC,Chiang TH,Yen AM,Lee YC,Wu MS,Chen HH

更新日期：2018-11-19 00:00:00

abstract：:Plasma nitric oxide (NO) levels in Duchenne muscular dystrophy (DMD) patients were significantly lower than those observed in both healthy controls and in patients with other neuromuscular disorders. The correlation between NO level and ejection fraction was significant (r = -0.384, p = 0.0391) in the DMD group. Disru...

journal_title：Journal of biomedical science

authors： Kasai T,Abeyama K,Hashiguchi T,Fukunaga H,Osame M,Maruyama I

更新日期：2004-07-01 00:00:00

abstract：:The HIV-1 Tat protein is an RNA-binding transcriptional transactivator. Recent findings suggest that Tat associates with a cellular kinase that phosphorylates the carboxyl-terminal domain of the largest subunit of RNA polymerase II. Here we review, in brief, the role of Tat-associated kinase in Tat-activated transcrip...

journal_title：Journal of biomedical science

authors： Jeang KT

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Granulocyte colony-stimulating factor (G-CSF), a hematopoietic cytokine, was recently used to treat patients of acute myocardial infarction with beneficial effect. However, controversy exists as some patients developed re-stenosis and worsened condition post G-CSF delivery. This study presents a new disease ...

journal_title：Journal of biomedical science

authors： Lian WS,Lin H,Cheng WT,Kikuchi T,Cheng CF

更新日期：2011-04-15 00:00:00

abstract：:DNA vaccines have emerged as an attractive approach for generating antigen-specific immunotherapy. Strategies that enhance antigen presentation may potentially be used to enhance DNA vaccine potency. Previous experiments showed that chimeric DNA vaccines utilizing endoplasmic reticulum (ER) chaperone molecules, such a...

journal_title：Journal of biomedical science

authors： Lin CT,Chang TC,Chao A,Dzeng E,Soong YK,Hung CF,Lai CH

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:NKG2D, an activating immunoreceptor, is primarily restricted to NK cells and CD8(+) T cells. The existence of an atypical cytotoxic CD4(+)NKG2D(+) T cell population has also been found in patients with autoimmune dysfunctions. Nonetheless, contradictory evidence has categorized this population with a regulat...

journal_title：Journal of biomedical science

authors： Garcia-Chagollan M,Jave-Suarez LF,Haramati J,Bueno-Topete MR,Aguilar-Lemarroy A,Estrada-Chavez C,Bastidas-Ramirez BE,Pereira-Suarez AL,Del Toro-Arreola S

更新日期：2015-10-20 00:00:00

abstract：BACKGROUND:Glioma stem-like cells (GSCs) are proposed to be responsible for high resistance in glioblastoma multiforme (GBM) treatment. In order to find new strategies aimed at reducing GSC stemness and improving GBM patient survival, we investigated the effects and mechanism of a histone deacetylases (HDACs) inhibitor...

journal_title：Journal of biomedical science

authors： Hsu CC,Chang WC,Hsu TI,Liu JJ,Yeh SH,Wang JY,Liou JP,Ko CY,Chang KY,Chuang JY

更新日期：2016-11-18 00:00:00