Abstract：
:Influence of adjuvants i.e., alpha-tocopherol (25 mg/kg, p.o.) and piperine (10 mg/kg, p.o.) on therapeutic potential of chelator tiferron (300 mg/kg, i.p.) was evaluated to encounter toxicogenic events of beryllium exposure. Albino rats were exposed to beryllium nitrate (1 mg/kg, i.p.) daily for 28 days followed by treatment of aforesaid therapeutic agents for 5 consecutive days. Results were considered to be significant at p < or =0.01 and p < or =0.05. Exposure to beryllium increased its concentration in liver, kidney and serum causing significant alterations in the activity of CYP-450 2E1 system, microsomal lipid peroxidation and protein; alkaline phosphtase, lactate dehydrogenase, gamma-glutamyl transpeptidase, bilirubin, creatinine and urea in serum; activity of acid phosphatase, alkaline phosphatase, adenosine triphosphatase, glucose-6-phosphatase and succinic dehydrogenase in liver and kidney. Beryllium exposure also induced severe alterations in histopathology and ultramorphology of liver and kidney proving its toxic consequences at cellular level. Tiferron along with adjuvants dramatically reversed alterations of all variables more towards control rather than individual treatment. Study concluded that tiferron in combination with alpha-tocopherol and piperine respectively was beneficial in diluting beryllium induced systemic toxicity; however, combination of tiferron and piperine presented more pronounced therapeutic potential.
journal_name
J Biomed Scijournal_title
Journal of biomedical scienceauthors
Nirala SK,Bhadauria M,Mathur R,Mathur Adoi
10.1007/s11373-007-9147-5subject
Has Abstractpub_date
2007-05-01 00:00:00pages
331-45issue
3eissn
1021-7770issn
1423-0127journal_volume
14pub_type
杂志文章abstract：BACKGROUND:Mounting evidences have showed the important role of transforming growth factor-β (TGF-β) in immunological surveillance of tumors. Some studies have also indicated human leukocyte antigen (HLA)-G-associated immune escape involving TGF-β management in gastric cancer (GC). However, the mechanism underlying it ...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1186/s12929-015-0177-4
更新日期：2015-12-02 00:00:00
abstract：BACKGROUND:Parkinson's disease is the second most common neurodegenerative disorders after Alzheimer's disease. The main cause of the disease is the massive degeneration of dopaminergic neurons in the substantia nigra. Neuronal apoptosis and neuroinflammation are thought to be the key contributors to the neuronal degen...
journal_title：Journal of biomedical science
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更新日期：2015-05-28 00:00:00
abstract：BACKGROUND:Helicobacter pylori bacteria colonize human gastric mucosa, cause chronic inflammation, peptic ulcers and gastric cancer. Colonization is mediated by H. pylori adhesins, which preferentially bind mucin 5 (MUC5AC) and Lewis (Le) determinants. The aim of this study was to evaluate the influence of H. pylori an...
journal_title：Journal of biomedical science
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doi：10.1186/s12929-019-0515-z
更新日期：2019-03-06 00:00:00
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journal_title：Journal of biomedical science
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abstract：:The envelope gene of Moloney murine leukemia virus (Mo-MLV) and its various functional domains have been studied extensively but not as much in terms of their biological effects on cell growth. In this study, we report the biological characterization of a truncated Mo-MLV envelope gene, LN11, which is devoid of a sign...
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journal_title：Journal of biomedical science
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更新日期：2010-08-24 00:00:00
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journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1007/BF02255859
更新日期：1998-07-01 00:00:00
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journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1007/BF02255905
更新日期：1999-05-01 00:00:00
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journal_title：Journal of biomedical science
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更新日期：1994-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1186/s12929-020-00642-1
更新日期：2020-04-20 00:00:00
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journal_title：Journal of biomedical science
pub_type： 杂志文章,评审
doi：10.1186/s12929-020-00674-7
更新日期：2020-07-21 00:00:00
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journal_title：Journal of biomedical science
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doi：10.1186/s12929-017-0320-5
更新日期：2017-02-07 00:00:00
abstract：:Induction of tumoricidal activity is one of the major functions of activated macrophages. Our previous study demonstrated that P388D1 murine macrophage-like cells secreted a plasmacytoma cytotoxic factor (PCF) that selectively killed certain tumor cell lines including MOPC-315 plasmacytoma in vitro. Our subsequent stu...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1007/BF02255919
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:Dioscin, a typical steroid saponin, is isolated from Dioscorea nipponica Makino and Dioscorea zingiberensis Wright. It has estrogenic activity and many studies have also reported that dioscorea plants have an effect in preventing and treating osteoporosis. However, the molecular mechanisms underlying their e...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1186/1423-0127-21-30
更新日期：2014-04-17 00:00:00
abstract：:Ischemia and reperfusion (I/R) - induced injury has been described as one of the main factors that contribute to the observed morbidity and mortality in a variety of clinical entities, including myocardial infarction, ischemic stroke, cardiac arrest and trauma. An imbalance between oxygen demand and supply, within the...
journal_title：Journal of biomedical science
pub_type： 杂志文章,评审
doi：10.1186/s12929-016-0220-0
更新日期：2016-01-19 00:00:00
abstract：BACKGROUND:Whether microgravity might influence tumour growth and carcinogenesis is still an open issue. It is not clear also if and how normal and transformed cells are differently solicited by microgravity. The present study was designed to verify this issue. METHODS:Two normal, LB and HSC93, and two transformed, Ju...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1186/1423-0127-17-63
更新日期：2010-07-28 00:00:00
abstract：:Mediation of the respiratory reflex effects of an exogenous serotonin challenge goes beyond the lung vagi and is suggested to involve the nodose ganglia. In the present experiments the effects of an intravenous serotonin challenge on breathing pattern were studied in 8 pentobarbitone-chloralose anaesthetised cats. Bol...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1007/BF02256323
更新日期：2003-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1186/1423-0127-16-78
更新日期：2009-09-02 00:00:00
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更新日期：2013-07-12 00:00:00
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journal_title：Journal of biomedical science
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更新日期：2004-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1186/s12929-019-0529-6
更新日期：2019-05-16 00:00:00
abstract：BACKGROUND:RNA interference (RNAi) is a powerful tool to silence gene expression post-transcriptionally. Delivering sequences of RNAi in vivo remains a problem. The aim of this study was to use JC virus (JCV) virus-like particles (VLPs) as a vector for delivering RNAi in silencing the cytokine gene of IL-10. METHODS:J...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1186/1423-0127-17-51
更新日期：2010-06-24 00:00:00
abstract：BACKGROUND:Noopept (N-phenyl-acetyl-L-prolylglycine ethyl ester) was constructed as a dipeptide analog of the standard cognition enhancer, piracetam. Our previous experiments have demonstrated the cognition restoring effect of noopept in several animal models of Alzheimer disease (AD). Noopept was also shown to prevent...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1186/s12929-014-0074-2
更新日期：2014-08-06 00:00:00
abstract：BACKGROUND:Pseudomonas aeruginosa is a Gram-negative pathogen that frequently causes life-threatening infections in immunocompromised patients. We previously showed that subinhibitory concentrations of short synthetic peptides permeabilize P. aeruginosa and enhance the lethal action of co-administered antibiotics. MET...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1186/s12929-020-00678-3
更新日期：2020-08-06 00:00:00
abstract：:The polymeric immunoglobulin receptor (PIGR) mediates transport of IgA and IgM antibodies across mucosal and glandular epithelia. Several studies have utilized immunohistochemistry to demonstrate that PIGR expression varies in different types of lung carcinoma, and is down-regulated during tumor progression. We have p...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1007/s11373-004-8185-5
更新日期：2005-01-01 00:00:00
abstract：:Adeno-associated virus (AAV) vectors were shown capable of high efficiency transduction of both dividing and nondividing cells and tissues. AAV-mediated transduction leads to stable, long-term transgene expression in the absence of apparent immune response. These properties and the broad host range of AAV vectors indi...
journal_title：Journal of biomedical science
pub_type： 杂志文章,评审
doi：10.1007/BF02253246
更新日期：2000-07-01 00:00:00
abstract：BACKGROUND:Detection of cholangiocarcinoma (CCA) remains a diagnostic challenge. We established diagnostic peptide biomarkers in bile and urine based on capillary electrophoresis coupled to mass spectrometry (CE-MS) to detect both local and systemic changes during CCA progression. In a prospective cohort study we recen...
journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1186/s12929-019-0599-5
更新日期：2020-01-03 00:00:00
