In vitro and in vivo targeted delivery of IL-10 interfering RNA by JC virus-like particles.

abstract：BACKGROUND:Autophagy has been shown recently to play an important role in the intracellular survival of several pathogenic bacteria. In this study, we investigated the effect of a novel small-molecule autophagy-inducing agent, AR-12, on the survival of Francisella tularensis, the causative bacterium of tularemia in hum...

journal_title：Journal of biomedical science

authors： Chiu HC,Soni S,Kulp SK,Curry H,Wang D,Gunn JS,Schlesinger LS,Chen CS

更新日期：2009-12-09 00:00:00

abstract：:Zebrafish tbx5 expresses in the heart, pectoral fins and eyes of zebrafish during embryonic development. In zebrafish, injection of tbx5 morpholino antisense RNA caused changes of heart conformation, defect of heart looping, pericardium effusion, dropsy of ventral position and decreased heart rate. We suggested that c...

journal_title：Journal of biomedical science

authors： Lu JH,Lu JK,Choo SL,Li YC,Yeh HW,Shiue JF,Yeh VC

更新日期：2008-11-01 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) promoter 1 (LP1) is an inducible and cell type-specific promoter involved in regulating the production of an 8.3-kb primary LAT transcript during acute and latent infection of peripheral sensory neurons and during subsequent virus reactivation...

journal_title：Journal of biomedical science

authors： Millhouse S,Kenny JJ,Quinn PG,Lee V,Wigdahl B

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Acid-sensing ion channels (ASICs) are a group of amiloride-sensitive ligand-gated ion channels belonging to the family of degenerin/epithelial sodium channels. ASICs are predominantly expressed in both the peripheral and central nervous system and have been characterized as potent proton sensors to detect ex...

journal_title：Journal of biomedical science

authors： Cheng YR,Jiang BY,Chen CC

更新日期：2018-05-24 00:00:00

abstract：:The sigma-1 receptor (Sig-1R) is a chaperone that resides mainly at the mitochondrion-associated endoplasmic reticulum (ER) membrane (called the MAMs) and acts as a dynamic pluripotent modulator in living systems. At the MAM, the Sig-1R is known to play a role in regulating the Ca2+ signaling between ER and mitochondr...

journal_title：Journal of biomedical science

authors： Weng TY,Tsai SA,Su TP

更新日期：2017-09-16 00:00:00

abstract：BACKGROUND:To mimic systemic inflammation in humans, different animal models have been developed. Since these models are still discussed controversially, we aimed to comparatively evaluate the most widely used models with respect to the systemic effects, the influence on organ functions and to the underlying pathophysi...

journal_title：Journal of biomedical science

authors： Seemann S,Zohles F,Lupp A

更新日期：2017-08-24 00:00:00

abstract：BACKGROUND:Fat embolism syndrome (FES) associated with acute lung injury (ALI) is a clinical condition following long bone fracture. We have reported 14 victims due to ALI with FES. Our laboratory has developed an animal model that produced fat emboli (FE). The major purpose of this study was to test whether neutrophil...

journal_title：Journal of biomedical science

authors： Lin CC,Liu PH,Kao SJ,Chen HI

更新日期：2012-01-05 00:00:00

abstract：:Adeno-associated virus (AAV) vectors were shown capable of high efficiency transduction of both dividing and nondividing cells and tissues. AAV-mediated transduction leads to stable, long-term transgene expression in the absence of apparent immune response. These properties and the broad host range of AAV vectors indi...

journal_title：Journal of biomedical science

authors： Tal J

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Pulmonary emphysema is characterized histologically by destruction of alveolar walls and enlargement of air spaces due to lung epithelial cell apoptosis. Cell adhesion molecule 1 (CADM1) is an immunoglobulin superfamily member expressed in lung epithelial cells. CADM1 generates a membrane-associated C-termin...

journal_title：Journal of biomedical science

authors： Hagiyama M,Yoneshige A,Inoue T,Sato Y,Mimae T,Okada M,Ito A

更新日期：2015-08-11 00:00:00

abstract：BACKGROUND:Activating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER)-localised protein and member of the leucine zipper family of transcription factors. Best known for its role in transducing signals linked to stress to the endoplasmic reticulum, the 50 kDa activated form of ATF6 is now emerging as a ma...

journal_title：Journal of biomedical science

authors： Hillary RF,FitzGerald U

更新日期：2018-05-25 00:00:00

abstract：:Purinergic P2X7 receptor (P2X7R), an ATP-gated cation channel, is unique among all other family members because of its ability to respond to various stimuli and to modulate pro-inflammatory signaling. The activation of P2X7R in immune cells is absolutely required for mature interleukin -1beta (IL-1beta) and IL-18 prod...

journal_title：Journal of biomedical science

authors： Mishra A

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:LncRNA Gas5 is known to be a key control element during growth, differentiation and development in mammalian species. However, the role and function of Gas5 in growth plate chondrocytes has not been determined. METHODS:The overexpression and knockdown models of Gas5 and miR-21 in cells and animals were cons...

journal_title：Journal of biomedical science

authors： Liu X,She Y,Wu H,Zhong D,Zhang J

更新日期：2018-02-28 00:00:00

abstract：:Myostatin, a member of the TGF-beta superfamily, is a potent negative regulator of skeletal muscle and growth. Previously, we reported Mstn1 from zebrafish and studied its influence on muscle development. In this study, we identified another form of Myostatin protein which is referred to as Mstn2. The size of Mstn2 cD...

journal_title：Journal of biomedical science

authors： Amali AA,Lin CJ,Chen YH,Wang WL,Gong HY,Rekha RD,Lu JK,Chen TT,Wu JL

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Most of the circulating Vitamin D (VitD) is transported bound to vitamin D-binding protein (DBP), and several DBP single nucleotide polymorphisms (SNPs) have been related to circulating VitD concentration and disease. In this study, we evaluated the association among DBP SNPs and AIDS progression in antiretr...

journal_title：Journal of biomedical science

authors： Jiménez-Sousa MÁ,Jiménez JL,Fernández-Rodríguez A,Bellón JM,Rodríguez C,Riera M,Portilla J,Castro Á,Muñoz-Fernández MÁ,Resino S

更新日期：2019-10-23 00:00:00

abstract：BACKGROUND:Lipopolysaccharide (LPS) is recognized as the most potent microbial mediator presaging the threat of invasion of Gram-negative bacteria that implicated in the pathogenesis of sepsis and septic shock. This study was designed to examine the microRNA (miRNA) expression in whole blood from mice injected with int...

journal_title：Journal of biomedical science

authors： Hsieh CH,Rau CS,Jeng JC,Chen YC,Lu TH,Wu CJ,Wu YC,Tzeng SL,Yang JC

更新日期：2012-07-31 00:00:00

abstract：:The ability of cells of the human monocyte/macrophage lineage to host HIV-1 replication while resisting cell death is believed to significantly contribute to their ability to serve as a reservoir for viral replication in the host. Although macrophages are generally resistant to apoptosis, interruption of anti-apoptoti...

journal_title：Journal of biomedical science

authors： Zhang M,Li X,Pang X,Ding L,Wood O,Clouse KA,Hewlett I,Dayton AI

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Tumor necrosis factor-α (TNF-α) is a proinflammatory cytokine and elevated in the regions of tissue injury and inflammatory diseases. The deleterious effects of TNF-α on fibroblasts may aggravate heart inflammation mediated through the up-regulation of adhesion molecules such as vascular cell adhesion molecu...

journal_title：Journal of biomedical science

authors： Lin CC,Pan CS,Wang CY,Liu SW,Hsiao LD,Yang CM

更新日期：2015-07-15 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS) can be associated with various disorders. Among these, coronavirus infection may cause life-threatening severe acute respiratory syndrome (SARS). In this review, we present animal models and techniques for the study of ARDS, and discuss the roles and possible mechanisms of va...

journal_title：Journal of biomedical science

authors： Chen HI,Kao SJ,Wang D,Lee RP,Su CF

更新日期：2003-01-01 00:00:00

abstract：:Hypoxia is an important microenvironmental factor that induces cancer metastasis. Hypoxia/hypoxia-inducible factor-1α (HIF-1α) regulates many important steps of the metastatic processes, especially epithelial-mesenchymal transition (EMT) that is one of the crucial mechanisms to cause early stage of tumor metastasis. T...

journal_title：Journal of biomedical science

authors： Tsai YP,Wu KJ

更新日期：2012-12-14 00:00:00

abstract：:The midbrain periaqueductal gray matter (PAG) is an important brain region for the coordination of mu-opioid-induced pharmacological actions. The present study was designed to determine whether newly isolated mu-opioid peptide endomorphins can activate G proteins through mu-opioid receptors in the PAG by monitoring th...

journal_title：Journal of biomedical science

authors： Narita M,Mizoguchi H,Narita M,Dun NJ,Hwang BH,Endoh T,Suzuki T,Nagase H,Suzuki T,Tseng LF

更新日期：2000-05-01 00:00:00

abstract：:Human mesenchymal stem cells (MSCs) are multilineage somatic progenitor/stem cells that have been shown to possess immunomodulatory properties in recent years. Initially met with much skepticism, MSC immunomodulation has now been well reproduced across tissue sources and species to be clinically relevant. This has ope...

journal_title：Journal of biomedical science

authors： Wang LT,Ting CH,Yen ML,Liu KJ,Sytwu HK,Wu KK,Yen BL

更新日期：2016-11-04 00:00:00

abstract：:Lysosome-associated membrane protein (LAMP)-1, one of the major protein components of the lysosomal membrane, is upregulated in the human glioblastoma cell lines, U-373 MG and LN-Z308, which undergo cisplatin-induced apoptosis. These human brain tumor cell lines demonstrated apoptosis in response to cisplatin/nifedipi...

journal_title：Journal of biomedical science

authors： Chen JW,Madamanchi N,Madamanchi NR,Trier TT,Keherly MJ

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:The association of TGF beta1 polymorphisms and atrial fibrillation (AF) in essential hypertensive (EH) subjects remains unknown. Methods EH subjects with AF (EH+AF+) and sinus rhythm (EH+AF-) were enrolled. The polymorphisms of +869 T --> C at codon 10 and + 915 G --> C at codon 25, were genotyped. The clini...

journal_title：Journal of biomedical science

authors： Wang Y,Hou X,Li Y

更新日期：2010-03-31 00:00:00

abstract：:The nucleotide sequences of the putative envelope region (E1) and the junction between the E1 and envelope 2/nonstructural 1 (E2/NS1) region of the hepatitis C virus (HCV) genome are divergent among different genotypes. To characterize them, we introduced a set of nested primers that are conserved among four different...

journal_title：Journal of biomedical science

authors： Kao JH,Chen PJ,Lai MY,Yang PM,Sheu JC,Wang TH,Chen DS

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND:The association of functionality and phenotype of follicular helper T cells (Tfh) with dengue virus (DENV) specific antibody responses and clinical disease severity has not been well studied. METHODS:We investigated the phenotype and functionality of Tfh cells and plasmablasts in adult patients (DF = 18, DH...

journal_title：Journal of biomedical science

authors： Wijesinghe A,Gamage J,Goonewardena H,Gomes L,Jayathilaka D,Wijeratne DT,de Alwis R,Jeewandara C,Wijewickrama A,Ogg GS,Malavige GN

更新日期：2020-04-08 00:00:00

abstract：BACKGROUND:The enzyme-prodrug system is considered a promising tool for tumor treatment when conjugated with a targeting molecule. The asparagine-glycine-arginine (NGR) motif is a developing and interesting targeting peptide that could specifically bind to aminopeptidase N (APN), which is an NGR receptor expressed on t...

journal_title：Journal of biomedical science

authors： Li JJ,Chang SF,Liau II,Chan PC,Liu RS,Yen SH,Wang HE,Chang CA

更新日期：2016-01-22 00:00:00

abstract：BACKGROUND:Bisphosphonates are an important class of antiresorptive drugs used in the treatment of metabolic bone diseases. Recent studies have shown that nitrogen-containing bisphosphonates induced apoptosis in rabbit osteoclasts and prevented prenylated small GTPase. However, whether bisphosphonates inhibit osteoclas...

journal_title：Journal of biomedical science

authors： Tsubaki M,Komai M,Itoh T,Imano M,Sakamoto K,Shimaoka H,Takeda T,Ogawa N,Mashimo K,Fujiwara D,Mukai J,Sakaguchi K,Satou T,Nishida S

更新日期：2014-02-03 00:00:00

abstract：BACKGROUND:Human papillomavirus (HPV) is the most common sexually transmitted virus in women worldwide. The persistence of the virus may cause warts that are considered benign lesions and low or high grade intraepithelial lesions (LSIL/HSIL). Immunological system plays an important role in the resolution of infections....

journal_title：Journal of biomedical science

authors： Okuyama NCM,Cezar-Dos-Santos F,Pereira ÉR,Trugilo KP,Cebinelli GCM,Sena MM,Pereira APL,Aranome AMF,Mangieri LFL,Ferreira RS,Watanabe MAE,de Oliveira KB

更新日期：2018-09-18 00:00:00

abstract：:Exposure of cells and organs to heat shock is associated with numerous changes in various cellular metabolic parameters and overexpression of proteins collectively known as heat shock proteins (HSP). In this communication we review the cell-signaling events that are altered in response to heat shock as they relate to ...

journal_title：Journal of biomedical science

authors： Gong Kiang J,Tsokos GC

更新日期：1996-11-01 00:00:00

abstract：:Fibroblasts derived from glucose-6-phosphate dehydrogenase (G6PD)-deficient patients display retarded growth and accelerated cellular senescence that is attributable to increased accumulation of oxidative DNA damage and increased sensitivity to oxidant-induced senescence, but not to accelerated telomere attrition. Her...

journal_title：Journal of biomedical science

authors： Wu YH,Cheng ML,Ho HY,Chiu DT,Wang TC

更新日期：2009-02-05 00:00:00