Abstract:
:The ability of cells of the human monocyte/macrophage lineage to host HIV-1 replication while resisting cell death is believed to significantly contribute to their ability to serve as a reservoir for viral replication in the host. Although macrophages are generally resistant to apoptosis, interruption of anti-apoptotic pathways can render them susceptible to apoptosis. Here we report that HIV-1(BAL )infection of primary human monocyte-derived macrophages (MDM) upregulates the mRNA and protein levels of the anti-apoptic gene, Bcl-2. Furthermore, this upregulation can be quantitatively mimicked by treating MDM with soluble HIV-1 Tat-86 protein. These results suggest that in infecting cells of the monocyte/macrophage lineage, HIV-1 may be benefiting from additional protection against apoptosis caused by specific upregulation of cellular anti-apoptotic genes.
journal_name
J Biomed Scijournal_title
Journal of biomedical scienceauthors
Zhang M,Li X,Pang X,Ding L,Wood O,Clouse KA,Hewlett I,Dayton AIdoi
10.1007/BF02256024keywords:
subject
Has Abstractpub_date
2002-03-01 00:00:00pages
133-9issue
2eissn
1021-7770issn
1423-0127pii
48209journal_volume
9pub_type
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