Abstract:
:With the advances in deep sequencing-based transcriptome profiling technology, it is now known that human genome is transcribed more pervasively than previously thought. Up to 90% of the human DNA is transcribed, and a large proportion of the human genome is transcribed as long noncoding RNAs (lncRNAs), a heterogenous group of non-coding transcripts longer than 200 nucleotides. Emerging evidence suggests that lncRNAs are functional and contribute to the complex regulatory networks involved in cardiovascular development and diseases. In this article, we will review recent evidence on the roles of lncRNAs in the biological processes of cardiovascular development and disorders. The potential applications of lncRNAs as biomarkers and targets for therapeutics are also discussed.
journal_name
J Biomed Scijournal_title
Journal of biomedical scienceauthors
Yeh CF,Chang YE,Lu CY,Hsuan CF,Chang WT,Yang KCdoi
10.1186/s12929-020-00647-wsubject
Has Abstractpub_date
2020-04-02 00:00:00pages
48issue
1eissn
1021-7770issn
1423-0127pii
10.1186/s12929-020-00647-wjournal_volume
27pub_type
杂志文章,评审abstract:BACKGROUND:Granulocyte colony-stimulating factor (G-CSF), a hematopoietic cytokine, was recently used to treat patients of acute myocardial infarction with beneficial effect. However, controversy exists as some patients developed re-stenosis and worsened condition post G-CSF delivery. This study presents a new disease ...
journal_title:Journal of biomedical science
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doi:10.1186/1423-0127-18-26
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abstract::To search for cellular genes up-regulated by vaccinia virus (VV) infection, differential display-reverse transcription-polymerase chain reaction (ddRT-PCR) assays were used to examine the expression of mRNAs from mock-infected and VV-infected HeLa cells. Two mitochondrial genes for proteins that are part of the electr...
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abstract::The Tat proteins of human immunodeficiency virus types 1 (HIV-1) and 2 (HIV-2), termed Tat-1 and Tat-2, respectively, are essential for efficient viral replication. Tat proteins activate viral transcription by binding to the TAR RNA stem-loop structure at the 5' end of viral transcripts. We used an in vitro selection ...
journal_title:Journal of biomedical science
pub_type: 杂志文章
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abstract:BACKGROUND:The conserved Notch signaling pathway regulates cell fate decisions and maintains stem cells in multicellular organisms. Up-regulation of Notch signaling is observed in several types of cancer and is causally involved in proliferation and survival of cancer cells. Thus, it is of great interest to look for an...
journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1186/1423-0127-18-42
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abstract:BACKGROUND:NKG2D, an activating immunoreceptor, is primarily restricted to NK cells and CD8(+) T cells. The existence of an atypical cytotoxic CD4(+)NKG2D(+) T cell population has also been found in patients with autoimmune dysfunctions. Nonetheless, contradictory evidence has categorized this population with a regulat...
journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1186/s12929-015-0190-7
更新日期:2015-10-20 00:00:00
abstract:BACKGROUND:Fat embolism syndrome (FES) associated with acute lung injury (ALI) is a clinical condition following long bone fracture. We have reported 14 victims due to ALI with FES. Our laboratory has developed an animal model that produced fat emboli (FE). The major purpose of this study was to test whether neutrophil...
journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1186/1423-0127-19-3
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journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1186/1423-0127-17-8
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journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1186/1423-0127-21-44
更新日期:2014-05-13 00:00:00
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journal_title:Journal of biomedical science
pub_type: 杂志文章,评审
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更新日期:2019-08-07 00:00:00
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journal_title:Journal of biomedical science
pub_type: 杂志文章
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更新日期:2010-08-24 00:00:00
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journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1007/BF02255469
更新日期:2000-05-01 00:00:00
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journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1007/BF02254441
更新日期:2004-05-01 00:00:00
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journal_title:Journal of biomedical science
pub_type: 杂志文章,评审
doi:10.1186/s12929-016-0289-5
更新日期:2016-11-04 00:00:00
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journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1186/s12929-019-0515-z
更新日期:2019-03-06 00:00:00
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journal_title:Journal of biomedical science
pub_type: 杂志文章,评审
doi:10.1186/s12929-018-0448-y
更新日期:2018-05-24 00:00:00
abstract:BACKGROUND:CIP4 is a scaffold protein that regulates membrane deformation and tubulation, organization of the actin cytoskeleton, endocytosis of growth factor receptors, and vesicle trafficking. Although expressed in the heart, CIP4 has not been studied with regards to its potential function in cardiac myocytes. RESUL...
journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1186/1423-0127-20-56
更新日期:2013-08-03 00:00:00
abstract::Permanent functional deficit in patients with spinal cord injury (SCI) is in part due to severe neural cell death. Therefore, cell replacement using stem cells and neural progenitors that give rise to neurons and glia is thought to be a potent strategy to promote tissue repair after SCI. Many studies have shown that s...
journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1007/BF02256573
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Increased lipid accumulation and mitochondrial dysfunction within skeletal muscle have been shown to be strongly associated with insulin resistance. However, the role of mitofusion-2 (MFN2), a key factor in mitochondrial function and energy metabolism, in skeletal muscle lipid intermediate accumulation remai...
journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1186/1423-0127-20-45
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:The association of functionality and phenotype of follicular helper T cells (Tfh) with dengue virus (DENV) specific antibody responses and clinical disease severity has not been well studied. METHODS:We investigated the phenotype and functionality of Tfh cells and plasmablasts in adult patients (DF = 18, DH...
journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1186/s12929-020-00641-2
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journal_title:Journal of biomedical science
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更新日期:2001-09-01 00:00:00
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journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1186/1423-0127-17-63
更新日期:2010-07-28 00:00:00
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journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1186/1423-0127-17-1
更新日期:2010-01-07 00:00:00
abstract::The technology of "Lab-on-a-Chip" allows the synthesis and analysis of chemicals and biological substance within a portable or handheld device. The 3D printed structures enable precise control of various geometries. The combination of these two technologies in recent years makes a significant progress. The current app...
journal_title:Journal of biomedical science
pub_type: 杂志文章,评审
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更新日期:2017-10-18 00:00:00
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journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1007/BF02253384
更新日期:1995-08-01 00:00:00
abstract:INTRODUCTION:Head and neck squamous carcinoma (HNSCC) is one of the most invasive types of cancer with high mortality. A previous study has indicated that low levels of let-7d and miR-205 in HNSCC patients are correlated with poor survival. Let-7d and miR-205 are tumor suppressors and regulators of epithelial-to-mesenc...
journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1186/s12929-019-0511-3
更新日期:2019-02-13 00:00:00
abstract::Our goal was to develop a system to study proteins that associate in vivo with the Moloney murine leukemia virus (M-MuLV) enhancer elements by the isolation of intact proviral chromatin. The M-MuLV long terminal repeats (LTRs) contain tandemly repeated transcriptional enhancer sequences consisting of smaller motifs th...
journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1007/BF02256602
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND:Autophagy has been shown recently to play an important role in the intracellular survival of several pathogenic bacteria. In this study, we investigated the effect of a novel small-molecule autophagy-inducing agent, AR-12, on the survival of Francisella tularensis, the causative bacterium of tularemia in hum...
journal_title:Journal of biomedical science
pub_type: 杂志文章
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journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1186/1423-0127-16-33
更新日期:2009-01-01 00:00:00
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journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1007/BF02256111
更新日期:2003-09-01 00:00:00
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journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1186/1423-0127-18-38
更新日期:2011-06-13 00:00:00