RNAs Selected in vitro by the HIV-2 Tat Protein.

abstract：:As a neurotropic virus, enterovirus A71 (EV-A71) emerge and remerge in the Asia-Pacific region since the 1990s, and has continuously been a threat to global public health, especially in children. Annually, EV-A71 results in hand-foot-and-mouth disease (HFMD) and occasionally causes severe neurological disease. Here we...

journal_title：Journal of biomedical science

authors： Huang SW,Cheng D,Wang JR

更新日期：2019-10-21 00:00:00

abstract：BACKGROUND:Chemotherapy and targeted therapies have made important strides in cancer treatment yet they often fail and new therapies are still needed. Here, we employed a phenotypic screen to identify and analyze the mechanism of action of novel small molecules that interfere with critical pathways involved in tumor ce...

journal_title：Journal of biomedical science

authors： Ghosh SK,Ganta A,Spanjaard RA

更新日期：2018-02-08 00:00:00

abstract：:DNA vaccines have emerged as an attractive approach for generating antigen-specific immunotherapy. Strategies that enhance antigen presentation may potentially be used to enhance DNA vaccine potency. Previous experiments showed that chimeric DNA vaccines utilizing endoplasmic reticulum (ER) chaperone molecules, such a...

journal_title：Journal of biomedical science

authors： Lin CT,Chang TC,Chao A,Dzeng E,Soong YK,Hung CF,Lai CH

更新日期：2005-01-01 00:00:00

abstract：:The detailed mechanism of how lysophosphatidylcholine (LPC) suppresses endothelium-dependent vasodilatation is unclear at present. We investigated the effects of LPC on endothelial intracellular calcium (EC [Ca(2+)](i)) signaling and vascular tone simultaneously using a new technique we developed. Fura-2-labeled rat a...

journal_title：Journal of biomedical science

authors： Huang TY,Chen HI,Liu CY,Jen CJ

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Oxidized low-density lipoprotein (oxLDL) mediates the transformation of macrophages (MΦ) to cholesterol-rich foam cells and the release of pro-inflammatory cytokines during atherogenesis. JAB1 (Jun activation domain binding protein-1) is present in all stages of human plaques, involved in the Toll-like recep...

journal_title：Journal of biomedical science

authors： Schwarz A,Bonaterra GA,Schwarzbach H,Kinscherf R

更新日期：2017-02-07 00:00:00

abstract：:The HIV-1 Tat protein is an RNA-binding transcriptional transactivator. Recent findings suggest that Tat associates with a cellular kinase that phosphorylates the carboxyl-terminal domain of the largest subunit of RNA polymerase II. Here we review, in brief, the role of Tat-associated kinase in Tat-activated transcrip...

journal_title：Journal of biomedical science

authors： Jeang KT

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Among a variety of inflammatory mediators, visfatin is a proinflammatory adipocytokine associated with inflammatory reactions in obesity, metabolic syndrome, chronic inflammatory disease, and autoimmune disease. However, the biological role of visfatin in secretion of major mucins in human airway epithelial ...

journal_title：Journal of biomedical science

authors： Song SY,Jung EC,Bae CH,Choi YS,Kim YD

更新日期：2014-05-20 00:00:00

abstract：:Obesity is one of the most invaliding and preventable diseases in the United States. Growing evidence suggests that there are sex differences in obesity in human and experimental animals. However, the specific mechanisms of this disease are unknown. Consequently, there is any particular treatment according to the sex/...

journal_title：Journal of biomedical science

authors： Fitzgerald SJ,Janorkar AV,Barnes A,Maranon RO

更新日期：2018-12-03 00:00:00

abstract：BACKGROUND:Acid-sensing ion channels (ASICs) are a group of amiloride-sensitive ligand-gated ion channels belonging to the family of degenerin/epithelial sodium channels. ASICs are predominantly expressed in both the peripheral and central nervous system and have been characterized as potent proton sensors to detect ex...

journal_title：Journal of biomedical science

authors： Cheng YR,Jiang BY,Chen CC

更新日期：2018-05-24 00:00:00

abstract：:The effects of N omega-nitro-L: -arginine (L: -NOARG) and N(G)-monomethyl-L: -arginine (L: -NMMA) on the spatial distribution of diaphragmatic microvascular blood flow were assessed in anesthetized, mechanically ventilated rats. Microvascular blood flow was measured after different periods at either a fixed site (Q st...

journal_title：Journal of biomedical science

authors： Lee CH,Chang HY,Chen CW,Hsiue TR

更新日期：2005-01-01 00:00:00

abstract：:The progression and metastasis of solid tumors, including head and neck squamous cell carcinoma (HNSCC), have been related to the behavior of a small subpopulation of cancer stem cells. Here, we have established a highly malignant HNSCC cell line, SASVO3, from primary tumors using three sequential rounds of xenotransp...

journal_title：Journal of biomedical science

authors： Chen CY,Chiou SH,Huang CY,Jan CI,Lin SC,Tsai ML,Lo JF

更新日期：2009-11-16 00:00:00

abstract：BACKGROUND:Mutations in mitogen-activated protein kinase (MAPK) kinase 1 (MEK1) that occur during cell proliferation and tumor formation are well described. Information on the roles of MEK2 in these effects is still limited. We established a constitutive MEK2 transgenic zebrafish, Tg(krt14:MEK2S219D-GFP), to elucidate ...

journal_title：Journal of biomedical science

authors： Chou CM,Chen YC,Su S,Chen GD,Huang KY,Lien HW,Huang CJ,Cheng CH

更新日期：2015-11-17 00:00:00

abstract：:The CDC4 gene of Saccharomyces cerevisiae encodes an essential function that is required for G1-S and G2-M transitions during mitosis and at various stages during meiosis. We have isolated a functional homologue of CDC4 (CaCDC4) from the pathogenic yeast Candida albicans by complementing the S. cerevisiae cdc4-3 mutat...

journal_title：Journal of biomedical science

authors： Shieh JC,White A,Cheng YC,Rosamond J

更新日期：2005-12-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：Journal of biomedical science

authors： Huber RJ

更新日期：2020-09-21 00:00:00

abstract：:In all eukaryotes, the plasma membrane is critically important as it maintains the architectural integrity of the cell. Proper anchorage and interaction between the plasma membrane and the cytoskeleton is critical for normal cellular processes. The ERM (ezrin-radixin-moesin) proteins are a class of highly homologous p...

journal_title：Journal of biomedical science

authors： Ponuwei GA

更新日期：2016-03-17 00:00:00

abstract：:Dengue virus infection presents a wide spectrum of manifestations including asymptomatic condition, dengue fever (DF), or severe forms, such as dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) in affected individuals. The early prediction of severe dengue in patients without any warning signs who may lat...

journal_title：Journal of biomedical science

authors： John DV,Lin YS,Perng GC

更新日期：2015-10-14 00:00:00

abstract：BACKGROUND:Noopept (N-phenyl-acetyl-L-prolylglycine ethyl ester) was constructed as a dipeptide analog of the standard cognition enhancer, piracetam. Our previous experiments have demonstrated the cognition restoring effect of noopept in several animal models of Alzheimer disease (AD). Noopept was also shown to prevent...

journal_title：Journal of biomedical science

authors： Ostrovskaya RU,Vakhitova YV,Kuzmina USh,Salimgareeva MKh,Zainullina LF,Gudasheva TA,Vakhitov VA,Seredenin SB

更新日期：2014-08-06 00:00:00

abstract：:Schistosomiasis causes significant levels of morbidity and mortality in many geographical regions of the world. The disease is caused by infections with parasitic blood flukes known as schistosomes. The control of schistosomiasis over the last several decades has been centered on the mass drug administration (MDA) of ...

journal_title：Journal of biomedical science

authors： Molehin AJ

更新日期：2020-01-22 00:00:00

abstract：:Death-associated protein (DAP)-kinase, an actin-cytoskeleton localized serine/threonine kinase, functions as a novel tumor suppressor and participates in a wide variety of cell death systems. Recent studies indicate that DAP-kinase elicits a potent cytoskeletal reorganization effect and is capable of modulating integr...

journal_title：Journal of biomedical science

authors： Chen RH,Wang WJ,Kuo JC

更新日期：2006-03-01 00:00:00

abstract：:Serologically defined primary dengue virus infection and/or subsequent homologous serotype infection is known to be associated with less severe disease as compared with secondary subsequent heterologous serotype infection. In geographical locales of high dengue endemicity, almost all individuals in the population are ...

journal_title：Journal of biomedical science

authors： Perng GC,Chokephaibulkit K

更新日期：2013-05-31 00:00:00

abstract：:Upon cell adhesion to extracellular matrix proteins, focal adhesion kinase (FAK) rapidly undergoes autophosphorylation on its Tyr-397 which consequently serves as a binding site for the Src homology 2 domains of the Src family protein kinases and several other intracellular signaling molecules. In this study, we have ...

journal_title：Journal of biomedical science

authors： Chang LC,Huang CH,Cheng CH,Chen BH,Chen HC

更新日期：2005-01-01 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS) can be associated with various disorders. Among these, coronavirus infection may cause life-threatening severe acute respiratory syndrome (SARS). In this review, we present animal models and techniques for the study of ARDS, and discuss the roles and possible mechanisms of va...

journal_title：Journal of biomedical science

authors： Chen HI,Kao SJ,Wang D,Lee RP,Su CF

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Previous study demonstrated the improvement of cardiac function was proportional to the number of cells implanted. Therefore, increasing cell survival in the infarcted myocardium might contribute to the improvement of the functional benefit of cell transplantation. METHODS AND RESULTS:MSCs were treated with...

journal_title：Journal of biomedical science

authors： Guo J,Lin G,Bao C,Hu Z,Chu H,Hu M

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Asthma has become an important public health issue and approximately 300 million people have suffered from the disease worldwide. Nowadays, the use of acupuncture in asthma is increasing. This study intended to systematically analyze and compare the gene expression profiles between the asthmatic and acupunct...

journal_title：Journal of biomedical science

authors： Yin LM,Jiang GH,Wang Y,Wang Y,Liu YY,Jin WR,Xu YD,Zhang QH,Yang YQ

更新日期：2009-05-06 00:00:00

abstract：:The likelihood that expression of a foreign gene in a mammalian cell is deleterious to viability is confronted whenever novel transgenic animals are made. A pathological response to transgene expression is even desired in transgenic mouse models of human disease. The derivation of HIV-transgenic mice in our laboratory...

journal_title：Journal of biomedical science

authors： Dickie P

更新日期：1995-04-01 00:00:00

abstract：:The envelope gene of Moloney murine leukemia virus (Mo-MLV) and its various functional domains have been studied extensively but not as much in terms of their biological effects on cell growth. In this study, we report the biological characterization of a truncated Mo-MLV envelope gene, LN11, which is devoid of a sign...

journal_title：Journal of biomedical science

authors： Chen H,Chung SW,Wong PM

更新日期：2000-11-01 00:00:00

abstract：:Peptidoglycan-activated gene expression is mediated through various transcription factors including CCAAT/enhancer-binding protein delta (C/EBPdelta). The purpose of the present study is to elucidate the mechanism of PGN-activated C/EBPdelta gene. PGN stimulated C/EBPdelta protein and mRNA expression in mouse macropha...

journal_title：Journal of biomedical science

authors： Huang YC,Chang WC,Su JG,Cai JL,Chen CC,Hung JJ,Liu YW

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Pneumococcal conjugate vaccine (PCV) reduces both invasive pneumococcal disease (IPD) and other pneumococcal infections worldwide. We investigated the impact of stepwise implementation of childhood PCV programs on the prevalence of pneumococcal pneumonia, severity of acute inflammation, and associations betw...

journal_title：Journal of biomedical science

authors： Shen CF,Wang SM,Chi H,Huang YC,Huang LM,Huang YC,Lin HC,Ho YH,Hsiung CA,Liu CC,Taiwan Pediatric Infectious Disease Alliance.

更新日期：2020-08-19 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV), also designated human herpesvirus 8 (HHV-8), has been linked to Kaposi's sarcoma, as well as to primary effusion lymphoma (PEL), and a subset of multicentric Castleman's disease. KSHV genomes are maintained as episomes within infected cells and the virus exhibits a bipha...

journal_title：Journal of biomedical science

authors： Campbell M,Izumiya Y

更新日期：2020-03-07 00:00:00

abstract：BACKGROUND:Interleukin 12B (IL12B) gene polymorphisms have been linked to several inflammatory diseases, but their role in the development of Graves ophthalmopathy (GO) in Graves disease (GD) patients is unclear. The purpose of this study was to investigate the disease association of IL12B single nucleotide polymorphis...

journal_title：Journal of biomedical science

authors： Liu YH,Chen CC,Liao LL,Wan L,Tsai CH,Tsai FJ

更新日期：2012-11-19 00:00:00