Abstract:
:As a neurotropic virus, enterovirus A71 (EV-A71) emerge and remerge in the Asia-Pacific region since the 1990s, and has continuously been a threat to global public health, especially in children. Annually, EV-A71 results in hand-foot-and-mouth disease (HFMD) and occasionally causes severe neurological disease. Here we reviewed the global epidemiology and genotypic evolution of EV-A71 since 1997. The natural selection, mutation and recombination events observed in the genetic evolution were described. In addition, we have updated the antigenicity and virulence determinants that are known to date. Understanding EV-A71 epidemiology, genetic evolution, antigenicity, and virulence determinants can expand our insights of EV-A71 pathogenesis, which may benefit us in the future.
journal_name
J Biomed Scijournal_title
Journal of biomedical scienceauthors
Huang SW,Cheng D,Wang JRdoi
10.1186/s12929-019-0574-1subject
Has Abstractpub_date
2019-10-21 00:00:00pages
81issue
1eissn
1021-7770issn
1423-0127pii
10.1186/s12929-019-0574-1journal_volume
26pub_type
杂志文章,评审abstract::DNA vaccines have emerged as an attractive approach for generating antigen-specific immunotherapy. Strategies that enhance antigen presentation may potentially be used to enhance DNA vaccine potency. Previous experiments showed that chimeric DNA vaccines utilizing endoplasmic reticulum (ER) chaperone molecules, such a...
journal_title:Journal of biomedical science
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journal_title:Journal of biomedical science
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of biomedical science
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journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1159/000073968
更新日期:2003-11-01 00:00:00
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journal_title:Journal of biomedical science
pub_type: 杂志文章,评审
doi:10.1186/s12929-016-0246-3
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journal_title:Journal of biomedical science
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journal_title:Journal of biomedical science
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doi:10.1186/s12929-019-0599-5
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doi:10.1186/1423-0127-21-10
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abstract:BACKGROUND:To develop an individually-tailored dynamic risk assessment model following a multistep, multifactorial process of the Correa's gastric cancer model. METHODS:First, we estimated the state-to-state transition rates following Correa's five-step carcinogenic model and assessed the effect of risk factors, inclu...
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journal_title:Journal of biomedical science
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