A new approach to study the sex differences in adipose tissue.

abstract：BACKGROUND:Increased lipid accumulation and mitochondrial dysfunction within skeletal muscle have been shown to be strongly associated with insulin resistance. However, the role of mitofusion-2 (MFN2), a key factor in mitochondrial function and energy metabolism, in skeletal muscle lipid intermediate accumulation remai...

journal_title：Journal of biomedical science

authors： Zhang X,Wang C,Song G,Gan K,Kong D,Nie Q,Ren L

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:To develop an individually-tailored dynamic risk assessment model following a multistep, multifactorial process of the Correa's gastric cancer model. METHODS:First, we estimated the state-to-state transition rates following Correa's five-step carcinogenic model and assessed the effect of risk factors, inclu...

journal_title：Journal of biomedical science

authors： Fann JC,Chiang TH,Yen AM,Lee YC,Wu MS,Chen HH

更新日期：2018-11-19 00:00:00

abstract：:Oxidative stress and inflammation contributed to the propagation of acute liver injury (ALI). The present study was undertaken to determine whether D-galactosamine (D-GalN) induces ALI via the mitochondrial apoptosis- and proinflammatory cytokine-signaling pathways, and possible mechanism(s) by which green tea (GT) ex...

journal_title：Journal of biomedical science

authors： Lin BR,Yu CJ,Chen WC,Lee HS,Chang HM,Lee YC,Chien CT,Chen CF

更新日期：2009-03-25 00:00:00

abstract：:The signaling pathways leading to extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) activation by N-formyl-Met-Leu-Phe (fMLP) or platelet activating factor (PAF) in human neutrophils were examined. Previously, we found that changes of intracellular Ca2+ ([Ca2+]i) stimulated by...

journal_title：Journal of biomedical science

authors： Chen LW,Lin MW,Hsu CM

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Hyaluronic acid (HA) is present in many tissues; its presence in serum may be related to certain inflammatory conditions, tissue damage, sepsis, liver malfunction and some malignancies. In the present work, our goal was to investigate the significance of hyaluronic acid effect on erythrocyte flow properties....

journal_title：Journal of biomedical science

authors： Luquita A,Urli L,Svetaz MJ,Gennaro AM,Giorgetti ME,Pistone G,Volpintesta R,Palatnik S,Rasia M

更新日期：2010-02-12 00:00:00

abstract：:The antitumor activity of Anoectochilus formosanus Hayata (Orchidaceae), a popularly used folk medicine in the treatment of cancers in Asia, was investigated in MCF-7 human mammary carcinoma cells. Plant extracts of A. formosanus were observed to induce apoptosis of MCF-7 cells as evidenced by cell-morphological chang...

journal_title：Journal of biomedical science

authors： Shyur LF,Chen CH,Lo CP,Wang SY,Kang PL,Sun SJ,Chang CA,Tzeng CM,Yang NS

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:The enzyme-prodrug system is considered a promising tool for tumor treatment when conjugated with a targeting molecule. The asparagine-glycine-arginine (NGR) motif is a developing and interesting targeting peptide that could specifically bind to aminopeptidase N (APN), which is an NGR receptor expressed on t...

journal_title：Journal of biomedical science

authors： Li JJ,Chang SF,Liau II,Chan PC,Liu RS,Yen SH,Wang HE,Chang CA

更新日期：2016-01-22 00:00:00

abstract：:The interactive role of rostral ventrolateral medulla (RVL) cardiovascular neurons and brain angiotensin II (Ang II) in regulating the arterial blood pressure was examined by recording simultaneously the spontaneous activity of these spinal projecting neurons and the arterial blood pressure in the pentobarbital-anesth...

journal_title：Journal of biomedical science

authors： Chan RK,Chan YS,Wong TM

更新日期：1996-05-01 00:00:00

abstract：:Spinal muscular atrophy (SMA) is an autosomal recessive disorder characterized by degeneration of lower motor neurons. We have assayed deletions in two candidate genes, the survival motor neuron (SMN) and neuronal apoptosis inhibitory protein (NAIP) genes, in 108 samples, of which 46 were from SMA patients, and 62 wer...

journal_title：Journal of biomedical science

authors： Haider MZ,Moosa A,Dalal H,Habib Y,Reynold L

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Noopept (N-phenyl-acetyl-L-prolylglycine ethyl ester) was constructed as a dipeptide analog of the standard cognition enhancer, piracetam. Our previous experiments have demonstrated the cognition restoring effect of noopept in several animal models of Alzheimer disease (AD). Noopept was also shown to prevent...

journal_title：Journal of biomedical science

authors： Ostrovskaya RU,Vakhitova YV,Kuzmina USh,Salimgareeva MKh,Zainullina LF,Gudasheva TA,Vakhitov VA,Seredenin SB

更新日期：2014-08-06 00:00:00

abstract：BACKGROUND:Endothelial cell (EC) dysfunctions, including turnover enrichment, gap junction disruption, inflammation, and oxidation, play vital roles in the initiation of vascular disorders and atherosclerosis. Hemodynamic forces, i.e., atherprotective pulsatile (PS) and pro-atherogenic oscillatory shear stress (OS), ca...

journal_title：Journal of biomedical science

authors： Lee DY,Chiu JJ

更新日期：2019-08-07 00:00:00

abstract：BACKGROUND:Mounting evidences have showed the important role of transforming growth factor-β (TGF-β) in immunological surveillance of tumors. Some studies have also indicated human leukocyte antigen (HLA)-G-associated immune escape involving TGF-β management in gastric cancer (GC). However, the mechanism underlying it ...

journal_title：Journal of biomedical science

authors： Guan Z,Song B,Liu F,Sun D,Wang K,Qu H

更新日期：2015-12-02 00:00:00

abstract：BACKGROUNDS:Homozygous 32-bp deletion of the chemokine receptor 5 gene (CCR5) is associated with resistance to human immunodeficiency virus (HIV) infection, while heterozygosity delays HIV progression. Bone marrow transplantation (BMT) from a 32/32 donor has been shown to cure an HIV-infected patient. However, the rari...

journal_title：Journal of biomedical science

authors： Manotham K,Chattong S,Setpakdee A

更新日期：2015-03-26 00:00:00

abstract：BACKGROUND:Type I Bartter syndrome is a recessive human nephropathy caused by loss-of-function mutations in the SLC12A1 gene coding for the Na+-K+-2Cl- cotransporter NKCC2. We recently established the mutant mouse line Slc12a1I299F exhibiting kidney defects highly similar to the late-onset manifestation of this heredit...

journal_title：Journal of biomedical science

authors： Kemter E,Rathkolb B,Becker L,Bolle I,Busch DH,Dalke C,Elvert R,Favor J,Graw J,Hans W,Ivandic B,Kalaydjiev S,Klopstock T,Rácz I,Rozman J,Schrewe A,Schulz H,Zimmer A,Fuchs H,Gailus-Durner V,Hrabe de Angelis M,Wolf

更新日期：2014-08-02 00:00:00

abstract：:The envelope gene of Moloney murine leukemia virus (Mo-MLV) and its various functional domains have been studied extensively but not as much in terms of their biological effects on cell growth. In this study, we report the biological characterization of a truncated Mo-MLV envelope gene, LN11, which is devoid of a sign...

journal_title：Journal of biomedical science

authors： Chen H,Chung SW,Wong PM

更新日期：2000-11-01 00:00:00

abstract：:Maternal exposure to dietary factors during pregnancy can influence embryonic development and may modulate the phenotype of offspring through epigenetic programming. Folate is critical for nucleotide synthesis, and preconceptional intake of dietary folic acid (FA) is credited with reduced incidences of neural tube def...

journal_title：Journal of biomedical science

authors： Barua S,Kuizon S,Junaid MA

更新日期：2014-08-19 00:00:00

abstract：:The nucleotide sequences of the putative envelope region (E1) and the junction between the E1 and envelope 2/nonstructural 1 (E2/NS1) region of the hepatitis C virus (HCV) genome are divergent among different genotypes. To characterize them, we introduced a set of nested primers that are conserved among four different...

journal_title：Journal of biomedical science

authors： Kao JH,Chen PJ,Lai MY,Yang PM,Sheu JC,Wang TH,Chen DS

更新日期：1994-06-01 00:00:00

abstract：:Our objective was to determine the role that bone marrow-derived stromal cells have on human hematopoiesis in HIV infection. In particular, we dissected the heterogeneous bone marrow microenvironment to study the effect HIV expression might have on the cell population capable of producing the cytokines which will supp...

journal_title：Journal of biomedical science

authors： Mosca JD,Kaushal S,Gartner S,Kessler SW,La Russa VF,Terwilliger EF,Kim JH,Carroll RG,Hall ER,Perera LP,Yu Z,Ritchey DW,Xu J,St Louis DC,Mayers DL

更新日期：1995-10-01 00:00:00

abstract：:Purinergic P2X7 receptor (P2X7R), an ATP-gated cation channel, is unique among all other family members because of its ability to respond to various stimuli and to modulate pro-inflammatory signaling. The activation of P2X7R in immune cells is absolutely required for mature interleukin -1beta (IL-1beta) and IL-18 prod...

journal_title：Journal of biomedical science

authors： Mishra A

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Iron homeostasis is chiefly regulated by hepcidin whose expression is tightly controlled by inflammation, iron stores, and hypoxia. Hemojuvelin (HJV) is a bone morphogenetic protein co-receptor that has been identified as a main upstream regulator of hepcidin expression; HJV mutations are associated with a s...

journal_title：Journal of biomedical science

authors： Salama MF,Bayele HK,Srai SS

更新日期：2012-09-21 00:00:00

abstract：:The polymeric immunoglobulin receptor (PIGR) mediates transport of IgA and IgM antibodies across mucosal and glandular epithelia. Several studies have utilized immunohistochemistry to demonstrate that PIGR expression varies in different types of lung carcinoma, and is down-regulated during tumor progression. We have p...

journal_title：Journal of biomedical science

authors： Khattar NH,Lele SM,Kaetzel CS

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Lipopolysaccharide (LPS) is recognized as the most potent microbial mediator presaging the threat of invasion of Gram-negative bacteria that implicated in the pathogenesis of sepsis and septic shock. This study was designed to examine the microRNA (miRNA) expression in whole blood from mice injected with int...

journal_title：Journal of biomedical science

authors： Hsieh CH,Rau CS,Jeng JC,Chen YC,Lu TH,Wu CJ,Wu YC,Tzeng SL,Yang JC

更新日期：2012-07-31 00:00:00

abstract：BACKGROUND:To mimic systemic inflammation in humans, different animal models have been developed. Since these models are still discussed controversially, we aimed to comparatively evaluate the most widely used models with respect to the systemic effects, the influence on organ functions and to the underlying pathophysi...

journal_title：Journal of biomedical science

authors： Seemann S,Zohles F,Lupp A

更新日期：2017-08-24 00:00:00

abstract：:Interferons (IFNs) are key regulators for both innate and adaptive immune responses. By screening ENU-mutagenized mice, we identified a pedigree- P117 which displayed impaired response to type I, but not type II, IFNs. Through inheritance test, genetic mapping and sequencing, we found a T to A point mutation in the 5'...

journal_title：Journal of biomedical science

authors： Chen LS,Wei PC,Liu T,Kao CH,Pai LM,Lee CK

更新日期：2009-02-19 00:00:00

abstract：BACKGROUND:Calcium oxalate (CaOx) is the major constituent of about 75% of all urinary stone and the secondary hyperoxaluria is a primary risk factor. Current treatment options for the patients with hyperoxaluria and CaOx stone diseases are limited. Oxalate degrading bacteria might have beneficial effects on urinary ox...

journal_title：Journal of biomedical science

authors： Sasikumar P,Gomathi S,Anbazhagan K,Abhishek A,Paul E,Vasudevan V,Sasikumar S,Selvam GS

更新日期：2014-08-30 00:00:00

abstract：:The ability of cells of the human monocyte/macrophage lineage to host HIV-1 replication while resisting cell death is believed to significantly contribute to their ability to serve as a reservoir for viral replication in the host. Although macrophages are generally resistant to apoptosis, interruption of anti-apoptoti...

journal_title：Journal of biomedical science

authors： Zhang M,Li X,Pang X,Ding L,Wood O,Clouse KA,Hewlett I,Dayton AI

更新日期：2002-03-01 00:00:00

abstract：:The apolipoprotein (Apo) E gene is known to be polymorphic. Three common alleles determine six phenotypes which can easily be detected by restriction fragment length polymorphism. We performed apo E genotyping in myocardial infarction survivors and healthy controls for the first time in the Turkish population. DNA was...

journal_title：Journal of biomedical science

authors： Hergenc G,Taga Y,Emerk K,Cirakoglu B

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Oxidized low-density lipoprotein (oxLDL) mediates the transformation of macrophages (MΦ) to cholesterol-rich foam cells and the release of pro-inflammatory cytokines during atherogenesis. JAB1 (Jun activation domain binding protein-1) is present in all stages of human plaques, involved in the Toll-like recep...

journal_title：Journal of biomedical science

authors： Schwarz A,Bonaterra GA,Schwarzbach H,Kinscherf R

更新日期：2017-02-07 00:00:00

abstract：BACKGROUND:Zerumbone, a sesquiterpene compound isolated from subtropical ginger, Zingiber zerumbet Smith, has been documented to exert antitumoral and anti- inflammatory activities. In this study, we demonstrate that zerumbone induces apoptosis in human glioblastoma multiforme (GBM8401) cells and investigate the apopto...

journal_title：Journal of biomedical science

authors： Weng HY,Hsu MJ,Wang CC,Chen BC,Hong CY,Chen MC,Chiu WT,Lin CH

更新日期：2012-10-05 00:00:00

abstract：BACKGROUND:Wedelolactone (WEL), a major coumestan ingredient in Wedelia chinensis, has been used to treat septic shock, hepatitis and venom poisoning in traditional Chinese medicines. The objective of the study was to elucidate the anti-inflammatory effects and mechanism of WEL with a cellular model of lipopolysacchari...

journal_title：Journal of biomedical science

authors： Yuan F,Chen J,Sun PP,Guan S,Xu J

更新日期：2013-10-31 00:00:00