Down-regulation of the polymeric immunoglobulin receptor in non-small cell lung carcinoma: correlation with dysregulated expression of the transcription factors USF and AP2.

abstract：:We have generated peptide antisera against selected regions in HIV-1 and HIV-2 reverse transcriptase (RT) and integrase (IN) to investigate the specificity of determinants governing the immune response. Peptides representing homologous regions (>50%) in the N- and C-termini and central portions of these proteins were ...

journal_title：Journal of biomedical science

authors： Klutch M,Woerner AM,Marcus-Sekura CJ,Levin JG

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:The association of TGF beta1 polymorphisms and atrial fibrillation (AF) in essential hypertensive (EH) subjects remains unknown. Methods EH subjects with AF (EH+AF+) and sinus rhythm (EH+AF-) were enrolled. The polymorphisms of +869 T --> C at codon 10 and + 915 G --> C at codon 25, were genotyped. The clini...

journal_title：Journal of biomedical science

authors： Wang Y,Hou X,Li Y

更新日期：2010-03-31 00:00:00

abstract：BACKGROUND:Asthma has become an important public health issue and approximately 300 million people have suffered from the disease worldwide. Nowadays, the use of acupuncture in asthma is increasing. This study intended to systematically analyze and compare the gene expression profiles between the asthmatic and acupunct...

journal_title：Journal of biomedical science

authors： Yin LM,Jiang GH,Wang Y,Wang Y,Liu YY,Jin WR,Xu YD,Zhang QH,Yang YQ

更新日期：2009-05-06 00:00:00

abstract：:The intracellular mechanisms underlying oxidized low-density lipoprotein (oxLDL)-signaling pathways in platelets are not yet completely understood. Therefore, the aim of this study was to further examine the effects of oxLDL in prevention of platelet aggregation. In this study, oxLDL concentration-dependently (40-120 ...

journal_title：Journal of biomedical science

authors： Chou DS,Chan CH,Hsiao G,Shen MY,Tsai YJ,Chen TF,Sheu JR

更新日期：2006-05-01 00:00:00

abstract：:After streptococcal pyrogenic exotoxin B (SPE B) induces apoptosis, its fate is unknown. Using confocal time-course microscopy at 37 degrees C, we detected green fluorescence 20 min after adding FITC-SPE B. Orange fluorescence, an indication of co-localization of SPE B with lysosomes which were labeled with a red fluo...

journal_title：Journal of biomedical science

authors： Chang CW,Tsai WH,Chuang WJ,Lin YS,Wu JJ,Liu CC,Tsai PJ,Lin MT

更新日期：2007-05-01 00:00:00

abstract：:The goal of this study was to evaluate the effect of chronic Zn2+ administration (1 mg/kg/day for 1 month) in Sprague-Dawley rats (n = 11) on motility and rearing behaviors (number of events/10 min measured in motility cage), on memory (percentage of failures using a foot-shock double T maze), on the number of muscari...

journal_title：Journal of biomedical science

authors： Bonfante-Cabarcas R,Bravo I,Nello C,Gutiérrez-Reyes E,Loureiro Dos Santos NE,Moreno-Yanes JA

更新日期：2002-11-01 00:00:00

abstract：:Schistosomiasis causes significant levels of morbidity and mortality in many geographical regions of the world. The disease is caused by infections with parasitic blood flukes known as schistosomes. The control of schistosomiasis over the last several decades has been centered on the mass drug administration (MDA) of ...

journal_title：Journal of biomedical science

authors： Molehin AJ

更新日期：2020-01-22 00:00:00

abstract：:Accumulative evidence has supported the role of nitric oxide (NO) in a variety of normal physiological functions as well as many pathological conditions. In this study, we examined the possible diabetogenicity of NO by measuring the expression of the insulin receptor substrate (IRS)-1 in rat hepatocytes and skeletal m...

journal_title：Journal of biomedical science

authors： Badal S,Brown PD,Ragoobirsingh D

更新日期：2006-07-01 00:00:00

abstract：:Cancer has been the leading cause of death in Taiwan over the past two decades and liver cancer is the leading cause of all cancer deaths in Taiwan with a trend of increase in incidence. Therapeutic options and efficacy for liver cancer have been limited and the 5-year survival rate is less than 7% in the Unite States...

journal_title：Journal of biomedical science

authors： Chuu JJ,Liu JM,Tsou MH,Huang CL,Chen CP,Wang HS,Chen CT

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Glioma stem-like cells (GSCs) are proposed to be responsible for high resistance in glioblastoma multiforme (GBM) treatment. In order to find new strategies aimed at reducing GSC stemness and improving GBM patient survival, we investigated the effects and mechanism of a histone deacetylases (HDACs) inhibitor...

journal_title：Journal of biomedical science

authors： Hsu CC,Chang WC,Hsu TI,Liu JJ,Yeh SH,Wang JY,Liou JP,Ko CY,Chang KY,Chuang JY

更新日期：2016-11-18 00:00:00

abstract：BACKGROUND:Type I Bartter syndrome is a recessive human nephropathy caused by loss-of-function mutations in the SLC12A1 gene coding for the Na+-K+-2Cl- cotransporter NKCC2. We recently established the mutant mouse line Slc12a1I299F exhibiting kidney defects highly similar to the late-onset manifestation of this heredit...

journal_title：Journal of biomedical science

authors： Kemter E,Rathkolb B,Becker L,Bolle I,Busch DH,Dalke C,Elvert R,Favor J,Graw J,Hans W,Ivandic B,Kalaydjiev S,Klopstock T,Rácz I,Rozman J,Schrewe A,Schulz H,Zimmer A,Fuchs H,Gailus-Durner V,Hrabe de Angelis M,Wolf

更新日期：2014-08-02 00:00:00

abstract：:The effects of a single or repeated dermal administration of methyl parathion on motor function, learning and memory were investigated in adult female rats and correlated with blood cholinesterase activity. Exposure to a single dose of 50 mg/kg methyl parathion (75% of the dermal LD(50)) resulted in an 88% inhibition ...

journal_title：Journal of biomedical science

authors： Zhu H,Rockhold RW,Baker RC,Kramer RE,Ho IK

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:Noopept (N-phenyl-acetyl-L-prolylglycine ethyl ester) was constructed as a dipeptide analog of the standard cognition enhancer, piracetam. Our previous experiments have demonstrated the cognition restoring effect of noopept in several animal models of Alzheimer disease (AD). Noopept was also shown to prevent...

journal_title：Journal of biomedical science

authors： Ostrovskaya RU,Vakhitova YV,Kuzmina USh,Salimgareeva MKh,Zainullina LF,Gudasheva TA,Vakhitov VA,Seredenin SB

更新日期：2014-08-06 00:00:00

abstract：:The technology of "Lab-on-a-Chip" allows the synthesis and analysis of chemicals and biological substance within a portable or handheld device. The 3D printed structures enable precise control of various geometries. The combination of these two technologies in recent years makes a significant progress. The current app...

journal_title：Journal of biomedical science

authors： Zhou Y

更新日期：2017-10-18 00:00:00

abstract：BACKGROUND:Hyaluronic acid (HA) is present in many tissues; its presence in serum may be related to certain inflammatory conditions, tissue damage, sepsis, liver malfunction and some malignancies. In the present work, our goal was to investigate the significance of hyaluronic acid effect on erythrocyte flow properties....

journal_title：Journal of biomedical science

authors： Luquita A,Urli L,Svetaz MJ,Gennaro AM,Giorgetti ME,Pistone G,Volpintesta R,Palatnik S,Rasia M

更新日期：2010-02-12 00:00:00

abstract：:Glycine N-methyltransferase (GNMT) is a protein with multiple functions. Recently, two Italian siblings who had hepatomegaly and chronic elevation of serum transaminases were diagnosed to have GNMT deficiency caused by inherited compound heterozygosity of the GNMT gene with missence mutations. To evaluate the expressi...

journal_title：Journal of biomedical science

authors： Liu HH,Chen KH,Shih YP,Lui WY,Wong FH,Chen YM

更新日期：2003-01-01 00:00:00

abstract：:Mutations at codon 215 of HIV-1 reverse transcriptase (RT) confer resistance to nucleoside analogs through RT-catalyzed ATP-dependent phosphorolysis. We showed that mutation T215Y is predominant over T215F (respectively 38.8 vs. 7.04% of 7312 sequences from a cohort of patients receiving antiretroviral therapy in Fran...

journal_title：Journal of biomedical science

authors： Yahi N,Fantini J,Henry M,Tourrès C,Tamalet C

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:Ionizing radiation (IR) activate the early growth response-1 (Egr-1) promoter by production of radical oxygen intermediates (ROIs). Egr-EF, an expression vector pCIneo containing Egr-1 promoter cloned upstream of the cDNA for Flt3 ligand, was used to treat hematopoietic damage. 5-fluorouracil, a commonly use...

journal_title：Journal of biomedical science

authors： Du N,Pei X,Zhou J,Zhao H,Li X,Fu Y,Hao Y

更新日期：2009-09-21 00:00:00

abstract：:The HIV-1 Tat protein is an RNA-binding transcriptional transactivator. Recent findings suggest that Tat associates with a cellular kinase that phosphorylates the carboxyl-terminal domain of the largest subunit of RNA polymerase II. Here we review, in brief, the role of Tat-associated kinase in Tat-activated transcrip...

journal_title：Journal of biomedical science

authors： Jeang KT

更新日期：1998-01-01 00:00:00

abstract：:The detailed mechanism of how lysophosphatidylcholine (LPC) suppresses endothelium-dependent vasodilatation is unclear at present. We investigated the effects of LPC on endothelial intracellular calcium (EC [Ca(2+)](i)) signaling and vascular tone simultaneously using a new technique we developed. Fura-2-labeled rat a...

journal_title：Journal of biomedical science

authors： Huang TY,Chen HI,Liu CY,Jen CJ

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Prenatal alcohol exposure may cause cardiac development defects, however, the underlying mechanisms are not yet clear. In the present study we have investigated the roles of histone modification by curcumin on alcohol induced fetal cardiac abnormalities during the development. METHODS AND RESULTS:Q-PCR and ...

journal_title：Journal of biomedical science

authors： Yan X,Pan B,Lv T,Liu L,Zhu J,Shen W,Huang X,Tian J

更新日期：2017-01-05 00:00:00

abstract：:Myostatin, a member of the TGF-beta superfamily, is a potent negative regulator of skeletal muscle and growth. Previously, we reported Mstn1 from zebrafish and studied its influence on muscle development. In this study, we identified another form of Myostatin protein which is referred to as Mstn2. The size of Mstn2 cD...

journal_title：Journal of biomedical science

authors： Amali AA,Lin CJ,Chen YH,Wang WL,Gong HY,Rekha RD,Lu JK,Chen TT,Wu JL

更新日期：2008-09-01 00:00:00

abstract：:The purpose of this study was to determine whether beta-adrenergically mediated cardiovascular functions such as arterial pressure (AP), heart rate (HR), stroke volume (SV), cardiac output (CO), peripheral resistance (R(p)), arterial impedance (Z(c)), mean arterial compliance (C(m)) and pulse wave reflection (P(b)) we...

journal_title：Journal of biomedical science

authors： Hu CT,Wu CY,Chen HI

更新日期：1996-07-01 00:00:00

abstract：:The SARS related Coronavirus genome contains a variety of novel accessory genes. One of these, called ORF7a or ORF8, code for a protein, known as 7a, U122 or X4. We set out to determine the three-dimensional structure of the soluble ectodomain of this type-I transmembrane protein by nuclear magnetic resonance spectros...

journal_title：Journal of biomedical science

authors： Hänel K,Stangler T,Stoldt M,Willbold D

更新日期：2006-05-01 00:00:00

abstract：:Adenosine was shown to inhibit norepinephrine (NE) release from sympathetic nerve endings. The purpose of this study was to examine whether endogenous adenosine restrains NE and epinephrine release from the adrenal medulla. The effects of an adenosine receptor antagonist, 1,3-dipropyl-8-(p-sulfophenyl) xanthine (DPSPX...

journal_title：Journal of biomedical science

authors： Tseng CJ,Chan JY,Lo WC,Jan CR

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Increased levels of blood plasma urea were used as phenotypic parameter for establishing novel mouse models for kidney diseases on the genetic background of C3H inbred mice in the phenotype-driven Munich ENU mouse mutagenesis project. The phenotypically dominant mutant line HST014 was established and further...

journal_title：Journal of biomedical science

authors： Kumar S,Rathkolb B,Sabrautzki S,Krebs S,Kemter E,Becker L,Beckers J,Bekeredjian R,Brommage R,Calzada-Wack J,Garrett L,Hölter SM,Horsch M,Klingenspor M,Klopstock T,Moreth K,Neff F,Rozman J,Fuchs H,Gailus-Durner V,H

更新日期：2017-08-17 00:00:00

abstract：BACKGROUND:The type VI adenylyl cyclase (AC6) is a main contributor of cAMP production in the heart. The amino acid (aa) sequence of AC6 is highly homologous to that of another major cardiac adenylyl cyclase, AC5, except for its N-terminus (AC6-N, aa 1-86). Activation of AC6, rather than AC5, produces cardioprotective ...

journal_title：Journal of biomedical science

authors： Wu YS,Chen CC,Chien CL,Lai HL,Jiang ST,Chen YC,Lai LP,Hsiao WF,Chen WP,Chern Y

更新日期：2017-09-04 00:00:00

abstract：BACKGROUND:Glutaminase predominates in periportal hepatocytes and it has been proposed that it determines the glutamine-derived nitrogen flow through the urea cycle. Glutamine-derived urea production should, thus, be considerably faster in periportal hepatocytes. This postulate, based on indirect observations, has not ...

journal_title：Journal of biomedical science

authors： Comar JF,Suzuki-Kemmelmeier F,Constantin J,Bracht A

更新日期：2010-01-07 00:00:00

abstract：:Maternal exposure to dietary factors during pregnancy can influence embryonic development and may modulate the phenotype of offspring through epigenetic programming. Folate is critical for nucleotide synthesis, and preconceptional intake of dietary folic acid (FA) is credited with reduced incidences of neural tube def...

journal_title：Journal of biomedical science

authors： Barua S,Kuizon S,Junaid MA

更新日期：2014-08-19 00:00:00

abstract：:Reactive oxygen species (ROS) have been long considered simply as harmful by-products of metabolism, which damage cellular proteins, lipids, and nucleic acids. ROS are also known as a weapon of phagocytes, employed against pathogens invading the host. However, during the last decade, an understanding has emerged that ...

journal_title：Journal of biomedical science

authors： Belikov AV,Schraven B,Simeoni L

更新日期：2015-10-15 00:00:00