Generation of HIV-1/HIV-2 cross-reactive peptide antisera by small sequence changes in HIV-1 reverse transcriptase and integrase immunizing peptides.

abstract：:Experimental allergic encephalomyelitis (EAE) is an accepted animal model for the human demyelinating disease multiple sclerosis. The continuously propagated line of Lewis rat T helper lymphocytes (GP1 T cells), specific for the encephalitogenic 68-86 sequence of guinea pig myelin basic protein (GPMBP), mediates the a...

journal_title：Journal of biomedical science

authors： Judge SI,Paterson PY,Mannie MD,Yeh JZ

更新日期：1997-03-01 00:00:00

abstract：:The purpose of this study was to determine whether beta-adrenergically mediated cardiovascular functions such as arterial pressure (AP), heart rate (HR), stroke volume (SV), cardiac output (CO), peripheral resistance (R(p)), arterial impedance (Z(c)), mean arterial compliance (C(m)) and pulse wave reflection (P(b)) we...

journal_title：Journal of biomedical science

authors： Hu CT,Wu CY,Chen HI

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:Autophagy has been shown recently to play an important role in the intracellular survival of several pathogenic bacteria. In this study, we investigated the effect of a novel small-molecule autophagy-inducing agent, AR-12, on the survival of Francisella tularensis, the causative bacterium of tularemia in hum...

journal_title：Journal of biomedical science

authors： Chiu HC,Soni S,Kulp SK,Curry H,Wang D,Gunn JS,Schlesinger LS,Chen CS

更新日期：2009-12-09 00:00:00

abstract：BACKGROUND:B cells play an essential role during dengue viral infection. While a major expansion of antibody secreting cells (ASCs) was observed, the importance of these increased frequencies of ASCs remains unclear. The alteration of B cell subsets may result from the expression of tissue specific homing molecules lea...

journal_title：Journal of biomedical science

authors： Pattanapanyasat K,Khowawisetsut L,Chuansumrit A,Chokephaibulkit K,Tangnararatchakit K,Apiwattanakul N,Techasaensiri C,Thitilertdecha P,Sae-Ung T,Onlamoon N

更新日期：2018-08-27 00:00:00

abstract：BACKGROUND:Despite the recent progress in screening and therapy, a majority of prostate cancer cases eventually attain hormone refractory and chemo-resistant attributes. Conventional chemotherapeutic strategies are effective at very high doses for only palliative management of these prostate cancers. Therefore chemo-se...

journal_title：Journal of biomedical science

authors： Gara RK,Srivastava VK,Duggal S,Bagga JK,Bhatt M,Sanyal S,Mishra DP

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:RNA interference (RNAi) is a powerful tool to silence gene expression post-transcriptionally. Delivering sequences of RNAi in vivo remains a problem. The aim of this study was to use JC virus (JCV) virus-like particles (VLPs) as a vector for delivering RNAi in silencing the cytokine gene of IL-10. METHODS:J...

journal_title：Journal of biomedical science

authors： Chou MI,Hsieh YF,Wang M,Chang JT,Chang D,Zouali M,Tsay GJ

更新日期：2010-06-24 00:00:00

abstract：:Recent transcriptome analyses have revealed that noncoding RNAs (ncRNAs) are broadly expressed in mammalian cells and abundant in the CNS, with tissue and cell type-specific expression patterns. Moreover, ncRNAs have been found to intricately and dynamically regulate various signaling pathways in neurodegeneration. As...

journal_title：Journal of biomedical science

authors： Wu YY,Kuo HC

更新日期：2020-04-07 00:00:00

abstract：:Liver cancer is the predominant cause of cancer mortality in males of Southern China and Taiwan. The current therapy is not satisfactory, and more effective treatments are needed. In the search for new therapies for liver tumor, we found that Concanavalin A (Con A), a lectin from Jack bean seeds, can have a potent ant...

journal_title：Journal of biomedical science

authors： Lei HY,Chang CP

更新日期：2009-01-19 00:00:00

abstract：:Angiogenesis is essential for development, growth and advancement of solid tumors. Cyclooxygenase (COX)-2 is recognized as an angiogenic factor in various tumors. This prompted us to study the clinical implications of COX-2 expression related to angiogenesis in uterine cervical cancers. There was a significant correla...

journal_title：Journal of biomedical science

authors： Fujimoto J,Toyoki H,Sato E,Sakaguchi H,Jahan I,Alam SM,Tamaya T

更新日期：2006-11-01 00:00:00

abstract：:Due to high prevalence and mortality and the lack of effective therapies, prostate cancer is one of the most crucial health problems in men. Drug resistance aggravates the situation, not only in human prostate cancer but also in other cancers. In this study, we report for the first time that cardiac glycosides (e.g. o...

journal_title：Journal of biomedical science

authors： Huang DM,Guh JH,Huang YT,Chueh SC,Wang HP,Teng CM

更新日期：2002-09-01 00:00:00

abstract：:Death-associated protein (DAP)-kinase, an actin-cytoskeleton localized serine/threonine kinase, functions as a novel tumor suppressor and participates in a wide variety of cell death systems. Recent studies indicate that DAP-kinase elicits a potent cytoskeletal reorganization effect and is capable of modulating integr...

journal_title：Journal of biomedical science

authors： Chen RH,Wang WJ,Kuo JC

更新日期：2006-03-01 00:00:00

abstract：:Diazoxide is a selective mitochondria ATP-sensitive potassium (K(ATP)) channel opener, which has been reported to preserve the microvascular integrity of ischemia-reperfusion (I/R)-injured tissues. Our study aimed to assess diazoxide's effects on I/R-injured cremaster muscles and to further elucidate its underlying me...

journal_title：Journal of biomedical science

authors： Wei W,Wei FC,Hung LM

更新日期：2005-01-01 00:00:00

abstract：:Microfluidics has become an important tool in diagnosing many diseases, including neurological and genetic disorders. Alzheimer's disease (AD) is a neurodegenerative disease that irreversibly and progressively destroys memory, language ability, and thinking skills. Commonly, detection of AD is expensive and complex. F...

journal_title：Journal of biomedical science

authors： Devadhasan JP,Kim S,An J

更新日期：2011-05-28 00:00:00

abstract：:Induction of tumoricidal activity is one of the major functions of activated macrophages. Our previous study demonstrated that P388D1 murine macrophage-like cells secreted a plasmacytoma cytotoxic factor (PCF) that selectively killed certain tumor cell lines including MOPC-315 plasmacytoma in vitro. Our subsequent stu...

journal_title：Journal of biomedical science

authors： Chu CY,Tseng J

更新日期：2000-01-01 00:00:00

abstract：:Serologically defined primary dengue virus infection and/or subsequent homologous serotype infection is known to be associated with less severe disease as compared with secondary subsequent heterologous serotype infection. In geographical locales of high dengue endemicity, almost all individuals in the population are ...

journal_title：Journal of biomedical science

authors： Perng GC,Chokephaibulkit K

更新日期：2013-05-31 00:00:00

abstract：:Advances in Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated system (CRISPR/Cas9) has dramatically reshaped our ability to edit genomes. The scientific community is using CRISPR/Cas9 for various biotechnological and medical purposes. One of its most important uses is developing potential the...

journal_title：Journal of biomedical science

authors： Khan S,Mahmood MS,Rahman SU,Zafar H,Habibullah S,Khan Z,Ahmad A

更新日期：2018-03-28 00:00:00

abstract：:Our goal was to develop a system to study proteins that associate in vivo with the Moloney murine leukemia virus (M-MuLV) enhancer elements by the isolation of intact proviral chromatin. The M-MuLV long terminal repeats (LTRs) contain tandemly repeated transcriptional enhancer sequences consisting of smaller motifs th...

journal_title：Journal of biomedical science

authors： Granger SW,Fan H

更新日期：2001-05-01 00:00:00

abstract：:Phospholipase D (PLD) is a phosphodiesterase that catalyses hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline. In the presence of ethanol, PLD also catalyses the formation of phosphatidylethanol, which is a unique characteristic of this enzyme. Muscarinic receptor-induced changes in the activi...

journal_title：Journal of biomedical science

authors： Mamoon AM,Smith J,Baker RC,Farley JM

更新日期：1999-03-01 00:00:00

abstract：:The midbrain periaqueductal gray matter (PAG) is an important brain region for the coordination of mu-opioid-induced pharmacological actions. The present study was designed to determine whether newly isolated mu-opioid peptide endomorphins can activate G proteins through mu-opioid receptors in the PAG by monitoring th...

journal_title：Journal of biomedical science

authors： Narita M,Mizoguchi H,Narita M,Dun NJ,Hwang BH,Endoh T,Suzuki T,Nagase H,Suzuki T,Tseng LF

更新日期：2000-05-01 00:00:00

abstract：:Hypoxia is an important microenvironmental factor that induces cancer metastasis. Hypoxia/hypoxia-inducible factor-1α (HIF-1α) regulates many important steps of the metastatic processes, especially epithelial-mesenchymal transition (EMT) that is one of the crucial mechanisms to cause early stage of tumor metastasis. T...

journal_title：Journal of biomedical science

authors： Tsai YP,Wu KJ

更新日期：2012-12-14 00:00:00

abstract：:DNA vaccines have emerged as an attractive approach for generating antigen-specific immunotherapy. Strategies that enhance antigen presentation may potentially be used to enhance DNA vaccine potency. Previous experiments showed that chimeric DNA vaccines utilizing endoplasmic reticulum (ER) chaperone molecules, such a...

journal_title：Journal of biomedical science

authors： Lin CT,Chang TC,Chao A,Dzeng E,Soong YK,Hung CF,Lai CH

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Previous study demonstrated the improvement of cardiac function was proportional to the number of cells implanted. Therefore, increasing cell survival in the infarcted myocardium might contribute to the improvement of the functional benefit of cell transplantation. METHODS AND RESULTS:MSCs were treated with...

journal_title：Journal of biomedical science

authors： Guo J,Lin G,Bao C,Hu Z,Chu H,Hu M

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Increased lipid accumulation and mitochondrial dysfunction within skeletal muscle have been shown to be strongly associated with insulin resistance. However, the role of mitofusion-2 (MFN2), a key factor in mitochondrial function and energy metabolism, in skeletal muscle lipid intermediate accumulation remai...

journal_title：Journal of biomedical science

authors： Zhang X,Wang C,Song G,Gan K,Kong D,Nie Q,Ren L

更新日期：2013-07-01 00:00:00

abstract：:Lysosome-associated membrane protein (LAMP)-1, one of the major protein components of the lysosomal membrane, is upregulated in the human glioblastoma cell lines, U-373 MG and LN-Z308, which undergo cisplatin-induced apoptosis. These human brain tumor cell lines demonstrated apoptosis in response to cisplatin/nifedipi...

journal_title：Journal of biomedical science

authors： Chen JW,Madamanchi N,Madamanchi NR,Trier TT,Keherly MJ

更新日期：2001-07-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：Journal of biomedical science

authors： Huber RJ

更新日期：2020-09-21 00:00:00

abstract：BACKGROUND:To mimic systemic inflammation in humans, different animal models have been developed. Since these models are still discussed controversially, we aimed to comparatively evaluate the most widely used models with respect to the systemic effects, the influence on organ functions and to the underlying pathophysi...

journal_title：Journal of biomedical science

authors： Seemann S,Zohles F,Lupp A

更新日期：2017-08-24 00:00:00

abstract：BACKGROUND:Cervical cancer is the second-most-common cause of malignancies in women worldwide, and the oncogenic activity of the human papilloma virus types (HPV) E7 protein has a crucial role in anogenital tumors. In this study, we have designed a therapeutic vaccine based on chitosan nanodelivery systems to deliver H...

journal_title：Journal of biomedical science

authors： Tahamtan A,Ghaemi A,Gorji A,Kalhor HR,Sajadian A,Tabarraei A,Moradi A,Atyabi F,Kelishadi M

更新日期：2014-07-31 00:00:00

abstract：:Chronic inflammation may lead to endothelial dysfunction, which manifests as an impaired coronary reactivity. Impairment in coronary flow reserve (CFR), preceding the clinical symptoms of coronary artery disease, can be measured noninvasively by positron emission tomography. Myeloperoxidase (MPO) is an oxidative enzym...

journal_title：Journal of biomedical science

authors： Mäkelä R,Laaksonen R,Janatuinen T,Vesalainen R,Nuutila P,Jaakkola O,Knuuti J,Lehtimäki T

更新日期：2004-01-01 00:00:00

abstract：:The first- and second-generation epidermal growth factor receptor tyrosine kinase inhibitors (1/2G EGFR-TKIs) gefitinib, erlotinib, and afatinib have all been approved as standard first-line treatments for advanced EGFR mutation-positive non-small cell lung cancer. The third-generation (3G) EGFR-TKIs have been develop...

journal_title：Journal of biomedical science

authors： Liao BC,Lin CC,Lee JH,Yang JC

更新日期：2016-12-03 00:00:00

abstract：BACKGROUND:Fallopian tube epithelial cells (FTEC) were thought to be the origin of high-grade serous ovarian carcinoma (HGSOC). Knowledge of the stemness or initiating characteristics of FTEC is insufficient. Previously, we have characterized the stemness cell marker of FTEC, this study aims to further characterize the...

journal_title：Journal of biomedical science

authors： Chang YH,Chu TY,Ding DC

更新日期：2020-02-08 00:00:00