Abstract:
BACKGROUND:Increased lipid accumulation and mitochondrial dysfunction within skeletal muscle have been shown to be strongly associated with insulin resistance. However, the role of mitofusion-2 (MFN2), a key factor in mitochondrial function and energy metabolism, in skeletal muscle lipid intermediate accumulation remains to be elucidated. RESULTS:A high-fat diet resulted in insulin resistance as well as accumulation of cytosolic lipid intermediates and down-regulation of MFN2 and CPT1 in skeletal muscle in rats, while MFN2 overexpression improved insulin sensitivity and reduced lipid intermediates in muscle, possibly by upregulation of CPT1 expression. CONCLUSIONS:MFN2 overexpression can rescue insulin resistance, possibly by upregulating CPT1 expression leading to reduction in the accumulation of lipid intermediates in skeletal muscle. These observations contribute to the investigations of new diabetes therapies.
journal_name
J Biomed Scijournal_title
Journal of biomedical scienceauthors
Zhang X,Wang C,Song G,Gan K,Kong D,Nie Q,Ren Ldoi
10.1186/1423-0127-20-45subject
Has Abstractpub_date
2013-07-01 00:00:00pages
45eissn
1021-7770issn
1423-0127pii
1423-0127-20-45journal_volume
20pub_type
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