Characterization of a Human Stromal Cell Line Supporting Hematopoietic Progenitor Cell Proliferation: Effect of HIV Expression.

abstract：BACKGROUND:Sensing tissue acidosis is an important function of the somatosensory nervous system to response to noxious stimuli. MAIN BODY:In the pain clinic, acid or soreness sensation is a characteristic sensory phenotype of various acute and chronic pain syndromes, such as delayed onset muscle soreness, fibromyalgia...

journal_title：Journal of biomedical science

authors： Lin JH,Hung CH,Han DS,Chen ST,Lee CH,Sun WZ,Chen CC

更新日期：2018-11-29 00:00:00

abstract：:To determine the involvement of the globus pallidus in mediating epilepsy, the effects of microinjection of a GABA uptake blocker (tiagabine), a benzodiazepine agonist (zolpidem) and a GABA-B receptor agonist (baclofen) on pentylenetetrazol (PTZ)-induced tonic seizure were examined in adult rats. Administration of PTZ...

journal_title：Journal of biomedical science

authors： Chen L,Chan YS,Yung WH

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:B cells play an essential role during dengue viral infection. While a major expansion of antibody secreting cells (ASCs) was observed, the importance of these increased frequencies of ASCs remains unclear. The alteration of B cell subsets may result from the expression of tissue specific homing molecules lea...

journal_title：Journal of biomedical science

authors： Pattanapanyasat K,Khowawisetsut L,Chuansumrit A,Chokephaibulkit K,Tangnararatchakit K,Apiwattanakul N,Techasaensiri C,Thitilertdecha P,Sae-Ung T,Onlamoon N

更新日期：2018-08-27 00:00:00

abstract：BACKGROUND:Among a variety of inflammatory mediators, visfatin is a proinflammatory adipocytokine associated with inflammatory reactions in obesity, metabolic syndrome, chronic inflammatory disease, and autoimmune disease. However, the biological role of visfatin in secretion of major mucins in human airway epithelial ...

journal_title：Journal of biomedical science

authors： Song SY,Jung EC,Bae CH,Choi YS,Kim YD

更新日期：2014-05-20 00:00:00

abstract：BACKGROUND:Type I Bartter syndrome is a recessive human nephropathy caused by loss-of-function mutations in the SLC12A1 gene coding for the Na+-K+-2Cl- cotransporter NKCC2. We recently established the mutant mouse line Slc12a1I299F exhibiting kidney defects highly similar to the late-onset manifestation of this heredit...

journal_title：Journal of biomedical science

authors： Kemter E,Rathkolb B,Becker L,Bolle I,Busch DH,Dalke C,Elvert R,Favor J,Graw J,Hans W,Ivandic B,Kalaydjiev S,Klopstock T,Rácz I,Rozman J,Schrewe A,Schulz H,Zimmer A,Fuchs H,Gailus-Durner V,Hrabe de Angelis M,Wolf

更新日期：2014-08-02 00:00:00

abstract：:Purinergic P2X7 receptor (P2X7R), an ATP-gated cation channel, is unique among all other family members because of its ability to respond to various stimuli and to modulate pro-inflammatory signaling. The activation of P2X7R in immune cells is absolutely required for mature interleukin -1beta (IL-1beta) and IL-18 prod...

journal_title：Journal of biomedical science

authors： Mishra A

更新日期：2013-05-01 00:00:00

abstract：:The purpose of this study was to determine whether beta-adrenergically mediated cardiovascular functions such as arterial pressure (AP), heart rate (HR), stroke volume (SV), cardiac output (CO), peripheral resistance (R(p)), arterial impedance (Z(c)), mean arterial compliance (C(m)) and pulse wave reflection (P(b)) we...

journal_title：Journal of biomedical science

authors： Hu CT,Wu CY,Chen HI

更新日期：1996-07-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：Journal of biomedical science

authors： Huber RJ

更新日期：2020-09-21 00:00:00

abstract：:Sequencing of HIV-1(GER) long terminal repeat (LTR) has demonstrated, for the first time in an HIV-1 primary isolate, a TAR duplication referred to as TAR1 (nucleotides +1 through +68) and TAR2 (nucleotides +69 through +136). This TAR duplication is stable during replication of HIV-1(GER) isolate in CEM cells. Analysi...

journal_title：Journal of biomedical science

authors： Emiliani S,Coudronnière N,Delsert C,Devaux C

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Interleukin 12B (IL12B) gene polymorphisms have been linked to several inflammatory diseases, but their role in the development of Graves ophthalmopathy (GO) in Graves disease (GD) patients is unclear. The purpose of this study was to investigate the disease association of IL12B single nucleotide polymorphis...

journal_title：Journal of biomedical science

authors： Liu YH,Chen CC,Liao LL,Wan L,Tsai CH,Tsai FJ

更新日期：2012-11-19 00:00:00

abstract：:The first- and second-generation epidermal growth factor receptor tyrosine kinase inhibitors (1/2G EGFR-TKIs) gefitinib, erlotinib, and afatinib have all been approved as standard first-line treatments for advanced EGFR mutation-positive non-small cell lung cancer. The third-generation (3G) EGFR-TKIs have been develop...

journal_title：Journal of biomedical science

authors： Liao BC,Lin CC,Lee JH,Yang JC

更新日期：2016-12-03 00:00:00

abstract：BACKGROUND:Prevalence of metabolic syndrome (MS) is rapidly increasing worldwide. To investigate the spread of MS risks and its relationship with eating habits including fish intake, we carried out a health examination for young and middle-aged men. METHODS:The subjects were 97 healthy men (20 to 50 years) living in M...

journal_title：Journal of biomedical science

authors： Hamada A,Mori M,Mori H,Muhihi A,Njelekela M,Masesa Z,Mtabaji J,Yamori Y

更新日期：2010-08-24 00:00:00

abstract：BACKGROUND:The association of functionality and phenotype of follicular helper T cells (Tfh) with dengue virus (DENV) specific antibody responses and clinical disease severity has not been well studied. METHODS:We investigated the phenotype and functionality of Tfh cells and plasmablasts in adult patients (DF = 18, DH...

journal_title：Journal of biomedical science

authors： Wijesinghe A,Gamage J,Goonewardena H,Gomes L,Jayathilaka D,Wijeratne DT,de Alwis R,Jeewandara C,Wijewickrama A,Ogg GS,Malavige GN

更新日期：2020-04-08 00:00:00

abstract：:The apolipoprotein (Apo) E gene is known to be polymorphic. Three common alleles determine six phenotypes which can easily be detected by restriction fragment length polymorphism. We performed apo E genotyping in myocardial infarction survivors and healthy controls for the first time in the Turkish population. DNA was...

journal_title：Journal of biomedical science

authors： Hergenc G,Taga Y,Emerk K,Cirakoglu B

更新日期：1995-01-01 00:00:00

abstract：:Protein kinases play pivotal roles in the development of the nervous system. They are involved in almost every stage of neuronal development, from initial proliferation and differentiation of progenitor cells to pathfinding of neurites and formation of synapses. Activation of protein kinases is also critical for neuro...

journal_title：Journal of biomedical science

authors： Lin SD,Fann MJ

更新日期：1998-01-01 00:00:00

abstract：:The dual signal hypothesis of apoptosis holds that a common signal can activate both apoptotic and proliferative pathways. The fate of a cell is dependent on which of these two pathways predominates. In the MAPK family of kinases, ERK and JNK have been proposed to mediate apoptosis whereas the PI3K-stimulated kinase, ...

journal_title：Journal of biomedical science

authors： Chin LS,Murray SF,Harter DH,Doherty PF,Singh SK

更新日期：1999-05-01 00:00:00

abstract：:Peptidoglycan-activated gene expression is mediated through various transcription factors including CCAAT/enhancer-binding protein delta (C/EBPdelta). The purpose of the present study is to elucidate the mechanism of PGN-activated C/EBPdelta gene. PGN stimulated C/EBPdelta protein and mRNA expression in mouse macropha...

journal_title：Journal of biomedical science

authors： Huang YC,Chang WC,Su JG,Cai JL,Chen CC,Hung JJ,Liu YW

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Endothelial cell (EC) dysfunctions, including turnover enrichment, gap junction disruption, inflammation, and oxidation, play vital roles in the initiation of vascular disorders and atherosclerosis. Hemodynamic forces, i.e., atherprotective pulsatile (PS) and pro-atherogenic oscillatory shear stress (OS), ca...

journal_title：Journal of biomedical science

authors： Lee DY,Chiu JJ

更新日期：2019-08-07 00:00:00

abstract：:Ischemia and reperfusion (I/R) - induced injury has been described as one of the main factors that contribute to the observed morbidity and mortality in a variety of clinical entities, including myocardial infarction, ischemic stroke, cardiac arrest and trauma. An imbalance between oxygen demand and supply, within the...

journal_title：Journal of biomedical science

authors： Tasoulis MK,Douzinas EE

更新日期：2016-01-19 00:00:00

abstract：:In many solid tumor types, tumor-associated macrophages (TAMs) are important components of the tumor microenvironment (TME). Moreover, TAMs infiltration is strongly associated with poor survival in solid tumor patients. In this review, we describe the origins of TAMs and their polarization state dictated by the TME. W...

journal_title：Journal of biomedical science

authors： Chen Y,Song Y,Du W,Gong L,Chang H,Zou Z

更新日期：2019-10-20 00:00:00

abstract：:Diabetes is a multifactorial disease that has now been recognized to involve overproduction of reactive oxygen species and pro-inflammatory cytokines. Peroxisomes are subcellular organelles with several important metabolic functions, and their role in the regulation of cellular oxidative stress is now well established...

journal_title：Journal of biomedical science

authors： Dhaunsi GS,Bitar MS

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Although runt-related transcription factor 2 (RUNX2) has been considered a determinant of cleidocranial dysplasia (CCD), some CCD patients were free of RUNX2 mutations. CCAAT/enhancer-binding protein beta (Cebpb) is a key factor of Runx2 expression and our previous study has reported two CCD signs including ...

journal_title：Journal of biomedical science

authors： Huang B,Takahashi K,Jennings EA,Pumtang-On P,Kiso H,Togo Y,Saito K,Sugai M,Akira S,Shimizu A,Bessho K

更新日期：2014-05-13 00:00:00

abstract：BACKGROUND:Mounting evidences have showed the important role of transforming growth factor-β (TGF-β) in immunological surveillance of tumors. Some studies have also indicated human leukocyte antigen (HLA)-G-associated immune escape involving TGF-β management in gastric cancer (GC). However, the mechanism underlying it ...

journal_title：Journal of biomedical science

authors： Guan Z,Song B,Liu F,Sun D,Wang K,Qu H

更新日期：2015-12-02 00:00:00

abstract：:Mediation of the respiratory reflex effects of an exogenous serotonin challenge goes beyond the lung vagi and is suggested to involve the nodose ganglia. In the present experiments the effects of an intravenous serotonin challenge on breathing pattern were studied in 8 pentobarbitone-chloralose anaesthetised cats. Bol...

journal_title：Journal of biomedical science

authors： Kopczyńska B,Szereda-Przestaszewska M

更新日期：2003-11-01 00:00:00

abstract：:The antitumor activity of Anoectochilus formosanus Hayata (Orchidaceae), a popularly used folk medicine in the treatment of cancers in Asia, was investigated in MCF-7 human mammary carcinoma cells. Plant extracts of A. formosanus were observed to induce apoptosis of MCF-7 cells as evidenced by cell-morphological chang...

journal_title：Journal of biomedical science

authors： Shyur LF,Chen CH,Lo CP,Wang SY,Kang PL,Sun SJ,Chang CA,Tzeng CM,Yang NS

更新日期：2004-11-01 00:00:00

abstract：:Obesity is one of the most invaliding and preventable diseases in the United States. Growing evidence suggests that there are sex differences in obesity in human and experimental animals. However, the specific mechanisms of this disease are unknown. Consequently, there is any particular treatment according to the sex/...

journal_title：Journal of biomedical science

authors： Fitzgerald SJ,Janorkar AV,Barnes A,Maranon RO

更新日期：2018-12-03 00:00:00

abstract：BACKGROUND:Previous study demonstrated the improvement of cardiac function was proportional to the number of cells implanted. Therefore, increasing cell survival in the infarcted myocardium might contribute to the improvement of the functional benefit of cell transplantation. METHODS AND RESULTS:MSCs were treated with...

journal_title：Journal of biomedical science

authors： Guo J,Lin G,Bao C,Hu Z,Chu H,Hu M

更新日期：2008-01-01 00:00:00

abstract：:Fibroblasts derived from glucose-6-phosphate dehydrogenase (G6PD)-deficient patients display retarded growth and accelerated cellular senescence that is attributable to increased accumulation of oxidative DNA damage and increased sensitivity to oxidant-induced senescence, but not to accelerated telomere attrition. Her...

journal_title：Journal of biomedical science

authors： Wu YH,Cheng ML,Ho HY,Chiu DT,Wang TC

更新日期：2009-02-05 00:00:00

abstract：:Liver cancer is the predominant cause of cancer mortality in males of Southern China and Taiwan. The current therapy is not satisfactory, and more effective treatments are needed. In the search for new therapies for liver tumor, we found that Concanavalin A (Con A), a lectin from Jack bean seeds, can have a potent ant...

journal_title：Journal of biomedical science

authors： Lei HY,Chang CP

更新日期：2009-01-19 00:00:00

abstract：:The ARFP/F protein is synthesized from the +1 reading frame of the hepatitis C virus (HCV) core protein gene. The function of this protein remains unknown. To study the function of the HCV ARFP/F protein, we have conducted the yeast two-hybrid screening experiment to identify cellular proteins that may interact with t...

journal_title：Journal of biomedical science

authors： Ma HC,Lin TW,Li H,Iguchi-Ariga SM,Ariga H,Chuang YL,Ou JH,Lo SY

更新日期：2008-07-01 00:00:00