Sodium vanadate inhibits apoptosis in malignant glioma cells: a role for Akt/PKB.

abstract：:The sigma-1 receptor (Sig-1R) is a chaperone that resides mainly at the mitochondrion-associated endoplasmic reticulum (ER) membrane (called the MAMs) and acts as a dynamic pluripotent modulator in living systems. At the MAM, the Sig-1R is known to play a role in regulating the Ca2+ signaling between ER and mitochondr...

journal_title：Journal of biomedical science

authors： Weng TY,Tsai SA,Su TP

更新日期：2017-09-16 00:00:00

abstract：:Exposure of cells and organs to heat shock is associated with numerous changes in various cellular metabolic parameters and overexpression of proteins collectively known as heat shock proteins (HSP). In this communication we review the cell-signaling events that are altered in response to heat shock as they relate to ...

journal_title：Journal of biomedical science

authors： Gong Kiang J,Tsokos GC

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Type I Bartter syndrome is a recessive human nephropathy caused by loss-of-function mutations in the SLC12A1 gene coding for the Na+-K+-2Cl- cotransporter NKCC2. We recently established the mutant mouse line Slc12a1I299F exhibiting kidney defects highly similar to the late-onset manifestation of this heredit...

journal_title：Journal of biomedical science

authors： Kemter E,Rathkolb B,Becker L,Bolle I,Busch DH,Dalke C,Elvert R,Favor J,Graw J,Hans W,Ivandic B,Kalaydjiev S,Klopstock T,Rácz I,Rozman J,Schrewe A,Schulz H,Zimmer A,Fuchs H,Gailus-Durner V,Hrabe de Angelis M,Wolf

更新日期：2014-08-02 00:00:00

abstract：:The signaling pathways leading to extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) activation by N-formyl-Met-Leu-Phe (fMLP) or platelet activating factor (PAF) in human neutrophils were examined. Previously, we found that changes of intracellular Ca2+ ([Ca2+]i) stimulated by...

journal_title：Journal of biomedical science

authors： Chen LW,Lin MW,Hsu CM

更新日期：2005-01-01 00:00:00

abstract：:Adeno-associated virus (AAV) vectors were shown capable of high efficiency transduction of both dividing and nondividing cells and tissues. AAV-mediated transduction leads to stable, long-term transgene expression in the absence of apparent immune response. These properties and the broad host range of AAV vectors indi...

journal_title：Journal of biomedical science

authors： Tal J

更新日期：2000-07-01 00:00:00

abstract：:Over the past few years, long non-coding RNAs (lncRNAs) are recognized as key regulators of gene expression at chromatin, transcriptional and posttranscriptional level with pivotal roles in various biological and pathological processes, including cancer. Hypoxia, a common feature of the tumor microenvironment, profoun...

journal_title：Journal of biomedical science

authors： Kuo TC,Kung HJ,Shih JW

更新日期：2020-05-05 00:00:00

abstract：BACKGROUND:Oxidized low-density lipoprotein (oxLDL) mediates the transformation of macrophages (MΦ) to cholesterol-rich foam cells and the release of pro-inflammatory cytokines during atherogenesis. JAB1 (Jun activation domain binding protein-1) is present in all stages of human plaques, involved in the Toll-like recep...

journal_title：Journal of biomedical science

authors： Schwarz A,Bonaterra GA,Schwarzbach H,Kinscherf R

更新日期：2017-02-07 00:00:00

abstract：:Drosophila eye development is a progressive process including cell fate determination, pattern formation, and rhabdomere morphogenesis. During eye development, a dramatic change in cell shape, which involves turning and extension of the photoreceptor apical surface, occurs in the early pupal stages. It is known that a...

journal_title：Journal of biomedical science

authors： Fan SS

更新日期：2004-05-01 00:00:00

abstract：:Sensory innervation of the skin subserves protective sensations for the body to prevent thermal and noxious injuries. Neurophysiologically, they belong to the categories of Adelta and C fibers, usually with caliber less than one micro m in diameter. Morphological demonstration of the terminals of these nerves in the e...

journal_title：Journal of biomedical science

authors： Hsieh ST,Lin WM,Chiang HY,Huang IT,Ko MH,Chang YC,Chen WP

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Whereas brain death is a vitally important clinical phenomenon, our contemporary understanding on its underlying cellular mechanisms remains elusive. This study evaluated whether the ubiquitin-proteasome system (UPS) in the rostral ventrolateral medulla (RVLM), a neural substrate that our laboratory identifi...

journal_title：Journal of biomedical science

authors： Wu CH,Chan JY,Chou JL,Chan SH,Chang AY

更新日期：2012-04-30 00:00:00

abstract：:After streptococcal pyrogenic exotoxin B (SPE B) induces apoptosis, its fate is unknown. Using confocal time-course microscopy at 37 degrees C, we detected green fluorescence 20 min after adding FITC-SPE B. Orange fluorescence, an indication of co-localization of SPE B with lysosomes which were labeled with a red fluo...

journal_title：Journal of biomedical science

authors： Chang CW,Tsai WH,Chuang WJ,Lin YS,Wu JJ,Liu CC,Tsai PJ,Lin MT

更新日期：2007-05-01 00:00:00

abstract：:The technology of "Lab-on-a-Chip" allows the synthesis and analysis of chemicals and biological substance within a portable or handheld device. The 3D printed structures enable precise control of various geometries. The combination of these two technologies in recent years makes a significant progress. The current app...

journal_title：Journal of biomedical science

authors： Zhou Y

更新日期：2017-10-18 00:00:00

abstract：:In all eukaryotes, the plasma membrane is critically important as it maintains the architectural integrity of the cell. Proper anchorage and interaction between the plasma membrane and the cytoskeleton is critical for normal cellular processes. The ERM (ezrin-radixin-moesin) proteins are a class of highly homologous p...

journal_title：Journal of biomedical science

authors： Ponuwei GA

更新日期：2016-03-17 00:00:00

abstract：BACKGROUND:Human papillomavirus (HPV) is the most common sexually transmitted virus in women worldwide. The persistence of the virus may cause warts that are considered benign lesions and low or high grade intraepithelial lesions (LSIL/HSIL). Immunological system plays an important role in the resolution of infections....

journal_title：Journal of biomedical science

authors： Okuyama NCM,Cezar-Dos-Santos F,Pereira ÉR,Trugilo KP,Cebinelli GCM,Sena MM,Pereira APL,Aranome AMF,Mangieri LFL,Ferreira RS,Watanabe MAE,de Oliveira KB

更新日期：2018-09-18 00:00:00

abstract：:Sequencing of HIV-1(GER) long terminal repeat (LTR) has demonstrated, for the first time in an HIV-1 primary isolate, a TAR duplication referred to as TAR1 (nucleotides +1 through +68) and TAR2 (nucleotides +69 through +136). This TAR duplication is stable during replication of HIV-1(GER) isolate in CEM cells. Analysi...

journal_title：Journal of biomedical science

authors： Emiliani S,Coudronnière N,Delsert C,Devaux C

更新日期：1996-01-01 00:00:00

abstract：:Our objective was to determine the role that bone marrow-derived stromal cells have on human hematopoiesis in HIV infection. In particular, we dissected the heterogeneous bone marrow microenvironment to study the effect HIV expression might have on the cell population capable of producing the cytokines which will supp...

journal_title：Journal of biomedical science

authors： Mosca JD,Kaushal S,Gartner S,Kessler SW,La Russa VF,Terwilliger EF,Kim JH,Carroll RG,Hall ER,Perera LP,Yu Z,Ritchey DW,Xu J,St Louis DC,Mayers DL

更新日期：1995-10-01 00:00:00

abstract：:Spinal muscular atrophy (SMA) is an autosomal recessive disorder characterized by degeneration of lower motor neurons. We have assayed deletions in two candidate genes, the survival motor neuron (SMN) and neuronal apoptosis inhibitory protein (NAIP) genes, in 108 samples, of which 46 were from SMA patients, and 62 wer...

journal_title：Journal of biomedical science

authors： Haider MZ,Moosa A,Dalal H,Habib Y,Reynold L

更新日期：2001-03-01 00:00:00

abstract：:Glucocorticoids regulate the expression of many liver-specific genes via glucocorticoid receptors. The presence of glucocorticoid receptors in liver has been reported in many mammalian species but not in nude mice. In the present study, we demonstrate the presence of specific glucocorticoid receptors in nude mouse liv...

journal_title：Journal of biomedical science

authors： Chi CW,Liu TY,Chiang SH,Cheng SL,Lin CY,Ho CK

更新日期：1994-10-01 00:00:00

abstract：:Phospholipase D (PLD) is a phosphodiesterase that catalyses hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline. In the presence of ethanol, PLD also catalyses the formation of phosphatidylethanol, which is a unique characteristic of this enzyme. Muscarinic receptor-induced changes in the activi...

journal_title：Journal of biomedical science

authors： Mamoon AM,Smith J,Baker RC,Farley JM

更新日期：1999-03-01 00:00:00

abstract：:The aim of this study was to determine whether the common forms of dyslipidemia could affect either the lipid composition or insulin receptor processing (down-regulation) of erythrocytes. The study included 22 patients with type IIa hypercholesterolemia, 15 patients with type IV hypertriglyceridemia and 12 patients wi...

journal_title：Journal of biomedical science

authors： Masella R,Cantafora A,Maffì D,Volpe R,Ginnetti MG,Ricci G,Mace NL,Buxton GM,Peterson SW

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND:Despite the recent progress in screening and therapy, a majority of prostate cancer cases eventually attain hormone refractory and chemo-resistant attributes. Conventional chemotherapeutic strategies are effective at very high doses for only palliative management of these prostate cancers. Therefore chemo-se...

journal_title：Journal of biomedical science

authors： Gara RK,Srivastava VK,Duggal S,Bagga JK,Bhatt M,Sanyal S,Mishra DP

更新日期：2015-04-01 00:00:00

abstract：:A three-dimensional molecular model of the transmembrane domain of the 5-HT(1A) receptor (5-HT(1A)R) is presented in the context of a general strategy for modeling the macromolecular structure of a guanine nucleotide binding, regulatory protein coupled receptor (GPCR). The model of the 5-HT(1A)R rests on the definitio...

journal_title：Journal of biomedical science

authors： Pardo L,Batlle M,Duñach M,Weinstein H

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:Oxidative stress is a major factor in retinal pigment epithelium (RPE) cells injury that contributes to age-related macular degeneration (AMD). NaIO3 is an oxidative toxic agent and its selective RPE cell damage makes it as a reproducible model of AMD. Although NaIO3 is an oxidative stress inducer, the roles...

journal_title：Journal of biomedical science

authors： Chan CM,Huang DY,Sekar P,Hsu SH,Lin WW

更新日期：2019-05-22 00:00:00

abstract：:Cancer has been the leading cause of death in Taiwan over the past two decades and liver cancer is the leading cause of all cancer deaths in Taiwan with a trend of increase in incidence. Therapeutic options and efficacy for liver cancer have been limited and the 5-year survival rate is less than 7% in the Unite States...

journal_title：Journal of biomedical science

authors： Chuu JJ,Liu JM,Tsou MH,Huang CL,Chen CP,Wang HS,Chen CT

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Breast cancer is considered as an increasing major life-threatening concern among the malignancies encountered globally in females. Traditional therapy is far from satisfactory due to drug resistance and various side effects, thus a search for complementary/alternative medicines from natural sources with les...

journal_title：Journal of biomedical science

authors： Banerjee M,Chattopadhyay S,Choudhuri T,Bera R,Kumar S,Chakraborty B,Mukherjee SK

更新日期：2016-04-16 00:00:00

abstract：:Although hypercholesterolemia is a well-known risk factor for atherosclerosis, little is known about the effect of hypercholesterolemia on cardiac contractile function. The objective of this study was to examine the effect of hypercholesterolemia on myocardial contractility. Fifteen New Zealand white rabbits were fed ...

journal_title：Journal of biomedical science

authors： Luo TY,Su MJ,Yang YF,Liu YB,Liang HC,Wu CC,Lee YT

更新日期：2004-11-01 00:00:00

abstract：:Microfluidics has become an important tool in diagnosing many diseases, including neurological and genetic disorders. Alzheimer's disease (AD) is a neurodegenerative disease that irreversibly and progressively destroys memory, language ability, and thinking skills. Commonly, detection of AD is expensive and complex. F...

journal_title：Journal of biomedical science

authors： Devadhasan JP,Kim S,An J

更新日期：2011-05-28 00:00:00

abstract：:Developmentally regulated endothelial cell locus-1 (Del1) is an embryonic angiogenic factor expressed in early embryonic endothelial cells, but recently has been found to be expressed in some forms of cancers including colon and breast cancers, and melanoma, and human cancer cell lines. Overexpression of Del1 accelera...

journal_title：Journal of biomedical science

authors： Zou X,Qiao H,Jiang X,Dong X,Jiang H,Sun X

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Chemotherapy and targeted therapies have made important strides in cancer treatment yet they often fail and new therapies are still needed. Here, we employed a phenotypic screen to identify and analyze the mechanism of action of novel small molecules that interfere with critical pathways involved in tumor ce...

journal_title：Journal of biomedical science

authors： Ghosh SK,Ganta A,Spanjaard RA

更新日期：2018-02-08 00:00:00

abstract：BACKGROUND:Fat embolism syndrome (FES) associated with acute lung injury (ALI) is a clinical condition following long bone fracture. We have reported 14 victims due to ALI with FES. Our laboratory has developed an animal model that produced fat emboli (FE). The major purpose of this study was to test whether neutrophil...

journal_title：Journal of biomedical science

authors： Lin CC,Liu PH,Kao SJ,Chen HI

更新日期：2012-01-05 00:00:00