Identification and Characterization of Glucocorticoid Receptors in Liver of Nude Mice.

abstract：BACKGROUND:Next-generation sequencing (NGS) is a powerful and high-throughput method for the detection of viral mutations. This article provides a brief overview about optimization of NGS analysis for hepatocellular carcinoma (HCC)-associated hepatitis B virus (HBV) mutations, and hepatocarcinogenesis of relevant mutat...

journal_title：Journal of biomedical science

authors： Wu IC,Liu WC,Chang TT

更新日期：2018-06-02 00:00:00

abstract：:Death-associated protein (DAP)-kinase, an actin-cytoskeleton localized serine/threonine kinase, functions as a novel tumor suppressor and participates in a wide variety of cell death systems. Recent studies indicate that DAP-kinase elicits a potent cytoskeletal reorganization effect and is capable of modulating integr...

journal_title：Journal of biomedical science

authors： Chen RH,Wang WJ,Kuo JC

更新日期：2006-03-01 00:00:00

abstract：:To determine the involvement of the globus pallidus in mediating epilepsy, the effects of microinjection of a GABA uptake blocker (tiagabine), a benzodiazepine agonist (zolpidem) and a GABA-B receptor agonist (baclofen) on pentylenetetrazol (PTZ)-induced tonic seizure were examined in adult rats. Administration of PTZ...

journal_title：Journal of biomedical science

authors： Chen L,Chan YS,Yung WH

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Oxidized low-density lipoprotein (oxLDL) mediates the transformation of macrophages (MΦ) to cholesterol-rich foam cells and the release of pro-inflammatory cytokines during atherogenesis. JAB1 (Jun activation domain binding protein-1) is present in all stages of human plaques, involved in the Toll-like recep...

journal_title：Journal of biomedical science

authors： Schwarz A,Bonaterra GA,Schwarzbach H,Kinscherf R

更新日期：2017-02-07 00:00:00

abstract：BACKGROUND:The probability of local tumor control after radiotherapy (RT) remains still miserably poor in pediatric rhabdomyosarcoma (RMS). Thus, understanding the molecular mechanisms responsible of tumor relapse is essential to identify personalized RT-based strategies. Contrary to what has been done so far, a correc...

journal_title：Journal of biomedical science

authors： Petragnano F,Pietrantoni I,Camero S,Codenotti S,Milazzo L,Vulcano F,Macioce G,Giordani I,Tini P,Cheleschi S,Gravina GL,Festuccia C,Rossetti A,Delle Monache S,Ordinelli A,Ciccarelli C,Mauro A,Barbara B,Antinozzi C,Sc

更新日期：2020-08-27 00:00:00

abstract：BACKGROUND:Pseudomonas aeruginosa is a Gram-negative pathogen that frequently causes life-threatening infections in immunocompromised patients. We previously showed that subinhibitory concentrations of short synthetic peptides permeabilize P. aeruginosa and enhance the lethal action of co-administered antibiotics. MET...

journal_title：Journal of biomedical science

authors： Rázquin-Olazarán I,Shahrour H,Martínez-de-Tejada G

更新日期：2020-08-06 00:00:00

abstract：:Myostatin, a member of the TGF-beta superfamily, is a potent negative regulator of skeletal muscle and growth. Previously, we reported Mstn1 from zebrafish and studied its influence on muscle development. In this study, we identified another form of Myostatin protein which is referred to as Mstn2. The size of Mstn2 cD...

journal_title：Journal of biomedical science

authors： Amali AA,Lin CJ,Chen YH,Wang WL,Gong HY,Rekha RD,Lu JK,Chen TT,Wu JL

更新日期：2008-09-01 00:00:00

abstract：:Interferons (IFNs) are key regulators for both innate and adaptive immune responses. By screening ENU-mutagenized mice, we identified a pedigree- P117 which displayed impaired response to type I, but not type II, IFNs. Through inheritance test, genetic mapping and sequencing, we found a T to A point mutation in the 5'...

journal_title：Journal of biomedical science

authors： Chen LS,Wei PC,Liu T,Kao CH,Pai LM,Lee CK

更新日期：2009-02-19 00:00:00

abstract：BACKGROUND:Calcium oxalate (CaOx) is the major constituent of about 75% of all urinary stone and the secondary hyperoxaluria is a primary risk factor. Current treatment options for the patients with hyperoxaluria and CaOx stone diseases are limited. Oxalate degrading bacteria might have beneficial effects on urinary ox...

journal_title：Journal of biomedical science

authors： Sasikumar P,Gomathi S,Anbazhagan K,Abhishek A,Paul E,Vasudevan V,Sasikumar S,Selvam GS

更新日期：2014-08-30 00:00:00

abstract：:Mitochondria are the major intracellular source and target sites of reactive oxygen species (ROS) that are continually generated as by-products of aerobic metabolism in animal and human cells. It has been demonstrated that mitochondrial respiratory function declines with age in various human tissues and that a defecti...

journal_title：Journal of biomedical science

authors： Lee HC,Wei YH

更新日期：1997-11-01 00:00:00

abstract：:Advances in Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated system (CRISPR/Cas9) has dramatically reshaped our ability to edit genomes. The scientific community is using CRISPR/Cas9 for various biotechnological and medical purposes. One of its most important uses is developing potential the...

journal_title：Journal of biomedical science

authors： Khan S,Mahmood MS,Rahman SU,Zafar H,Habibullah S,Khan Z,Ahmad A

更新日期：2018-03-28 00:00:00

abstract：:A considerable number of animal studies on the effects of dopaminergic agents on alcohol intake behavior have been performed. Acute alcohol administration in rats induces dopamine release in the caudate nucleus and in the nucleus accumbens, an effect related among others to reinforcement. It has been repeatedly sugges...

journal_title：Journal of biomedical science

authors： Walter H,Ramskogler K,Semler B,Lesch OM,Platz W

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Helicobacter pylori bacteria colonize human gastric mucosa, cause chronic inflammation, peptic ulcers and gastric cancer. Colonization is mediated by H. pylori adhesins, which preferentially bind mucin 5 (MUC5AC) and Lewis (Le) determinants. The aim of this study was to evaluate the influence of H. pylori an...

journal_title：Journal of biomedical science

authors： Gonciarz W,Walencka M,Moran AP,Hinc K,Obuchowski M,Chmiela M

更新日期：2019-03-06 00:00:00

abstract：:Based on the tertiary structure of the ribosome-inactivating protein alpha-sarcin, domains that are responsible for hydrolyzing ribosomes and naked RNA have been dissected. In this study, we found that the head-to-tail interaction between the first amino beta-strand and the last carboxyl beta-strand is not involved in...

journal_title：Journal of biomedical science

authors： Hwu L,Huang K,Chen D,Lin A

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Dengue virus (DENV), a member of the family Flaviviridae, is at present the most widespread causative agent of a human viral disease transmitted by mosquitoes. Despite the increasing incidence of this pathogen, there are no antiviral drugs or vaccines currently available for treatment or prevention. In a pre...

journal_title：Journal of biomedical science

authors： Mazzucco MB,Talarico LB,Vatansever S,Carro AC,Fascio ML,D'Accorso NB,García CC,Damonte EB

更新日期：2015-04-17 00:00:00

abstract：BACKGROUND:The diastolic oscillatory after-potential Vos and pre-potential ThVos play an essential role in the pacemaker mechanism of sino-atrial node (SAN). The aim of this study was to investigate whether these oscillatory potentials are also involved in adrenergic control of SAN discharge. METHODS:Vos and ThVos wer...

journal_title：Journal of biomedical science

authors： Vassalle M,Catanzaro JN,Nett MP,Rota M

更新日期：2009-11-18 00:00:00

abstract：BACKGROUND:The type VI adenylyl cyclase (AC6) is a main contributor of cAMP production in the heart. The amino acid (aa) sequence of AC6 is highly homologous to that of another major cardiac adenylyl cyclase, AC5, except for its N-terminus (AC6-N, aa 1-86). Activation of AC6, rather than AC5, produces cardioprotective ...

journal_title：Journal of biomedical science

authors： Wu YS,Chen CC,Chien CL,Lai HL,Jiang ST,Chen YC,Lai LP,Hsiao WF,Chen WP,Chern Y

更新日期：2017-09-04 00:00:00

abstract：BACKGROUND:Whether microgravity might influence tumour growth and carcinogenesis is still an open issue. It is not clear also if and how normal and transformed cells are differently solicited by microgravity. The present study was designed to verify this issue. METHODS:Two normal, LB and HSC93, and two transformed, Ju...

journal_title：Journal of biomedical science

authors： Cuccarolo P,Barbieri F,Sancandi M,Viaggi S,Degan P

更新日期：2010-07-28 00:00:00

abstract：:The nucleotide sequences of the putative envelope region (E1) and the junction between the E1 and envelope 2/nonstructural 1 (E2/NS1) region of the hepatitis C virus (HCV) genome are divergent among different genotypes. To characterize them, we introduced a set of nested primers that are conserved among four different...

journal_title：Journal of biomedical science

authors： Kao JH,Chen PJ,Lai MY,Yang PM,Sheu JC,Wang TH,Chen DS

更新日期：1994-06-01 00:00:00

abstract：:Sequencing of HIV-1(GER) long terminal repeat (LTR) has demonstrated, for the first time in an HIV-1 primary isolate, a TAR duplication referred to as TAR1 (nucleotides +1 through +68) and TAR2 (nucleotides +69 through +136). This TAR duplication is stable during replication of HIV-1(GER) isolate in CEM cells. Analysi...

journal_title：Journal of biomedical science

authors： Emiliani S,Coudronnière N,Delsert C,Devaux C

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Pulmonary emphysema is characterized histologically by destruction of alveolar walls and enlargement of air spaces due to lung epithelial cell apoptosis. Cell adhesion molecule 1 (CADM1) is an immunoglobulin superfamily member expressed in lung epithelial cells. CADM1 generates a membrane-associated C-termin...

journal_title：Journal of biomedical science

authors： Hagiyama M,Yoneshige A,Inoue T,Sato Y,Mimae T,Okada M,Ito A

更新日期：2015-08-11 00:00:00

abstract：BACKGROUND:Granulocyte colony-stimulating factor (G-CSF), a hematopoietic cytokine, was recently used to treat patients of acute myocardial infarction with beneficial effect. However, controversy exists as some patients developed re-stenosis and worsened condition post G-CSF delivery. This study presents a new disease ...

journal_title：Journal of biomedical science

authors： Lian WS,Lin H,Cheng WT,Kikuchi T,Cheng CF

更新日期：2011-04-15 00:00:00

abstract：BACKGROUND:Activating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER)-localised protein and member of the leucine zipper family of transcription factors. Best known for its role in transducing signals linked to stress to the endoplasmic reticulum, the 50 kDa activated form of ATF6 is now emerging as a ma...

journal_title：Journal of biomedical science

authors： Hillary RF,FitzGerald U

更新日期：2018-05-25 00:00:00

abstract：BACKGROUND:Homeostasis of reactive oxygen species (ROS) in the skin is regulated by antioxidant defenses. The inflammatory states of skin diseases which range from acute rashes to chronic conditions are related to the level of ROS. The involvement of superoxide dismutase (SOD) in restoring the antioxidant capacity can ...

journal_title：Journal of biomedical science

authors： Liu TP,Chen YP,Chou CM,Chiu TT,Chen CT

更新日期：2016-01-20 00:00:00

abstract：BACKGROUND:Type I Bartter syndrome is a recessive human nephropathy caused by loss-of-function mutations in the SLC12A1 gene coding for the Na+-K+-2Cl- cotransporter NKCC2. We recently established the mutant mouse line Slc12a1I299F exhibiting kidney defects highly similar to the late-onset manifestation of this heredit...

journal_title：Journal of biomedical science

authors： Kemter E,Rathkolb B,Becker L,Bolle I,Busch DH,Dalke C,Elvert R,Favor J,Graw J,Hans W,Ivandic B,Kalaydjiev S,Klopstock T,Rácz I,Rozman J,Schrewe A,Schulz H,Zimmer A,Fuchs H,Gailus-Durner V,Hrabe de Angelis M,Wolf

更新日期：2014-08-02 00:00:00

abstract：BACKGROUNDS:Homozygous 32-bp deletion of the chemokine receptor 5 gene (CCR5) is associated with resistance to human immunodeficiency virus (HIV) infection, while heterozygosity delays HIV progression. Bone marrow transplantation (BMT) from a 32/32 donor has been shown to cure an HIV-infected patient. However, the rari...

journal_title：Journal of biomedical science

authors： Manotham K,Chattong S,Setpakdee A

更新日期：2015-03-26 00:00:00

abstract：:Human mesenchymal stem cells (hMSCs) are multipotent cells that can differentiate into various tissue types, including bone, cartilage, tendon, adipocytes, and marrow stroma, making them potentially useful for human cell and gene therapies. Our objective was to demonstrate the utility of glass needle-mediated microinj...

journal_title：Journal of biomedical science

authors： Tsulaia TV,Prokopishyn NL,Yao A,Carsrud ND,Carou MC,Brown DB,Davis BR,Yannariello-Brown J

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Oxidative stress is a major factor in retinal pigment epithelium (RPE) cells injury that contributes to age-related macular degeneration (AMD). NaIO3 is an oxidative toxic agent and its selective RPE cell damage makes it as a reproducible model of AMD. Although NaIO3 is an oxidative stress inducer, the roles...

journal_title：Journal of biomedical science

authors： Chan CM,Huang DY,Sekar P,Hsu SH,Lin WW

更新日期：2019-05-22 00:00:00

abstract：:Stem cell activity is subject to non-cell-autonomous regulation from the local microenvironment, or niche. In adaption to varying physiological conditions and the ever-changing external environment, the stem cell niche has evolved with multifunctionality that enables stem cells to detect these changes and to communica...

journal_title：Journal of biomedical science

authors： Chen CL,Huang WY,Wang EHC,Tai KY,Lin SJ

更新日期：2020-03-14 00:00:00

abstract：:In this study, we examined the postnatal expression patterns of p63 and other keratinocyte stem cell markers in the rat cornea in an attempt to determine the markers that best represent characteristics of corneal keratinocyte stem cells. We show that the expression of p63 in the rat cornea is unique and differs from t...

journal_title：Journal of biomedical science

authors： Hsueh YJ,Wang DY,Cheng CC,Chen JK

更新日期：2004-09-01 00:00:00