Detection of Divergent Hepatitis C Virus Envelope Sequences.

abstract：:Agents which block T cell K(+) currents can prohibit both proliferative and effector cell functions in T cells activated by mitogens or phorbol esters. This study examined the effects of some of these blocking agents on the immune responsiveness of guinea pig myelin basic protein (GPMBP)-reactive Lewis rat T lymphocyt...

journal_title：Journal of biomedical science

authors： Judge SI,Yeh JZ,Mannie MD,Pope Seifert L,Paterson PY

更新日期：1997-07-01 00:00:00

abstract：:Accumulative evidence has supported the role of nitric oxide (NO) in a variety of normal physiological functions as well as many pathological conditions. In this study, we examined the possible diabetogenicity of NO by measuring the expression of the insulin receptor substrate (IRS)-1 in rat hepatocytes and skeletal m...

journal_title：Journal of biomedical science

authors： Badal S,Brown PD,Ragoobirsingh D

更新日期：2006-07-01 00:00:00

abstract：:Increasing evidence suggests that immune responses are involved in the control of cancer and that the immune system can be manipulated in different ways to recognize and attack tumors. Progress in immune-based strategies has opened new therapeutic avenues using a number of techniques destined to eliminate malignant ce...

journal_title：Journal of biomedical science

authors： Matar P,Alaniz L,Rozados V,Aquino JB,Malvicini M,Atorrasagasti C,Gidekel M,Silva M,Scharovsky OG,Mazzolini G

更新日期：2009-03-06 00:00:00

abstract：:Developmentally regulated endothelial cell locus-1 (Del1) is an embryonic angiogenic factor expressed in early embryonic endothelial cells, but recently has been found to be expressed in some forms of cancers including colon and breast cancers, and melanoma, and human cancer cell lines. Overexpression of Del1 accelera...

journal_title：Journal of biomedical science

authors： Zou X,Qiao H,Jiang X,Dong X,Jiang H,Sun X

更新日期：2009-01-01 00:00:00

abstract：:Upon cell adhesion to extracellular matrix proteins, focal adhesion kinase (FAK) rapidly undergoes autophosphorylation on its Tyr-397 which consequently serves as a binding site for the Src homology 2 domains of the Src family protein kinases and several other intracellular signaling molecules. In this study, we have ...

journal_title：Journal of biomedical science

authors： Chang LC,Huang CH,Cheng CH,Chen BH,Chen HC

更新日期：2005-01-01 00:00:00

abstract：:The intracellular mechanisms underlying oxidized low-density lipoprotein (oxLDL)-signaling pathways in platelets are not yet completely understood. Therefore, the aim of this study was to further examine the effects of oxLDL in prevention of platelet aggregation. In this study, oxLDL concentration-dependently (40-120 ...

journal_title：Journal of biomedical science

authors： Chou DS,Chan CH,Hsiao G,Shen MY,Tsai YJ,Chen TF,Sheu JR

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:The diastolic oscillatory after-potential Vos and pre-potential ThVos play an essential role in the pacemaker mechanism of sino-atrial node (SAN). The aim of this study was to investigate whether these oscillatory potentials are also involved in adrenergic control of SAN discharge. METHODS:Vos and ThVos wer...

journal_title：Journal of biomedical science

authors： Vassalle M,Catanzaro JN,Nett MP,Rota M

更新日期：2009-11-18 00:00:00

abstract：:Adeno-associated virus (AAV)-2 was developed as a useful vector for human gene therapy. In this report, we analyzed the integration and expression of AAV-mediated ex vivo transferred human beta-globin gene in bone marrow (BM) reconstituted mice. Recombinant AAV (rAAV) containing human beta-globin gene was packaged by ...

journal_title：Journal of biomedical science

authors： Dong WJ,Wu XB,Liu DP,Li JL,Liu G,Zu ZX,Zhao N,Hou YD,Liang CC

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:NKG2D, an activating immunoreceptor, is primarily restricted to NK cells and CD8(+) T cells. The existence of an atypical cytotoxic CD4(+)NKG2D(+) T cell population has also been found in patients with autoimmune dysfunctions. Nonetheless, contradictory evidence has categorized this population with a regulat...

journal_title：Journal of biomedical science

authors： Garcia-Chagollan M,Jave-Suarez LF,Haramati J,Bueno-Topete MR,Aguilar-Lemarroy A,Estrada-Chavez C,Bastidas-Ramirez BE,Pereira-Suarez AL,Del Toro-Arreola S

更新日期：2015-10-20 00:00:00

abstract：:Autologous adipose stromal vascular fractions (SVFs) containing adipose tissue-derived stem cells (ASCs) are currently being used in clinical settings for various orthopedic applications for human patients. Due to its potential capability of regenerating cartilage, bone, and tendons, autologous adipose SVFs are being ...

journal_title：Journal of biomedical science

authors： Pak J,Lee JH,Park KS,Park M,Kang LW,Lee SH

更新日期：2017-01-31 00:00:00

abstract：:Exposure of cells and organs to heat shock is associated with numerous changes in various cellular metabolic parameters and overexpression of proteins collectively known as heat shock proteins (HSP). In this communication we review the cell-signaling events that are altered in response to heat shock as they relate to ...

journal_title：Journal of biomedical science

authors： Gong Kiang J,Tsokos GC

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Honokiol, a cell-permeable phenolic compound derived from the bark of magnolia trees and present in Asian herbal teas, has a unique array of pharmacological actions, including the inhibition of multiple autonomic responses. We determined the effects of honokiol on calcium signaling underlying transmission me...

journal_title：Journal of biomedical science

authors： Wang HJ,Martin AG,Chao PK,Reichard RA,Martin AL,Huang YW,Chan MH,Aronstam RS

更新日期：2013-02-23 00:00:00

abstract：:The ACTGCTGA sequence (CTG motif) is located immediately upstream of the NF-kappaB enhancer in the human immunodeficiency virus type-1 (HIV-1) long terminal repeat (LTR). We previously reported on the frequent duplication of this motif in HIV-1-infected individuals. In this study we further characterized the role of t...

journal_title：Journal of biomedical science

authors： Koken SE,van Wamel JL,Geelen JL,Berkhout B

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND:Whether microgravity might influence tumour growth and carcinogenesis is still an open issue. It is not clear also if and how normal and transformed cells are differently solicited by microgravity. The present study was designed to verify this issue. METHODS:Two normal, LB and HSC93, and two transformed, Ju...

journal_title：Journal of biomedical science

authors： Cuccarolo P,Barbieri F,Sancandi M,Viaggi S,Degan P

更新日期：2010-07-28 00:00:00

abstract：BACKGROUND:Pneumococcal conjugate vaccine (PCV) reduces both invasive pneumococcal disease (IPD) and other pneumococcal infections worldwide. We investigated the impact of stepwise implementation of childhood PCV programs on the prevalence of pneumococcal pneumonia, severity of acute inflammation, and associations betw...

journal_title：Journal of biomedical science

authors： Shen CF,Wang SM,Chi H,Huang YC,Huang LM,Huang YC,Lin HC,Ho YH,Hsiung CA,Liu CC,Taiwan Pediatric Infectious Disease Alliance.

更新日期：2020-08-19 00:00:00

abstract：BACKGROUND:The association of TGF beta1 polymorphisms and atrial fibrillation (AF) in essential hypertensive (EH) subjects remains unknown. Methods EH subjects with AF (EH+AF+) and sinus rhythm (EH+AF-) were enrolled. The polymorphisms of +869 T --> C at codon 10 and + 915 G --> C at codon 25, were genotyped. The clini...

journal_title：Journal of biomedical science

authors： Wang Y,Hou X,Li Y

更新日期：2010-03-31 00:00:00

abstract：BACKGROUND:Human keratinocytes and derived products are crucial for skin repair and regeneration. Despite substantial advances in engineered skin equivalents, their poor availability and immunorejection remain major challenges in skin grafting. METHODS:Induced keratinocyte-like cells (iKCs) were directly reprogrammed ...

journal_title：Journal of biomedical science

authors： Zheng J,Yun W,Park J,Kang PJ,Lee G,Song G,Kim IY,You S

更新日期：2020-04-20 00:00:00

abstract：:In many solid tumor types, tumor-associated macrophages (TAMs) are important components of the tumor microenvironment (TME). Moreover, TAMs infiltration is strongly associated with poor survival in solid tumor patients. In this review, we describe the origins of TAMs and their polarization state dictated by the TME. W...

journal_title：Journal of biomedical science

authors： Chen Y,Song Y,Du W,Gong L,Chang H,Zou Z

更新日期：2019-10-20 00:00:00

abstract：:Dehydroepiandrosterone (DHEA) is a putative anti-stress agent and stress is associated with the secretion of catecholamine from the adrenal gland, but the effects of DHEA on catecholamine secretion are not fully understood. Using bovine chromaffin cells, we found that DHEA inhibited catecholamine secretion and cytosol...

journal_title：Journal of biomedical science

authors： Liu PS,Wang PY

更新日期：2004-03-01 00:00:00

abstract：:Serologically defined primary dengue virus infection and/or subsequent homologous serotype infection is known to be associated with less severe disease as compared with secondary subsequent heterologous serotype infection. In geographical locales of high dengue endemicity, almost all individuals in the population are ...

journal_title：Journal of biomedical science

authors： Perng GC,Chokephaibulkit K

更新日期：2013-05-31 00:00:00

abstract：BACKGROUND:Whereas brain death is a vitally important clinical phenomenon, our contemporary understanding on its underlying cellular mechanisms remains elusive. This study evaluated whether the ubiquitin-proteasome system (UPS) in the rostral ventrolateral medulla (RVLM), a neural substrate that our laboratory identifi...

journal_title：Journal of biomedical science

authors： Wu CH,Chan JY,Chou JL,Chan SH,Chang AY

更新日期：2012-04-30 00:00:00

abstract：:Dengue virus infection presents a wide spectrum of manifestations including asymptomatic condition, dengue fever (DF), or severe forms, such as dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) in affected individuals. The early prediction of severe dengue in patients without any warning signs who may lat...

journal_title：Journal of biomedical science

authors： John DV,Lin YS,Perng GC

更新日期：2015-10-14 00:00:00

abstract：BACKGROUND:Dengue virus (DENV), a member of the family Flaviviridae, is at present the most widespread causative agent of a human viral disease transmitted by mosquitoes. Despite the increasing incidence of this pathogen, there are no antiviral drugs or vaccines currently available for treatment or prevention. In a pre...

journal_title：Journal of biomedical science

authors： Mazzucco MB,Talarico LB,Vatansever S,Carro AC,Fascio ML,D'Accorso NB,García CC,Damonte EB

更新日期：2015-04-17 00:00:00

abstract：:Lysosome-associated membrane protein (LAMP)-1, one of the major protein components of the lysosomal membrane, is upregulated in the human glioblastoma cell lines, U-373 MG and LN-Z308, which undergo cisplatin-induced apoptosis. These human brain tumor cell lines demonstrated apoptosis in response to cisplatin/nifedipi...

journal_title：Journal of biomedical science

authors： Chen JW,Madamanchi N,Madamanchi NR,Trier TT,Keherly MJ

更新日期：2001-07-01 00:00:00

abstract：:Two Chinese hamster ovary (CHO) cell lines stably transfected with human insulin receptor cDNA, CHO-wt and CHO-mut, which express an equivalent number of normal and kinase-defective human insulin receptors, respectively, were used to assess the roles of insulin receptor tyrosine kinase activity in insulin-regulated ge...

journal_title：Journal of biomedical science

authors： Lin SC,Chen MF,Chou CK

更新日期：1994-12-01 00:00:00

abstract：:A large group of small Rab GTPases which mediate secretory and endosomal membrane transport, as well as autophagosome biogenesis, are essential components of vesicle trafficking machinery. Specific Rab protein together with the cognate effectors coordinates the dynamics of trafficking pathway and determines the cargo ...

journal_title：Journal of biomedical science

authors： Tzeng HT,Wang YC

更新日期：2016-10-06 00:00:00

abstract：:Influence of adjuvants i.e., alpha-tocopherol (25 mg/kg, p.o.) and piperine (10 mg/kg, p.o.) on therapeutic potential of chelator tiferron (300 mg/kg, i.p.) was evaluated to encounter toxicogenic events of beryllium exposure. Albino rats were exposed to beryllium nitrate (1 mg/kg, i.p.) daily for 28 days followed by t...

journal_title：Journal of biomedical science

authors： Nirala SK,Bhadauria M,Mathur R,Mathur A

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Granulocyte colony-stimulating factor (G-CSF), a hematopoietic cytokine, was recently used to treat patients of acute myocardial infarction with beneficial effect. However, controversy exists as some patients developed re-stenosis and worsened condition post G-CSF delivery. This study presents a new disease ...

journal_title：Journal of biomedical science

authors： Lian WS,Lin H,Cheng WT,Kikuchi T,Cheng CF

更新日期：2011-04-15 00:00:00

abstract：:Angiogenesis is essential for development, growth and advancement of solid tumors. Cyclooxygenase (COX)-2 is recognized as an angiogenic factor in various tumors. This prompted us to study the clinical implications of COX-2 expression related to angiogenesis in uterine cervical cancers. There was a significant correla...

journal_title：Journal of biomedical science

authors： Fujimoto J,Toyoki H,Sato E,Sakaguchi H,Jahan I,Alam SM,Tamaya T

更新日期：2006-11-01 00:00:00

abstract：:The effects of N omega-nitro-L: -arginine (L: -NOARG) and N(G)-monomethyl-L: -arginine (L: -NMMA) on the spatial distribution of diaphragmatic microvascular blood flow were assessed in anesthetized, mechanically ventilated rats. Microvascular blood flow was measured after different periods at either a fixed site (Q st...

journal_title：Journal of biomedical science

authors： Lee CH,Chang HY,Chen CW,Hsiue TR

更新日期：2005-01-01 00:00:00