当前位置： SCI文献检索 > JOURNAL OF BIOMEDICAL SCIENCE期刊下所有文献 > Honokiol blocks store operated calcium entry in CHO cells expressing the M3 muscarinic receptor: honokiol and muscarinic signaling.

Honokiol blocks store operated calcium entry in CHO cells expressing the M3 muscarinic receptor: honokiol and muscarinic signaling.

Abstract：

BACKGROUND:Honokiol, a cell-permeable phenolic compound derived from the bark of magnolia trees and present in Asian herbal teas, has a unique array of pharmacological actions, including the inhibition of multiple autonomic responses. We determined the effects of honokiol on calcium signaling underlying transmission mediated by human M3 muscarinic receptors expressed in Chinese hamster ovary (CHO) cells. Receptor binding was determined in radiolabelled ligand binding assays; changes in intracellular calcium concentrations were determined using a fura-2 ratiometric imaging protocol; cytotoxicity was determined using a dye reduction assay. RESULTS:Honokiol had a potent (EC50 ≈ 5 μmol/l) inhibitory effect on store operated calcium entry (SOCE) that was induced by activation of the M3 receptors. This effect was specific, rapid and partially reversible, and was seen at concentrations not associated with cytotoxicity, inhibition of IP3 receptor-mediated calcium release, depletion of ER calcium stores, or disruption of M3 receptor binding. CONCLUSIONS:It is likely that an inhibition of SOCE contributes to honokiol disruption of parasympathetic motor functions, as well as many of its beneficial pharmacological properties.

journal_name

J Biomed Sci

journal_title

Journal of biomedical science

authors

Wang HJ,Martin AG,Chao PK,Reichard RA,Martin AL,Huang YW,Chan MH,Aronstam RS

doi

10.1186/1423-0127-20-11

subject

Has Abstract

pub_date

2013-02-23 00:00:00

pages

11

eissn

1021-7770

issn

1423-0127

pii

1423-0127-20-11

journal_volume

20

pub_type

杂志文章

相关文献

JOURNAL OF BIOMEDICAL SCIENCE文献大全
  • Clinically relevant radioresistant rhabdomyosarcoma cell lines: functional, molecular and immune-related characterization.

    abstract：BACKGROUND:The probability of local tumor control after radiotherapy (RT) remains still miserably poor in pediatric rhabdomyosarcoma (RMS). Thus, understanding the molecular mechanisms responsible of tumor relapse is essential to identify personalized RT-based strategies. Contrary to what has been done so far, a correc...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/s12929-020-00683-6

    authors： Petragnano F,Pietrantoni I,Camero S,Codenotti S,Milazzo L,Vulcano F,Macioce G,Giordani I,Tini P,Cheleschi S,Gravina GL,Festuccia C,Rossetti A,Delle Monache S,Ordinelli A,Ciccarelli C,Mauro A,Barbara B,Antinozzi C,Sc

    更新日期：2020-08-27 00:00:00

  • Short-term auricular electrical stimulation rapidly elevated cortical blood flow and promoted the expression of nicotinic acetylcholine receptor α4 in the 2 vessel occlusion rats model.

    abstract：BACKGROUND:Vascular dementia is the second dementing illness after Alzheimer's disease and caused by reduced blood flow to the brain, and affects cognitive abilities. Our previous study found that auricular electrical stimulation (ES) improved motor and learning impairment, and this phenomenon related with nicotinic ac...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/s12929-019-0526-9

    authors： Huang TH,Lin YW,Huang CP,Chen JM,Hsieh CL

    更新日期：2019-05-11 00:00:00

  • Fish-on-a-chip: a sensitive detection microfluidic system for Alzheimer's disease.

    abstract：:Microfluidics has become an important tool in diagnosing many diseases, including neurological and genetic disorders. Alzheimer's disease (AD) is a neurodegenerative disease that irreversibly and progressively destroys memory, language ability, and thinking skills. Commonly, detection of AD is expensive and complex. F...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章,评审

    doi：10.1186/1423-0127-18-33

    authors： Devadhasan JP,Kim S,An J

    更新日期：2011-05-28 00:00:00

  • Prospective signs of cleidocranial dysplasia in Cebpb deficiency.

    abstract：BACKGROUND:Although runt-related transcription factor 2 (RUNX2) has been considered a determinant of cleidocranial dysplasia (CCD), some CCD patients were free of RUNX2 mutations. CCAAT/enhancer-binding protein beta (Cebpb) is a key factor of Runx2 expression and our previous study has reported two CCD signs including ...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/1423-0127-21-44

    authors： Huang B,Takahashi K,Jennings EA,Pumtang-On P,Kiso H,Togo Y,Saito K,Sugai M,Akira S,Shimizu A,Bessho K

    更新日期：2014-05-13 00:00:00

  • Antitumor effect of therapeutic HPV DNA vaccines with chitosan-based nanodelivery systems.

    abstract：BACKGROUND:Cervical cancer is the second-most-common cause of malignancies in women worldwide, and the oncogenic activity of the human papilloma virus types (HPV) E7 protein has a crucial role in anogenital tumors. In this study, we have designed a therapeutic vaccine based on chitosan nanodelivery systems to deliver H...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/s12929-014-0069-z

    authors： Tahamtan A,Ghaemi A,Gorji A,Kalhor HR,Sajadian A,Tabarraei A,Moradi A,Atyabi F,Kelishadi M

    更新日期：2014-07-31 00:00:00

  • Differential effect of the focal adhesion kinase Y397F mutant on v-Src-stimulated cell invasion and tumor growth.

    abstract：:Upon cell adhesion to extracellular matrix proteins, focal adhesion kinase (FAK) rapidly undergoes autophosphorylation on its Tyr-397 which consequently serves as a binding site for the Src homology 2 domains of the Src family protein kinases and several other intracellular signaling molecules. In this study, we have ...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/s11373-005-7212-5

    authors： Chang LC,Huang CH,Cheng CH,Chen BH,Chen HC

    更新日期：2005-01-01 00:00:00

  • Immunotherapy for liver tumors: present status and future prospects.

    abstract：:Increasing evidence suggests that immune responses are involved in the control of cancer and that the immune system can be manipulated in different ways to recognize and attack tumors. Progress in immune-based strategies has opened new therapeutic avenues using a number of techniques destined to eliminate malignant ce...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章,评审

    doi：10.1186/1423-0127-16-30

    authors： Matar P,Alaniz L,Rozados V,Aquino JB,Malvicini M,Atorrasagasti C,Gidekel M,Silva M,Scharovsky OG,Mazzolini G

    更新日期：2009-03-06 00:00:00

  • Generation of CCR5-defective CD34 cells from ZFN-driven stop codon-integrated mesenchymal stem cell clones.

    abstract：BACKGROUNDS:Homozygous 32-bp deletion of the chemokine receptor 5 gene (CCR5) is associated with resistance to human immunodeficiency virus (HIV) infection, while heterozygosity delays HIV progression. Bone marrow transplantation (BMT) from a 32/32 donor has been shown to cure an HIV-infected patient. However, the rari...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/s12929-015-0130-6

    authors： Manotham K,Chattong S,Setpakdee A

    更新日期：2015-03-26 00:00:00

  • Hepatic zonation of carbon and nitrogen fluxes derived from glutamine and ammonia transformations.

    abstract：BACKGROUND:Glutaminase predominates in periportal hepatocytes and it has been proposed that it determines the glutamine-derived nitrogen flow through the urea cycle. Glutamine-derived urea production should, thus, be considerably faster in periportal hepatocytes. This postulate, based on indirect observations, has not ...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/1423-0127-17-1

    authors： Comar JF,Suzuki-Kemmelmeier F,Constantin J,Bracht A

    更新日期：2010-01-07 00:00:00

  • Apolipoprotein E Genotyping in Turkish Myocardial Infarction Survivors and Healthy Controls.

    abstract：:The apolipoprotein (Apo) E gene is known to be polymorphic. Three common alleles determine six phenotypes which can easily be detected by restriction fragment length polymorphism. We performed apo E genotyping in myocardial infarction survivors and healthy controls for the first time in the Turkish population. DNA was...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/BF02257924

    authors： Hergenc G,Taga Y,Emerk K,Cirakoglu B

    更新日期：1995-01-01 00:00:00

  • Reactive oxygen species-dependent mitochondrial dynamics and autophagy confer protective effects in retinal pigment epithelial cells against sodium iodate-induced cell death.

    abstract：BACKGROUND:Oxidative stress is a major factor in retinal pigment epithelium (RPE) cells injury that contributes to age-related macular degeneration (AMD). NaIO3 is an oxidative toxic agent and its selective RPE cell damage makes it as a reproducible model of AMD. Although NaIO3 is an oxidative stress inducer, the roles...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/s12929-019-0531-z

    authors： Chan CM,Huang DY,Sekar P,Hsu SH,Lin WW

    更新日期：2019-05-22 00:00:00

  • Down-regulation of the polymeric immunoglobulin receptor in non-small cell lung carcinoma: correlation with dysregulated expression of the transcription factors USF and AP2.

    abstract：:The polymeric immunoglobulin receptor (PIGR) mediates transport of IgA and IgM antibodies across mucosal and glandular epithelia. Several studies have utilized immunohistochemistry to demonstrate that PIGR expression varies in different types of lung carcinoma, and is down-regulated during tumor progression. We have p...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/s11373-004-8185-5

    authors： Khattar NH,Lele SM,Kaetzel CS

    更新日期：2005-01-01 00:00:00

  • Purification of Moloney murine leukemia virus chromatin from infected cells by an affinity method.

    abstract：:Our goal was to develop a system to study proteins that associate in vivo with the Moloney murine leukemia virus (M-MuLV) enhancer elements by the isolation of intact proviral chromatin. The M-MuLV long terminal repeats (LTRs) contain tandemly repeated transcriptional enhancer sequences consisting of smaller motifs th...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/BF02256602

    authors： Granger SW,Fan H

    更新日期：2001-05-01 00:00:00

  • Ciz1, Cip1 interacting zinc finger protein 1 binds the consensus DNA sequence ARYSR(0-2)YYAC.

    abstract：:The matrin 3 family of nuclear proteins consists of members with potentially diverse activities. Matrin 3 and NP220 share RNA-binding domains, and NP220 has been shown to recognize and bind to the DNA sequence, CCCCC (G/C). We have isolated and characterized another member of the matrin 3 family, designated NP94, from...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/BF02256432

    authors： Warder DE,Keherly MJ

    更新日期：2003-07-01 00:00:00

  • Insulin Receptor Processing and Lipid Composition of Erythrocyte Membrane in Patients with Hyperlipidemia.

    abstract：:The aim of this study was to determine whether the common forms of dyslipidemia could affect either the lipid composition or insulin receptor processing (down-regulation) of erythrocytes. The study included 22 patients with type IIa hypercholesterolemia, 15 patients with type IV hypertriglyceridemia and 12 patients wi...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/BF02253384

    authors： Masella R,Cantafora A,Maffì D,Volpe R,Ginnetti MG,Ricci G,Mace NL,Buxton GM,Peterson SW

    更新日期：1995-08-01 00:00:00

  • The recent development and applications of fluidic channels by 3D printing.

    abstract：:The technology of "Lab-on-a-Chip" allows the synthesis and analysis of chemicals and biological substance within a portable or handheld device. The 3D printed structures enable precise control of various geometries. The combination of these two technologies in recent years makes a significant progress. The current app...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章,评审

    doi：10.1186/s12929-017-0384-2

    authors： Zhou Y

    更新日期：2017-10-18 00:00:00

  • Phenotype and functionality of follicular helper T cells in patients with acute dengue infection.

    abstract：BACKGROUND:The association of functionality and phenotype of follicular helper T cells (Tfh) with dengue virus (DENV) specific antibody responses and clinical disease severity has not been well studied. METHODS:We investigated the phenotype and functionality of Tfh cells and plasmablasts in adult patients (DF = 18, DH...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/s12929-020-00641-2

    authors： Wijesinghe A,Gamage J,Goonewardena H,Gomes L,Jayathilaka D,Wijeratne DT,de Alwis R,Jeewandara C,Wijewickrama A,Ogg GS,Malavige GN

    更新日期：2020-04-08 00:00:00

  • Induction of Fas and Fas-ligand expression in plasmacytoma cells by a cytotoxic factor secreted by murine macrophages.

    abstract：:Induction of tumoricidal activity is one of the major functions of activated macrophages. Our previous study demonstrated that P388D1 murine macrophage-like cells secreted a plasmacytoma cytotoxic factor (PCF) that selectively killed certain tumor cell lines including MOPC-315 plasmacytoma in vitro. Our subsequent stu...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/BF02255919

    authors： Chu CY,Tseng J

    更新日期：2000-01-01 00:00:00

  • A glimpse of the ERM proteins.

    abstract：:In all eukaryotes, the plasma membrane is critically important as it maintains the architectural integrity of the cell. Proper anchorage and interaction between the plasma membrane and the cytoskeleton is critical for normal cellular processes. The ERM (ezrin-radixin-moesin) proteins are a class of highly homologous p...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章,评审

    doi：10.1186/s12929-016-0246-3

    authors： Ponuwei GA

    更新日期：2016-03-17 00:00:00

  • Effect of beta-alanine treatment on mitochondrial taurine level and 5-taurinomethyluridine content.

    abstract：BACKGROUND:The beta-amino acid, taurine, is a nutritional requirement in some species. In these species, the depletion of intracellular stores of taurine leads to the development of severe organ dysfunction. The basis underlying these defects is poorly understood, although there is some suggestion that oxidative stress...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/1423-0127-17-S1-S25

    authors： Jong CJ,Ito T,Mozaffari M,Azuma J,Schaffer S

    更新日期：2010-08-24 00:00:00

  • Involvement of an alternatively spliced mitochondrial oxodicarboxylate carrier in adipogenesis in 3T3-L1 cells.

    abstract：BACKGROUND:Adipogenesis is a complex process that involves many genes/proteins at different stages of differentiation. In order to identify genes critical for adipogenesis, we took a novel approach based on phenotype change of individual cell, to search for genes with regulatory roles in adipogenesis genome-wide in 3T3...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/1423-0127-16-92

    authors： Niimi M,Tao L,Lin SH,Yin J,Wu X,Fukui H,Kambayashi J,Ye J,Sun B

    更新日期：2009-10-13 00:00:00

  • Insulin-like growth factor 1 improves the efficacy of mesenchymal stem cells transplantation in a rat model of myocardial infarction.

    abstract：BACKGROUND:Previous study demonstrated the improvement of cardiac function was proportional to the number of cells implanted. Therefore, increasing cell survival in the infarcted myocardium might contribute to the improvement of the functional benefit of cell transplantation. METHODS AND RESULTS:MSCs were treated with...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/s11373-007-9207-x

    authors： Guo J,Lin G,Bao C,Hu Z,Chu H,Hu M

    更新日期：2008-01-01 00:00:00

  • Structure and Activity of Membrane Receptors: Modeling and Computational Simulation of Ligand Recognition in a Three-Dimensional Model of the 5-Hydroxytryptamine(1A) Receptor.

    abstract：:A three-dimensional molecular model of the transmembrane domain of the 5-HT(1A) receptor (5-HT(1A)R) is presented in the context of a general strategy for modeling the macromolecular structure of a guanine nucleotide binding, regulatory protein coupled receptor (GPCR). The model of the 5-HT(1A)R rests on the definitio...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/BF02255537

    authors： Pardo L,Batlle M,Duñach M,Weinstein H

    更新日期：1996-04-01 00:00:00

  • The intracellular domain of cell adhesion molecule 1 is present in emphysematous lungs and induces lung epithelial cell apoptosis.

    abstract：BACKGROUND:Pulmonary emphysema is characterized histologically by destruction of alveolar walls and enlargement of air spaces due to lung epithelial cell apoptosis. Cell adhesion molecule 1 (CADM1) is an immunoglobulin superfamily member expressed in lung epithelial cells. CADM1 generates a membrane-associated C-termin...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/s12929-015-0173-8

    authors： Hagiyama M,Yoneshige A,Inoue T,Sato Y,Mimae T,Okada M,Ito A

    更新日期：2015-08-11 00:00:00

  • Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1 I27N mutant mice.

    abstract：BACKGROUND:Increased levels of blood plasma urea were used as phenotypic parameter for establishing novel mouse models for kidney diseases on the genetic background of C3H inbred mice in the phenotype-driven Munich ENU mouse mutagenesis project. The phenotypically dominant mutant line HST014 was established and further...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/s12929-017-0365-5

    authors： Kumar S,Rathkolb B,Sabrautzki S,Krebs S,Kemter E,Becker L,Beckers J,Bekeredjian R,Brommage R,Calzada-Wack J,Garrett L,Hölter SM,Horsch M,Klingenspor M,Klopstock T,Moreth K,Neff F,Rozman J,Fuchs H,Gailus-Durner V,H

    更新日期：2017-08-17 00:00:00

  • Epigallocatechin-3-gallate-mediated cardioprotection by Akt/GSK-3β/caveolin signalling in H9c2 rat cardiomyoblasts.

    abstract：BACKGROUND:Epigallocatechin-3-gallate (EGCg) with its potent anti-oxidative capabilities is known for its beneficial effects ameliorating oxidative injury to cardiac cells. Although studies have provided convincing evidence to support the cardioprotective effects of EGCg, it remains unclear whether EGCg affect trans-me...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/1423-0127-20-86

    authors： Hsieh SR,Hsu CS,Lu CH,Chen WC,Chiu CH,Liou YM

    更新日期：2013-11-19 00:00:00

  • Short-term exposure to somatostatin or muscarinic agonists reduce acetylcholine-induced 3H-MPP+ release from bovine adrenal medullary cells.

    abstract：:The aim of this work was to investigate the effect of a short-term exposure to somatostatin (SS), its receptors (SSTR) selective agonists as well as muscarinic receptors agonists upon acetylcholine-induced release of (3)H-MPP(+ )from bovine adrenal medullary cells. Acetylcholine (ACH, 100, 500 microM) was found to inc...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/s11373-006-9144-0

    authors： Ribeiro L,Martel F,Azevedo I

    更新日期：2007-05-01 00:00:00

  • Acid-sensing ion channels: dual function proteins for chemo-sensing and mechano-sensing.

    abstract：BACKGROUND:Acid-sensing ion channels (ASICs) are a group of amiloride-sensitive ligand-gated ion channels belonging to the family of degenerin/epithelial sodium channels. ASICs are predominantly expressed in both the peripheral and central nervous system and have been characterized as potent proton sensors to detect ex...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章,评审

    doi：10.1186/s12929-018-0448-y

    authors： Cheng YR,Jiang BY,Chen CC

    更新日期：2018-05-24 00:00:00

  • Role of NADPH oxidase in cytomegalovirus-induced proliferation of human coronary artery smooth muscle cells.

    abstract：:A number of infectious agents have been implicated in the development of vascular diseases such as atherosclerosis and posttransplantation arterial restenosis. Cytomegalovirus (CMV) has been reported to cause obliteration of coronary arteries by a progressive vasculopathy that involves proliferation of medial smooth m...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/BF02256111

    authors： Dhaunsi GS,Kaur J,Turner RB

    更新日期：2003-09-01 00:00:00

  • Cytotoxicity and cell cycle arrest induced by andrographolide lead to programmed cell death of MDA-MB-231 breast cancer cell line.

    abstract：BACKGROUND:Breast cancer is considered as an increasing major life-threatening concern among the malignancies encountered globally in females. Traditional therapy is far from satisfactory due to drug resistance and various side effects, thus a search for complementary/alternative medicines from natural sources with les...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/s12929-016-0257-0

    authors： Banerjee M,Chattopadhyay S,Choudhuri T,Bera R,Kumar S,Chakraborty B,Mukherjee SK

    更新日期：2016-04-16 00:00:00