Short-term auricular electrical stimulation rapidly elevated cortical blood flow and promoted the expression of nicotinic acetylcholine receptor α4 in the 2 vessel occlusion rats model.

abstract：:Different human retroviruses, such as Human Immunodeficiency Virus (HIV) and Human T-cell Lymphotropic Virus (HTLV), can cause neurologic infection. However, a definitive diagnosis may be hampered by several factors. Quantification of the viral or proviral load in cerebrospinal fluid (CSF) may be helpful in the diagno...

journal_title：Journal of biomedical science

authors： Rosadas C,Puccioni-Sohler M

更新日期：2015-08-08 00:00:00

abstract：:The present study was undertaken to elucidate the mechanism of intra-arterial propofol-induced vascular permeability change resulting in tissue edema. The mechanism of propofol-induced hyperpermeability was examined in a rat femoral artery injection model. Vascular permeability was determined by measuring the Evans bl...

journal_title：Journal of biomedical science

authors： Chen YS,Chen KH,Liu CC,Lee CT,Yang CH,Chuang KC,Lin CR

更新日期：2007-09-01 00:00:00

abstract：:Diabetes is a multifactorial disease that has now been recognized to involve overproduction of reactive oxygen species and pro-inflammatory cytokines. Peroxisomes are subcellular organelles with several important metabolic functions, and their role in the regulation of cellular oxidative stress is now well established...

journal_title：Journal of biomedical science

authors： Dhaunsi GS,Bitar MS

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:RNA interference (RNAi) is a powerful tool to silence gene expression post-transcriptionally. Delivering sequences of RNAi in vivo remains a problem. The aim of this study was to use JC virus (JCV) virus-like particles (VLPs) as a vector for delivering RNAi in silencing the cytokine gene of IL-10. METHODS:J...

journal_title：Journal of biomedical science

authors： Chou MI,Hsieh YF,Wang M,Chang JT,Chang D,Zouali M,Tsay GJ

更新日期：2010-06-24 00:00:00

abstract：BACKGROUND:Prenatal alcohol exposure may cause cardiac development defects, however, the underlying mechanisms are not yet clear. In the present study we have investigated the roles of histone modification by curcumin on alcohol induced fetal cardiac abnormalities during the development. METHODS AND RESULTS:Q-PCR and ...

journal_title：Journal of biomedical science

authors： Yan X,Pan B,Lv T,Liu L,Zhu J,Shen W,Huang X,Tian J

更新日期：2017-01-05 00:00:00

abstract：BACKGROUND:Cervical cancer is the second-most-common cause of malignancies in women worldwide, and the oncogenic activity of the human papilloma virus types (HPV) E7 protein has a crucial role in anogenital tumors. In this study, we have designed a therapeutic vaccine based on chitosan nanodelivery systems to deliver H...

journal_title：Journal of biomedical science

authors： Tahamtan A,Ghaemi A,Gorji A,Kalhor HR,Sajadian A,Tabarraei A,Moradi A,Atyabi F,Kelishadi M

更新日期：2014-07-31 00:00:00

abstract：BACKGROUND:Sensing tissue acidosis is an important function of the somatosensory nervous system to response to noxious stimuli. MAIN BODY:In the pain clinic, acid or soreness sensation is a characteristic sensory phenotype of various acute and chronic pain syndromes, such as delayed onset muscle soreness, fibromyalgia...

journal_title：Journal of biomedical science

authors： Lin JH,Hung CH,Han DS,Chen ST,Lee CH,Sun WZ,Chen CC

更新日期：2018-11-29 00:00:00

abstract：:A number of infectious agents have been implicated in the development of vascular diseases such as atherosclerosis and posttransplantation arterial restenosis. Cytomegalovirus (CMV) has been reported to cause obliteration of coronary arteries by a progressive vasculopathy that involves proliferation of medial smooth m...

journal_title：Journal of biomedical science

authors： Dhaunsi GS,Kaur J,Turner RB

更新日期：2003-09-01 00:00:00

abstract：:Plasma nitric oxide (NO) levels in Duchenne muscular dystrophy (DMD) patients were significantly lower than those observed in both healthy controls and in patients with other neuromuscular disorders. The correlation between NO level and ejection fraction was significant (r = -0.384, p = 0.0391) in the DMD group. Disru...

journal_title：Journal of biomedical science

authors： Kasai T,Abeyama K,Hashiguchi T,Fukunaga H,Osame M,Maruyama I

更新日期：2004-07-01 00:00:00

abstract：:The nuclear envelope (NE) consists of two membrane layers that segregate the nuclear from the cytoplasmic contents. Recent progress in our understanding of nuclear-lamina associated diseases has revealed intriguing connections between the envelope components and nuclear processes. Here, we review the functions of the ...

journal_title：Journal of biomedical science

authors： Chi YH,Chen ZJ,Jeang KT

更新日期：2009-10-22 00:00:00

abstract：:The interactive role of rostral ventrolateral medulla (RVL) cardiovascular neurons and brain angiotensin II (Ang II) in regulating the arterial blood pressure was examined by recording simultaneously the spontaneous activity of these spinal projecting neurons and the arterial blood pressure in the pentobarbital-anesth...

journal_title：Journal of biomedical science

authors： Chan RK,Chan YS,Wong TM

更新日期：1996-05-01 00:00:00

abstract：:While virus-like particles (VLPs) containing subgenomic replicons, which can transduce replicons into target cells efficiently for studying viral replication and vectors of gene therapy and vaccine, have been established for several flaviviruses, none has been reported for the four serotypes of dengue virus, the causa...

journal_title：Journal of biomedical science

authors： Lai CY,Hu HP,King CC,Wang WK

更新日期：2008-01-01 00:00:00

abstract：:Developmentally regulated endothelial cell locus-1 (Del1) is an embryonic angiogenic factor expressed in early embryonic endothelial cells, but recently has been found to be expressed in some forms of cancers including colon and breast cancers, and melanoma, and human cancer cell lines. Overexpression of Del1 accelera...

journal_title：Journal of biomedical science

authors： Zou X,Qiao H,Jiang X,Dong X,Jiang H,Sun X

更新日期：2009-01-01 00:00:00

abstract：:5-methoxytryptophan (5-MTP) is an endothelial factor with anti-inflammatory properties. It is synthesized from L-tryptophan via two enzymatic steps: tryptophan hydroxylase-1 (TPH-1) and hydroxyindole O-methyltransferase. Lipopolysaccharide (LPS) and pro-inflammatory cytokines suppress endothelial 5-MTP production by i...

journal_title：Journal of biomedical science

authors： Wu KK,Kuo CC,Yet SF,Lee CM,Liou JY

更新日期：2020-07-07 00:00:00

abstract：:After streptococcal pyrogenic exotoxin B (SPE B) induces apoptosis, its fate is unknown. Using confocal time-course microscopy at 37 degrees C, we detected green fluorescence 20 min after adding FITC-SPE B. Orange fluorescence, an indication of co-localization of SPE B with lysosomes which were labeled with a red fluo...

journal_title：Journal of biomedical science

authors： Chang CW,Tsai WH,Chuang WJ,Lin YS,Wu JJ,Liu CC,Tsai PJ,Lin MT

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:The enzyme-prodrug system is considered a promising tool for tumor treatment when conjugated with a targeting molecule. The asparagine-glycine-arginine (NGR) motif is a developing and interesting targeting peptide that could specifically bind to aminopeptidase N (APN), which is an NGR receptor expressed on t...

journal_title：Journal of biomedical science

authors： Li JJ,Chang SF,Liau II,Chan PC,Liu RS,Yen SH,Wang HE,Chang CA

更新日期：2016-01-22 00:00:00

abstract：:Previously we have reported the presence of endogenous ligands that are involved in the regulation of the binding of muscimol to the GABA binding site of the GABAA receptors. Here, we report the presence of multiple forms of endogenous ligands in the brain which modulate the binding of flunitrazepam (FNZP) to the benz...

journal_title：Journal of biomedical science

authors： Yarom M,Tang XW,Wu E,Carlson RG,Vander Velde D,Lee X,Wu J

更新日期：1998-07-01 00:00:00

abstract：:Dengue virus infection presents a wide spectrum of manifestations including asymptomatic condition, dengue fever (DF), or severe forms, such as dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) in affected individuals. The early prediction of severe dengue in patients without any warning signs who may lat...

journal_title：Journal of biomedical science

authors： John DV,Lin YS,Perng GC

更新日期：2015-10-14 00:00:00

abstract：:As a neurotropic virus, enterovirus A71 (EV-A71) emerge and remerge in the Asia-Pacific region since the 1990s, and has continuously been a threat to global public health, especially in children. Annually, EV-A71 results in hand-foot-and-mouth disease (HFMD) and occasionally causes severe neurological disease. Here we...

journal_title：Journal of biomedical science

authors： Huang SW,Cheng D,Wang JR

更新日期：2019-10-21 00:00:00

abstract：:The ARFP/F protein is synthesized from the +1 reading frame of the hepatitis C virus (HCV) core protein gene. The function of this protein remains unknown. To study the function of the HCV ARFP/F protein, we have conducted the yeast two-hybrid screening experiment to identify cellular proteins that may interact with t...

journal_title：Journal of biomedical science

authors： Ma HC,Lin TW,Li H,Iguchi-Ariga SM,Ariga H,Chuang YL,Ou JH,Lo SY

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Breast cancer is considered as an increasing major life-threatening concern among the malignancies encountered globally in females. Traditional therapy is far from satisfactory due to drug resistance and various side effects, thus a search for complementary/alternative medicines from natural sources with les...

journal_title：Journal of biomedical science

authors： Banerjee M,Chattopadhyay S,Choudhuri T,Bera R,Kumar S,Chakraborty B,Mukherjee SK

更新日期：2016-04-16 00:00:00

abstract：:A large group of small Rab GTPases which mediate secretory and endosomal membrane transport, as well as autophagosome biogenesis, are essential components of vesicle trafficking machinery. Specific Rab protein together with the cognate effectors coordinates the dynamics of trafficking pathway and determines the cargo ...

journal_title：Journal of biomedical science

authors： Tzeng HT,Wang YC

更新日期：2016-10-06 00:00:00

abstract：:The Tat proteins of human immunodeficiency virus types 1 (HIV-1) and 2 (HIV-2), termed Tat-1 and Tat-2, respectively, are essential for efficient viral replication. Tat proteins activate viral transcription by binding to the TAR RNA stem-loop structure at the 5' end of viral transcripts. We used an in vitro selection ...

journal_title：Journal of biomedical science

authors： Rhim H,Rice AP

更新日期：1997-01-01 00:00:00

abstract：:Diazoxide is a selective mitochondria ATP-sensitive potassium (K(ATP)) channel opener, which has been reported to preserve the microvascular integrity of ischemia-reperfusion (I/R)-injured tissues. Our study aimed to assess diazoxide's effects on I/R-injured cremaster muscles and to further elucidate its underlying me...

journal_title：Journal of biomedical science

authors： Wei W,Wei FC,Hung LM

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:The association between ischemic stroke and 2 single nucleotide polymorphisms (SNPs) on chromosome 12p13, rs12425791 and rs11833579 appears inconsistent across different samples. These SNPs are close to the ninjurin2 gene which may alter the risk of stroke by affecting brain response to ischemic injury. The ...

journal_title：Journal of biomedical science

authors： Hsieh YC,Seshadri S,Chung WT,Hsieh FI,Hsu YH,Lin HJ,Tseng HP,Lien LM,Bai CH,Hu CJ,Jeng JS,Tang SC,Chen CI,Yu CC,Chiou HY,Formosa Stroke Genetic Consortium (FSGC).

更新日期：2012-01-03 00:00:00

abstract：BACKGROUND:The association of functionality and phenotype of follicular helper T cells (Tfh) with dengue virus (DENV) specific antibody responses and clinical disease severity has not been well studied. METHODS:We investigated the phenotype and functionality of Tfh cells and plasmablasts in adult patients (DF = 18, DH...

journal_title：Journal of biomedical science

authors： Wijesinghe A,Gamage J,Goonewardena H,Gomes L,Jayathilaka D,Wijeratne DT,de Alwis R,Jeewandara C,Wijewickrama A,Ogg GS,Malavige GN

更新日期：2020-04-08 00:00:00

abstract：BACKGROUND:The apolipoprotein E4 (apoE4) genotype is a major risk factor for developing late-onset Alzheimer's disease (AD). Inheritance of apoE4 is also associated with impairments in olfactory function in early stages of AD. In this project we examined the effects of the three common isoforms of human apoE (apoE2, ap...

journal_title：Journal of biomedical science

authors： Hussain A,Luong M,Pooley A,Nathan BP

更新日期：2013-07-12 00:00:00

abstract：:Hypoxia is an important microenvironmental factor that induces cancer metastasis. Hypoxia/hypoxia-inducible factor-1α (HIF-1α) regulates many important steps of the metastatic processes, especially epithelial-mesenchymal transition (EMT) that is one of the crucial mechanisms to cause early stage of tumor metastasis. T...

journal_title：Journal of biomedical science

authors： Tsai YP,Wu KJ

更新日期：2012-12-14 00:00:00

abstract：BACKGROUND:Oxidized low-density lipoprotein (oxLDL) mediates the transformation of macrophages (MΦ) to cholesterol-rich foam cells and the release of pro-inflammatory cytokines during atherogenesis. JAB1 (Jun activation domain binding protein-1) is present in all stages of human plaques, involved in the Toll-like recep...

journal_title：Journal of biomedical science

authors： Schwarz A,Bonaterra GA,Schwarzbach H,Kinscherf R

更新日期：2017-02-07 00:00:00

abstract：:Two Chinese hamster ovary (CHO) cell lines stably transfected with human insulin receptor cDNA, CHO-wt and CHO-mut, which express an equivalent number of normal and kinase-defective human insulin receptors, respectively, were used to assess the roles of insulin receptor tyrosine kinase activity in insulin-regulated ge...

journal_title：Journal of biomedical science

authors： Lin SC,Chen MF,Chou CK

更新日期：1994-12-01 00:00:00