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Sensing acidosis: nociception or sngception?

Abstract：

BACKGROUND:Sensing tissue acidosis is an important function of the somatosensory nervous system to response to noxious stimuli. MAIN BODY:In the pain clinic, acid or soreness sensation is a characteristic sensory phenotype of various acute and chronic pain syndromes, such as delayed onset muscle soreness, fibromyalgia, and radicular pain. However, soreness sensation is a sign of successful analgesia for acupuncture and noxipoint therapy. Thus, the nature of acid or soreness sensation is not always nociceptive (or painful) and could be anti-nociceptive. To facilitate the investigation of the molecular and neurobiological mechanisms of soreness sensation, we propose a concept called "sngception (sng- ception)" to describe the response of the somatosensory nervous system to sense tissue acidosis and to distinguish it from nociception. "Sng" is a Taiwanese word that represents the state of soreness while at the same time imitates the natural vocalization of humans feeling sore. CONCLUSION:Here we propose sngception as a specific somatosensory function that transmits the acid sensation from the peripheral to the central nervous system. Sngception could partially overlap with nociception, but it could also transmit antinociception, proprioception, and pruriception.

journal_name

J Biomed Sci

journal_title

Journal of biomedical science

authors

Lin JH,Hung CH,Han DS,Chen ST,Lee CH,Sun WZ,Chen CC

doi

10.1186/s12929-018-0486-5

subject

Has Abstract

pub_date

2018-11-29 00:00:00

pages

85

issue

1

eissn

1021-7770

issn

1423-0127

pii

10.1186/s12929-018-0486-5

journal_volume

25

pub_type

杂志文章,评审

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