当前位置： SCI文献检索 > JOURNAL OF BIOMEDICAL SCIENCE期刊下所有文献 > Rab-mediated vesicle trafficking in cancer.

Rab-mediated vesicle trafficking in cancer.

Abstract：

:A large group of small Rab GTPases which mediate secretory and endosomal membrane transport, as well as autophagosome biogenesis, are essential components of vesicle trafficking machinery. Specific Rab protein together with the cognate effectors coordinates the dynamics of trafficking pathway and determines the cargo proteins destination. Functional impairments of Rab proteins by mutations or post-translational modifications disrupting the regulatory network of vesicle trafficking have been implicated in tumorigenesis. Therefore, the vesicle transport regulators play essential roles in the mediation of cancer cell biology, including uncontrolled cell growth, invasion and metastasis. The context-dependent role of the same Rab to act as either an oncoprotein or tumor suppressor in different cancers is found. Such discrepancies may be due in part to the interaction of specific Rab protein with different effectors or cargos in various tumors. Here, we review recent advances in the roles of Rab GTPases in communicating with other effectors in tumor progression. In this review, we also emphasize dysregulation of Rab-mediated membrane delivery shifting normal cell behaviors toward malignancy. Thus, recovery of the dysregulated vesicle trafficking systems in cancer cells may provide future directions for potential strategy to restrain tumor progression.

journal_name

J Biomed Sci

journal_title

Journal of biomedical science

authors

Tzeng HT,Wang YC

doi

10.1186/s12929-016-0287-7

subject

Has Abstract

pub_date

2016-10-06 00:00:00

pages

70

issue

1

eissn

1021-7770

issn

1423-0127

pii

10.1186/s12929-016-0287-7

journal_volume

23

pub_type

杂志文章,评审

相关文献

JOURNAL OF BIOMEDICAL SCIENCE文献大全
  • Expression of EIF3-p48/INT6, TID1 and Patched in cancer, a profiling of multiple tumor types and correlation of expression.

    abstract：:Alterations in eIF3-p48/INT6 gene expression have been implicated in murine and human mammary carcinogenesis. We examined levels of INT6 protein in human tumors and determined that breast and colon tumors clustered into distinct groups based on levels of INT6 expression and clinicopathological variables. We performed ...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/s11373-007-9149-3

    authors： Traicoff JL,Chung JY,Braunschweig T,Mazo I,Shu Y,Ramesh A,D'Amico MW,Galperin MM,Knezevic V,Hewitt SM

    更新日期：2007-05-01 00:00:00

  • Zerumbone suppresses IKKα, Akt, and FOXO1 activation, resulting in apoptosis of GBM 8401 cells.

    abstract：BACKGROUND:Zerumbone, a sesquiterpene compound isolated from subtropical ginger, Zingiber zerumbet Smith, has been documented to exert antitumoral and anti- inflammatory activities. In this study, we demonstrate that zerumbone induces apoptosis in human glioblastoma multiforme (GBM8401) cells and investigate the apopto...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/1423-0127-19-86

    authors： Weng HY,Hsu MJ,Wang CC,Chen BC,Hong CY,Chen MC,Chiu WT,Lin CH

    更新日期：2012-10-05 00:00:00

  • PLCβ1-SHP-2 complex, PLCβ1 tyrosine dephosphorylation and SHP-2 phosphatase activity: a new part of Angiotensin II signaling?

    abstract：BACKGROUND:Angiotensin II (Ang II) signaling occurs via two major receptors which activate non-receptor tyrosin kinases that then interact with protein tyrosin-phosphatases (PTPs) to regulate cell function. SHP-2 is one such important PTP that also functions as an adaptor to promote downstream signaling pathway. Its ro...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/1423-0127-18-38

    authors： Calò LA,Bordin L,Davis PA,Pagnin E,Dal Maso L,Rossi GP,Pessina AC,Clari G

    更新日期：2011-06-13 00:00:00

  • Discovery and cellular stress pathway analysis of 1,4-naphthoquinone derivatives with novel, highly potent broad-spectrum anticancer activity.

    abstract：BACKGROUND:Chemotherapy and targeted therapies have made important strides in cancer treatment yet they often fail and new therapies are still needed. Here, we employed a phenotypic screen to identify and analyze the mechanism of action of novel small molecules that interfere with critical pathways involved in tumor ce...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/s12929-018-0408-6

    authors： Ghosh SK,Ganta A,Spanjaard RA

    更新日期：2018-02-08 00:00:00

  • Lysophosphatidylcholine alters vascular tone in rat aorta by suppressing endothelial [Ca(2+)](I) signaling.

    abstract：:The detailed mechanism of how lysophosphatidylcholine (LPC) suppresses endothelium-dependent vasodilatation is unclear at present. We investigated the effects of LPC on endothelial intracellular calcium (EC [Ca(2+)](i)) signaling and vascular tone simultaneously using a new technique we developed. Fura-2-labeled rat a...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/BF02256588

    authors： Huang TY,Chen HI,Liu CY,Jen CJ

    更新日期：2002-07-01 00:00:00

  • Inhibitory mechanisms of low concentrations of oxidized low-density lipoprotein on platelet aggregation.

    abstract：:The intracellular mechanisms underlying oxidized low-density lipoprotein (oxLDL)-signaling pathways in platelets are not yet completely understood. Therefore, the aim of this study was to further examine the effects of oxLDL in prevention of platelet aggregation. In this study, oxLDL concentration-dependently (40-120 ...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/s11373-005-9042-x

    authors： Chou DS,Chan CH,Hsiao G,Shen MY,Tsai YJ,Chen TF,Sheu JR

    更新日期：2006-05-01 00:00:00

  • Hepatitis B virus X protein (HBx) enhances centrosomal P4.1-associated protein (CPAP) expression to promote hepatocarcinogenesis.

    abstract：BACKGROUND:Our previous report suggested that centrosomal P4.1-associated protein (CPAP) is required for Hepatitis B virus (HBV) encoded non-structure protein X (HBx)-mediated nuclear factor kappa light chain enhancer of activated B cells (NF-κB) activation. CPAP is overexpressed in HBV-associated hepatocellular carcin...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/s12929-019-0534-9

    authors： Yen CJ,Yang ST,Chen RY,Huang W,Chayama K,Lee MH,Yang SJ,Lai HS,Yen HY,Hsiao YW,Wang JM,Lin YJ,Hung LY

    更新日期：2019-06-06 00:00:00

  • Amino acid residues 201-205 in C-terminal acidic tail region plays a crucial role in antibacterial activity of HMGB1.

    abstract：BACKGROUND:Antibacterial activity is a novel function of high-mobility group box 1 (HMGB1). However, the functional site for this new effect is presently unknown. METHODS AND RESULTS:In this study, recombinant human HMGB1 A box and B box (rHMGB1 A box, rHMGB1 B box), recombinant human HMGB1 (rHMGB1) and the truncated ...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/1423-0127-16-83

    authors： Gong W,Li Y,Chao F,Huang G,He F

    更新日期：2009-09-14 00:00:00

  • Cytotoxicity and cell cycle arrest induced by andrographolide lead to programmed cell death of MDA-MB-231 breast cancer cell line.

    abstract：BACKGROUND:Breast cancer is considered as an increasing major life-threatening concern among the malignancies encountered globally in females. Traditional therapy is far from satisfactory due to drug resistance and various side effects, thus a search for complementary/alternative medicines from natural sources with les...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/s12929-016-0257-0

    authors： Banerjee M,Chattopadhyay S,Choudhuri T,Bera R,Kumar S,Chakraborty B,Mukherjee SK

    更新日期：2016-04-16 00:00:00

  • Expedition to the missing link: Long noncoding RNAs in cardiovascular diseases.

    abstract：:With the advances in deep sequencing-based transcriptome profiling technology, it is now known that human genome is transcribed more pervasively than previously thought. Up to 90% of the human DNA is transcribed, and a large proportion of the human genome is transcribed as long noncoding RNAs (lncRNAs), a heterogenous...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章,评审

    doi：10.1186/s12929-020-00647-w

    authors： Yeh CF,Chang YE,Lu CY,Hsuan CF,Chang WT,Yang KC

    更新日期：2020-04-02 00:00:00

  • Association between genetic variant on chromosome 12p13 and stroke survival and recurrence: a one year prospective study in Taiwan.

    abstract：BACKGROUND:The association between ischemic stroke and 2 single nucleotide polymorphisms (SNPs) on chromosome 12p13, rs12425791 and rs11833579 appears inconsistent across different samples. These SNPs are close to the ninjurin2 gene which may alter the risk of stroke by affecting brain response to ischemic injury. The ...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章,多中心研究

    doi：10.1186/1423-0127-19-1

    authors： Hsieh YC,Seshadri S,Chung WT,Hsieh FI,Hsu YH,Lin HJ,Tseng HP,Lien LM,Bai CH,Hu CJ,Jeng JS,Tang SC,Chen CI,Yu CC,Chiou HY,Formosa Stroke Genetic Consortium (FSGC).

    更新日期：2012-01-03 00:00:00

  • Insulin-like growth factor 1 improves the efficacy of mesenchymal stem cells transplantation in a rat model of myocardial infarction.

    abstract：BACKGROUND:Previous study demonstrated the improvement of cardiac function was proportional to the number of cells implanted. Therefore, increasing cell survival in the infarcted myocardium might contribute to the improvement of the functional benefit of cell transplantation. METHODS AND RESULTS:MSCs were treated with...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/s11373-007-9207-x

    authors： Guo J,Lin G,Bao C,Hu Z,Chu H,Hu M

    更新日期：2008-01-01 00:00:00

  • Differential behaviour of normal, transformed and Fanconi's anemia lymphoblastoid cells to modeled microgravity.

    abstract：BACKGROUND:Whether microgravity might influence tumour growth and carcinogenesis is still an open issue. It is not clear also if and how normal and transformed cells are differently solicited by microgravity. The present study was designed to verify this issue. METHODS:Two normal, LB and HSC93, and two transformed, Ju...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/1423-0127-17-63

    authors： Cuccarolo P,Barbieri F,Sancandi M,Viaggi S,Degan P

    更新日期：2010-07-28 00:00:00

  • Amelioration of beryllium induced alterations in hepatorenal biochemistry and ultramorphology by co-administration of tiferron and adjuvants.

    abstract：:Influence of adjuvants i.e., alpha-tocopherol (25 mg/kg, p.o.) and piperine (10 mg/kg, p.o.) on therapeutic potential of chelator tiferron (300 mg/kg, i.p.) was evaluated to encounter toxicogenic events of beryllium exposure. Albino rats were exposed to beryllium nitrate (1 mg/kg, i.p.) daily for 28 days followed by t...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/s11373-007-9147-5

    authors： Nirala SK,Bhadauria M,Mathur R,Mathur A

    更新日期：2007-05-01 00:00:00

  • Diazoxide ameliorates microcirculatory disturbances through PKC-dependent pathway in I/R-injured rat cremaster muscles.

    abstract：:Diazoxide is a selective mitochondria ATP-sensitive potassium (K(ATP)) channel opener, which has been reported to preserve the microvascular integrity of ischemia-reperfusion (I/R)-injured tissues. Our study aimed to assess diazoxide's effects on I/R-injured cremaster muscles and to further elucidate its underlying me...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/s11373-005-3730-4

    authors： Wei W,Wei FC,Hung LM

    更新日期：2005-01-01 00:00:00

  • Association between polymorphisms of biotransformation and DNA-repair genes and risk of colorectal cancer in Taiwan.

    abstract：:The relationship between diet and colorectal cancer has been previously demonstrated and supported with strong epidemiological evidence. The role of genetic polymorphisms has, however, been less well elaborated upon. We conducted a hospital-based case-control study including 727 cases and 736 healthy controls to evalu...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/s11373-006-9139-x

    authors： Yeh CC,Sung FC,Tang R,Chang-Chieh CR,Hsieh LL

    更新日期：2007-03-01 00:00:00

  • Identification of inosine as an endogenous modulator for the benzodiazepine binding site of the GABAA receptors.

    abstract：:Previously we have reported the presence of endogenous ligands that are involved in the regulation of the binding of muscimol to the GABA binding site of the GABAA receptors. Here, we report the presence of multiple forms of endogenous ligands in the brain which modulate the binding of flunitrazepam (FNZP) to the benz...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/BF02255859

    authors： Yarom M,Tang XW,Wu E,Carlson RG,Vander Velde D,Lee X,Wu J

    更新日期：1998-07-01 00:00:00

  • Shikonin selectively induces apoptosis in human prostate cancer cells through the endoplasmic reticulum stress and mitochondrial apoptotic pathway.

    abstract：BACKGROUND:Despite the recent progress in screening and therapy, a majority of prostate cancer cases eventually attain hormone refractory and chemo-resistant attributes. Conventional chemotherapeutic strategies are effective at very high doses for only palliative management of these prostate cancers. Therefore chemo-se...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/s12929-015-0127-1

    authors： Gara RK,Srivastava VK,Duggal S,Bagga JK,Bhatt M,Sanyal S,Mishra DP

    更新日期：2015-04-01 00:00:00

  • Hypoxemic reperfusion of ischemic states: an alternative approach for the attenuation of oxidative stress mediated reperfusion injury.

    abstract：:Ischemia and reperfusion (I/R) - induced injury has been described as one of the main factors that contribute to the observed morbidity and mortality in a variety of clinical entities, including myocardial infarction, ischemic stroke, cardiac arrest and trauma. An imbalance between oxygen demand and supply, within the...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章,评审

    doi：10.1186/s12929-016-0220-0

    authors： Tasoulis MK,Douzinas EE

    更新日期：2016-01-19 00:00:00

  • Expression of a truncated retroviral envelope gene enhances expression of normal cellular phenotypes.

    abstract：:The envelope gene of Moloney murine leukemia virus (Mo-MLV) and its various functional domains have been studied extensively but not as much in terms of their biological effects on cell growth. In this study, we report the biological characterization of a truncated Mo-MLV envelope gene, LN11, which is devoid of a sign...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/BF02253367

    authors： Chen H,Chung SW,Wong PM

    更新日期：2000-11-01 00:00:00

  • A synthetic peptide sensitizes multi-drug resistant Pseudomonas aeruginosa to antibiotics for more than two hours and permeabilizes its envelope for twenty hours.

    abstract：BACKGROUND:Pseudomonas aeruginosa is a Gram-negative pathogen that frequently causes life-threatening infections in immunocompromised patients. We previously showed that subinhibitory concentrations of short synthetic peptides permeabilize P. aeruginosa and enhance the lethal action of co-administered antibiotics. MET...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/s12929-020-00678-3

    authors： Rázquin-Olazarán I,Shahrour H,Martínez-de-Tejada G

    更新日期：2020-08-06 00:00:00

  • Sympathetic-correlated c-Fos expression in the neonatal rat spinal cord in vitro.

    abstract：:An isolated thoracic spinal cord of the neonatal rat in vitro spontaneously generates sympathetic nerve discharge (SND) at ~25 degrees C, but it fails in SND genesis at < or = 10 degrees C. Basal levels of the c-Fos expression in the spinal cords incubated at < or = 10 degrees C and ~25 degrees C were compared to dete...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/1423-0127-16-44

    authors： Su CK,Ho CM,Kuo HH,Wen YC,Chai CY

    更新日期：2009-05-01 00:00:00

  • Enhancement of DNA vaccine potency through linkage of antigen gene to ER chaperone molecules, ER-60, tapasin, and calnexin.

    abstract：:DNA vaccines have emerged as an attractive approach for generating antigen-specific immunotherapy. Strategies that enhance antigen presentation may potentially be used to enhance DNA vaccine potency. Previous experiments showed that chimeric DNA vaccines utilizing endoplasmic reticulum (ER) chaperone molecules, such a...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/s11373-005-0334-y

    authors： Lin CT,Chang TC,Chao A,Dzeng E,Soong YK,Hung CF,Lai CH

    更新日期：2005-01-01 00:00:00

  • Essential role of diastolic oscillatory potentials in adrenergic control of guinea pig sino-atrial node discharge.

    abstract：BACKGROUND:The diastolic oscillatory after-potential Vos and pre-potential ThVos play an essential role in the pacemaker mechanism of sino-atrial node (SAN). The aim of this study was to investigate whether these oscillatory potentials are also involved in adrenergic control of SAN discharge. METHODS:Vos and ThVos wer...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/1423-0127-16-101

    authors： Vassalle M,Catanzaro JN,Nett MP,Rota M

    更新日期：2009-11-18 00:00:00

  • GABA-B receptor activation in the rat globus pallidus potently suppresses pentylenetetrazol-induced tonic seizures.

    abstract：:To determine the involvement of the globus pallidus in mediating epilepsy, the effects of microinjection of a GABA uptake blocker (tiagabine), a benzodiazepine agonist (zolpidem) and a GABA-B receptor agonist (baclofen) on pentylenetetrazol (PTZ)-induced tonic seizure were examined in adult rats. Administration of PTZ...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/BF02256094

    authors： Chen L,Chan YS,Yung WH

    更新日期：2004-07-01 00:00:00

  • Tumor-associated macrophages: an accomplice in solid tumor progression.

    abstract：:In many solid tumor types, tumor-associated macrophages (TAMs) are important components of the tumor microenvironment (TME). Moreover, TAMs infiltration is strongly associated with poor survival in solid tumor patients. In this review, we describe the origins of TAMs and their polarization state dictated by the TME. W...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章,评审

    doi：10.1186/s12929-019-0568-z

    authors： Chen Y,Song Y,Du W,Gong L,Chang H,Zou Z

    更新日期：2019-10-20 00:00:00

  • Gastroprotective effect of leptin in indomethacin-induced gastric injury.

    abstract：:This study investigated the involvement of neutrophil infiltration, disturbances in nitric oxide (NO) generation and oxidative stress in indomethacin-induced gastric ulcer, and the possible gastroprotective potentials of leptin, known for its angiogenic effect. Male Wistar albino rats (180-220 g) were allocated into a...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/s11373-007-9227-6

    authors： Motawi TK,Abd Elgawad HM,Shahin NN

    更新日期：2008-05-01 00:00:00

  • Supranodose vagotomy precludes reflex respiratory responses to serotonin in cats.

    abstract：:Mediation of the respiratory reflex effects of an exogenous serotonin challenge goes beyond the lung vagi and is suggested to involve the nodose ganglia. In the present experiments the effects of an intravenous serotonin challenge on breathing pattern were studied in 8 pentobarbitone-chloralose anaesthetised cats. Bol...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/BF02256323

    authors： Kopczyńska B,Szereda-Przestaszewska M

    更新日期：2003-11-01 00:00:00

  • Telomerase prevents accelerated senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts.

    abstract：:Fibroblasts derived from glucose-6-phosphate dehydrogenase (G6PD)-deficient patients display retarded growth and accelerated cellular senescence that is attributable to increased accumulation of oxidative DNA damage and increased sensitivity to oxidant-induced senescence, but not to accelerated telomere attrition. Her...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/1423-0127-16-18

    authors： Wu YH,Cheng ML,Ho HY,Chiu DT,Wang TC

    更新日期：2009-02-05 00:00:00

  • Identification of okadaic-acid-induced genes by mRNA differential display in glioma cells.

    abstract：:To identify novel genes associated with apoptosis in glioma cells, we treated T98G glioma cells with okadaic acid (OA). Differential display using 15 random primers was performed on RNA extracted from these cells. Upregulated bands were excised from polyacrylamide gels and cloned. Northern blots were used to confirm R...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/BF02256622

    authors： Chin LS,Singh SK,Wang Q,Murray SF

    更新日期：2000-03-01 00:00:00