当前位置： SCI文献检索 > JOURNAL OF BIOMEDICAL SCIENCE期刊下所有文献 > GABA-B receptor activation in the rat globus pallidus potently suppresses pentylenetetrazol-induced tonic seizures.

GABA-B receptor activation in the rat globus pallidus potently suppresses pentylenetetrazol-induced tonic seizures.

Abstract：

:To determine the involvement of the globus pallidus in mediating epilepsy, the effects of microinjection of a GABA uptake blocker (tiagabine), a benzodiazepine agonist (zolpidem) and a GABA-B receptor agonist (baclofen) on pentylenetetrazol (PTZ)-induced tonic seizure were examined in adult rats. Administration of PTZ induced tonic seizures in all control animals, accompanied with a 100% mortality rate. Pretreatment with bilateral intrapallidal microinjection of tiagabine (1 mM) suppressed the incidence of tonic seizures to 67.7% and reduced the mortality rate to 16.7%. Furthermore, the latency to tonic seizures was 1,275 +/- 277 s, which was significantly longer than that of the corresponding control animals (319 +/- 225 s). On the other hand, administration of zolpidem (1 mM) was without significant effects on the mortality rate, the incidence and latency of the tonic seizure. In sharp contrast, microinjection of baclofen (1 mM) completely suppressed PTZ-induced tonic seizures and reduced the mortality rate to 0%. This effect was largely abolished by co-injection of the GABA-B receptor antagonist CGP55845. To elucidate the direct cellular action of baclofen, the excitability and membrane potential of globus pallidus neurons were studied by cell-attached and whole-cell patch-clamp recordings in the brain slice. Bath application of baclofen (50 microM) significantly reduced the firing of these neurons, and was often accompanied by a clear membrane hyperpolarization, in a CGP55845-sensitive manner. These data suggest that activation of GABA-B receptors in globus pallidus could significantly modulate PTZ-induced tonic seizures.

journal_name

J Biomed Sci

journal_title

Journal of biomedical science

authors

Chen L,Chan YS,Yung WH

doi

10.1007/BF02256094

keywords:

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

457-64

issue

4

eissn

1021-7770

issn

1423-0127

pii

77895

journal_volume

11

pub_type

杂志文章

相关文献

JOURNAL OF BIOMEDICAL SCIENCE文献大全
  • In vitro and in vivo targeted delivery of IL-10 interfering RNA by JC virus-like particles.

    abstract：BACKGROUND:RNA interference (RNAi) is a powerful tool to silence gene expression post-transcriptionally. Delivering sequences of RNAi in vivo remains a problem. The aim of this study was to use JC virus (JCV) virus-like particles (VLPs) as a vector for delivering RNAi in silencing the cytokine gene of IL-10. METHODS:J...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/1423-0127-17-51

    authors： Chou MI,Hsieh YF,Wang M,Chang JT,Chang D,Zouali M,Tsay GJ

    更新日期：2010-06-24 00:00:00

  • Genetic variant in CXCL12 gene raises susceptibility to HPV infection and squamous intraepithelial lesions development: a case-control study.

    abstract：BACKGROUND:Human papillomavirus (HPV) is the most common sexually transmitted virus in women worldwide. The persistence of the virus may cause warts that are considered benign lesions and low or high grade intraepithelial lesions (LSIL/HSIL). Immunological system plays an important role in the resolution of infections....

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/s12929-018-0472-y

    authors： Okuyama NCM,Cezar-Dos-Santos F,Pereira ÉR,Trugilo KP,Cebinelli GCM,Sena MM,Pereira APL,Aranome AMF,Mangieri LFL,Ferreira RS,Watanabe MAE,de Oliveira KB

    更新日期：2018-09-18 00:00:00

  • Antioxidants attenuate diabetes-induced activation of peroxisomal functions in the rat kidney.

    abstract：:Diabetes is a multifactorial disease that has now been recognized to involve overproduction of reactive oxygen species and pro-inflammatory cytokines. Peroxisomes are subcellular organelles with several important metabolic functions, and their role in the regulation of cellular oxidative stress is now well established...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1159/000079667

    authors： Dhaunsi GS,Bitar MS

    更新日期：2004-09-01 00:00:00

  • Generation of HIV-1/HIV-2 cross-reactive peptide antisera by small sequence changes in HIV-1 reverse transcriptase and integrase immunizing peptides.

    abstract：:We have generated peptide antisera against selected regions in HIV-1 and HIV-2 reverse transcriptase (RT) and integrase (IN) to investigate the specificity of determinants governing the immune response. Peptides representing homologous regions (>50%) in the N- and C-termini and central portions of these proteins were ...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/BF02253469

    authors： Klutch M,Woerner AM,Marcus-Sekura CJ,Levin JG

    更新日期：1998-01-01 00:00:00

  • Dopamine and alcohol relapse: D1 and D2 antagonists increase relapse rates in animal studies and in clinical trials.

    abstract：:A considerable number of animal studies on the effects of dopaminergic agents on alcohol intake behavior have been performed. Acute alcohol administration in rats induces dopamine release in the caudate nucleus and in the nucleus accumbens, an effect related among others to reinforcement. It has been repeatedly sugges...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章,评审

    doi：10.1007/BF02255975

    authors： Walter H,Ramskogler K,Semler B,Lesch OM,Platz W

    更新日期：2001-01-01 00:00:00

  • Expression of a truncated retroviral envelope gene enhances expression of normal cellular phenotypes.

    abstract：:The envelope gene of Moloney murine leukemia virus (Mo-MLV) and its various functional domains have been studied extensively but not as much in terms of their biological effects on cell growth. In this study, we report the biological characterization of a truncated Mo-MLV envelope gene, LN11, which is devoid of a sign...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/BF02253367

    authors： Chen H,Chung SW,Wong PM

    更新日期：2000-11-01 00:00:00

  • Down-regulation of the polymeric immunoglobulin receptor in non-small cell lung carcinoma: correlation with dysregulated expression of the transcription factors USF and AP2.

    abstract：:The polymeric immunoglobulin receptor (PIGR) mediates transport of IgA and IgM antibodies across mucosal and glandular epithelia. Several studies have utilized immunohistochemistry to demonstrate that PIGR expression varies in different types of lung carcinoma, and is down-regulated during tumor progression. We have p...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/s11373-004-8185-5

    authors： Khattar NH,Lele SM,Kaetzel CS

    更新日期：2005-01-01 00:00:00

  • Deterioration of traditional dietary custom increases the risk of lifestyle-related diseases in young male Africans.

    abstract：BACKGROUND:Prevalence of metabolic syndrome (MS) is rapidly increasing worldwide. To investigate the spread of MS risks and its relationship with eating habits including fish intake, we carried out a health examination for young and middle-aged men. METHODS:The subjects were 97 healthy men (20 to 50 years) living in M...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/1423-0127-17-S1-S34

    authors： Hamada A,Mori M,Mori H,Muhihi A,Njelekela M,Masesa Z,Mtabaji J,Yamori Y

    更新日期：2010-08-24 00:00:00

  • Potassium Channel Blockers Inhibit Adoptive Transfer of Experimental Allergic Encephalomyelitis by Myelin-Basic-Protein-Stimulated Rat T Lymphocytes.

    abstract：:Agents which block T cell K(+) currents can prohibit both proliferative and effector cell functions in T cells activated by mitogens or phorbol esters. This study examined the effects of some of these blocking agents on the immune responsiveness of guinea pig myelin basic protein (GPMBP)-reactive Lewis rat T lymphocyt...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/BF02255646

    authors： Judge SI,Yeh JZ,Mannie MD,Pope Seifert L,Paterson PY

    更新日期：1997-07-01 00:00:00

  • Antiviral activity of an N-allyl acridone against dengue virus.

    abstract：BACKGROUND:Dengue virus (DENV), a member of the family Flaviviridae, is at present the most widespread causative agent of a human viral disease transmitted by mosquitoes. Despite the increasing incidence of this pathogen, there are no antiviral drugs or vaccines currently available for treatment or prevention. In a pre...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/s12929-015-0134-2

    authors： Mazzucco MB,Talarico LB,Vatansever S,Carro AC,Fascio ML,D'Accorso NB,García CC,Damonte EB

    更新日期：2015-04-17 00:00:00

  • Nitrogen-containing bisphosphonates inhibit RANKL- and M-CSF-induced osteoclast formation through the inhibition of ERK1/2 and Akt activation.

    abstract：BACKGROUND:Bisphosphonates are an important class of antiresorptive drugs used in the treatment of metabolic bone diseases. Recent studies have shown that nitrogen-containing bisphosphonates induced apoptosis in rabbit osteoclasts and prevented prenylated small GTPase. However, whether bisphosphonates inhibit osteoclas...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/1423-0127-21-10

    authors： Tsubaki M,Komai M,Itoh T,Imano M,Sakamoto K,Shimaoka H,Takeda T,Ogawa N,Mashimo K,Fujiwara D,Mukai J,Sakaguchi K,Satou T,Nishida S

    更新日期：2014-02-03 00:00:00

  • Different pathways leading to activation of extracellular signal-regulated kinase and p38 MAP kinase by formyl-methionyl-leucyl-phenylalanine or platelet activating factor in human neutrophils.

    abstract：:The signaling pathways leading to extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) activation by N-formyl-Met-Leu-Phe (fMLP) or platelet activating factor (PAF) in human neutrophils were examined. Previously, we found that changes of intracellular Ca2+ ([Ca2+]i) stimulated by...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/s11373-005-1704-1

    authors： Chen LW,Lin MW,Hsu CM

    更新日期：2005-01-01 00:00:00

  • Apolipoprotein E Genotyping in Turkish Myocardial Infarction Survivors and Healthy Controls.

    abstract：:The apolipoprotein (Apo) E gene is known to be polymorphic. Three common alleles determine six phenotypes which can easily be detected by restriction fragment length polymorphism. We performed apo E genotyping in myocardial infarction survivors and healthy controls for the first time in the Turkish population. DNA was...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/BF02257924

    authors： Hergenc G,Taga Y,Emerk K,Cirakoglu B

    更新日期：1995-01-01 00:00:00

  • Rab-mediated vesicle trafficking in cancer.

    abstract：:A large group of small Rab GTPases which mediate secretory and endosomal membrane transport, as well as autophagosome biogenesis, are essential components of vesicle trafficking machinery. Specific Rab protein together with the cognate effectors coordinates the dynamics of trafficking pathway and determines the cargo ...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章,评审

    doi：10.1186/s12929-016-0287-7

    authors： Tzeng HT,Wang YC

    更新日期：2016-10-06 00:00:00

  • Induction of Fas and Fas-ligand expression in plasmacytoma cells by a cytotoxic factor secreted by murine macrophages.

    abstract：:Induction of tumoricidal activity is one of the major functions of activated macrophages. Our previous study demonstrated that P388D1 murine macrophage-like cells secreted a plasmacytoma cytotoxic factor (PCF) that selectively killed certain tumor cell lines including MOPC-315 plasmacytoma in vitro. Our subsequent stu...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/BF02255919

    authors： Chu CY,Tseng J

    更新日期：2000-01-01 00:00:00

  • Gene deletion patterns in spinal muscular atrophy patients with different clinical phenotypes.

    abstract：:Spinal muscular atrophy (SMA) is an autosomal recessive disorder characterized by degeneration of lower motor neurons. We have assayed deletions in two candidate genes, the survival motor neuron (SMN) and neuronal apoptosis inhibitory protein (NAIP) genes, in 108 samples, of which 46 were from SMA patients, and 62 wer...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/BF02256412

    authors： Haider MZ,Moosa A,Dalal H,Habib Y,Reynold L

    更新日期：2001-03-01 00:00:00

  • Ubiquitination by HUWE1 in tumorigenesis and beyond.

    abstract：:Ubiquitination modulates a large repertoire of cellular functions and thus, dysregulation of the ubiquitin system results in multiple human diseases, including cancer. Ubiquitination requires an E3 ligase, which is responsible for substrate recognition and conferring specificity to ubiquitination. HUWE1 is a multiface...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章,评审

    doi：10.1186/s12929-018-0470-0

    authors： Kao SH,Wu HT,Wu KJ

    更新日期：2018-09-04 00:00:00

  • The tumor suppressor DAP-kinase links cell adhesion and cytoskeleton reorganization to cell death regulation.

    abstract：:Death-associated protein (DAP)-kinase, an actin-cytoskeleton localized serine/threonine kinase, functions as a novel tumor suppressor and participates in a wide variety of cell death systems. Recent studies indicate that DAP-kinase elicits a potent cytoskeletal reorganization effect and is capable of modulating integr...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章,评审

    doi：10.1007/s11373-005-9063-5

    authors： Chen RH,Wang WJ,Kuo JC

    更新日期：2006-03-01 00:00:00

  • DHEA attenuates catecholamine secretion from bovine adrenal chromaffin cells.

    abstract：:Dehydroepiandrosterone (DHEA) is a putative anti-stress agent and stress is associated with the secretion of catecholamine from the adrenal gland, but the effects of DHEA on catecholamine secretion are not fully understood. Using bovine chromaffin cells, we found that DHEA inhibited catecholamine secretion and cytosol...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/BF02256563

    authors： Liu PS,Wang PY

    更新日期：2004-03-01 00:00:00

  • Inhibition of histone acetylation by curcumin reduces alcohol-induced fetal cardiac apoptosis.

    abstract：BACKGROUND:Prenatal alcohol exposure may cause cardiac development defects, however, the underlying mechanisms are not yet clear. In the present study we have investigated the roles of histone modification by curcumin on alcohol induced fetal cardiac abnormalities during the development. METHODS AND RESULTS:Q-PCR and ...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/s12929-016-0310-z

    authors： Yan X,Pan B,Lv T,Liu L,Zhu J,Shen W,Huang X,Tian J

    更新日期：2017-01-05 00:00:00

  • Telomerase prevents accelerated senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts.

    abstract：:Fibroblasts derived from glucose-6-phosphate dehydrogenase (G6PD)-deficient patients display retarded growth and accelerated cellular senescence that is attributable to increased accumulation of oxidative DNA damage and increased sensitivity to oxidant-induced senescence, but not to accelerated telomere attrition. Her...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/1423-0127-16-18

    authors： Wu YH,Cheng ML,Ho HY,Chiu DT,Wang TC

    更新日期：2009-02-05 00:00:00

  • Activation of muscarinic receptors in porcine airway smooth muscle elicits a transient increase in phospholipase D activity.

    abstract：:Phospholipase D (PLD) is a phosphodiesterase that catalyses hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline. In the presence of ethanol, PLD also catalyses the formation of phosphatidylethanol, which is a unique characteristic of this enzyme. Muscarinic receptor-induced changes in the activi...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/BF02256440

    authors： Mamoon AM,Smith J,Baker RC,Farley JM

    更新日期：1999-03-01 00:00:00

  • Molecular oncology focus - is carcinogenesis a 'mitochondriopathy'?

    abstract：:Mitochondria are sub-cellular organelles that produce adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS). As suggested over 70 years ago by Otto Warburg and recently confirmed with molecular techniques, alterations in respiratory activity and in mitochondrial DNA (mtDNA) appear to be common featur...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章,评审

    doi：10.1186/1423-0127-17-31

    authors： Czarnecka AM,Czarnecki JS,Kukwa W,Cappello F,Scińska A,Kukwa A

    更新日期：2010-04-25 00:00:00

  • Exogenous nitric oxide inhibits IRS-1 expression in rat hepatocytes and skeletal myocytes.

    abstract：:Accumulative evidence has supported the role of nitric oxide (NO) in a variety of normal physiological functions as well as many pathological conditions. In this study, we examined the possible diabetogenicity of NO by measuring the expression of the insulin receptor substrate (IRS)-1 in rat hepatocytes and skeletal m...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/s11373-006-9073-y

    authors： Badal S,Brown PD,Ragoobirsingh D

    更新日期：2006-07-01 00:00:00

  • Shikonin selectively induces apoptosis in human prostate cancer cells through the endoplasmic reticulum stress and mitochondrial apoptotic pathway.

    abstract：BACKGROUND:Despite the recent progress in screening and therapy, a majority of prostate cancer cases eventually attain hormone refractory and chemo-resistant attributes. Conventional chemotherapeutic strategies are effective at very high doses for only palliative management of these prostate cancers. Therefore chemo-se...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/s12929-015-0127-1

    authors： Gara RK,Srivastava VK,Duggal S,Bagga JK,Bhatt M,Sanyal S,Mishra DP

    更新日期：2015-04-01 00:00:00

  • Long non-coding RNA Gas5 regulates proliferation and apoptosis in HCS-2/8 cells and growth plate chondrocytes by controlling FGF1 expression via miR-21 regulation.

    abstract：BACKGROUND:LncRNA Gas5 is known to be a key control element during growth, differentiation and development in mammalian species. However, the role and function of Gas5 in growth plate chondrocytes has not been determined. METHODS:The overexpression and knockdown models of Gas5 and miR-21 in cells and animals were cons...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/s12929-018-0424-6

    authors： Liu X,She Y,Wu H,Zhong D,Zhang J

    更新日期：2018-02-28 00:00:00

  • TGF-β induces HLA-G expression through inhibiting miR-152 in gastric cancer cells.

    abstract：BACKGROUND:Mounting evidences have showed the important role of transforming growth factor-β (TGF-β) in immunological surveillance of tumors. Some studies have also indicated human leukocyte antigen (HLA)-G-associated immune escape involving TGF-β management in gastric cancer (GC). However, the mechanism underlying it ...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/s12929-015-0177-4

    authors： Guan Z,Song B,Liu F,Sun D,Wang K,Qu H

    更新日期：2015-12-02 00:00:00

  • Short-term exposure to somatostatin or muscarinic agonists reduce acetylcholine-induced 3H-MPP+ release from bovine adrenal medullary cells.

    abstract：:The aim of this work was to investigate the effect of a short-term exposure to somatostatin (SS), its receptors (SSTR) selective agonists as well as muscarinic receptors agonists upon acetylcholine-induced release of (3)H-MPP(+ )from bovine adrenal medullary cells. Acetylcholine (ACH, 100, 500 microM) was found to inc...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/s11373-006-9144-0

    authors： Ribeiro L,Martel F,Azevedo I

    更新日期：2007-05-01 00:00:00

  • Reactive oxygen species-dependent mitochondrial dynamics and autophagy confer protective effects in retinal pigment epithelial cells against sodium iodate-induced cell death.

    abstract：BACKGROUND:Oxidative stress is a major factor in retinal pigment epithelium (RPE) cells injury that contributes to age-related macular degeneration (AMD). NaIO3 is an oxidative toxic agent and its selective RPE cell damage makes it as a reproducible model of AMD. Although NaIO3 is an oxidative stress inducer, the roles...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/s12929-019-0531-z

    authors： Chan CM,Huang DY,Sekar P,Hsu SH,Lin WW

    更新日期：2019-05-22 00:00:00

  • Effects of Angiotensin II on the Spontaneous Activity of Rostral Ventrolateral Medullary Cardiovascular Neurons and Blood Pressure in Spontaneously Hypertensive Rats.

    abstract：:The interactive role of rostral ventrolateral medulla (RVL) cardiovascular neurons and brain angiotensin II (Ang II) in regulating the arterial blood pressure was examined by recording simultaneously the spontaneous activity of these spinal projecting neurons and the arterial blood pressure in the pentobarbital-anesth...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/BF02253100

    authors： Chan RK,Chan YS,Wong TM

    更新日期：1996-05-01 00:00:00