Gene deletion patterns in spinal muscular atrophy patients with different clinical phenotypes.

abstract：BACKGROUND:Sensing tissue acidosis is an important function of the somatosensory nervous system to response to noxious stimuli. MAIN BODY:In the pain clinic, acid or soreness sensation is a characteristic sensory phenotype of various acute and chronic pain syndromes, such as delayed onset muscle soreness, fibromyalgia...

journal_title：Journal of biomedical science

authors： Lin JH,Hung CH,Han DS,Chen ST,Lee CH,Sun WZ,Chen CC

更新日期：2018-11-29 00:00:00

abstract：:Induction of tumoricidal activity is one of the major functions of activated macrophages. Our previous study demonstrated that P388D1 murine macrophage-like cells secreted a plasmacytoma cytotoxic factor (PCF) that selectively killed certain tumor cell lines including MOPC-315 plasmacytoma in vitro. Our subsequent stu...

journal_title：Journal of biomedical science

authors： Chu CY,Tseng J

更新日期：2000-01-01 00:00:00

abstract：:The progression and metastasis of solid tumors, including head and neck squamous cell carcinoma (HNSCC), have been related to the behavior of a small subpopulation of cancer stem cells. Here, we have established a highly malignant HNSCC cell line, SASVO3, from primary tumors using three sequential rounds of xenotransp...

journal_title：Journal of biomedical science

authors： Chen CY,Chiou SH,Huang CY,Jan CI,Lin SC,Tsai ML,Lo JF

更新日期：2009-11-16 00:00:00

abstract：:Angiogenesis is essential for development, growth and advancement of solid tumors. Cyclooxygenase (COX)-2 is recognized as an angiogenic factor in various tumors. This prompted us to study the clinical implications of COX-2 expression related to angiogenesis in uterine cervical cancers. There was a significant correla...

journal_title：Journal of biomedical science

authors： Fujimoto J,Toyoki H,Sato E,Sakaguchi H,Jahan I,Alam SM,Tamaya T

更新日期：2006-11-01 00:00:00

abstract：:The matrin 3 family of nuclear proteins consists of members with potentially diverse activities. Matrin 3 and NP220 share RNA-binding domains, and NP220 has been shown to recognize and bind to the DNA sequence, CCCCC (G/C). We have isolated and characterized another member of the matrin 3 family, designated NP94, from...

journal_title：Journal of biomedical science

authors： Warder DE,Keherly MJ

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:Oxidative stress is a major factor in retinal pigment epithelium (RPE) cells injury that contributes to age-related macular degeneration (AMD). NaIO3 is an oxidative toxic agent and its selective RPE cell damage makes it as a reproducible model of AMD. Although NaIO3 is an oxidative stress inducer, the roles...

journal_title：Journal of biomedical science

authors： Chan CM,Huang DY,Sekar P,Hsu SH,Lin WW

更新日期：2019-05-22 00:00:00

abstract：:In this study, we examined the postnatal expression patterns of p63 and other keratinocyte stem cell markers in the rat cornea in an attempt to determine the markers that best represent characteristics of corneal keratinocyte stem cells. We show that the expression of p63 in the rat cornea is unique and differs from t...

journal_title：Journal of biomedical science

authors： Hsueh YJ,Wang DY,Cheng CC,Chen JK

更新日期：2004-09-01 00:00:00

abstract：:DNA vaccines have emerged as an attractive approach for generating antigen-specific immunotherapy. Strategies that enhance antigen presentation may potentially be used to enhance DNA vaccine potency. Previous experiments showed that chimeric DNA vaccines utilizing endoplasmic reticulum (ER) chaperone molecules, such a...

journal_title：Journal of biomedical science

authors： Lin CT,Chang TC,Chao A,Dzeng E,Soong YK,Hung CF,Lai CH

更新日期：2005-01-01 00:00:00

abstract：:The nucleotide sequences of the putative envelope region (E1) and the junction between the E1 and envelope 2/nonstructural 1 (E2/NS1) region of the hepatitis C virus (HCV) genome are divergent among different genotypes. To characterize them, we introduced a set of nested primers that are conserved among four different...

journal_title：Journal of biomedical science

authors： Kao JH,Chen PJ,Lai MY,Yang PM,Sheu JC,Wang TH,Chen DS

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND:Whether microgravity might influence tumour growth and carcinogenesis is still an open issue. It is not clear also if and how normal and transformed cells are differently solicited by microgravity. The present study was designed to verify this issue. METHODS:Two normal, LB and HSC93, and two transformed, Ju...

journal_title：Journal of biomedical science

authors： Cuccarolo P,Barbieri F,Sancandi M,Viaggi S,Degan P

更新日期：2010-07-28 00:00:00

abstract：BACKGROUND:Calcium oxalate (CaOx) is the major constituent of about 75% of all urinary stone and the secondary hyperoxaluria is a primary risk factor. Current treatment options for the patients with hyperoxaluria and CaOx stone diseases are limited. Oxalate degrading bacteria might have beneficial effects on urinary ox...

journal_title：Journal of biomedical science

authors： Sasikumar P,Gomathi S,Anbazhagan K,Abhishek A,Paul E,Vasudevan V,Sasikumar S,Selvam GS

更新日期：2014-08-30 00:00:00

abstract：BACKGROUND:Glioma stem-like cells (GSCs) are proposed to be responsible for high resistance in glioblastoma multiforme (GBM) treatment. In order to find new strategies aimed at reducing GSC stemness and improving GBM patient survival, we investigated the effects and mechanism of a histone deacetylases (HDACs) inhibitor...

journal_title：Journal of biomedical science

authors： Hsu CC,Chang WC,Hsu TI,Liu JJ,Yeh SH,Wang JY,Liou JP,Ko CY,Chang KY,Chuang JY

更新日期：2016-11-18 00:00:00

abstract：:Death-associated protein (DAP)-kinase, an actin-cytoskeleton localized serine/threonine kinase, functions as a novel tumor suppressor and participates in a wide variety of cell death systems. Recent studies indicate that DAP-kinase elicits a potent cytoskeletal reorganization effect and is capable of modulating integr...

journal_title：Journal of biomedical science

authors： Chen RH,Wang WJ,Kuo JC

更新日期：2006-03-01 00:00:00

abstract：:Influence of adjuvants i.e., alpha-tocopherol (25 mg/kg, p.o.) and piperine (10 mg/kg, p.o.) on therapeutic potential of chelator tiferron (300 mg/kg, i.p.) was evaluated to encounter toxicogenic events of beryllium exposure. Albino rats were exposed to beryllium nitrate (1 mg/kg, i.p.) daily for 28 days followed by t...

journal_title：Journal of biomedical science

authors： Nirala SK,Bhadauria M,Mathur R,Mathur A

更新日期：2007-05-01 00:00:00

abstract：:Human mesenchymal stem cells (hMSCs) are multipotent cells that can differentiate into various tissue types, including bone, cartilage, tendon, adipocytes, and marrow stroma, making them potentially useful for human cell and gene therapies. Our objective was to demonstrate the utility of glass needle-mediated microinj...

journal_title：Journal of biomedical science

authors： Tsulaia TV,Prokopishyn NL,Yao A,Carsrud ND,Carou MC,Brown DB,Davis BR,Yannariello-Brown J

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:To mimic systemic inflammation in humans, different animal models have been developed. Since these models are still discussed controversially, we aimed to comparatively evaluate the most widely used models with respect to the systemic effects, the influence on organ functions and to the underlying pathophysi...

journal_title：Journal of biomedical science

authors： Seemann S,Zohles F,Lupp A

更新日期：2017-08-24 00:00:00

abstract：BACKGROUND:Mounting evidences have showed the important role of transforming growth factor-β (TGF-β) in immunological surveillance of tumors. Some studies have also indicated human leukocyte antigen (HLA)-G-associated immune escape involving TGF-β management in gastric cancer (GC). However, the mechanism underlying it ...

journal_title：Journal of biomedical science

authors： Guan Z,Song B,Liu F,Sun D,Wang K,Qu H

更新日期：2015-12-02 00:00:00

abstract：:Adeno-associated virus (AAV) vectors were shown capable of high efficiency transduction of both dividing and nondividing cells and tissues. AAV-mediated transduction leads to stable, long-term transgene expression in the absence of apparent immune response. These properties and the broad host range of AAV vectors indi...

journal_title：Journal of biomedical science

authors： Tal J

更新日期：2000-07-01 00:00:00

abstract：:Protein kinases play pivotal roles in the development of the nervous system. They are involved in almost every stage of neuronal development, from initial proliferation and differentiation of progenitor cells to pathfinding of neurites and formation of synapses. Activation of protein kinases is also critical for neuro...

journal_title：Journal of biomedical science

authors： Lin SD,Fann MJ

更新日期：1998-01-01 00:00:00

abstract：:The signaling pathways leading to extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) activation by N-formyl-Met-Leu-Phe (fMLP) or platelet activating factor (PAF) in human neutrophils were examined. Previously, we found that changes of intracellular Ca2+ ([Ca2+]i) stimulated by...

journal_title：Journal of biomedical science

authors： Chen LW,Lin MW,Hsu CM

更新日期：2005-01-01 00:00:00

abstract：:The Peutz-Jeghers syndrome (PJS) is a hereditary disorder that predisposes an individual to benign and malignant tumors in multiple organ systems. Recently, the locus responsible for PJS was mapped genetically to the LKB1 gene, with a subsequent investigation proving that it is responsible for most cases of PJS. LKB1 ...

journal_title：Journal of biomedical science

authors： Liu WK,Chien CY,Chou CK,Su JY

更新日期：2003-03-01 00:00:00

abstract：:Our goal was to develop a system to study proteins that associate in vivo with the Moloney murine leukemia virus (M-MuLV) enhancer elements by the isolation of intact proviral chromatin. The M-MuLV long terminal repeats (LTRs) contain tandemly repeated transcriptional enhancer sequences consisting of smaller motifs th...

journal_title：Journal of biomedical science

authors： Granger SW,Fan H

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Cell adhesion has been shown to induce activation of certain growth factor receptors in a ligand-independent manner. However, the mechanism for such activation remains obscure. METHODS:Human epidermal carcinoma A431 cells were used as a model to examine the mechanism for adhesion-induced activation of hepat...

journal_title：Journal of biomedical science

authors： Lu YC,Chen HC

更新日期：2011-10-27 00:00:00

abstract：BACKGROUND:Lipopolysaccharide (LPS) is recognized as the most potent microbial mediator presaging the threat of invasion of Gram-negative bacteria that implicated in the pathogenesis of sepsis and septic shock. This study was designed to examine the microRNA (miRNA) expression in whole blood from mice injected with int...

journal_title：Journal of biomedical science

authors： Hsieh CH,Rau CS,Jeng JC,Chen YC,Lu TH,Wu CJ,Wu YC,Tzeng SL,Yang JC

更新日期：2012-07-31 00:00:00

abstract：:The apolipoprotein (Apo) E gene is known to be polymorphic. Three common alleles determine six phenotypes which can easily be detected by restriction fragment length polymorphism. We performed apo E genotyping in myocardial infarction survivors and healthy controls for the first time in the Turkish population. DNA was...

journal_title：Journal of biomedical science

authors： Hergenc G,Taga Y,Emerk K,Cirakoglu B

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:The apolipoprotein E4 (apoE4) genotype is a major risk factor for developing late-onset Alzheimer's disease (AD). Inheritance of apoE4 is also associated with impairments in olfactory function in early stages of AD. In this project we examined the effects of the three common isoforms of human apoE (apoE2, ap...

journal_title：Journal of biomedical science

authors： Hussain A,Luong M,Pooley A,Nathan BP

更新日期：2013-07-12 00:00:00

abstract：:Extracellular vesicles (EVs) are cell-derived membrane-bound vesicles that serve a means of cell-cell communication. Studying EVs at a single-particle level is important because EVs are inherently heterogeneous. Novel micro- and nanotechnological tools have open opportunities for realizing single-EV measurements explo...

journal_title：Journal of biomedical science

authors： Chiang CY,Chen C

更新日期：2019-01-15 00:00:00

abstract：:The HIV pol sequentially encodes protease (PR), reverse transcriptase (RT), and integrase (IN) from the 5'-3' direction. We explored the significance of this gene arrangement. All six possible gene dispositions were examined. In two situations where PR was removed from the leading place and no two genes were in their ...

journal_title：Journal of biomedical science

authors： Chang YY,Yu SL,Syu WJ

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Epigallocatechin-3-gallate (EGCg) with its potent anti-oxidative capabilities is known for its beneficial effects ameliorating oxidative injury to cardiac cells. Although studies have provided convincing evidence to support the cardioprotective effects of EGCg, it remains unclear whether EGCg affect trans-me...

journal_title：Journal of biomedical science

authors： Hsieh SR,Hsu CS,Lu CH,Chen WC,Chiu CH,Liou YM

更新日期：2013-11-19 00:00:00

abstract：BACKGROUND:The association between ischemic stroke and 2 single nucleotide polymorphisms (SNPs) on chromosome 12p13, rs12425791 and rs11833579 appears inconsistent across different samples. These SNPs are close to the ninjurin2 gene which may alter the risk of stroke by affecting brain response to ischemic injury. The ...

journal_title：Journal of biomedical science

authors： Hsieh YC,Seshadri S,Chung WT,Hsieh FI,Hsu YH,Lin HJ,Tseng HP,Lien LM,Bai CH,Hu CJ,Jeng JS,Tang SC,Chen CI,Yu CC,Chiou HY,Formosa Stroke Genetic Consortium (FSGC).

更新日期：2012-01-03 00:00:00