Ubiquitination by HUWE1 in tumorigenesis and beyond.

abstract：BACKGROUND:Poly(ADP-ribose) is a NAD+-requiring, DNA-repairing, enzyme playing a central role in pancreatic beta-cell death and in the development of endothelial dysfunction in humans and experimental animals. PARP activation is also relevant to the development of complications of diabetes. Hence, agents capable of inh...

journal_title：Journal of biomedical science

authors： Pandya KG,Patel MR,Lau-Cam CA

更新日期：2010-08-24 00:00:00

abstract：:Mediation of the respiratory reflex effects of an exogenous serotonin challenge goes beyond the lung vagi and is suggested to involve the nodose ganglia. In the present experiments the effects of an intravenous serotonin challenge on breathing pattern were studied in 8 pentobarbitone-chloralose anaesthetised cats. Bol...

journal_title：Journal of biomedical science

authors： Kopczyńska B,Szereda-Przestaszewska M

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Human papillomavirus (HPV) is the most common sexually transmitted virus in women worldwide. The persistence of the virus may cause warts that are considered benign lesions and low or high grade intraepithelial lesions (LSIL/HSIL). Immunological system plays an important role in the resolution of infections....

journal_title：Journal of biomedical science

authors： Okuyama NCM,Cezar-Dos-Santos F,Pereira ÉR,Trugilo KP,Cebinelli GCM,Sena MM,Pereira APL,Aranome AMF,Mangieri LFL,Ferreira RS,Watanabe MAE,de Oliveira KB

更新日期：2018-09-18 00:00:00

abstract：BACKGROUND:Sensing tissue acidosis is an important function of the somatosensory nervous system to response to noxious stimuli. MAIN BODY:In the pain clinic, acid or soreness sensation is a characteristic sensory phenotype of various acute and chronic pain syndromes, such as delayed onset muscle soreness, fibromyalgia...

journal_title：Journal of biomedical science

authors： Lin JH,Hung CH,Han DS,Chen ST,Lee CH,Sun WZ,Chen CC

更新日期：2018-11-29 00:00:00

abstract：BACKGROUND:Dengue virus (DENV), a member of the family Flaviviridae, is at present the most widespread causative agent of a human viral disease transmitted by mosquitoes. Despite the increasing incidence of this pathogen, there are no antiviral drugs or vaccines currently available for treatment or prevention. In a pre...

journal_title：Journal of biomedical science

authors： Mazzucco MB,Talarico LB,Vatansever S,Carro AC,Fascio ML,D'Accorso NB,García CC,Damonte EB

更新日期：2015-04-17 00:00:00

abstract：:The isoprostanes (IsoPs) are a unique series of prostaglandin-like compounds formed in vivo from the free radical-catalyzed peroxidation of arachidonic acid. This review summarizes our current knowledge regarding these compounds. Novel aspects of the biochemistry and bioactivity of IsoPs are detailed and methods by wh...

journal_title：Journal of biomedical science

authors： Liu T,Stern A,Roberts LJ,Morrow JD

更新日期：1999-07-01 00:00:00

abstract：:Adeno-associated virus (AAV) vectors were shown capable of high efficiency transduction of both dividing and nondividing cells and tissues. AAV-mediated transduction leads to stable, long-term transgene expression in the absence of apparent immune response. These properties and the broad host range of AAV vectors indi...

journal_title：Journal of biomedical science

authors： Tal J

更新日期：2000-07-01 00:00:00

abstract：:The CDC4 gene of Saccharomyces cerevisiae encodes an essential function that is required for G1-S and G2-M transitions during mitosis and at various stages during meiosis. We have isolated a functional homologue of CDC4 (CaCDC4) from the pathogenic yeast Candida albicans by complementing the S. cerevisiae cdc4-3 mutat...

journal_title：Journal of biomedical science

authors： Shieh JC,White A,Cheng YC,Rosamond J

更新日期：2005-12-01 00:00:00

abstract：:Although hypercholesterolemia is a well-known risk factor for atherosclerosis, little is known about the effect of hypercholesterolemia on cardiac contractile function. The objective of this study was to examine the effect of hypercholesterolemia on myocardial contractility. Fifteen New Zealand white rabbits were fed ...

journal_title：Journal of biomedical science

authors： Luo TY,Su MJ,Yang YF,Liu YB,Liang HC,Wu CC,Lee YT

更新日期：2004-11-01 00:00:00

abstract：:Adeno-associated virus (AAV)-2 was developed as a useful vector for human gene therapy. In this report, we analyzed the integration and expression of AAV-mediated ex vivo transferred human beta-globin gene in bone marrow (BM) reconstituted mice. Recombinant AAV (rAAV) containing human beta-globin gene was packaged by ...

journal_title：Journal of biomedical science

authors： Dong WJ,Wu XB,Liu DP,Li JL,Liu G,Zu ZX,Zhao N,Hou YD,Liang CC

更新日期：2002-05-01 00:00:00

abstract：:The signaling pathways leading to extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) activation by N-formyl-Met-Leu-Phe (fMLP) or platelet activating factor (PAF) in human neutrophils were examined. Previously, we found that changes of intracellular Ca2+ ([Ca2+]i) stimulated by...

journal_title：Journal of biomedical science

authors： Chen LW,Lin MW,Hsu CM

更新日期：2005-01-01 00:00:00

abstract：:The intracellular mechanisms underlying oxidized low-density lipoprotein (oxLDL)-signaling pathways in platelets are not yet completely understood. Therefore, the aim of this study was to further examine the effects of oxLDL in prevention of platelet aggregation. In this study, oxLDL concentration-dependently (40-120 ...

journal_title：Journal of biomedical science

authors： Chou DS,Chan CH,Hsiao G,Shen MY,Tsai YJ,Chen TF,Sheu JR

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:B cells play an essential role during dengue viral infection. While a major expansion of antibody secreting cells (ASCs) was observed, the importance of these increased frequencies of ASCs remains unclear. The alteration of B cell subsets may result from the expression of tissue specific homing molecules lea...

journal_title：Journal of biomedical science

authors： Pattanapanyasat K,Khowawisetsut L,Chuansumrit A,Chokephaibulkit K,Tangnararatchakit K,Apiwattanakul N,Techasaensiri C,Thitilertdecha P,Sae-Ung T,Onlamoon N

更新日期：2018-08-27 00:00:00

abstract：BACKGROUND:The conserved Notch signaling pathway regulates cell fate decisions and maintains stem cells in multicellular organisms. Up-regulation of Notch signaling is observed in several types of cancer and is causally involved in proliferation and survival of cancer cells. Thus, it is of great interest to look for an...

journal_title：Journal of biomedical science

authors： Pi H,Huang YC,Chen IC,Lin CD,Yeh HF,Pai LM

更新日期：2011-06-17 00:00:00

abstract：:The ARFP/F protein is synthesized from the +1 reading frame of the hepatitis C virus (HCV) core protein gene. The function of this protein remains unknown. To study the function of the HCV ARFP/F protein, we have conducted the yeast two-hybrid screening experiment to identify cellular proteins that may interact with t...

journal_title：Journal of biomedical science

authors： Ma HC,Lin TW,Li H,Iguchi-Ariga SM,Ariga H,Chuang YL,Ou JH,Lo SY

更新日期：2008-07-01 00:00:00

abstract：:Maternal exposure to dietary factors during pregnancy can influence embryonic development and may modulate the phenotype of offspring through epigenetic programming. Folate is critical for nucleotide synthesis, and preconceptional intake of dietary folic acid (FA) is credited with reduced incidences of neural tube def...

journal_title：Journal of biomedical science

authors： Barua S,Kuizon S,Junaid MA

更新日期：2014-08-19 00:00:00

abstract：:Myostatin, a member of the TGF-beta superfamily, is a potent negative regulator of skeletal muscle and growth. Previously, we reported Mstn1 from zebrafish and studied its influence on muscle development. In this study, we identified another form of Myostatin protein which is referred to as Mstn2. The size of Mstn2 cD...

journal_title：Journal of biomedical science

authors： Amali AA,Lin CJ,Chen YH,Wang WL,Gong HY,Rekha RD,Lu JK,Chen TT,Wu JL

更新日期：2008-09-01 00:00:00

abstract：:The HIV pol sequentially encodes protease (PR), reverse transcriptase (RT), and integrase (IN) from the 5'-3' direction. We explored the significance of this gene arrangement. All six possible gene dispositions were examined. In two situations where PR was removed from the leading place and no two genes were in their ...

journal_title：Journal of biomedical science

authors： Chang YY,Yu SL,Syu WJ

更新日期：1999-09-01 00:00:00

abstract：BACKGROUNDS:Homozygous 32-bp deletion of the chemokine receptor 5 gene (CCR5) is associated with resistance to human immunodeficiency virus (HIV) infection, while heterozygosity delays HIV progression. Bone marrow transplantation (BMT) from a 32/32 donor has been shown to cure an HIV-infected patient. However, the rari...

journal_title：Journal of biomedical science

authors： Manotham K,Chattong S,Setpakdee A

更新日期：2015-03-26 00:00:00

abstract：:Retrograde transport of Wheat germ agglutinin conjugated to Horseradish peroxidase (WGA-HRP) was used in labeling vagal neurons projecting to the stomach from the dorsal motor nucleus of the vagus nerve (DMNV) in Streptozotocin (STZ)-induced diabetic rats. Diabetes was induced in the experimental rats by intraperitone...

journal_title：Journal of biomedical science

authors： Odekunle A

更新日期：2006-09-01 00:00:00

abstract：:Extracellular vesicles (EVs) are cell-derived membrane-bound vesicles that serve a means of cell-cell communication. Studying EVs at a single-particle level is important because EVs are inherently heterogeneous. Novel micro- and nanotechnological tools have open opportunities for realizing single-EV measurements explo...

journal_title：Journal of biomedical science

authors： Chiang CY,Chen C

更新日期：2019-01-15 00:00:00

abstract：:Plasma nitric oxide (NO) levels in Duchenne muscular dystrophy (DMD) patients were significantly lower than those observed in both healthy controls and in patients with other neuromuscular disorders. The correlation between NO level and ejection fraction was significant (r = -0.384, p = 0.0391) in the DMD group. Disru...

journal_title：Journal of biomedical science

authors： Kasai T,Abeyama K,Hashiguchi T,Fukunaga H,Osame M,Maruyama I

更新日期：2004-07-01 00:00:00

abstract：:In many solid tumor types, tumor-associated macrophages (TAMs) are important components of the tumor microenvironment (TME). Moreover, TAMs infiltration is strongly associated with poor survival in solid tumor patients. In this review, we describe the origins of TAMs and their polarization state dictated by the TME. W...

journal_title：Journal of biomedical science

authors： Chen Y,Song Y,Du W,Gong L,Chang H,Zou Z

更新日期：2019-10-20 00:00:00

abstract：BACKGROUND:The enzyme-prodrug system is considered a promising tool for tumor treatment when conjugated with a targeting molecule. The asparagine-glycine-arginine (NGR) motif is a developing and interesting targeting peptide that could specifically bind to aminopeptidase N (APN), which is an NGR receptor expressed on t...

journal_title：Journal of biomedical science

authors： Li JJ,Chang SF,Liau II,Chan PC,Liu RS,Yen SH,Wang HE,Chang CA

更新日期：2016-01-22 00:00:00

abstract：:We studied 42 individuals, including 8 patients with either complete or partial syndrome of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS), 8 patients with either complete or partial syndrome of myoclonic epilepsy with ragged-red fibers (MERRF) and 26 maternal family members w...

journal_title：Journal of biomedical science

authors： Huang CC,Kuo HC,Chu CC,Liou CW,Ma YS,Wei YH

更新日期：2002-01-01 00:00:00

abstract：:Two Chinese hamster ovary (CHO) cell lines stably transfected with human insulin receptor cDNA, CHO-wt and CHO-mut, which express an equivalent number of normal and kinase-defective human insulin receptors, respectively, were used to assess the roles of insulin receptor tyrosine kinase activity in insulin-regulated ge...

journal_title：Journal of biomedical science

authors： Lin SC,Chen MF,Chou CK

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:LncRNA Gas5 is known to be a key control element during growth, differentiation and development in mammalian species. However, the role and function of Gas5 in growth plate chondrocytes has not been determined. METHODS:The overexpression and knockdown models of Gas5 and miR-21 in cells and animals were cons...

journal_title：Journal of biomedical science

authors： Liu X,She Y,Wu H,Zhong D,Zhang J

更新日期：2018-02-28 00:00:00

abstract：BACKGROUND:Homeostasis of reactive oxygen species (ROS) in the skin is regulated by antioxidant defenses. The inflammatory states of skin diseases which range from acute rashes to chronic conditions are related to the level of ROS. The involvement of superoxide dismutase (SOD) in restoring the antioxidant capacity can ...

journal_title：Journal of biomedical science

authors： Liu TP,Chen YP,Chou CM,Chiu TT,Chen CT

更新日期：2016-01-20 00:00:00

abstract：:Spinal muscular atrophy (SMA) is an autosomal recessive disorder characterized by degeneration of lower motor neurons. We have assayed deletions in two candidate genes, the survival motor neuron (SMN) and neuronal apoptosis inhibitory protein (NAIP) genes, in 108 samples, of which 46 were from SMA patients, and 62 wer...

journal_title：Journal of biomedical science

authors： Haider MZ,Moosa A,Dalal H,Habib Y,Reynold L

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Bisphosphonates are an important class of antiresorptive drugs used in the treatment of metabolic bone diseases. Recent studies have shown that nitrogen-containing bisphosphonates induced apoptosis in rabbit osteoclasts and prevented prenylated small GTPase. However, whether bisphosphonates inhibit osteoclas...

journal_title：Journal of biomedical science

authors： Tsubaki M,Komai M,Itoh T,Imano M,Sakamoto K,Shimaoka H,Takeda T,Ogawa N,Mashimo K,Fujiwara D,Mukai J,Sakaguchi K,Satou T,Nishida S

更新日期：2014-02-03 00:00:00