当前位置： SCI文献检索 > JOURNAL OF BIOMEDICAL SCIENCE期刊下所有文献 > The potential role of pneumococcal conjugate vaccine in reducing acute respiratory inflammation in community-acquired pneumococcal pneumonia.

The potential role of pneumococcal conjugate vaccine in reducing acute respiratory inflammation in community-acquired pneumococcal pneumonia.

Abstract：

BACKGROUND:Pneumococcal conjugate vaccine (PCV) reduces both invasive pneumococcal disease (IPD) and other pneumococcal infections worldwide. We investigated the impact of stepwise implementation of childhood PCV programs on the prevalence of pneumococcal pneumonia, severity of acute inflammation, and associations between breakthrough pneumonia and pneumococcal serotypes in Taiwan. METHODS:In total, 983 children diagnosed with community-acquired pneumococcal pneumonia were enrolled between January 2010 and December 2015. RESULTS:Proportions of pneumococcal vaccinations increased each year in age-stratified groups with PCV7 (32.2%) as the majority, followed by PCV13 (12.2%). The proportion of pneumococcal pneumonia decreased each year in age-stratified groups, especially in 2-5 year group. Serotype 19A is the leading serotype either in vaccinated (6.4%) or unvaccinated patients (5.2%). In particular, vaccinated patients had significantly higher lowest WBC, lower neutrophils, lower lymphocytes and lower CRP values than non-vaccinated patients (p < 0.05). After stratifying patients by breakthrough infection, those with breakthrough pneumococcal infection with vaccine coverage serotypes had more severe pneumonia disease (p < 0.05). CONCLUSION:Systematic childhood pneumococcal vaccination reduced the prevalence of community-acquired pneumococcal pneumonia, especially in 2-5 year group. Serotype 19A was the major serotype for all vaccine types in patients with pneumococcal pneumonia and severity of acute inflammatory response was reduced in vaccinated patients.

journal_name

J Biomed Sci

journal_title

Journal of biomedical science

authors

Shen CF,Wang SM,Chi H,Huang YC,Huang LM,Huang YC,Lin HC,Ho YH,Hsiung CA,Liu CC,Taiwan Pediatric Infectious Disease Alliance.

doi

10.1186/s12929-020-00680-9

subject

Has Abstract

pub_date

2020-08-19 00:00:00

pages

88

issue

1

eissn

1021-7770

issn

1423-0127

pii

10.1186/s12929-020-00680-9

journal_volume

27

pub_type

杂志文章

相关文献

JOURNAL OF BIOMEDICAL SCIENCE文献大全
  • Cardiac glycosides induce resistance to tubulin-dependent anticancer drugs in androgen-independent human prostate cancer.

    abstract：:Due to high prevalence and mortality and the lack of effective therapies, prostate cancer is one of the most crucial health problems in men. Drug resistance aggravates the situation, not only in human prostate cancer but also in other cancers. In this study, we report for the first time that cardiac glycosides (e.g. o...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/BF02256539

    authors： Huang DM,Guh JH,Huang YT,Chueh SC,Wang HP,Teng CM

    更新日期：2002-09-01 00:00:00

  • The type VI adenylyl cyclase protects cardiomyocytes from β-adrenergic stress by a PKA/STAT3-dependent pathway.

    abstract：BACKGROUND:The type VI adenylyl cyclase (AC6) is a main contributor of cAMP production in the heart. The amino acid (aa) sequence of AC6 is highly homologous to that of another major cardiac adenylyl cyclase, AC5, except for its N-terminus (AC6-N, aa 1-86). Activation of AC6, rather than AC5, produces cardioprotective ...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/s12929-017-0367-3

    authors： Wu YS,Chen CC,Chien CL,Lai HL,Jiang ST,Chen YC,Lai LP,Hsiao WF,Chen WP,Chern Y

    更新日期：2017-09-04 00:00:00

  • CIP4 is required for the hypertrophic growth of neonatal cardiac myocytes.

    abstract：BACKGROUND:CIP4 is a scaffold protein that regulates membrane deformation and tubulation, organization of the actin cytoskeleton, endocytosis of growth factor receptors, and vesicle trafficking. Although expressed in the heart, CIP4 has not been studied with regards to its potential function in cardiac myocytes. RESUL...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/1423-0127-20-56

    authors： Rusconi F,Thakur H,Li J,Kapiloff MS

    更新日期：2013-08-03 00:00:00

  • Dextromethorphan prevents circulatory failure in rats with endotoxemia.

    abstract：:Dextromethorphan (DM), an antitussive agent, has been claimed to have anti-inflammatory and immunomodulatory effects in vitro. Thus, the aim of this study was to evaluate the effects of DM on sepsis induced by intravenous (i.v.) administration of lipopolysaccharide (LPS) in anesthetized Wistar rats and by intraperiton...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/BF02254358

    authors： Wang CC,Lee YM,Wei HP,Chu CC,Yen MH

    更新日期：2004-11-01 00:00:00

  • The nuclear envelopathies and human diseases.

    abstract：:The nuclear envelope (NE) consists of two membrane layers that segregate the nuclear from the cytoplasmic contents. Recent progress in our understanding of nuclear-lamina associated diseases has revealed intriguing connections between the envelope components and nuclear processes. Here, we review the functions of the ...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章,评审

    doi：10.1186/1423-0127-16-96

    authors： Chi YH,Chen ZJ,Jeang KT

    更新日期：2009-10-22 00:00:00

  • Hepatitis B virus X protein (HBx) enhances centrosomal P4.1-associated protein (CPAP) expression to promote hepatocarcinogenesis.

    abstract：BACKGROUND:Our previous report suggested that centrosomal P4.1-associated protein (CPAP) is required for Hepatitis B virus (HBV) encoded non-structure protein X (HBx)-mediated nuclear factor kappa light chain enhancer of activated B cells (NF-κB) activation. CPAP is overexpressed in HBV-associated hepatocellular carcin...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/s12929-019-0534-9

    authors： Yen CJ,Yang ST,Chen RY,Huang W,Chayama K,Lee MH,Yang SJ,Lai HS,Yen HY,Hsiao YW,Wang JM,Lin YJ,Hung LY

    更新日期：2019-06-06 00:00:00

  • Effects of Angiotensin II on the Spontaneous Activity of Rostral Ventrolateral Medullary Cardiovascular Neurons and Blood Pressure in Spontaneously Hypertensive Rats.

    abstract：:The interactive role of rostral ventrolateral medulla (RVL) cardiovascular neurons and brain angiotensin II (Ang II) in regulating the arterial blood pressure was examined by recording simultaneously the spontaneous activity of these spinal projecting neurons and the arterial blood pressure in the pentobarbital-anesth...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/BF02253100

    authors： Chan RK,Chan YS,Wong TM

    更新日期：1996-05-01 00:00:00

  • Effects of paclitaxel and doxorubicin in histocultures of hepatocelular carcinomas.

    abstract：:Cancer has been the leading cause of death in Taiwan over the past two decades and liver cancer is the leading cause of all cancer deaths in Taiwan with a trend of increase in incidence. Therapeutic options and efficacy for liver cancer have been limited and the 5-year survival rate is less than 7% in the Unite States...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/s11373-006-9141-3

    authors： Chuu JJ,Liu JM,Tsou MH,Huang CL,Chen CP,Wang HS,Chen CT

    更新日期：2007-03-01 00:00:00

  • Acute respiratory distress syndrome.

    abstract：:Acute respiratory distress syndrome (ARDS) can be associated with various disorders. Among these, coronavirus infection may cause life-threatening severe acute respiratory syndrome (SARS). In this review, we present animal models and techniques for the study of ARDS, and discuss the roles and possible mechanisms of va...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章,评审

    doi：10.1159/000073523

    authors： Chen HI,Kao SJ,Wang D,Lee RP,Su CF

    更新日期：2003-01-01 00:00:00

  • Human fallopian tube epithelial cells exhibit stemness features, self-renewal capacity, and Wnt-related organoid formation.

    abstract：BACKGROUND:Fallopian tube epithelial cells (FTEC) were thought to be the origin of high-grade serous ovarian carcinoma (HGSOC). Knowledge of the stemness or initiating characteristics of FTEC is insufficient. Previously, we have characterized the stemness cell marker of FTEC, this study aims to further characterize the...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/s12929-019-0602-1

    authors： Chang YH,Chu TY,Ding DC

    更新日期：2020-02-08 00:00:00

  • The action mode of the ribosome-inactivating protein alpha-sarcin.

    abstract：:Based on the tertiary structure of the ribosome-inactivating protein alpha-sarcin, domains that are responsible for hydrolyzing ribosomes and naked RNA have been dissected. In this study, we found that the head-to-tail interaction between the first amino beta-strand and the last carboxyl beta-strand is not involved in...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/BF02255817

    authors： Hwu L,Huang K,Chen D,Lin A

    更新日期：2000-09-01 00:00:00

  • CRISPR/Cas9: the Jedi against the dark empire of diseases.

    abstract：:Advances in Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated system (CRISPR/Cas9) has dramatically reshaped our ability to edit genomes. The scientific community is using CRISPR/Cas9 for various biotechnological and medical purposes. One of its most important uses is developing potential the...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章,评审

    doi：10.1186/s12929-018-0425-5

    authors： Khan S,Mahmood MS,Rahman SU,Zafar H,Habibullah S,Khan Z,Ahmad A

    更新日期：2018-03-28 00:00:00

  • Effects of phorbol myristate acetate and sivelestat on the lung injury caused by fat embolism in isolated lungs.

    abstract：BACKGROUND:Fat embolism syndrome (FES) associated with acute lung injury (ALI) is a clinical condition following long bone fracture. We have reported 14 victims due to ALI with FES. Our laboratory has developed an animal model that produced fat emboli (FE). The major purpose of this study was to test whether neutrophil...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/1423-0127-19-3

    authors： Lin CC,Liu PH,Kao SJ,Chen HI

    更新日期：2012-01-05 00:00:00

  • Comparative study of the binding characteristics to and inhibitory potencies towards PARP and in vivo antidiabetogenic potencies of taurine, 3-aminobenzamide and nicotinamide.

    abstract：BACKGROUND:Poly(ADP-ribose) is a NAD+-requiring, DNA-repairing, enzyme playing a central role in pancreatic beta-cell death and in the development of endothelial dysfunction in humans and experimental animals. PARP activation is also relevant to the development of complications of diabetes. Hence, agents capable of inh...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/1423-0127-17-S1-S16

    authors： Pandya KG,Patel MR,Lau-Cam CA

    更新日期：2010-08-24 00:00:00

  • Applications of next-generation sequencing analysis for the detection of hepatocellular carcinoma-associated hepatitis B virus mutations.

    abstract：BACKGROUND:Next-generation sequencing (NGS) is a powerful and high-throughput method for the detection of viral mutations. This article provides a brief overview about optimization of NGS analysis for hepatocellular carcinoma (HCC)-associated hepatitis B virus (HBV) mutations, and hepatocarcinogenesis of relevant mutat...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章,评审

    doi：10.1186/s12929-018-0442-4

    authors： Wu IC,Liu WC,Chang TT

    更新日期：2018-06-02 00:00:00

  • Skin Innervation and Its Effects on the Epidermis.

    abstract：:Sensory innervation of the skin subserves protective sensations for the body to prevent thermal and noxious injuries. Neurophysiologically, they belong to the categories of Adelta and C fibers, usually with caliber less than one micro m in diameter. Morphological demonstration of the terminals of these nerves in the e...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/BF02253428

    authors： Hsieh ST,Lin WM,Chiang HY,Huang IT,Ko MH,Chang YC,Chen WP

    更新日期：1997-01-01 00:00:00

  • Sympathetic-correlated c-Fos expression in the neonatal rat spinal cord in vitro.

    abstract：:An isolated thoracic spinal cord of the neonatal rat in vitro spontaneously generates sympathetic nerve discharge (SND) at ~25 degrees C, but it fails in SND genesis at < or = 10 degrees C. Basal levels of the c-Fos expression in the spinal cords incubated at < or = 10 degrees C and ~25 degrees C were compared to dete...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/1423-0127-16-44

    authors： Su CK,Ho CM,Kuo HH,Wen YC,Chai CY

    更新日期：2009-05-01 00:00:00

  • Downregulation of developmentally regulated endothelial cell locus-1 inhibits the growth of colon cancer.

    abstract：:Developmentally regulated endothelial cell locus-1 (Del1) is an embryonic angiogenic factor expressed in early embryonic endothelial cells, but recently has been found to be expressed in some forms of cancers including colon and breast cancers, and melanoma, and human cancer cell lines. Overexpression of Del1 accelera...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/1423-0127-16-33

    authors： Zou X,Qiao H,Jiang X,Dong X,Jiang H,Sun X

    更新日期：2009-01-01 00:00:00

  • Organization of HIV-1 pol is critical for Pol polyprotein processing.

    abstract：:The HIV pol sequentially encodes protease (PR), reverse transcriptase (RT), and integrase (IN) from the 5'-3' direction. We explored the significance of this gene arrangement. All six possible gene dispositions were examined. In two situations where PR was removed from the leading place and no two genes were in their ...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/BF02253522

    authors： Chang YY,Yu SL,Syu WJ

    更新日期：1999-09-01 00:00:00

  • Protective effect of a sesamin derivative, 3-bis (3-methoxybenzyl) butane-1, 4-diol on ischemic and hypoxic neuronal injury.

    abstract：BACKGROUND:Stroke is one of the leading causes of neuronal death. Sesamin is known for neuroprotection by its antioxidant and anti-inflammatory properties but it lacks blood-brain barrier (BBB) activity. A panel of sesamin derivatives was screened and 3-bis (3-methoxybenzyl) butane-1,4-diol (BBD) was selected for high ...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/1423-0127-21-15

    authors： Hou CW,Chen YL,Chuang SH,Wang JS,Jeng KC

    更新日期：2014-02-18 00:00:00

  • Relevance of retrovirus quantification in cerebrospinal fluid for neurologic diagnosis.

    abstract：:Different human retroviruses, such as Human Immunodeficiency Virus (HIV) and Human T-cell Lymphotropic Virus (HTLV), can cause neurologic infection. However, a definitive diagnosis may be hampered by several factors. Quantification of the viral or proviral load in cerebrospinal fluid (CSF) may be helpful in the diagno...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/s12929-015-0170-y

    authors： Rosadas C,Puccioni-Sohler M

    更新日期：2015-08-08 00:00:00

  • Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1 I27N mutant mice.

    abstract：BACKGROUND:Increased levels of blood plasma urea were used as phenotypic parameter for establishing novel mouse models for kidney diseases on the genetic background of C3H inbred mice in the phenotype-driven Munich ENU mouse mutagenesis project. The phenotypically dominant mutant line HST014 was established and further...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/s12929-017-0365-5

    authors： Kumar S,Rathkolb B,Sabrautzki S,Krebs S,Kemter E,Becker L,Beckers J,Bekeredjian R,Brommage R,Calzada-Wack J,Garrett L,Hölter SM,Horsch M,Klingenspor M,Klopstock T,Moreth K,Neff F,Rozman J,Fuchs H,Gailus-Durner V,H

    更新日期：2017-08-17 00:00:00

  • Antioxidants attenuate diabetes-induced activation of peroxisomal functions in the rat kidney.

    abstract：:Diabetes is a multifactorial disease that has now been recognized to involve overproduction of reactive oxygen species and pro-inflammatory cytokines. Peroxisomes are subcellular organelles with several important metabolic functions, and their role in the regulation of cellular oxidative stress is now well established...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1159/000079667

    authors： Dhaunsi GS,Bitar MS

    更新日期：2004-09-01 00:00:00

  • Characterization of a Human Stromal Cell Line Supporting Hematopoietic Progenitor Cell Proliferation: Effect of HIV Expression.

    abstract：:Our objective was to determine the role that bone marrow-derived stromal cells have on human hematopoiesis in HIV infection. In particular, we dissected the heterogeneous bone marrow microenvironment to study the effect HIV expression might have on the cell population capable of producing the cytokines which will supp...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/BF02255220

    authors： Mosca JD,Kaushal S,Gartner S,Kessler SW,La Russa VF,Terwilliger EF,Kim JH,Carroll RG,Hall ER,Perera LP,Yu Z,Ritchey DW,Xu J,St Louis DC,Mayers DL

    更新日期：1995-10-01 00:00:00

  • DBP rs16846876 and rs12512631 polymorphisms are associated with progression to AIDS naïve HIV-infected patients: a retrospective study.

    abstract：BACKGROUND:Most of the circulating Vitamin D (VitD) is transported bound to vitamin D-binding protein (DBP), and several DBP single nucleotide polymorphisms (SNPs) have been related to circulating VitD concentration and disease. In this study, we evaluated the association among DBP SNPs and AIDS progression in antiretr...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/s12929-019-0577-y

    authors： Jiménez-Sousa MÁ,Jiménez JL,Fernández-Rodríguez A,Bellón JM,Rodríguez C,Riera M,Portilla J,Castro Á,Muñoz-Fernández MÁ,Resino S

    更新日期：2019-10-23 00:00:00

  • Signaling in and out: long-noncoding RNAs in tumor hypoxia.

    abstract：:Over the past few years, long non-coding RNAs (lncRNAs) are recognized as key regulators of gene expression at chromatin, transcriptional and posttranscriptional level with pivotal roles in various biological and pathological processes, including cancer. Hypoxia, a common feature of the tumor microenvironment, profoun...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章,评审

    doi：10.1186/s12929-020-00654-x

    authors： Kuo TC,Kung HJ,Shih JW

    更新日期：2020-05-05 00:00:00

  • Visfatin induces MUC8 and MUC5B expression via p38 MAPK/ROS/NF-κB in human airway epithelial cells.

    abstract：BACKGROUND:Among a variety of inflammatory mediators, visfatin is a proinflammatory adipocytokine associated with inflammatory reactions in obesity, metabolic syndrome, chronic inflammatory disease, and autoimmune disease. However, the biological role of visfatin in secretion of major mucins in human airway epithelial ...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/1423-0127-21-49

    authors： Song SY,Jung EC,Bae CH,Choi YS,Kim YD

    更新日期：2014-05-20 00:00:00

  • Gastroprotective effect of leptin in indomethacin-induced gastric injury.

    abstract：:This study investigated the involvement of neutrophil infiltration, disturbances in nitric oxide (NO) generation and oxidative stress in indomethacin-induced gastric ulcer, and the possible gastroprotective potentials of leptin, known for its angiogenic effect. Male Wistar albino rats (180-220 g) were allocated into a...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/s11373-007-9227-6

    authors： Motawi TK,Abd Elgawad HM,Shahin NN

    更新日期：2008-05-01 00:00:00

  • Differential expression of protein kinases in cultured primary neurons derived from the cerebral cortex, hippocampus, and sympathetic ganglia.

    abstract：:Protein kinases play pivotal roles in the development of the nervous system. They are involved in almost every stage of neuronal development, from initial proliferation and differentiation of progenitor cells to pathfinding of neurites and formation of synapses. Activation of protein kinases is also critical for neuro...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1007/BF02258364

    authors： Lin SD,Fann MJ

    更新日期：1998-01-01 00:00:00

  • Inhibition of histone acetylation by curcumin reduces alcohol-induced fetal cardiac apoptosis.

    abstract：BACKGROUND:Prenatal alcohol exposure may cause cardiac development defects, however, the underlying mechanisms are not yet clear. In the present study we have investigated the roles of histone modification by curcumin on alcohol induced fetal cardiac abnormalities during the development. METHODS AND RESULTS:Q-PCR and ...

    journal_title：Journal of biomedical science

    pub_type： 杂志文章

    doi：10.1186/s12929-016-0310-z

    authors： Yan X,Pan B,Lv T,Liu L,Zhu J,Shen W,Huang X,Tian J

    更新日期：2017-01-05 00:00:00