Abstract：
:Acute respiratory distress syndrome (ARDS) can be associated with various disorders. Among these, coronavirus infection may cause life-threatening severe acute respiratory syndrome (SARS). In this review, we present animal models and techniques for the study of ARDS, and discuss the roles and possible mechanisms of various chemical factors, including nitric oxide (NO). Our early work revealed that cerebral compression elicits severe hemorrhagic pulmonary edema (PE), leading to central sympathetic activation that results in systemic vasoconstriction. The consequence of systemic vasoconstriction is volume and pressure loading in the pulmonary circulation. Vasodilators, but not oxidant radical scavengers, are effective in the prevention of centrogenic PE. In isolated perfused lung, exogenous and endogenous NO enhances lung injury following air embolism and ischemia/reperfusion. In contrast, NO synthase (NOS) inhibitors reverse such lung injury. Although NO is important in maintaining vasodilator tone, hypoxia-induced pulmonary vasoconstriction is accompanied by an increase instead of a decrease in NO release. In animal and isolated lung studies, endotoxin produces acute lung injury that is associated with increases in cytokines and inducible NOS mRNA expression, suggesting that NO is toxic to the lung in endotoxin shock. Recently, we reported several rare cases that indicate that ARDS in patients with Japanese B encephalitis, lymphangitis with breast cancer and fat embolism is caused by different mechanisms. Our early and recent studies on ARDS and PE may provide information for clinical practice and the understanding of the pathogenesis of SARS.
journal_name
J Biomed Scijournal_title
Journal of biomedical scienceauthors
Chen HI,Kao SJ,Wang D,Lee RP,Su CFdoi
10.1159/000073523keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
588-92issue
6 Pt 1eissn
1021-7770issn
1423-0127pii
73523journal_volume
10pub_type
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journal_title：Journal of biomedical science
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更新日期：2007-03-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2010-08-24 00:00:00
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pub_type： 杂志文章
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更新日期：2013-08-03 00:00:00
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journal_title：Journal of biomedical science
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doi：10.1007/BF02254441
更新日期：2004-05-01 00:00:00
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journal_title：Journal of biomedical science
pub_type： 杂志文章
doi：10.1186/1423-0127-19-97
更新日期：2012-11-19 00:00:00
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更新日期：2005-01-01 00:00:00
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更新日期：2019-04-18 00:00:00
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更新日期：2005-12-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2008-11-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Journal of biomedical science
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更新日期：2014-07-31 00:00:00
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更新日期：2020-08-27 00:00:00
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journal_title：Journal of biomedical science
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更新日期：2009-05-01 00:00:00
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journal_title：Journal of biomedical science
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更新日期：2013-02-23 00:00:00
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journal_title：Journal of biomedical science
pub_type： 杂志文章
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更新日期：2013-07-12 00:00:00
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journal_title：Journal of biomedical science
pub_type： 杂志文章
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更新日期：1999-01-01 00:00:00
abstract：BACKGROUND:The diastolic oscillatory after-potential Vos and pre-potential ThVos play an essential role in the pacemaker mechanism of sino-atrial node (SAN). The aim of this study was to investigate whether these oscillatory potentials are also involved in adrenergic control of SAN discharge. METHODS:Vos and ThVos wer...
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