Human fallopian tube epithelial cells exhibit stemness features, self-renewal capacity, and Wnt-related organoid formation.

abstract：:While virus-like particles (VLPs) containing subgenomic replicons, which can transduce replicons into target cells efficiently for studying viral replication and vectors of gene therapy and vaccine, have been established for several flaviviruses, none has been reported for the four serotypes of dengue virus, the causa...

journal_title：Journal of biomedical science

authors： Lai CY,Hu HP,King CC,Wang WK

更新日期：2008-01-01 00:00:00

abstract：:Ubiquitination modulates a large repertoire of cellular functions and thus, dysregulation of the ubiquitin system results in multiple human diseases, including cancer. Ubiquitination requires an E3 ligase, which is responsible for substrate recognition and conferring specificity to ubiquitination. HUWE1 is a multiface...

journal_title：Journal of biomedical science

authors： Kao SH,Wu HT,Wu KJ

更新日期：2018-09-04 00:00:00

abstract：:Permanent functional deficit in patients with spinal cord injury (SCI) is in part due to severe neural cell death. Therefore, cell replacement using stem cells and neural progenitors that give rise to neurons and glia is thought to be a potent strategy to promote tissue repair after SCI. Many studies have shown that s...

journal_title：Journal of biomedical science

authors： Tzeng SF

更新日期：2002-01-01 00:00:00

abstract：:The HIV-1 Tat protein is an RNA-binding transcriptional transactivator. Recent findings suggest that Tat associates with a cellular kinase that phosphorylates the carboxyl-terminal domain of the largest subunit of RNA polymerase II. Here we review, in brief, the role of Tat-associated kinase in Tat-activated transcrip...

journal_title：Journal of biomedical science

authors： Jeang KT

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Interleukin 12B (IL12B) gene polymorphisms have been linked to several inflammatory diseases, but their role in the development of Graves ophthalmopathy (GO) in Graves disease (GD) patients is unclear. The purpose of this study was to investigate the disease association of IL12B single nucleotide polymorphis...

journal_title：Journal of biomedical science

authors： Liu YH,Chen CC,Liao LL,Wan L,Tsai CH,Tsai FJ

更新日期：2012-11-19 00:00:00

abstract：:In many solid tumor types, tumor-associated macrophages (TAMs) are important components of the tumor microenvironment (TME). Moreover, TAMs infiltration is strongly associated with poor survival in solid tumor patients. In this review, we describe the origins of TAMs and their polarization state dictated by the TME. W...

journal_title：Journal of biomedical science

authors： Chen Y,Song Y,Du W,Gong L,Chang H,Zou Z

更新日期：2019-10-20 00:00:00

abstract：:Advances in Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated system (CRISPR/Cas9) has dramatically reshaped our ability to edit genomes. The scientific community is using CRISPR/Cas9 for various biotechnological and medical purposes. One of its most important uses is developing potential the...

journal_title：Journal of biomedical science

authors： Khan S,Mahmood MS,Rahman SU,Zafar H,Habibullah S,Khan Z,Ahmad A

更新日期：2018-03-28 00:00:00

abstract：:Our objective was to determine the role that bone marrow-derived stromal cells have on human hematopoiesis in HIV infection. In particular, we dissected the heterogeneous bone marrow microenvironment to study the effect HIV expression might have on the cell population capable of producing the cytokines which will supp...

journal_title：Journal of biomedical science

authors： Mosca JD,Kaushal S,Gartner S,Kessler SW,La Russa VF,Terwilliger EF,Kim JH,Carroll RG,Hall ER,Perera LP,Yu Z,Ritchey DW,Xu J,St Louis DC,Mayers DL

更新日期：1995-10-01 00:00:00

abstract：:Oxidative stress and inflammation contributed to the propagation of acute liver injury (ALI). The present study was undertaken to determine whether D-galactosamine (D-GalN) induces ALI via the mitochondrial apoptosis- and proinflammatory cytokine-signaling pathways, and possible mechanism(s) by which green tea (GT) ex...

journal_title：Journal of biomedical science

authors： Lin BR,Yu CJ,Chen WC,Lee HS,Chang HM,Lee YC,Chien CT,Chen CF

更新日期：2009-03-25 00:00:00

abstract：:The likelihood that expression of a foreign gene in a mammalian cell is deleterious to viability is confronted whenever novel transgenic animals are made. A pathological response to transgene expression is even desired in transgenic mouse models of human disease. The derivation of HIV-transgenic mice in our laboratory...

journal_title：Journal of biomedical science

authors： Dickie P

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND:Chemotherapy and targeted therapies have made important strides in cancer treatment yet they often fail and new therapies are still needed. Here, we employed a phenotypic screen to identify and analyze the mechanism of action of novel small molecules that interfere with critical pathways involved in tumor ce...

journal_title：Journal of biomedical science

authors： Ghosh SK,Ganta A,Spanjaard RA

更新日期：2018-02-08 00:00:00

abstract：:Purinergic P2X7 receptor (P2X7R), an ATP-gated cation channel, is unique among all other family members because of its ability to respond to various stimuli and to modulate pro-inflammatory signaling. The activation of P2X7R in immune cells is absolutely required for mature interleukin -1beta (IL-1beta) and IL-18 prod...

journal_title：Journal of biomedical science

authors： Mishra A

更新日期：2013-05-01 00:00:00

abstract：:Glycine N-methyltransferase (GNMT) is a protein with multiple functions. Recently, two Italian siblings who had hepatomegaly and chronic elevation of serum transaminases were diagnosed to have GNMT deficiency caused by inherited compound heterozygosity of the GNMT gene with missence mutations. To evaluate the expressi...

journal_title：Journal of biomedical science

authors： Liu HH,Chen KH,Shih YP,Lui WY,Wong FH,Chen YM

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Despite the recent progress in screening and therapy, a majority of prostate cancer cases eventually attain hormone refractory and chemo-resistant attributes. Conventional chemotherapeutic strategies are effective at very high doses for only palliative management of these prostate cancers. Therefore chemo-se...

journal_title：Journal of biomedical science

authors： Gara RK,Srivastava VK,Duggal S,Bagga JK,Bhatt M,Sanyal S,Mishra DP

更新日期：2015-04-01 00:00:00

abstract：:Different human retroviruses, such as Human Immunodeficiency Virus (HIV) and Human T-cell Lymphotropic Virus (HTLV), can cause neurologic infection. However, a definitive diagnosis may be hampered by several factors. Quantification of the viral or proviral load in cerebrospinal fluid (CSF) may be helpful in the diagno...

journal_title：Journal of biomedical science

authors： Rosadas C,Puccioni-Sohler M

更新日期：2015-08-08 00:00:00

abstract：BACKGROUND:Lead (Pb2+) is an environmental neurotoxicant that disrupts neurodevelopment, communication, and organization through competition with Ca2+ signaling. How perinatal Pb2+ exposure affects Ca2+-related gene regulation remains unclear. However, Ca2+ activates the L-Type voltage sensitive calcium channel β-3 sub...

journal_title：Journal of biomedical science

authors： Neuwirth LS,Phillips GR,El Idrissi A

更新日期：2018-05-24 00:00:00

abstract：BACKGROUND:Epigallocatechin-3-gallate (EGCg) with its potent anti-oxidative capabilities is known for its beneficial effects ameliorating oxidative injury to cardiac cells. Although studies have provided convincing evidence to support the cardioprotective effects of EGCg, it remains unclear whether EGCg affect trans-me...

journal_title：Journal of biomedical science

authors： Hsieh SR,Hsu CS,Lu CH,Chen WC,Chiu CH,Liou YM

更新日期：2013-11-19 00:00:00

abstract：BACKGROUND:Zerumbone, a sesquiterpene compound isolated from subtropical ginger, Zingiber zerumbet Smith, has been documented to exert antitumoral and anti- inflammatory activities. In this study, we demonstrate that zerumbone induces apoptosis in human glioblastoma multiforme (GBM8401) cells and investigate the apopto...

journal_title：Journal of biomedical science

authors： Weng HY,Hsu MJ,Wang CC,Chen BC,Hong CY,Chen MC,Chiu WT,Lin CH

更新日期：2012-10-05 00:00:00

abstract：:Adeno-associated virus (AAV) vectors were shown capable of high efficiency transduction of both dividing and nondividing cells and tissues. AAV-mediated transduction leads to stable, long-term transgene expression in the absence of apparent immune response. These properties and the broad host range of AAV vectors indi...

journal_title：Journal of biomedical science

authors： Tal J

更新日期：2000-07-01 00:00:00

abstract：:The ability of cells of the human monocyte/macrophage lineage to host HIV-1 replication while resisting cell death is believed to significantly contribute to their ability to serve as a reservoir for viral replication in the host. Although macrophages are generally resistant to apoptosis, interruption of anti-apoptoti...

journal_title：Journal of biomedical science

authors： Zhang M,Li X,Pang X,Ding L,Wood O,Clouse KA,Hewlett I,Dayton AI

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:RNA interference (RNAi) is a powerful tool to silence gene expression post-transcriptionally. Delivering sequences of RNAi in vivo remains a problem. The aim of this study was to use JC virus (JCV) virus-like particles (VLPs) as a vector for delivering RNAi in silencing the cytokine gene of IL-10. METHODS:J...

journal_title：Journal of biomedical science

authors： Chou MI,Hsieh YF,Wang M,Chang JT,Chang D,Zouali M,Tsay GJ

更新日期：2010-06-24 00:00:00

abstract：BACKGROUND:Activating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER)-localised protein and member of the leucine zipper family of transcription factors. Best known for its role in transducing signals linked to stress to the endoplasmic reticulum, the 50 kDa activated form of ATF6 is now emerging as a ma...

journal_title：Journal of biomedical science

authors： Hillary RF,FitzGerald U

更新日期：2018-05-25 00:00:00

abstract：BACKGROUND:The association of functionality and phenotype of follicular helper T cells (Tfh) with dengue virus (DENV) specific antibody responses and clinical disease severity has not been well studied. METHODS:We investigated the phenotype and functionality of Tfh cells and plasmablasts in adult patients (DF = 18, DH...

journal_title：Journal of biomedical science

authors： Wijesinghe A,Gamage J,Goonewardena H,Gomes L,Jayathilaka D,Wijeratne DT,de Alwis R,Jeewandara C,Wijewickrama A,Ogg GS,Malavige GN

更新日期：2020-04-08 00:00:00

abstract：BACKGROUND:Prenatal alcohol exposure may cause cardiac development defects, however, the underlying mechanisms are not yet clear. In the present study we have investigated the roles of histone modification by curcumin on alcohol induced fetal cardiac abnormalities during the development. METHODS AND RESULTS:Q-PCR and ...

journal_title：Journal of biomedical science

authors： Yan X,Pan B,Lv T,Liu L,Zhu J,Shen W,Huang X,Tian J

更新日期：2017-01-05 00:00:00

abstract：BACKGROUND:Honokiol, a cell-permeable phenolic compound derived from the bark of magnolia trees and present in Asian herbal teas, has a unique array of pharmacological actions, including the inhibition of multiple autonomic responses. We determined the effects of honokiol on calcium signaling underlying transmission me...

journal_title：Journal of biomedical science

authors： Wang HJ,Martin AG,Chao PK,Reichard RA,Martin AL,Huang YW,Chan MH,Aronstam RS

更新日期：2013-02-23 00:00:00

abstract：:We previously reported that transgenic ablation of gonadotrophs results in impaired development of cells immunostainable for prolactin (PRL) but not of cells immunostainable for growth hormone (GH) or pro-opiomelanocortin (POMC) in pituitary of newborn mice. The question remained whether this reduction in PRL protein ...

journal_title：Journal of biomedical science

authors： Vankelecom H,Seuntjens E,Hauspie A,Denef C

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Angiotensin II (Ang II) signaling occurs via two major receptors which activate non-receptor tyrosin kinases that then interact with protein tyrosin-phosphatases (PTPs) to regulate cell function. SHP-2 is one such important PTP that also functions as an adaptor to promote downstream signaling pathway. Its ro...

journal_title：Journal of biomedical science

authors： Calò LA,Bordin L,Davis PA,Pagnin E,Dal Maso L,Rossi GP,Pessina AC,Clari G

更新日期：2011-06-13 00:00:00

abstract：:The interactive role of rostral ventrolateral medulla (RVL) cardiovascular neurons and brain angiotensin II (Ang II) in regulating the arterial blood pressure was examined by recording simultaneously the spontaneous activity of these spinal projecting neurons and the arterial blood pressure in the pentobarbital-anesth...

journal_title：Journal of biomedical science

authors： Chan RK,Chan YS,Wong TM

更新日期：1996-05-01 00:00:00

abstract：:Acetylcholine (ACh), the first neurotransmitter to be identified, regulate the activities of central and peripheral functions through interactions with muscarinic receptors. Changes in muscarinic acetylcholine receptor (mAChR) have been implicated in the pathophysiology of many major diseases of the central nervous sy...

journal_title：Journal of biomedical science

authors： Gireesh G,Kumar TP,Mathew J,Paulose C

更新日期：2009-04-03 00:00:00

abstract：BACKGROUND:Pneumococcal conjugate vaccine (PCV) reduces both invasive pneumococcal disease (IPD) and other pneumococcal infections worldwide. We investigated the impact of stepwise implementation of childhood PCV programs on the prevalence of pneumococcal pneumonia, severity of acute inflammation, and associations betw...

journal_title：Journal of biomedical science

authors： Shen CF,Wang SM,Chi H,Huang YC,Huang LM,Huang YC,Lin HC,Ho YH,Hsiung CA,Liu CC,Taiwan Pediatric Infectious Disease Alliance.

更新日期：2020-08-19 00:00:00