New insights of P2X7 receptor signaling pathway in alveolar functions.

abstract：:The antitumor activity of Anoectochilus formosanus Hayata (Orchidaceae), a popularly used folk medicine in the treatment of cancers in Asia, was investigated in MCF-7 human mammary carcinoma cells. Plant extracts of A. formosanus were observed to induce apoptosis of MCF-7 cells as evidenced by cell-morphological chang...

journal_title：Journal of biomedical science

authors： Shyur LF,Chen CH,Lo CP,Wang SY,Kang PL,Sun SJ,Chang CA,Tzeng CM,Yang NS

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Dioscin, a typical steroid saponin, is isolated from Dioscorea nipponica Makino and Dioscorea zingiberensis Wright. It has estrogenic activity and many studies have also reported that dioscorea plants have an effect in preventing and treating osteoporosis. However, the molecular mechanisms underlying their e...

journal_title：Journal of biomedical science

authors： Zhang C,Peng J,Wu S,Jin Y,Xia F,Wang C,Liu K,Sun H,Liu M

更新日期：2014-04-17 00:00:00

abstract：:Recent transcriptome analyses have revealed that noncoding RNAs (ncRNAs) are broadly expressed in mammalian cells and abundant in the CNS, with tissue and cell type-specific expression patterns. Moreover, ncRNAs have been found to intricately and dynamically regulate various signaling pathways in neurodegeneration. As...

journal_title：Journal of biomedical science

authors： Wu YY,Kuo HC

更新日期：2020-04-07 00:00:00

abstract：BACKGROUND:Oxidized LDL (oxLDL) is involved in the development of atherosclerotic heart disease through a mechanism that is not fully understood. In this study, we examined the role of malondialdehyde (MDA), an important oxidative stress epitope of oxLDL, in mediating coronary endothelial cytotoxicity. RESULTS:Human c...

journal_title：Journal of biomedical science

authors： Yang TC,Chen YJ,Chang SF,Chen CH,Chang PY,Lu SC

更新日期：2014-02-03 00:00:00

abstract：BACKGROUND:Glioma stem-like cells (GSCs) are proposed to be responsible for high resistance in glioblastoma multiforme (GBM) treatment. In order to find new strategies aimed at reducing GSC stemness and improving GBM patient survival, we investigated the effects and mechanism of a histone deacetylases (HDACs) inhibitor...

journal_title：Journal of biomedical science

authors： Hsu CC,Chang WC,Hsu TI,Liu JJ,Yeh SH,Wang JY,Liou JP,Ko CY,Chang KY,Chuang JY

更新日期：2016-11-18 00:00:00

abstract：:The ability of cells of the human monocyte/macrophage lineage to host HIV-1 replication while resisting cell death is believed to significantly contribute to their ability to serve as a reservoir for viral replication in the host. Although macrophages are generally resistant to apoptosis, interruption of anti-apoptoti...

journal_title：Journal of biomedical science

authors： Zhang M,Li X,Pang X,Ding L,Wood O,Clouse KA,Hewlett I,Dayton AI

更新日期：2002-03-01 00:00:00

abstract：:Increasing evidence suggests that immune responses are involved in the control of cancer and that the immune system can be manipulated in different ways to recognize and attack tumors. Progress in immune-based strategies has opened new therapeutic avenues using a number of techniques destined to eliminate malignant ce...

journal_title：Journal of biomedical science

authors： Matar P,Alaniz L,Rozados V,Aquino JB,Malvicini M,Atorrasagasti C,Gidekel M,Silva M,Scharovsky OG,Mazzolini G

更新日期：2009-03-06 00:00:00

abstract：:Reactive oxygen species (ROS) have been long considered simply as harmful by-products of metabolism, which damage cellular proteins, lipids, and nucleic acids. ROS are also known as a weapon of phagocytes, employed against pathogens invading the host. However, during the last decade, an understanding has emerged that ...

journal_title：Journal of biomedical science

authors： Belikov AV,Schraven B,Simeoni L

更新日期：2015-10-15 00:00:00

abstract：:Chronic inflammation may lead to endothelial dysfunction, which manifests as an impaired coronary reactivity. Impairment in coronary flow reserve (CFR), preceding the clinical symptoms of coronary artery disease, can be measured noninvasively by positron emission tomography. Myeloperoxidase (MPO) is an oxidative enzym...

journal_title：Journal of biomedical science

authors： Mäkelä R,Laaksonen R,Janatuinen T,Vesalainen R,Nuutila P,Jaakkola O,Knuuti J,Lehtimäki T

更新日期：2004-01-01 00:00:00

abstract：:Myostatin, a member of the TGF-beta superfamily, is a potent negative regulator of skeletal muscle and growth. Previously, we reported Mstn1 from zebrafish and studied its influence on muscle development. In this study, we identified another form of Myostatin protein which is referred to as Mstn2. The size of Mstn2 cD...

journal_title：Journal of biomedical science

authors： Amali AA,Lin CJ,Chen YH,Wang WL,Gong HY,Rekha RD,Lu JK,Chen TT,Wu JL

更新日期：2008-09-01 00:00:00

abstract：:Accumulative evidence has supported the role of nitric oxide (NO) in a variety of normal physiological functions as well as many pathological conditions. In this study, we examined the possible diabetogenicity of NO by measuring the expression of the insulin receptor substrate (IRS)-1 in rat hepatocytes and skeletal m...

journal_title：Journal of biomedical science

authors： Badal S,Brown PD,Ragoobirsingh D

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Epigallocatechin-3-gallate (EGCg) with its potent anti-oxidative capabilities is known for its beneficial effects ameliorating oxidative injury to cardiac cells. Although studies have provided convincing evidence to support the cardioprotective effects of EGCg, it remains unclear whether EGCg affect trans-me...

journal_title：Journal of biomedical science

authors： Hsieh SR,Hsu CS,Lu CH,Chen WC,Chiu CH,Liou YM

更新日期：2013-11-19 00:00:00

abstract：:Lysosome-associated membrane protein (LAMP)-1, one of the major protein components of the lysosomal membrane, is upregulated in the human glioblastoma cell lines, U-373 MG and LN-Z308, which undergo cisplatin-induced apoptosis. These human brain tumor cell lines demonstrated apoptosis in response to cisplatin/nifedipi...

journal_title：Journal of biomedical science

authors： Chen JW,Madamanchi N,Madamanchi NR,Trier TT,Keherly MJ

更新日期：2001-07-01 00:00:00

abstract：:The CDC4 gene of Saccharomyces cerevisiae encodes an essential function that is required for G1-S and G2-M transitions during mitosis and at various stages during meiosis. We have isolated a functional homologue of CDC4 (CaCDC4) from the pathogenic yeast Candida albicans by complementing the S. cerevisiae cdc4-3 mutat...

journal_title：Journal of biomedical science

authors： Shieh JC,White A,Cheng YC,Rosamond J

更新日期：2005-12-01 00:00:00

abstract：:The midbrain periaqueductal gray matter (PAG) is an important brain region for the coordination of mu-opioid-induced pharmacological actions. The present study was designed to determine whether newly isolated mu-opioid peptide endomorphins can activate G proteins through mu-opioid receptors in the PAG by monitoring th...

journal_title：Journal of biomedical science

authors： Narita M,Mizoguchi H,Narita M,Dun NJ,Hwang BH,Endoh T,Suzuki T,Nagase H,Suzuki T,Tseng LF

更新日期：2000-05-01 00:00:00

abstract：:The dual signal hypothesis of apoptosis holds that a common signal can activate both apoptotic and proliferative pathways. The fate of a cell is dependent on which of these two pathways predominates. In the MAPK family of kinases, ERK and JNK have been proposed to mediate apoptosis whereas the PI3K-stimulated kinase, ...

journal_title：Journal of biomedical science

authors： Chin LS,Murray SF,Harter DH,Doherty PF,Singh SK

更新日期：1999-05-01 00:00:00

abstract：:The likelihood that expression of a foreign gene in a mammalian cell is deleterious to viability is confronted whenever novel transgenic animals are made. A pathological response to transgene expression is even desired in transgenic mouse models of human disease. The derivation of HIV-transgenic mice in our laboratory...

journal_title：Journal of biomedical science

authors： Dickie P

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND:Pulmonary emphysema is characterized histologically by destruction of alveolar walls and enlargement of air spaces due to lung epithelial cell apoptosis. Cell adhesion molecule 1 (CADM1) is an immunoglobulin superfamily member expressed in lung epithelial cells. CADM1 generates a membrane-associated C-termin...

journal_title：Journal of biomedical science

authors： Hagiyama M,Yoneshige A,Inoue T,Sato Y,Mimae T,Okada M,Ito A

更新日期：2015-08-11 00:00:00

abstract：:The apolipoprotein (Apo) E gene is known to be polymorphic. Three common alleles determine six phenotypes which can easily be detected by restriction fragment length polymorphism. We performed apo E genotyping in myocardial infarction survivors and healthy controls for the first time in the Turkish population. DNA was...

journal_title：Journal of biomedical science

authors： Hergenc G,Taga Y,Emerk K,Cirakoglu B

更新日期：1995-01-01 00:00:00

abstract：:We studied 42 individuals, including 8 patients with either complete or partial syndrome of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS), 8 patients with either complete or partial syndrome of myoclonic epilepsy with ragged-red fibers (MERRF) and 26 maternal family members w...

journal_title：Journal of biomedical science

authors： Huang CC,Kuo HC,Chu CC,Liou CW,Ma YS,Wei YH

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Chemotherapy and targeted therapies have made important strides in cancer treatment yet they often fail and new therapies are still needed. Here, we employed a phenotypic screen to identify and analyze the mechanism of action of novel small molecules that interfere with critical pathways involved in tumor ce...

journal_title：Journal of biomedical science

authors： Ghosh SK,Ganta A,Spanjaard RA

更新日期：2018-02-08 00:00:00

abstract：:To determine the involvement of the globus pallidus in mediating epilepsy, the effects of microinjection of a GABA uptake blocker (tiagabine), a benzodiazepine agonist (zolpidem) and a GABA-B receptor agonist (baclofen) on pentylenetetrazol (PTZ)-induced tonic seizure were examined in adult rats. Administration of PTZ...

journal_title：Journal of biomedical science

authors： Chen L,Chan YS,Yung WH

更新日期：2004-07-01 00:00:00

abstract：:The aim of this study was to determine whether the common forms of dyslipidemia could affect either the lipid composition or insulin receptor processing (down-regulation) of erythrocytes. The study included 22 patients with type IIa hypercholesterolemia, 15 patients with type IV hypertriglyceridemia and 12 patients wi...

journal_title：Journal of biomedical science

authors： Masella R,Cantafora A,Maffì D,Volpe R,Ginnetti MG,Ricci G,Mace NL,Buxton GM,Peterson SW

更新日期：1995-08-01 00:00:00

abstract：:We previously reported that transgenic ablation of gonadotrophs results in impaired development of cells immunostainable for prolactin (PRL) but not of cells immunostainable for growth hormone (GH) or pro-opiomelanocortin (POMC) in pituitary of newborn mice. The question remained whether this reduction in PRL protein ...

journal_title：Journal of biomedical science

authors： Vankelecom H,Seuntjens E,Hauspie A,Denef C

更新日期：2003-11-01 00:00:00

abstract：:Retrograde transport of Wheat germ agglutinin conjugated to Horseradish peroxidase (WGA-HRP) was used in labeling vagal neurons projecting to the stomach from the dorsal motor nucleus of the vagus nerve (DMNV) in Streptozotocin (STZ)-induced diabetic rats. Diabetes was induced in the experimental rats by intraperitone...

journal_title：Journal of biomedical science

authors： Odekunle A

更新日期：2006-09-01 00:00:00

abstract：:The SARS related Coronavirus genome contains a variety of novel accessory genes. One of these, called ORF7a or ORF8, code for a protein, known as 7a, U122 or X4. We set out to determine the three-dimensional structure of the soluble ectodomain of this type-I transmembrane protein by nuclear magnetic resonance spectros...

journal_title：Journal of biomedical science

authors： Hänel K,Stangler T,Stoldt M,Willbold D

更新日期：2006-05-01 00:00:00

abstract：:The present study was undertaken to elucidate the mechanism of intra-arterial propofol-induced vascular permeability change resulting in tissue edema. The mechanism of propofol-induced hyperpermeability was examined in a rat femoral artery injection model. Vascular permeability was determined by measuring the Evans bl...

journal_title：Journal of biomedical science

authors： Chen YS,Chen KH,Liu CC,Lee CT,Yang CH,Chuang KC,Lin CR

更新日期：2007-09-01 00:00:00

abstract：:Critical assessment of experimental muscle-pain models resulting from maximal muscle contraction may provide a means of assessing hypersensitivity and the central nociceptive mechanisms involved in diffused muscle pain. The aim of the present study was, therefore, to investigate the patterns of nociceptive behavior an...

journal_title：Journal of biomedical science

authors： Wang SF,Chen CC,Liao WS,Shyu BC

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Despite the recent progress in screening and therapy, a majority of prostate cancer cases eventually attain hormone refractory and chemo-resistant attributes. Conventional chemotherapeutic strategies are effective at very high doses for only palliative management of these prostate cancers. Therefore chemo-se...

journal_title：Journal of biomedical science

authors： Gara RK,Srivastava VK,Duggal S,Bagga JK,Bhatt M,Sanyal S,Mishra DP

更新日期：2015-04-01 00:00:00

abstract：INTRODUCTION:Head and neck squamous carcinoma (HNSCC) is one of the most invasive types of cancer with high mortality. A previous study has indicated that low levels of let-7d and miR-205 in HNSCC patients are correlated with poor survival. Let-7d and miR-205 are tumor suppressors and regulators of epithelial-to-mesenc...

journal_title：Journal of biomedical science

authors： Kolenda T,Guglas K,Teresiak A,Bliźniak R,Lamperska K

更新日期：2019-02-13 00:00:00