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Different types of variant muscle nociception after intermittent and continuous neuromuscular stimulation in rats.

Abstract：

:Critical assessment of experimental muscle-pain models resulting from maximal muscle contraction may provide a means of assessing hypersensitivity and the central nociceptive mechanisms involved in diffused muscle pain. The aim of the present study was, therefore, to investigate the patterns of nociceptive behavior and neuronal changes in the rat spinal cord after two modes of maximal muscle contraction. The gastrocnemius muscle of adult male Sprague-Dawley rats was subjected to continuous (10 min) or intermittent (60 min, 10/50 s on/off ratio) premodulated electrical stimulation of median frequency. Similar peak forces but different patterns of contraction output were generated by these two stimulation modes. Nociceptive behavioral scores and hind-leg oedema were significantly greater in the continuous group compared to the controls; however, significant difference was not demonstrated for either parameter comparing the intermittent and control groups. The sensory threshold was slightly reduced after the intermittent stimulation, and elevated after the continuous modality. The elevation of sensory threshold could be reversed by naloxone administration. More Fos-labeled nuclei were noted for both of the stimulation groups relative to the controls. The Fos-labeled nuclei were larger for the intermittent group than for the continuous and control analogs. The results of the present study suggest that prolonged contraction from continuous stimulation results in specific nociceptive neuron activation, muscle lesion and endogenous opioid release causing exaggerated nociception.

journal_name

J Biomed Sci

journal_title

Journal of biomedical science

authors

Wang SF,Chen CC,Liao WS,Shyu BC

doi

10.1007/s11373-005-6595-7

keywords:

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

467-79

issue

3

eissn

1021-7770

issn

1423-0127

journal_volume

12

pub_type

杂志文章

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