Role of Mitochondria in Human Aging.

abstract：:Extracellular vesicles (EVs) are cell-derived membrane-bound vesicles that serve a means of cell-cell communication. Studying EVs at a single-particle level is important because EVs are inherently heterogeneous. Novel micro- and nanotechnological tools have open opportunities for realizing single-EV measurements explo...

journal_title：Journal of biomedical science

authors： Chiang CY,Chen C

更新日期：2019-01-15 00:00:00

abstract：BACKGROUND:Honokiol, a cell-permeable phenolic compound derived from the bark of magnolia trees and present in Asian herbal teas, has a unique array of pharmacological actions, including the inhibition of multiple autonomic responses. We determined the effects of honokiol on calcium signaling underlying transmission me...

journal_title：Journal of biomedical science

authors： Wang HJ,Martin AG,Chao PK,Reichard RA,Martin AL,Huang YW,Chan MH,Aronstam RS

更新日期：2013-02-23 00:00:00

abstract：BACKGROUND:Whereas brain death is a vitally important clinical phenomenon, our contemporary understanding on its underlying cellular mechanisms remains elusive. This study evaluated whether the ubiquitin-proteasome system (UPS) in the rostral ventrolateral medulla (RVLM), a neural substrate that our laboratory identifi...

journal_title：Journal of biomedical science

authors： Wu CH,Chan JY,Chou JL,Chan SH,Chang AY

更新日期：2012-04-30 00:00:00

abstract：BACKGROUND:Developing brain is a major target for alcohol's actions and neurological/functional abnormalities include microencephaly, reduced frontal cortex, mental retardation and attention-deficits. Previous studies have shown that ethanol altered the lateral ventricular neuroepithelial cell proliferation. However, t...

journal_title：Journal of biomedical science

authors： Riar AK,Narasimhan M,Rathinam ML,Henderson GI,Mahimainathan L

更新日期：2016-01-19 00:00:00

abstract：BACKGROUND:The conserved Notch signaling pathway regulates cell fate decisions and maintains stem cells in multicellular organisms. Up-regulation of Notch signaling is observed in several types of cancer and is causally involved in proliferation and survival of cancer cells. Thus, it is of great interest to look for an...

journal_title：Journal of biomedical science

authors： Pi H,Huang YC,Chen IC,Lin CD,Yeh HF,Pai LM

更新日期：2011-06-17 00:00:00

abstract：:The apolipoprotein (Apo) E gene is known to be polymorphic. Three common alleles determine six phenotypes which can easily be detected by restriction fragment length polymorphism. We performed apo E genotyping in myocardial infarction survivors and healthy controls for the first time in the Turkish population. DNA was...

journal_title：Journal of biomedical science

authors： Hergenc G,Taga Y,Emerk K,Cirakoglu B

更新日期：1995-01-01 00:00:00

abstract：:Liver cancer is the predominant cause of cancer mortality in males of Southern China and Taiwan. The current therapy is not satisfactory, and more effective treatments are needed. In the search for new therapies for liver tumor, we found that Concanavalin A (Con A), a lectin from Jack bean seeds, can have a potent ant...

journal_title：Journal of biomedical science

authors： Lei HY,Chang CP

更新日期：2009-01-19 00:00:00

abstract：BACKGROUND:The diastolic oscillatory after-potential Vos and pre-potential ThVos play an essential role in the pacemaker mechanism of sino-atrial node (SAN). The aim of this study was to investigate whether these oscillatory potentials are also involved in adrenergic control of SAN discharge. METHODS:Vos and ThVos wer...

journal_title：Journal of biomedical science

authors： Vassalle M,Catanzaro JN,Nett MP,Rota M

更新日期：2009-11-18 00:00:00

abstract：BACKGROUND:Increased lipid accumulation and mitochondrial dysfunction within skeletal muscle have been shown to be strongly associated with insulin resistance. However, the role of mitofusion-2 (MFN2), a key factor in mitochondrial function and energy metabolism, in skeletal muscle lipid intermediate accumulation remai...

journal_title：Journal of biomedical science

authors： Zhang X,Wang C,Song G,Gan K,Kong D,Nie Q,Ren L

更新日期：2013-07-01 00:00:00

abstract：:To determine the involvement of the globus pallidus in mediating epilepsy, the effects of microinjection of a GABA uptake blocker (tiagabine), a benzodiazepine agonist (zolpidem) and a GABA-B receptor agonist (baclofen) on pentylenetetrazol (PTZ)-induced tonic seizure were examined in adult rats. Administration of PTZ...

journal_title：Journal of biomedical science

authors： Chen L,Chan YS,Yung WH

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Parkinson's disease is the second most common neurodegenerative disorders after Alzheimer's disease. The main cause of the disease is the massive degeneration of dopaminergic neurons in the substantia nigra. Neuronal apoptosis and neuroinflammation are thought to be the key contributors to the neuronal degen...

journal_title：Journal of biomedical science

authors： Lin YL,Tsay HJ,Lai TH,Tzeng TT,Shiao YJ

更新日期：2015-05-28 00:00:00

abstract：BACKGROUND:Previous study demonstrated the improvement of cardiac function was proportional to the number of cells implanted. Therefore, increasing cell survival in the infarcted myocardium might contribute to the improvement of the functional benefit of cell transplantation. METHODS AND RESULTS:MSCs were treated with...

journal_title：Journal of biomedical science

authors： Guo J,Lin G,Bao C,Hu Z,Chu H,Hu M

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:This study aimed at developing nerve growth factor (NGF) mimetics that selectively activate specific biological signals and, as a result, lack the side effects of the full-length protein. Two dimeric dipeptides, bis-(N-aminocaproyl-glycyl-L-lysine) hexamethylenediamide (GK-6) and bis(N-succinyl-L-glutamyl-L-...

journal_title：Journal of biomedical science

authors： Gudasheva TA,Povarnina PY,Antipova TA,Firsova YN,Konstantinopolsky MA,Seredenin SB

更新日期：2015-12-08 00:00:00

abstract：:Developmentally regulated endothelial cell locus-1 (Del1) is an embryonic angiogenic factor expressed in early embryonic endothelial cells, but recently has been found to be expressed in some forms of cancers including colon and breast cancers, and melanoma, and human cancer cell lines. Overexpression of Del1 accelera...

journal_title：Journal of biomedical science

authors： Zou X,Qiao H,Jiang X,Dong X,Jiang H,Sun X

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Human keratinocytes and derived products are crucial for skin repair and regeneration. Despite substantial advances in engineered skin equivalents, their poor availability and immunorejection remain major challenges in skin grafting. METHODS:Induced keratinocyte-like cells (iKCs) were directly reprogrammed ...

journal_title：Journal of biomedical science

authors： Zheng J,Yun W,Park J,Kang PJ,Lee G,Song G,Kim IY,You S

更新日期：2020-04-20 00:00:00

abstract：:The aim of this work was to investigate the effect of a short-term exposure to somatostatin (SS), its receptors (SSTR) selective agonists as well as muscarinic receptors agonists upon acetylcholine-induced release of (3)H-MPP(+ )from bovine adrenal medullary cells. Acetylcholine (ACH, 100, 500 microM) was found to inc...

journal_title：Journal of biomedical science

authors： Ribeiro L,Martel F,Azevedo I

更新日期：2007-05-01 00:00:00

abstract：:Exposure of cells and organs to heat shock is associated with numerous changes in various cellular metabolic parameters and overexpression of proteins collectively known as heat shock proteins (HSP). In this communication we review the cell-signaling events that are altered in response to heat shock as they relate to ...

journal_title：Journal of biomedical science

authors： Gong Kiang J,Tsokos GC

更新日期：1996-11-01 00:00:00

abstract：:Adenosine was shown to inhibit norepinephrine (NE) release from sympathetic nerve endings. The purpose of this study was to examine whether endogenous adenosine restrains NE and epinephrine release from the adrenal medulla. The effects of an adenosine receptor antagonist, 1,3-dipropyl-8-(p-sulfophenyl) xanthine (DPSPX...

journal_title：Journal of biomedical science

authors： Tseng CJ,Chan JY,Lo WC,Jan CR

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Breast cancer is considered as an increasing major life-threatening concern among the malignancies encountered globally in females. Traditional therapy is far from satisfactory due to drug resistance and various side effects, thus a search for complementary/alternative medicines from natural sources with les...

journal_title：Journal of biomedical science

authors： Banerjee M,Chattopadhyay S,Choudhuri T,Bera R,Kumar S,Chakraborty B,Mukherjee SK

更新日期：2016-04-16 00:00:00

abstract：:Schistosomiasis causes significant levels of morbidity and mortality in many geographical regions of the world. The disease is caused by infections with parasitic blood flukes known as schistosomes. The control of schistosomiasis over the last several decades has been centered on the mass drug administration (MDA) of ...

journal_title：Journal of biomedical science

authors： Molehin AJ

更新日期：2020-01-22 00:00:00

abstract：BACKGROUND:The enzyme-prodrug system is considered a promising tool for tumor treatment when conjugated with a targeting molecule. The asparagine-glycine-arginine (NGR) motif is a developing and interesting targeting peptide that could specifically bind to aminopeptidase N (APN), which is an NGR receptor expressed on t...

journal_title：Journal of biomedical science

authors： Li JJ,Chang SF,Liau II,Chan PC,Liu RS,Yen SH,Wang HE,Chang CA

更新日期：2016-01-22 00:00:00

abstract：:To search for cellular genes up-regulated by vaccinia virus (VV) infection, differential display-reverse transcription-polymerase chain reaction (ddRT-PCR) assays were used to examine the expression of mRNAs from mock-infected and VV-infected HeLa cells. Two mitochondrial genes for proteins that are part of the electr...

journal_title：Journal of biomedical science

authors： Chang CW,Li HC,Hsu CF,Chang CY,Lo SY

更新日期：2009-09-02 00:00:00

abstract：:The sigma-1 receptor (Sig-1R) is a chaperone that resides mainly at the mitochondrion-associated endoplasmic reticulum (ER) membrane (called the MAMs) and acts as a dynamic pluripotent modulator in living systems. At the MAM, the Sig-1R is known to play a role in regulating the Ca2+ signaling between ER and mitochondr...

journal_title：Journal of biomedical science

authors： Weng TY,Tsai SA,Su TP

更新日期：2017-09-16 00:00:00

abstract：BACKGROUND:Since our previous report on WHO CARDIAC Study data demonstrated that 24-hour urinary (24U) taurine (Tau) excretion was a useful biomarker of seafood (SF) intake and inversely related to the mortality rates of stroke and coronary heart diseases in the world, we determined that SF is important in the risk red...

journal_title：Journal of biomedical science

authors： Mori M,Mori H,Hamada A,Yamori Y

更新日期：2010-08-24 00:00:00

abstract：:Maternal exposure to dietary factors during pregnancy can influence embryonic development and may modulate the phenotype of offspring through epigenetic programming. Folate is critical for nucleotide synthesis, and preconceptional intake of dietary folic acid (FA) is credited with reduced incidences of neural tube def...

journal_title：Journal of biomedical science

authors： Barua S,Kuizon S,Junaid MA

更新日期：2014-08-19 00:00:00

abstract：:We studied 42 individuals, including 8 patients with either complete or partial syndrome of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS), 8 patients with either complete or partial syndrome of myoclonic epilepsy with ragged-red fibers (MERRF) and 26 maternal family members w...

journal_title：Journal of biomedical science

authors： Huang CC,Kuo HC,Chu CC,Liou CW,Ma YS,Wei YH

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Pneumococcal conjugate vaccine (PCV) reduces both invasive pneumococcal disease (IPD) and other pneumococcal infections worldwide. We investigated the impact of stepwise implementation of childhood PCV programs on the prevalence of pneumococcal pneumonia, severity of acute inflammation, and associations betw...

journal_title：Journal of biomedical science

authors： Shen CF,Wang SM,Chi H,Huang YC,Huang LM,Huang YC,Lin HC,Ho YH,Hsiung CA,Liu CC,Taiwan Pediatric Infectious Disease Alliance.

更新日期：2020-08-19 00:00:00

abstract：:Acetylcholine (ACh), the first neurotransmitter to be identified, regulate the activities of central and peripheral functions through interactions with muscarinic receptors. Changes in muscarinic acetylcholine receptor (mAChR) have been implicated in the pathophysiology of many major diseases of the central nervous sy...

journal_title：Journal of biomedical science

authors： Gireesh G,Kumar TP,Mathew J,Paulose C

更新日期：2009-04-03 00:00:00

abstract：:Purinergic P2X7 receptor (P2X7R), an ATP-gated cation channel, is unique among all other family members because of its ability to respond to various stimuli and to modulate pro-inflammatory signaling. The activation of P2X7R in immune cells is absolutely required for mature interleukin -1beta (IL-1beta) and IL-18 prod...

journal_title：Journal of biomedical science

authors： Mishra A

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Prevalence of metabolic syndrome (MS) is rapidly increasing worldwide. To investigate the spread of MS risks and its relationship with eating habits including fish intake, we carried out a health examination for young and middle-aged men. METHODS:The subjects were 97 healthy men (20 to 50 years) living in M...

journal_title：Journal of biomedical science

authors： Hamada A,Mori M,Mori H,Muhihi A,Njelekela M,Masesa Z,Mtabaji J,Yamori Y

更新日期：2010-08-24 00:00:00