Abstract:
:Serologically defined primary dengue virus infection and/or subsequent homologous serotype infection is known to be associated with less severe disease as compared with secondary subsequent heterologous serotype infection. In geographical locales of high dengue endemicity, almost all individuals in the population are infected at some point in time and should therefore are at high risk of secondary infection. Interestingly, dengue viremia in healthy blood donors whose sera apparently lack detectable levels of specific antibody to dengue viral antigens has been reported. The incidence rate of potential immunologic hypo- or non-responders following natural primary dengue virus infection in dengue endemic regions, who do become immune responders only after repeated exposure, has not been described. These are the patients who may be diagnosed as primary infection in the subsequent infection, but actually are secondary infection. This concept has important implications with regards to the hypothesis of immunological enhancement of dengue pathogenesis, which has largely been advanced based on empirical observations and/or from in vitro experimental assays. The fact that dengue naïve travelers can suffer from severe dengue upon primary exposure while visiting dengue endemic countries underscores one of the major problems in explaining the role of immune enhancement in the pathogenesis of severe dengue virus infection. This evidence suggests that the mechanism(s) leading to severe dengue may not be associated with pre-existing enhancing antibody. Consequently, we propose a new paradigm for dengue virus infection classification. These include a) patients with naïve primary infection, b) those that are serologically defined primary in dengue endemic zones and c) those who are serologically defined secondary dengue virus infection. We submit that clarity with regards to such definitions may help facilitate the delineation of the potential mechanisms of severe dengue virus infection.
journal_name
J Biomed Scijournal_title
Journal of biomedical scienceauthors
Perng GC,Chokephaibulkit Kdoi
10.1186/1423-0127-20-34subject
Has Abstractpub_date
2013-05-31 00:00:00pages
34eissn
1021-7770issn
1423-0127pii
1423-0127-20-34journal_volume
20pub_type
杂志文章abstract::While virus-like particles (VLPs) containing subgenomic replicons, which can transduce replicons into target cells efficiently for studying viral replication and vectors of gene therapy and vaccine, have been established for several flaviviruses, none has been reported for the four serotypes of dengue virus, the causa...
journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1007/s11373-007-9204-0
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journal_title:Journal of biomedical science
pub_type: 杂志文章
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abstract:BACKGROUND:Breast cancer is considered as an increasing major life-threatening concern among the malignancies encountered globally in females. Traditional therapy is far from satisfactory due to drug resistance and various side effects, thus a search for complementary/alternative medicines from natural sources with les...
journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1186/s12929-016-0257-0
更新日期:2016-04-16 00:00:00
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journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1007/s11373-007-9146-6
更新日期:2007-05-01 00:00:00
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journal_title:Journal of biomedical science
pub_type: 杂志文章,评审
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journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1186/1423-0127-16-83
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pub_type: 杂志文章
doi:10.1186/s12929-019-0529-6
更新日期:2019-05-16 00:00:00
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journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1007/s11373-008-9268-5
更新日期:2008-11-01 00:00:00
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journal_title:Journal of biomedical science
pub_type: 杂志文章,多中心研究
doi:10.1186/1423-0127-19-1
更新日期:2012-01-03 00:00:00
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journal_title:Journal of biomedical science
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doi:10.1186/1423-0127-16-38
更新日期:2009-04-03 00:00:00
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journal_title:Journal of biomedical science
pub_type: 杂志文章,评审
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更新日期:2016-12-03 00:00:00
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journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1007/BF02256588
更新日期:2002-07-01 00:00:00
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journal_title:Journal of biomedical science
pub_type: 杂志文章
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更新日期:1995-08-01 00:00:00
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journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1186/1423-0127-20-86
更新日期:2013-11-19 00:00:00
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journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1007/BF02256024
更新日期:2002-03-01 00:00:00
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journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1186/1423-0127-16-44
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:The association of functionality and phenotype of follicular helper T cells (Tfh) with dengue virus (DENV) specific antibody responses and clinical disease severity has not been well studied. METHODS:We investigated the phenotype and functionality of Tfh cells and plasmablasts in adult patients (DF = 18, DH...
journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1186/s12929-020-00641-2
更新日期:2020-04-08 00:00:00
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journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1186/s12929-014-0068-0
更新日期:2014-08-02 00:00:00
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journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1007/BF02258357
更新日期:1997-11-01 00:00:00
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journal_title:Journal of biomedical science
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更新日期:2006-11-01 00:00:00
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journal_title:Journal of biomedical science
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doi:10.1186/1423-0127-19-83
更新日期:2012-09-21 00:00:00
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journal_title:Journal of biomedical science
pub_type: 杂志文章,评审
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更新日期:2018-11-29 00:00:00
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journal_title:Journal of biomedical science
pub_type: 杂志文章
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更新日期:2000-11-01 00:00:00
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journal_title:Journal of biomedical science
pub_type: 杂志文章,评审
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更新日期:2016-03-17 00:00:00
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journal_title:Journal of biomedical science
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doi:10.1186/1423-0127-21-11
更新日期:2014-02-03 00:00:00
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journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1007/BF02255859
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND:Peroxisome proliferator activated receptor gamma (PPARG) belongs to the nuclear receptor superfamily functioning as transcription factors to regulate cellular differentiation, development and metabolism. Moreover, it has been implicated in the regulation of lipid metabolism, as well as the maturation of mono...
journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1186/s12929-020-00694-3
更新日期:2020-11-30 00:00:00
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journal_title:Journal of biomedical science
pub_type: 杂志文章,评审
doi:10.1186/1423-0127-16-10
更新日期:2009-01-19 00:00:00
abstract::The ACTGCTGA sequence (CTG motif) is located immediately upstream of the NF-kappaB enhancer in the human immunodeficiency virus type-1 (HIV-1) long terminal repeat (LTR). We previously reported on the frequent duplication of this motif in HIV-1-infected individuals. In this study we further characterized the role of t...
journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1007/BF02257981
更新日期:1994-03-01 00:00:00
abstract:BACKGROUND:Since our previous report on WHO CARDIAC Study data demonstrated that 24-hour urinary (24U) taurine (Tau) excretion was a useful biomarker of seafood (SF) intake and inversely related to the mortality rates of stroke and coronary heart diseases in the world, we determined that SF is important in the risk red...
journal_title:Journal of biomedical science
pub_type: 杂志文章
doi:10.1186/1423-0127-17-S1-S43
更新日期:2010-08-24 00:00:00