Abstract:
:Cellular ageing is characterized by the accumulation of oxidatively modified proteins which may be due to increased protein damage and/or decreased elimination of oxidized protein. Since the proteasome is in charge of protein turnover and removal of oxidized protein, its fate during ageing and upon oxidative stress has received special attention, and evidence has been provided for an age-related impairment of proteasome function. However, proteins when oxidized at the level of sulfur-containing amino acids can also be repaired. Therefore, the fate of the methionine sulfoxide reductase system during ageing has also been addressed as well as its role in protection against oxidative stress.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Friguet Bdoi
10.1016/j.febslet.2006.03.028keywords:
subject
Has Abstractpub_date
2006-05-22 00:00:00pages
2910-6issue
12eissn
0014-5793issn
1873-3468pii
S0014-5793(06)00330-9journal_volume
580pub_type
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