Abstract:
:Neurotrophins are a family of growth factors critical for the development and functioning of the nervous system. Although originally identified as neuronal survival factors, neurotrophins elicit many biological effects, ranging from proliferation to synaptic modulation to axonal pathfinding. Recent data indicate that the nature of the signaling cascades activated by neurotrophins, and the biological responses that ensue, are specified not only by the ligand itself but also by the temporal pattern and spatial location of stimulation. Studies on neurotrophin signaling have revealed variations in the Ras/MAP kinase, PI3 kinase, and phospholipase C pathways, which transmit spatial and temporal information. The anatomy of neurons makes them particularly appropriate for studying how the location and tempo of stimulation determine the signal cascades that are activated by receptor tyrosine kinases such as the Trk receptors. These signaling variations may represent a general mechanism eliciting specificity in growth factor responses.
journal_name
Annu Rev Neuroscijournal_title
Annual review of neuroscienceauthors
Segal RAdoi
10.1146/annurev.neuro.26.041002.131421keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
299-330eissn
0147-006Xissn
1545-4126pii
041002.131421journal_volume
26pub_type
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