Transcriptional codes and the control of neuronal identity.

Abstract:

:The topographic assembly of neural circuits is dependent upon the generation of specific neuronal subtypes, each subtype displaying unique properties that direct the formation of selective connections with appropriate target cells. Studies of motor neuron development in the spinal cord have begun to elucidate the molecular mechanisms involved in controlling motor projections. In this review, we first describe the actions of transcription factors within motor neuron progenitors, which initiate a cascade of transcriptional interactions that lead to motor neuron specification. We next highlight the contribution of the LIM homeodomain (LIM-HD) transcription factors in establishing motor neuron subtype identity. Importantly, it has recently been shown that the combinatorial expression of LIM-HD transcription factors, the LIM code, confers motor neuron subtypes with the ability to select specific axon pathways to reach their distinct muscle targets. Finally, the downstream targets of the LIM code are discussed, especially in the context of subtype-specific motor axon pathfinding.

journal_name

Annu Rev Neurosci

authors

Shirasaki R,Pfaff SL

doi

10.1146/annurev.neuro.25.112701.142916

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

251-81

eissn

0147-006X

issn

1545-4126

pii

112701.142916

journal_volume

25

pub_type

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