Abstract:
:The blood-brain barrier (BBB) is formed by brain capillary endothelial cells (ECs). In the late embryonic and early postnatal period, these cells respond to inducing factors found in the brain environment by adopting a set of defined characteristics, including high-electrical-resistance tight junctions. Although the factors have not been identified definitively, a great deal of information about brain ECs has been obtained, especially recently. This review concentrates on a cell biological analysis of the BBB, with an emphasis on regulation of the specialized intercellular junctions. The development of these junctions seems to depend on two primary processes: the appearance of high levels of the tight junction protein occludin and intracellular signaling processes that control the state of phosphorylation of junctional proteins. Recent studies have revealed that the BBB can be modulated in an ongoing way to respond to environmental stimuli.
journal_name
Annu Rev Neuroscijournal_title
Annual review of neuroscienceauthors
Rubin LL,Staddon JMdoi
10.1146/annurev.neuro.22.1.11keywords:
subject
Has Abstractpub_date
1999-01-01 00:00:00pages
11-28eissn
0147-006Xissn
1545-4126journal_volume
22pub_type
杂志文章,评审abstract::Long-term depression (LTD) is a lasting decrease in synaptic effectiveness that follows some types of electrical stimulation in the hippocampus. Two broad types of LTD may be distinguished. Heterosynaptic LTD can occur at synapses that are inactive, normally during high-frequency stimulation of a converging synaptic i...
journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.ne.19.030196.002253
更新日期:1996-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev-neuro-062012-170433
更新日期:2013-07-08 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.28.061604.135718
更新日期:2005-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev-neuro-070815-013913
更新日期:2016-07-08 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
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更新日期:2001-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev-neuro-072116-031548
更新日期:2017-07-25 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
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更新日期:2013-07-08 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.27.070203.144230
更新日期:2004-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
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更新日期:1998-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.25.112701.142822
更新日期:2002-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.ne.12.030189.000435
更新日期:1989-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev-neuro-112210-112917
更新日期:2011-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev-neuro-060909-153252
更新日期:2010-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.26.010302.081210
更新日期:2003-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.22.1.261
更新日期:1999-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.31.060407.125529
更新日期:2008-01-01 00:00:00
abstract::Elucidating the roles of neuronal cell types for physiology and behavior is essential for understanding brain functions. Perturbation of neuron electrical activity can be used to probe the causal relationship between neuronal cell types and behavior. New genetically encoded neuron perturbation tools have been develope...
journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev-neuro-071013-014048
更新日期:2014-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.29.051605.112851
更新日期:2008-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev-neuro-072116-031250
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
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journal_title:Annual review of neuroscience
pub_type: 杂志文章
doi:10.1146/annurev-neuro-101920-112225
更新日期:2021-01-06 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.25.112701.142916
更新日期:2002-01-01 00:00:00
abstract::Spatial normalization--applying standardized coordinates as anatomical addresses within a reference space--was introduced to human neuroimaging research nearly 30 years ago. Over these three decades, an impressive series of methodological advances have adopted, extended, and popularized this standard. Collectively, th...
journal_title:Annual review of neuroscience
pub_type: 杂志文章,meta分析
doi:10.1146/annurev-neuro-062012-170320
更新日期:2014-01-01 00:00:00
abstract::Quantitative differences are observed for most complex behavioral and pharmacological traits within any population. Both environmental and genetic influences regulate such individual differences. The mouse has proven to be a superb model in which to investigate the genetic basis for quantitative differences in complex...
journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.24.1.845
更新日期:2001-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.29.051605.112830
更新日期:2007-01-01 00:00:00
abstract::The defining neuropathological characteristics of Alzheimer's disease are abundant filamentous tau lesions and deposits of fibrillar amyloid beta peptides. Prominent filamentous tau inclusions and brain degeneration in the absence of beta-amyloid deposits are also hallmarks of neurodegenerative tauopathies exemplified...
journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.24.1.1121
更新日期:2001-01-01 00:00:00
abstract::Dendrites of neurons in the central nervous system are the principal sites for excitatory synaptic input. Although little is known about their function, two disparate perspectives have arisen to describe the activity patterns inherent to these diverse tree-like structures. Dendrites are thus considered either passive ...
journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
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更新日期:1996-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev-neuro-062012-170313
更新日期:2013-07-08 00:00:00
abstract::Medications, psychotherapy, and other treatments are effective for many patients with psychiatric disorders. However, with currently available interventions, a substantial number of patients experience incomplete resolution of symptoms, and relapse rates are high. In the search for better treatments, increasing intere...
journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev-neuro-061010-113638
更新日期:2011-01-01 00:00:00
abstract::Prion diseases are transmissible neurodegenerative conditions that include Creutzfeldt-Jakob disease (CJD) in humans and bovine spongiform encephalopathy (BSE) and scrapie in animals. Prions appear to be composed principally or entirely of abnormal isoforms of a host-encoded glycoprotein, prion protein. Prion propagat...
journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.24.1.519
更新日期:2001-01-01 00:00:00