Abstract:
:Neurons have their own systems for regulating RNA. Several multigene families encode RNA binding proteins (RNABPs) that are uniquely expressed in neurons, including the well-known neuron-specific markers ELAV and NeuN and the disease antigen NOVA. New technologies have emerged in recent years to assess the function of these proteins in vivo, and the answers are yielding insights into how and why neurons may regulate RNA in special ways-to increase cellular complexity, to localize messenger RNA (mRNA) spatially, and to regulate their expression in response to synaptic stimuli. The functions of such restricted neuronal proteins are likely to be complemented by more widely expressed RNABPs that may themselves have developed specialized functions in neurons, including Argonaute/microRNAs (miRNAs). Here we review what is known about such RNABPs and explore the potential biologic and neurologic significance of neuronal RNA regulatory systems.
journal_name
Annu Rev Neuroscijournal_title
Annual review of neuroscienceauthors
Darnell RBdoi
10.1146/annurev-neuro-062912-114322subject
Has Abstractpub_date
2013-07-08 00:00:00pages
243-70eissn
0147-006Xissn
1545-4126journal_volume
36pub_type
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