RNA protein interaction in neurons.

Abstract:

:Neurons have their own systems for regulating RNA. Several multigene families encode RNA binding proteins (RNABPs) that are uniquely expressed in neurons, including the well-known neuron-specific markers ELAV and NeuN and the disease antigen NOVA. New technologies have emerged in recent years to assess the function of these proteins in vivo, and the answers are yielding insights into how and why neurons may regulate RNA in special ways-to increase cellular complexity, to localize messenger RNA (mRNA) spatially, and to regulate their expression in response to synaptic stimuli. The functions of such restricted neuronal proteins are likely to be complemented by more widely expressed RNABPs that may themselves have developed specialized functions in neurons, including Argonaute/microRNAs (miRNAs). Here we review what is known about such RNABPs and explore the potential biologic and neurologic significance of neuronal RNA regulatory systems.

journal_name

Annu Rev Neurosci

authors

Darnell RB

doi

10.1146/annurev-neuro-062912-114322

subject

Has Abstract

pub_date

2013-07-08 00:00:00

pages

243-70

eissn

0147-006X

issn

1545-4126

journal_volume

36

pub_type

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