The neurobiology of individual differences in complex behavioral traits.

Abstract:

:Neuroimaging, especially BOLD fMRI, has begun to identify how variability in brain function contributes to individual differences in complex behavioral traits. In parallel, pharmacological fMRI and multimodal PET/fMRI are identifying how variability in molecular signaling pathways influences individual differences in brain function. Against this background, functional genetic polymorphisms are being utilized to understand the origins of variability in signaling pathways as well as to model efficiently how such emergent variability impacts behaviorally relevant brain function. This article provides an overview of a research strategy seeking to integrate these complementary technologies and utilizes existing empirical data to illustrate its effectiveness in illuminating the neurobiology of individual differences in complex behavioral traits. The article also discusses how such efforts can contribute to the identification of predictive markers that interact with environmental factors to precipitate disease and to develop more effective and individually tailored treatment regimes.

journal_name

Annu Rev Neurosci

authors

Hariri AR

doi

10.1146/annurev.neuro.051508.135335

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

225-47

eissn

0147-006X

issn

1545-4126

journal_volume

32

pub_type

杂志文章,评审
  • The specification of dorsal cell fates in the vertebrate central nervous system.

    abstract::The generation of distinct classes of neurons at defined positions within the developing vertebrate nervous system depends on inductive signals provided by local cell groups that act as organizing centers. Genetic and embryological studies have begun to elucidate the processes that control the pattern and identity of ...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.neuro.22.1.261

    authors: Lee KJ,Jessell TM

    更新日期:1999-01-01 00:00:00

  • Magnetic Strategies for Nervous System Control.

    abstract::Magnetic fields pass through tissue undiminished and without producing harmful effects, motivating their use as a wireless, minimally invasive means to control neural activity. Here, we review mechanisms and techniques coupling magnetic fields to changes in electrochemical potentials across neuronal membranes. Biologi...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-neuro-070918-050241

    authors: Christiansen MG,Senko AW,Anikeeva P

    更新日期:2019-07-08 00:00:00

  • The cell biology of the blood-brain barrier.

    abstract::The blood-brain barrier (BBB) is formed by brain capillary endothelial cells (ECs). In the late embryonic and early postnatal period, these cells respond to inducing factors found in the brain environment by adopting a set of defined characteristics, including high-electrical-resistance tight junctions. Although the f...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.neuro.22.1.11

    authors: Rubin LL,Staddon JM

    更新日期:1999-01-01 00:00:00

  • Functional and structural complexity of signal transduction via G-protein-coupled receptors.

    abstract::A prerequisite for the maintenance of homeostasis in a living organism is fine-tuned communication between different cells. The majority of extracellular signaling molecules, such as hormones and neurotransmitters, interact with a three-protein transmembrane signaling system consisting of a receptor, a G protein, and ...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.neuro.20.1.399

    authors: Gudermann T,Schöneberg T,Schultz G

    更新日期:1997-01-01 00:00:00

  • The Dynamic Basis of Respiratory Rhythm Generation: One Breath at a Time.

    abstract::Rhythmicity is a universal timing mechanism in the brain, and the rhythmogenic mechanisms are generally dynamic. This is illustrated for the neuronal control of breathing, a behavior that occurs as a one-, two-, or three-phase rhythm. Each breath is assembled stochastically, and increasing evidence suggests that each ...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-neuro-080317-061756

    authors: Ramirez JM,Baertsch NA

    更新日期:2018-07-08 00:00:00

  • How is the olfactory map formed and interpreted in the mammalian brain?

    abstract::Odor signals received by odorant receptors (ORs) expressed by olfactory sensory neurons (OSNs) in the olfactory epithelium (OE) are represented as an odor map in the olfactory bulb (OB). In the mouse, there are ~1,000 different OR species, and each OSN expresses only one functional OR gene in a monoallelic manner. Fur...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-neuro-112210-112917

    authors: Mori K,Sakano H

    更新日期:2011-01-01 00:00:00

  • Watching synaptogenesis in the adult brain.

    abstract::Although the lifelong addition of new neurons to the olfactory bulb and dentate gyrus of mammalian brains is by now an accepted fact, the function of adult-generated neurons still largely remains a mystery. The ability of new neurons to form synapses with preexisting neurons without disrupting circuit function is cent...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-neuro-060909-153252

    authors: Kelsch W,Sim S,Lois C

    更新日期:2010-01-01 00:00:00

  • The neuropsychopharmacology of fronto-executive function: monoaminergic modulation.

    abstract::We review the modulatory effects of the catecholamine neurotransmitters noradrenaline and dopamine on prefrontal cortical function. The effects of pharmacologic manipulations of these systems, sometimes in comparison with the indoleamine serotonin (5-HT), on performance on a variety of tasks that tap working memory, a...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.neuro.051508.135535

    authors: Robbins TW,Arnsten AF

    更新日期:2009-01-01 00:00:00

  • Neuromodulation and Strategic Action Choice in Drosophila Aggression.

    abstract::In this review, I discuss current knowledge and outstanding questions on the neuromodulators that influence aggressive behavior of the fruit fly Drosophila melanogaster. I first present evidence that Drosophila exchange information during an agonistic interaction and choose appropriate actions based on this informatio...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-neuro-072116-031240

    authors: Asahina K

    更新日期:2017-07-25 00:00:00

  • Genes Involved in the Development and Physiology of Both the Peripheral and Central Auditory Systems.

    abstract::The genetic approach, based on the study of inherited forms of deafness, has proven to be particularly effective for deciphering the molecular mechanisms underlying the development of the peripheral auditory system, the cochlea and its afferent auditory neurons, and how this system extracts the physical parameters of ...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-neuro-070918-050428

    authors: Michalski N,Petit C

    更新日期:2019-07-08 00:00:00

  • Zinc and brain injury.

    abstract::Zinc is an essential catalytic or structural element of many proteins, and a signaling messenger that is released by neural activity at many central excitatory synapses. Growing evidence suggests that zinc may also be a key mediator and modulator of the neuronal death associated with transient global ischemia and sust...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.neuro.21.1.347

    authors: Choi DW,Koh JY

    更新日期:1998-01-01 00:00:00

  • Quantitative genetics and mouse behavior.

    abstract::Quantitative differences are observed for most complex behavioral and pharmacological traits within any population. Both environmental and genetic influences regulate such individual differences. The mouse has proven to be a superb model in which to investigate the genetic basis for quantitative differences in complex...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.neuro.24.1.845

    authors: Wehner JM,Radcliffe RA,Bowers BJ

    更新日期:2001-01-01 00:00:00

  • The mirror-neuron system.

    abstract::A category of stimuli of great importance for primates, humans in particular, is that formed by actions done by other individuals. If we want to survive, we must understand the actions of others. Furthermore, without action understanding, social organization is impossible. In the case of humans, there is another facul...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.neuro.27.070203.144230

    authors: Rizzolatti G,Craighero L

    更新日期:2004-01-01 00:00:00

  • Structure of the adrenergic and related receptors.

    abstract::The isolation and sequencing of a number of G protein-coupled receptors has now provided extensive primary structure information for this family of homologous proteins. The diverse nature of these receptors suggests that the family of proteins may grow to include receptors for many neurotransmitters and perhaps many p...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.ne.12.030189.000435

    authors: O'Dowd BF,Lefkowitz RJ,Caron MG

    更新日期:1989-01-01 00:00:00

  • RNA protein interaction in neurons.

    abstract::Neurons have their own systems for regulating RNA. Several multigene families encode RNA binding proteins (RNABPs) that are uniquely expressed in neurons, including the well-known neuron-specific markers ELAV and NeuN and the disease antigen NOVA. New technologies have emerged in recent years to assess the function of...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-neuro-062912-114322

    authors: Darnell RB

    更新日期:2013-07-08 00:00:00

  • Catastrophic Epilepsies of Childhood.

    abstract::The tragedy of epilepsy emerges from the combination of its high prevalence, impact upon sufferers and their families, and unpredictability. Childhood epilepsies are frequently severe, presenting in infancy with pharmaco-resistant seizures; are often accompanied by debilitating neuropsychiatric and systemic comorbidit...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-neuro-072116-031250

    authors: Howard MA,Baraban SC

    更新日期:2017-07-25 00:00:00

  • The cognitive neuroscience of human memory since H.M.

    abstract::Work with patient H.M., beginning in the 1950s, established key principles about the organization of memory that inspired decades of experimental work. Since H.M., the study of human memory and its disorders has continued to yield new insights and to improve understanding of the structure and organization of memory. H...

    journal_title:Annual review of neuroscience

    pub_type: 历史文章,杂志文章,评审

    doi:10.1146/annurev-neuro-061010-113720

    authors: Squire LR,Wixted JT

    更新日期:2011-01-01 00:00:00

  • Cortical folding: when, where, how, and why?

    abstract::Why the cerebral cortex folds in some mammals but not in others has long fascinated and mystified neurobiologists. Over the past century-especially the past decade-researchers have used theory and experiment to support different folding mechanisms such as tissue buckling from mechanical stress, axon tethering, localiz...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-neuro-071714-034128

    authors: Striedter GF,Srinivasan S,Monuki ES

    更新日期:2015-07-08 00:00:00

  • Long-term depression in hippocampus.

    abstract::Long-term depression (LTD) is a lasting decrease in synaptic effectiveness that follows some types of electrical stimulation in the hippocampus. Two broad types of LTD may be distinguished. Heterosynaptic LTD can occur at synapses that are inactive, normally during high-frequency stimulation of a converging synaptic i...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.ne.19.030196.002253

    authors: Bear MF,Abraham WC

    更新日期:1996-01-01 00:00:00

  • Transcriptional codes and the control of neuronal identity.

    abstract::The topographic assembly of neural circuits is dependent upon the generation of specific neuronal subtypes, each subtype displaying unique properties that direct the formation of selective connections with appropriate target cells. Studies of motor neuron development in the spinal cord have begun to elucidate the mole...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.neuro.25.112701.142916

    authors: Shirasaki R,Pfaff SL

    更新日期:2002-01-01 00:00:00

  • Active properties of neuronal dendrites.

    abstract::Dendrites of neurons in the central nervous system are the principal sites for excitatory synaptic input. Although little is known about their function, two disparate perspectives have arisen to describe the activity patterns inherent to these diverse tree-like structures. Dendrites are thus considered either passive ...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.ne.19.030196.001121

    authors: Johnston D,Magee JC,Colbert CM,Cristie BR

    更新日期:1996-01-01 00:00:00

  • The Role of Variability in Motor Learning.

    abstract::Trial-to-trial variability in the execution of movements and motor skills is ubiquitous and widely considered to be the unwanted consequence of a noisy nervous system. However, recent studies have suggested that motor variability may also be a feature of how sensorimotor systems operate and learn. This view, rooted in...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-neuro-072116-031548

    authors: Dhawale AK,Smith MA,Ölveczky BP

    更新日期:2017-07-25 00:00:00

  • The physiology of stereopsis.

    abstract::Binocular disparity provides the visual system with information concerning the three-dimensional layout of the environment. Recent physiological studies in the primary visual cortex provide a successful account of the mechanisms by which single neurons are able to signal disparity. This work also reveals that addition...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.neuro.24.1.203

    authors: Cumming BG,DeAngelis GC

    更新日期:2001-01-01 00:00:00

  • Vestibular mechanisms.

    abstract::It is apparent from this and other reviews of the subject that our knowledge of vestibular function is most complete for the primary canal and otolithic afferents. Relatively little progress has been made in the understanding of receptor mechanisms and the functional importance of the efferent vestibular system. Since...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.ne.02.030179.001405

    authors: Precht W

    更新日期:1979-01-01 00:00:00

  • Embodied cognition and mirror neurons: a critical assessment.

    abstract::According to embodied cognition theories, higher cognitive abilities depend on the reenactment of sensory and motor representations. In the first part of this review, we critically analyze the central claims of embodied theories and argue that the existing behavioral and neuroimaging data do not allow investigators to...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-neuro-071013-013950

    authors: Caramazza A,Anzellotti S,Strnad L,Lingnau A

    更新日期:2014-01-01 00:00:00

  • Guanylyl cyclases as a family of putative odorant receptors.

    abstract::Mammals can discriminate among a large number (> 10,000) of unique odorants. The most highly supported explanation for this ability is that olfactory neurons express a large number of seven transmembrane receptors that are not spatially organized at the level of the olfactory epithelium, but whose axonal projections f...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.neuro.23.1.417

    authors: Gibson AD,Garbers DL

    更新日期:2000-01-01 00:00:00

  • Noncanonical Wnt signaling and neural polarity.

    abstract::The Wnt signaling pathway regulates multiple events in development and disease in both vertebrates and invertebrates. Recently, the noncanonical Wnt signaling cascades, those that do not signal through beta-catenin, have gained prominence for their role in the regulation of cellular polarity. It is not surprising that...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.neuro.29.051605.112933

    authors: Montcouquiol M,Crenshaw EB 3rd,Kelley MW

    更新日期:2006-01-01 00:00:00

  • Neuropeptides in identified Aplysia neurons.

    abstract::Extensive electrophysiological experiments on Aplysia neurons have resulted in an understanding of simple behaviors in terms of the activities of a single identified neurons. Beginning with the work of Kupfermann & Kandel, neuropeptides in Aplysia have become increasingly implicated as chemical agents that control or ...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.ne.08.030185.002243

    authors: Kaldany RR,Nambu JR,Scheller RH

    更新日期:1985-01-01 00:00:00

  • Synaptic Plasticity Forms and Functions.

    abstract::Synaptic plasticity, the activity-dependent change in neuronal connection strength, has long been considered an important component of learning and memory. Computational and engineering work corroborate the power of learning through the directed adjustment of connection weights. Here we review the fundamental elements...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章

    doi:10.1146/annurev-neuro-090919-022842

    authors: Magee JC,Grienberger C

    更新日期:2020-07-08 00:00:00

  • The neurobiology of the ascidian tadpole larva: recent developments in an ancient chordate.

    abstract::With little more than 330 cells, two thirds within the sensory vesicle, the CNS of the tadpole larva of the ascidian Ciona intestinalis provides us with a chordate nervous system in miniature. Neurulation, neurogenesis and its genetic bases, as well as the gene expression territories of this tiny constituency of cells...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.neuro.27.070203.144255

    authors: Meinertzhagen IA,Lemaire P,Okamura Y

    更新日期:2004-01-01 00:00:00