Abstract:
:The Wnt signaling pathway regulates multiple events in development and disease in both vertebrates and invertebrates. Recently, the noncanonical Wnt signaling cascades, those that do not signal through beta-catenin, have gained prominence for their role in the regulation of cellular polarity. It is not surprising that cellular polarization influences a number of different developmental events within the nervous system, including neurulation and neural tube closure, cellular migration, and uniform orientation of cells within an epithelial plane (planar cell polarity). In this review, we describe the differences between the canonical and noncanonical pathways, summarize recent data illustrating the roles of the noncanonical Wnt pathway in different polarizing events during neural development, and discuss the potential molecular mechanisms that underlie the generation of cellular asymmetry and polarity.
journal_name
Annu Rev Neuroscijournal_title
Annual review of neuroscienceauthors
Montcouquiol M,Crenshaw EB 3rd,Kelley MWdoi
10.1146/annurev.neuro.29.051605.112933subject
Has Abstractpub_date
2006-01-01 00:00:00pages
363-86eissn
0147-006Xissn
1545-4126journal_volume
29pub_type
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